Differential reactivity between two copper sites in Peptidylglycine α-hydroxylating monooxygenase

Journal of the American Chemical Society

Volumn 132, Issue 44, 2010, Pages 15565-15572

  Chufán, Eduardo E ^a   Prigge, Sean T ^b   Siebert, Xavier ^a   Eipper, Betty A ^c   Mains, Richard E ^c   Amzel, L Mario ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACIDS; CATALYTIC MECHANISMS; COCRYSTALLIZATION; COORDINATION SITES; COPPER IONS; COPPER SITES; ELECTRON TRANSFER; ELECTRON-TRANSFER SITES; GROWTH FACTOR; HIGH CONCENTRATION; MONOOXYGENASES; MOTHER LIQUOR; NITRITE ANION; PEPTIDE HORMONES; REDOX POTENTIALS; REDUCTANTS; RESTING STATE; SMALL MOLECULES; STEREOSPECIFIC; T-SHAPED GEOMETRY; TETRAHEDRAL GEOMETRY; WATER MOLECULE;

AMINO ACIDS; CARBON MONOXIDE; CATALYSIS; ENZYMES; HORMONES; INTERNET PROTOCOLS; KETONES; LIGANDS; METAL IONS; MOLECULES; ORGANIC ACIDS; PEPTIDES; QUANTUM CHEMISTRY; REDOX REACTIONS; SECONDARY BATTERIES;

CRYSTAL STRUCTURE;

ALPHA AMIDATING ENZYME; CARBON MONOXIDE; GLYCINE; HISTIDINE; METHIONINE; NITRITE; PEPTIDYLGLYCINE ALPHA HYDROXYLATING MONOOXYGENASE; REDOX EFFECTOR FACTOR 1; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; WATER;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME STRUCTURE; GEOMETRY; HYDROXYLATION; LIGAND BINDING; OXIDATION REDUCTION REACTION;

AZIDES; BINDING SITES; CATALYSIS; COPPER; CRYSTALLOGRAPHY, X-RAY; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; STEREOISOMERISM;

EID: 78649758579     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103117r     Document Type: Article

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