The catalytic role of the copper ligand H172 of peptidylglycine α-hydroxylating monooxygenase: A kinetic study of the H172A mutant

Biochemistry

Volumn 45, Issue 51, 2006, Pages 15419-15429

  Evans, John P ^a,c   Blackburn, Ninian J ^b   Klinman, Judith P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER BINDING; COPPER LIGANDS; PEPTIDYLGLYCINE Α-HYDROXYLATING MONOOXYGENASE (PHMCC); RATE LIMITING;

AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; COPPER; DEUTERIUM; HYDROXYLATION; KINETIC THEORY;

ENZYMES;

ALPHA AMIDATING ENZYME; COPPER; DOPAMINE BETA MONOOXYGENASE; HIPPURIC ACID; HISTIDINE; LIGAND; PEPTIDYLGLYCINE ALPHA HYDROXYLATING MONOOXYGENASE; POTASSIUM FERRICYANIDE; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; CATALYSIS; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; ENZYME KINETICS; ENZYME PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MICHAELIS CONSTANT; MUTATION; PRIORITY JOURNAL; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYSIS; CHO CELLS; COPPER; CRICETINAE; CRICETULUS; HISTIDINE; HYDROXYLATION; KINETICS; LIGANDS; MIXED FUNCTION OXYGENASES; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; OXYGEN; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 33845924482     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061734c     Document Type: Article

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