7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity

Journal of Steroid Biochemistry and Molecular Biology

Volumn 140, Issue , 2014, Pages 7-16

  Endo Umeda, Kaori ^a   Yasuda, Kaori ^b   Sugita, Kazuyuki ^c   Honda, Akira ^e   Ohta, Miho ^d   Ishikawa, Minoru ^c   Hashimoto, Yuichi ^c   Sakaki, Toshiyuki ^b   Makishima, Makoto ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d Soai University   (Japan)

^e TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

7 Dehydrocholesterol; CYP27A1; Liver X receptor; Transcription; Vitamin D receptor

Indexed keywords

22 HYDROXYCHOLESTEROL; 25 HYDROXY 7 DEHYDROCHOLESTEROL; 25 HYDROXYCHOLESTEROL; 26 27 HYDROXY 7 DEHYDROCHOLESTEROL; 7 DEHYDROCHOLESTEROL; ABC TRANSPORTER A1; CHOLESTANETRIOL 26 MONOOXYGENASE; CYTOCHROME P450; DRUG METABOLITE; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG METABOLISM; DRUG RETENTION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; SMITH LEMLI OPITZ SYNDROME; TRANSACTIVATION; XENOBIOTIC METABOLISM;

MAMMALIA;

1,25(OH)(2)D(3); 1Α,25-DIHYDROXYVITAMIN D(3); 25-HYDROXYVITAMIN D 1Α-HYDROXYLASE; 3Β-HYDROXYSTEROL-Δ(7)-REDUCTASE; 7-DEHYDROCHOLESTEROL; 7-DHC; ABCA1; ATP-BINDING CASSETTE TRANSPORTER A1; CYP27A1; CYP27B1; DHCR7; GLUTATHIONE S-TRANSFERASE; GST; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HPLC; LIVER X RECEPTOR; LXR; SIRNA; SLOS; SMALL INTERFERING RNA; SMITH-LEMLI-OPITZ SYNDROME; SREBP; STEROL 27-HYDROXYLASE; STEROL REGULATORY ELEMENT-BINDING PROTEIN; TRANSCRIPTION; VITAMIN D RECEPTOR;

CHOLESTANETRIOL 26-MONOOXYGENASE; CHOLESTEROL; DEHYDROCHOLESTEROLS; HUMANS; ORPHAN NUCLEAR RECEPTORS; RECEPTORS, CALCITRIOL;

EID: 84889816297     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.11.010     Document Type: Article

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