-
1
-
-
33749444911
-
The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms
-
Cermak R and Wolffram S (2006) The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms. Curr Drug Metab 7:729-744.
-
(2006)
Curr Drug Metab
, vol.7
, pp. 729-744
-
-
Cermak, R.1
Wolffram, S.2
-
2
-
-
0142181023
-
Human cytochrome P450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components
-
Chatterjee P and Franklin MR (2003) Human cytochrome P450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 31:1391-1397.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1391-1397
-
-
Chatterjee, P.1
Franklin, M.R.2
-
3
-
-
0022263133
-
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism
-
Distlerath LM, Reilly PE, Martin MV, Davis GG, Wilkinson GR, and Guengerich FP (1985) Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. J Biol Chem 260:9057-9067.
-
(1985)
J Biol Chem
, vol.260
, pp. 9057-9067
-
-
Distlerath, L.M.1
Reilly, P.E.2
Martin, M.V.3
Davis, G.G.4
Wilkinson, G.R.5
Guengerich, F.P.6
-
4
-
-
77049143386
-
The determination of enzyme inhibitor constants
-
Dixon M (1953) The determination of enzyme inhibitor constants. Biochem J 55:170-171.
-
(1953)
Biochem J
, vol.55
, pp. 170-171
-
-
Dixon, M.1
-
5
-
-
67651166606
-
Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway
-
Hamada N, Fujita Y, Tanaka A, Naoi M, Nozawa Y, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, and Ito M (2009) Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway. J Neural Transm 116:841-852.
-
(2009)
J Neural Transm
, vol.116
, pp. 841-852
-
-
Hamada, N.1
Fujita, Y.2
Tanaka, A.3
Naoi, M.4
Nozawa, Y.5
Ono, Y.6
Kitagawa, Y.7
Tomimori, N.8
Kiso, Y.9
Ito, M.10
-
6
-
-
0034282681
-
Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b5 in yeast
-
Hayashi K, Sakaki T, Kominami S, Inouye K, and Yabusaki Y (2000) Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b5 in yeast. Arch Biochem Biophys 381:164-170.
-
(2000)
Arch Biochem Biophys
, vol.381
, pp. 164-170
-
-
Hayashi, K.1
Sakaki, T.2
Kominami, S.3
Inouye, K.4
Yabusaki, Y.5
-
7
-
-
0026793791
-
Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis
-
Hirose N, Doi F, Ueki T, Akazawa K, Chijiiwa K, Sugano M, Akimoto K, Shimizu S, and Yamada H (1992) Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis. Anticancer Res 12:1259-1265.
-
(1992)
Anticancer Res
, vol.12
, pp. 1259-1265
-
-
Hirose, N.1
Doi, F.2
Ueki, T.3
Akazawa, K.4
Chijiiwa, K.5
Sugano, M.6
Akimoto, K.7
Shimizu, S.8
Yamada, H.9
-
8
-
-
36349028530
-
Dietary sesame seed and its lignan increase both ascorbic acid concentration in some tissues and urinary excretion by stimulating biosynthesis in rats
-
Ikeda S, Abe C, Uchida T, Ichikawa T, Horio F, and Yamashita K (2007) Dietary sesame seed and its lignan increase both ascorbic acid concentration in some tissues and urinary excretion by stimulating biosynthesis in rats. J Nutr Sci Vitaminol (Tokyo) 53:383-392.
-
(2007)
J Nutr Sci Vitaminol (Tokyo)
, vol.53
, pp. 383-392
-
-
Ikeda, S.1
Abe, C.2
Uchida, T.3
Ichikawa, T.4
Horio, F.5
Yamashita, K.6
-
9
-
-
0141863199
-
Protective effect of sesamin administration on exercise-induced lipid peroxidation
-
Ikeda T, Nishijima Y, Shibata H, Kiso Y, Ohnuki K, Fushiki T, and Moritani T (2003) Protective effect of sesamin administration on exercise-induced lipid peroxidation. Int J Sports Med 24:530-534.
-
(2003)
Int J Sports Med
, vol.24
, pp. 530-534
-
-
Ikeda, T.1
Nishijima, Y.2
Shibata, H.3
Kiso, Y.4
Ohnuki, K.5
Fushiki, T.6
Moritani, T.7
-
10
-
-
0029971798
-
Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat
-
Imaoka S, Yamada T, Hiroi T, Hayashi K, Sakaki T, Yabusaki Y, and Funae Y (1996) Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat. Biochem Pharmacol 51:1041-1050.
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 1041-1050
-
-
Imaoka, S.1
Yamada, T.2
Hiroi, T.3
Hayashi, K.4
Sakaki, T.5
Yabusaki, Y.6
Funae, Y.7
-
11
-
-
0031003669
-
Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4′-hydroxylation activities in livers of Japanese and Caucasian populations
-
Inoue K, Yamazaki H, Imiya K, Akasaka S, Guengerich FP, and Shimada T (1997) Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4′-hydroxylation activities in livers of Japanese and Caucasian populations. Pharmacogenetics 7:103-113.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 103-113
-
-
Inoue, K.1
Yamazaki, H.2
Imiya, K.3
Akasaka, S.4
Guengerich, F.P.5
Shimada, T.6
-
12
-
-
0037063385
-
Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems
-
Inouye K, Shinkyo R, Takita T, Ohta M, and Sakaki T (2002) Metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) by human cytochrome P450-dependent monooxygenase systems. J Agric Food Chem 50:5496-5502.
-
(2002)
J Agric Food Chem
, vol.50
, pp. 5496-5502
-
-
Inouye, K.1
Shinkyo, R.2
Takita, T.3
Ohta, M.4
Sakaki, T.5
-
13
-
-
0034092057
-
Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs
-
Kreth K, Kovar K, Schwab M, and Zanger UM (2000) Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs. Biochem Pharmacol 59:1563-1571.
-
(2000)
Biochem Pharmacol
, vol.59
, pp. 1563-1571
-
-
Kreth, K.1
Kovar, K.2
Schwab, M.3
Zanger, U.M.4
-
14
-
-
0025837780
-
Metabolism of methylenedioxyphenyl compounds by rabbit liver preparations. Participation of different cytochrome P450 isozymes in the demethylenation reaction
-
Kumagai Y, Wickham KA, Schmitz DA, and Cho AK (1991) Metabolism of methylenedioxyphenyl compounds by rabbit liver preparations. Participation of different cytochrome P450 isozymes in the demethylenation reaction. Biochem Pharmacol 42:1061-1067.
-
(1991)
Biochem Pharmacol
, vol.42
, pp. 1061-1067
-
-
Kumagai, Y.1
Wickham, K.A.2
Schmitz, D.A.3
Cho, A.K.4
-
15
-
-
0030774772
-
Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6
-
Lin LY, Di Stefano EW, Schmitz DA, Hsu L, Ellis SW, Lennard MS, Tucker GT, and Cho AK (1997) Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6. Drug Metab Dispos 25:1059-1064.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1059-1064
-
-
Lin, L.Y.1
Di Stefano, E.W.2
Schmitz, D.A.3
Hsu, L.4
Ellis, S.W.5
Lennard, M.S.6
Tucker, G.T.7
Cho, A.K.8
-
16
-
-
33645530876
-
Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats
-
Liu Z, Saarinen NM, and Thompson LU (2006) Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats. J Nutr 136:906-912.
-
(2006)
J Nutr
, vol.136
, pp. 906-912
-
-
Liu, Z.1
Saarinen, N.M.2
Thompson, L.U.3
-
17
-
-
0023873591
-
Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations
-
Miners JO, Smith KJ, Robson RA, McManus ME, Veronese ME, and Birkett DJ (1988) Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations. Biochem Pharmacol 37: 1137-1144.
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 1137-1144
-
-
Miners, J.O.1
Smith, K.J.2
Robson, R.A.3
McManus, M.E.4
Veronese, M.E.5
Birkett, D.J.6
-
18
-
-
0034219465
-
Sesamin and episesamin induce apoptosis in human lymphoid leukemia Molt 4B cells
-
Miyahara Y, Komiya T, Katsuzaki H, Imai K, Nakagawa M, Ishi Y, and Hibasami H (2000) Sesamin and episesamin induce apoptosis in human lymphoid leukemia Molt 4B cells. Int J Mol Med 6:43-46.
-
(2000)
Int J Mol Med
, vol.6
, pp. 43-46
-
-
Miyahara, Y.1
Komiya, T.2
Katsuzaki, H.3
Imai, K.4
Nakagawa, M.5
Ishi, Y.6
Hibasami, H.7
-
19
-
-
11244335522
-
Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus
-
Miyake Y, Fukumoto S, Okada M, Sakaida K, Nakamura Y, and Osawa T (2005) Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus. J Agric Food Chem 53:22-27.
-
(2005)
J Agric Food Chem
, vol.53
, pp. 22-27
-
-
Miyake, Y.1
Fukumoto, S.2
Okada, M.3
Sakaida, K.4
Nakamura, Y.5
Osawa, T.6
-
20
-
-
66849140882
-
Antihypertensive effects of sesamin in humans
-
Miyawaki T, Aono H, Toyoda-Ono Y, Maeda H, Kiso Y, and Moriyama K (2009) Antihypertensive effects of sesamin in humans. J Nutr Sci Vitaminol (Tokyo) 55:87-91.
-
(2009)
J Nutr Sci Vitaminol (Tokyo)
, vol.55
, pp. 87-91
-
-
Miyawaki, T.1
Aono, H.2
Toyoda-Ono, Y.3
Maeda, H.4
Kiso, Y.5
Moriyama, K.6
-
21
-
-
34247168396
-
Quantitative NMR analysis of a sesamin catechol metabolite in human urine
-
Moazzami AA, Andersson RE, and Kamal-Eldin A (2007) Quantitative NMR analysis of a sesamin catechol metabolite in human urine. J Nutr 137:940-944.
-
(2007)
J Nutr
, vol.137
, pp. 940-944
-
-
Moazzami, A.A.1
Andersson, R.E.2
Kamal-Eldin, A.3
-
22
-
-
0034232506
-
Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation
-
Murray M (2000) Mechanisms of inhibitory and regulatory effects of methylenedioxyphenyl compounds on cytochrome P450-dependent drug oxidation. Curr Drug Metab 1:67-84.
-
(2000)
Curr Drug Metab
, vol.1
, pp. 67-84
-
-
Murray, M.1
-
23
-
-
0037433528
-
Novel antioxidative metabolites in rat liver with ingested sesamin
-
Nakai M, Harada M, Nakahara K, Akimoto K, Shibata H, Miki W, and Kiso Y (2003) Novel antioxidative metabolites in rat liver with ingested sesamin. J Agric Food Chem 51:1666-1670.
-
(2003)
J Agric Food Chem
, vol.51
, pp. 1666-1670
-
-
Nakai, M.1
Harada, M.2
Nakahara, K.3
Akimoto, K.4
Shibata, H.5
Miki, W.6
Kiso, Y.7
-
24
-
-
0033377106
-
Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds
-
Nakajima M, Suzuki M, Yamaji R, Takashina H, Shimada N, Yamazaki H, and Yokoi T (1999) Isoform selective inhibition and inactivation of human cytochrome P450s by methylenedioxyphenyl compounds. Xenobiotica 29:1191-1202.
-
(1999)
Xenobiotica
, vol.29
, pp. 1191-1202
-
-
Nakajima, M.1
Suzuki, M.2
Yamaji, R.3
Takashina, H.4
Shimada, N.5
Yamazaki, H.6
Yokoi, T.7
-
25
-
-
33745272561
-
Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: Possible involvement of the metabolites in the antihypertensive effect of sesamin
-
Nakano D, Kwak CJ, Fujii K, Ikemura K, Satake A, Ohkita M, Takaoka M, Ono Y, Nakai M, Tomimori N, et al. (2006) Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: possible involvement of the metabolites in the antihypertensive effect of sesamin. J Pharmacol Exp Ther 318:328-335.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 328-335
-
-
Nakano, D.1
Kwak, C.J.2
Fujii, K.3
Ikemura, K.4
Satake, A.5
Ohkita, M.6
Takaoka, M.7
Ono, Y.8
Nakai, M.9
Tomimori, N.10
-
26
-
-
0021880264
-
Expression of rat liver cytochrome P-450MC cDNA in Saccharomyces cerevisiae
-
Oeda K, Sakaki T, and Ohkawa H (1985) Expression of rat liver cytochrome P-450MC cDNA in Saccharomyces cerevisiae. DNA 4:203-210. (Pubitemid 15027392)
-
(1985)
DNA
, vol.4
, Issue.3
, pp. 203-210
-
-
Oeda, K.1
Sakaki, T.2
Ohkawa, H.3
-
27
-
-
50449100139
-
The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties
-
Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties. J Biol Chem 239:2379-2385.
-
(1964)
J Biol Chem
, vol.239
, pp. 2379-2385
-
-
Omura, T.1
Sato, R.2
-
29
-
-
0034515216
-
Practical application of mammalian cytochrome P450
-
DOI 10.1016/S1389-1723(00)90001-X
-
Sakaki T and Inouye K (2000) Practical application of mammalian cytochrome P450. J Biosci Bioeng 90:583-590. (Pubitemid 32065988)
-
(2000)
Journal of Bioscience and Bioengineering
, vol.90
, Issue.6
, pp. 583-590
-
-
Sakaki, T.1
Inouye, K.2
-
30
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada T, Yamazaki H, Mimura M, Inui Y, and Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 270:414-423.
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
Inui, Y.4
Guengerich, F.P.5
-
31
-
-
0037067711
-
Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status
-
Sontag TJ and Parker RS (2002) Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem 277:25290-25296.
-
(2002)
J Biol Chem
, vol.277
, pp. 25290-25296
-
-
Sontag, T.J.1
Parker, R.S.2
-
32
-
-
0036179579
-
(+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: New potent and selective in vitro inhibitors of CYP2C19
-
Suzuki H, Kneller MB, Haining RL, Trager WF, and Rettie AE (2002) (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19. Drug Metab Dispos 30:235-239.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 235-239
-
-
Suzuki, H.1
Kneller, M.B.2
Haining, R.L.3
Trager, W.F.4
Rettie, A.E.5
-
33
-
-
55349149643
-
Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: Metabolic actions
-
Trattner S, Kamal-Eldin A, Brännäs E, Moazzami A, Zlabek V, Larsson P, Ruyter B, Gjøen T, and Pickova J (2008) Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. Lipids 43:989-997.
-
(2008)
Lipids
, vol.43
, pp. 989-997
-
-
Trattner, S.1
Kamal-Eldin, A.2
Brännäs, E.3
Moazzami, A.4
Zlabek, V.5
Larsson, P.6
Ruyter, B.7
Gjøen, T.8
Pickova, J.9
-
34
-
-
15244338731
-
Modulating effect of sesamin, a functional lignan in sesame seeds, on the transcription levels of lipid- and alcohol-metabolizing enzymes in rat liver: A DNA microarray study
-
Tsuruoka N, Kidokoro A, Matsumoto I, Abe K, and Kiso Y (2005) Modulating effect of sesamin, a functional lignan in sesame seeds, on the transcription levels of lipid- and alcohol-metabolizing enzymes in rat liver: a DNA microarray study. Biosci Biotechnol Biochem 69:179-188.
-
(2005)
Biosci Biotechnol Biochem
, vol.69
, pp. 179-188
-
-
Tsuruoka, N.1
Kidokoro, A.2
Matsumoto, I.3
Abe, K.4
Kiso, Y.5
-
35
-
-
0028178550
-
The demethylenation of methylenedioxymethamphetamine ("ecstasy" ) by debrisoquine hydroxylase (CYP2D6)
-
Tucker GT, Lennard MS, Ellis SW, Woods HF, Cho AK, Lin LY, Hiratsuka A, Schmitz DA, and Chu TY (1994) The demethylenation of methylenedioxymethamphetamine ("ecstasy") by debrisoquine hydroxylase (CYP2D6). Biochem Pharmacol 47:1151-1156.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 1151-1156
-
-
Tucker, G.T.1
Lennard, M.S.2
Ellis, S.W.3
Woods, H.F.4
Cho, A.K.5
Lin, L.Y.6
Hiratsuka, A.7
Schmitz, D.A.8
Chu, T.Y.9
-
36
-
-
14644439295
-
Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: Mechanism-based inhibition
-
Usia T, Watabe T, Kadota S, and Tezuka Y (2005) Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: mechanism-based inhibition. Life Sci 76:2381-2391.
-
(2005)
Life Sci
, vol.76
, pp. 2381-2391
-
-
Usia, T.1
Watabe, T.2
Kadota, S.3
Tezuka, Y.4
-
37
-
-
0018993834
-
Kinetics of suicide substrates
-
Waley SG (1980) Kinetics of suicide substrates. Biochem J 185:771-773.
-
(1980)
Biochem J
, vol.185
, pp. 771-773
-
-
Waley, S.G.1
-
38
-
-
0021875282
-
Kinetics of suicide substrates. Practical procedures for determining parameters
-
Waley SG (1985) Kinetics of suicide substrates. Practical procedures for determining parameters. Biochem J 227:843-849.
-
(1985)
Biochem J
, vol.227
, pp. 843-849
-
-
Waley, S.G.1
-
39
-
-
4644308675
-
Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4
-
Zhou S, Chan E, Lim LY, Boelsterli UA, Li SC, Wang J, Zhang Q, Huang M, and Xu A (2004) Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. Curr Drug Metab 5:415-442.
-
(2004)
Curr Drug Metab
, vol.5
, pp. 415-442
-
-
Zhou, S.1
Chan, E.2
Lim, L.Y.3
Boelsterli, U.A.4
Li, S.C.5
Wang, J.6
Zhang, Q.7
Huang, M.8
Xu, A.9
|