-
1
-
-
0035895505
-
The sequence of the human genome
-
J. C. Venter et al., The sequence of the human genome, Science 2001, 291, 1304-1351.
-
(2001)
Science
, vol.291
, pp. 1304-1351
-
-
Venter, J.C.1
-
2
-
-
21744455897
-
Ion channel screening technologies today, Drug Discovery Today: Technologies
-
G. C. Terstappen, Ion channel screening technologies today, Drug Discovery Today: Technologies 2005, 2, 133-140.
-
(2005)
, vol.2
, pp. 133-140
-
-
Terstappen, G.C.1
-
3
-
-
0037066903
-
Pharmacological properties of rat alpha7 nicotinic receptors expressed in native and recombinant cell systems
-
C. Virginio, A. Giacometti, L. Aldegheri, J. M. Rimland, G. C. Terstappen, Pharmacological properties of rat alpha7 nicotinic receptors expressed in native and recombinant cell systems, Eur. J. Pharmacol. 2002, 445, 153-161.
-
(2002)
Eur. J. Pharmacol.
, vol.445
, pp. 153-161
-
-
Virginio, C.1
Giacometti, A.2
Aldegheri, L.3
Rimland, J.M.4
Terstappen, G.C.5
-
4
-
-
0021347623
-
Catterall, Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine
-
M. Willow, E. A. Kuenzel, Catterall, Inhibition of voltage-sensitive sodium channels in neuroblastoma cells and synaptosomes by the anticonvulsant drugs diphenylhydantoin and carbamazepine, Mol. Pharm. 1984, 25, 228-234.
-
(1984)
Mol. Pharm.
, vol.25
, pp. 228-234
-
-
Willow, M.1
Kuenzel, E.A.2
-
5
-
-
0023227646
-
Effects of ryanodine and caffeine on contractility, membrane voltage, and calcium exchange in cultured heart cells
-
C. A. Rasmussen, J. L. Sutko,W. H. Barry. Effects of ryanodine and caffeine on contractility, membrane voltage, and calcium exchange in cultured heart cells, Circ Res. 1987, 60, 495-504.
-
(1987)
Circ Res.
, vol.60
, pp. 495-504
-
-
Rasmussen, C.A.1
Sutko, J.L.2
Barry, W.H.3
-
6
-
-
0021334061
-
Gamma-aminobutyric acid-gated chloride channels in cultured cerebral neurons
-
K. G. Thampy, E. M. Barnes Jr., Gamma-aminobutyric acid-gated chloride channels in cultured cerebral neurons, J. Biol. Chem. 1984, 259, 1753-1757.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 1753-1757
-
-
Thampy, K.G.1
Barnes Jr, E.M.2
-
7
-
-
0022538268
-
The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels
-
S. W. Weir, A. H. Weston, The effects of BRL 34915 and nicorandil on electrical and mechanical activity and on 86Rb efflux in rat blood vessels, Brit. J. Pharmacol. 1986, 88, 121-128.
-
(1986)
Brit. J. Pharmacol.
, vol.88
, pp. 121-128
-
-
Weir, S.W.1
Weston, A.H.2
-
8
-
-
0344222200
-
HTS approaches to voltage-gated ion channel drug discovery, Drug Discovery Today
-
J. Denyer, J. Worley, B. Cox, G. Allenby, M Banks, HTS approaches to voltage-gated ion channel drug discovery, Drug Discovery Today 1998, 3, 323-332.
-
(1998)
, vol.3
, pp. 323-332
-
-
Denyer, J.1
Worley, J.2
Cox, B.3
Allenby, G.4
Banks, M.5
-
9
-
-
0032788953
-
Measurement of calcium flux through ionotropic glutamate receptors using Cytostar-T scintillating microplates
-
A. Cushing, M. J. Price-Jones, R. Graves, A. J. Harris, K. T. Hughes, D. Bleakman, D. Lodge, Measurement of calcium flux through ionotropic glutamate receptors using Cytostar-T scintillating microplates, J. Neurosci. Methods 1999, 90, 33-36.
-
(1999)
J. Neurosci. Methods
, vol.90
, pp. 33-36
-
-
Cushing, A.1
Price-Jones, M.J.2
Graves, R.3
Harris, A.J.4
Hughes, K.T.5
Bleakman, D.6
Lodge, D.7
-
10
-
-
0036240546
-
Potassium channels: gene family, therapeutic relevance, high-throughput References 183 screening technologies and drug discovery
-
J. W. Ford, E. B. Stevens, J. M. Treherne, J. Packer, M. Bushfield, Potassium channels: gene family, therapeutic relevance, high-throughput References 183 screening technologies and drug discovery, Prog. Drug Res. 2002, 58, 133-68.
-
(2002)
Prog. Drug Res.
, vol.58
, pp. 133-168
-
-
Ford, J.W.1
Stevens, E.B.2
Treherne, J.M.3
Packer, J.4
Bushfield, M.5
-
11
-
-
0033179793
-
Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay
-
G. C. Terstappen, Functional analysis of native and recombinant ion channels using a high-capacity nonradioactive rubidium efflux assay, Anal. Biochem. 1999, 272, 149-155.
-
(1999)
Anal. Biochem.
, vol.272
, pp. 149-155
-
-
Terstappen, G.C.1
-
12
-
-
0003443746
-
Ionic Channels of Excitable Membranes
-
Sinauer Associates, Sunderland, MA
-
B. Hille, Ionic Channels of Excitable Membranes, Sinauer Associates, Sunderland, MA, 1992
-
(1992)
-
-
Hille, B.1
-
13
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
J-H. Zhang,T. D. Y. Chung, K. R. Oldenburg, A simple statistical parameter for use in evaluation and validation of high throughput screening assays, J. Biomol. Screen. 1999, 4, 67-73.
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 67-73
-
-
Zhang, J.-H.1
Chung, T.D.Y.2
Oldenburg, K.R.3
-
14
-
-
0027979245
-
Purification and reconstitution of the highconductance, calcium-activated potassium channel from tracheal smooth muscle
-
M. Garcia-Calvo, H-G. Knaus, O. B. McManus, K. M. Giangiacomo, G. Kaczorowski, M. L. Garcia, Purification and reconstitution of the highconductance, calcium-activated potassium channel from tracheal smooth muscle, J. Biol. Chem. 1994, 269, 676-682.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 676-682
-
-
Garcia-Calvo, M.1
Knaus, H.-G.2
McManus, O.B.3
Giangiacomo, K.M.4
Kaczorowski, G.5
Garcia, M.L.6
-
15
-
-
9344266364
-
Effects of channel modulators on cloned large-conductance calcium-activated potassium channels
-
V. K. Gribkoff, et al., Effects of channel modulators on cloned large-conductance calcium-activated potassium channels, Mol. Pharmacol. 1996, 50, 206-217.
-
(1996)
Mol. Pharmacol.
, vol.50
, pp. 206-217
-
-
Gribkoff, V.K.1
-
16
-
-
1842675219
-
Functional analysis of large conductance Ca2+ activated K+ channels: ion flux studies by atomic absorption spectrometry
-
A. S. Parihar, D. R. Groebe,V. E. Scott, J. Feng, X-F. Zhang, U. Warrior, M. Gopalakrishnan, C-C. Shieh, Functional analysis of large conductance Ca2+ activated K+ channels: ion flux studies by atomic absorption spectrometry, Assay Drug Dev. Technol. 2003, 1, 647-654.
-
(2003)
Assay Drug Dev. Technol.
, vol.1
, pp. 647-654
-
-
Parihar, A.S.1
Groebe, D.R.2
Scott, V.E.3
Feng, J.4
Zhang, X.-F.5
Warrior, U.6
Gopalakrishnan, M.7
Shieh, C.-C.8
-
17
-
-
0029796983
-
Small-conductance Ca2+ activated K+ channels from mammalian brain
-
M. Kohler, B. Hirschberg, C. T. Bond, J. M. Kinzie, N. V. Marrion., J. Maylie, J. P. Adelman, Small-conductance Ca2+ activated K+ channels from mammalian brain, Science 1996, 273, 1709-1714.
-
(1996)
Science
, vol.273
, pp. 1709-1714
-
-
Kohler, M.1
Hirschberg, B.2
Bond, C.T.3
Kinzie, J.M.4
Marrion, N.V.5
Maylie, J.6
Adelman, J.P.7
-
18
-
-
0032189766
-
Mechanism of Ca2+ gating in small conductance Ca2+-activated K+ channels
-
X. M. Xia, et al., Mechanism of Ca2+ gating in small conductance Ca2+-activated K+ channels, Nature 1998, 395, 503-507.
-
(1998)
Nature
, vol.395
, pp. 503-507
-
-
Xia, X.M.1
-
19
-
-
0037707635
-
The antidepressant fluoxetine blocks the human small conductance calciumactivated potassium channels SK1, SK2 and SK3
-
G. C. Terstappen, A. Pellacani, L. Aldegheri, F. Graziani, C. Carignani, G. Pula, C. Virginio, The antidepressant fluoxetine blocks the human small conductance calciumactivated potassium channels SK1, SK2 and SK3, Neuroscience Lett. 2003, 346, 85-88.
-
(2003)
Neuroscience Lett.
, vol.346
, pp. 85-88
-
-
Terstappen, G.C.1
Pellacani, A.2
Aldegheri, L.3
Graziani, F.4
Carignani, C.5
Pula, G.6
Virginio, C.7
-
20
-
-
0037829355
-
A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectroscopy
-
C. W. Scott, D. E. Wilkins, S. Trivedi, D. J. Crankshaw, A medium-throughput functional assay of KCNQ2 potassium channels using rubidium efflux and atomic absorption spectroscopy, Anal. Biochem. 2003, 319, 251-257.
-
(2003)
Anal. Biochem.
, vol.319
, pp. 251-257
-
-
Scott, C.W.1
Wilkins, D.E.2
Trivedi, S.3
Crankshaw, D.J.4
-
21
-
-
10244239414
-
Validation of an atomic absorption rubidium ion efflux assay for KCNQ/M-channels using the Ion Channel Reader 8000
-
K. Wang, et al.,Validation of an atomic absorption rubidium ion efflux assay for KCNQ/M-channels using the Ion Channel Reader 8000, Assay Drug Dev. Technol. 2004, 2, 525-534.
-
(2004)
Assay Drug Dev. Technol.
, vol.2
, pp. 525-534
-
-
Wang, K.1
-
22
-
-
0035337145
-
HERK K+ channels: friend and foe
-
J. I. Vandenberg, B. W. Walker,T. J. Campbell, HERK K+ channels: friend and foe. Trends Pharmacol. Sci. 2001, 22, 240-246.
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, pp. 240-246
-
-
Vandenberg, J.I.1
Walker, B.W.2
Campbell, T.J.3
-
23
-
-
0034752849
-
Development and evaluation of high throughput functional assay methods for hERG potassium channel
-
W. Tang, J. Kang, X. Wu, D. Rampe, L. Wang, H. Shen, Z. Li, D. Dunnington, T. Garyantes, Development and evaluation of high throughput functional assay methods for hERG potassium channel, J. Biomol. Screen. 2001, 6, 325-331.
-
(2001)
J. Biomol. Screen.
, vol.6
, pp. 325-331
-
-
Tang, W.1
Kang, J.2
Wu, X.3
Rampe, D.4
Wang, L.5
Shen, H.6
Li, Z.7
Dunnington, D.8
Garyantes, T.9
-
24
-
-
10244264820
-
Atomic absorption spectroscopy in ion channel screening
-
L. Stankovich, D. Wicks, S. Despotovski, D. Liang, Atomic absorption spectroscopy in ion channel screening, Assay Drug Dev. Technol. 2004, 2, 569-574.
-
(2004)
Assay Drug Dev. Technol.
, vol.2
, pp. 569-574
-
-
Stankovich, L.1
Wicks, D.2
Despotovski, S.3
Liang, D.4
-
25
-
-
10244237790
-
Nonradioactive Rb+ efflux assay and its applications in drug discovery and development
-
G. C. Terstappen, Nonradioactive Rb+ efflux assay and its applications in drug discovery and development, Assay Drug Dev. Technol. 2004, 2, 553-559.
-
(2004)
Assay Drug Dev. Technol.
, vol.2
, pp. 553-559
-
-
Terstappen, G.C.1
-
26
-
-
0027027517
-
Molecular properties of the sodium channel: a receptor for multiple neurotoxins
-
W. A. Catterall,V. Trainer, D. G. Baden, Molecular properties of the sodium channel: a receptor for multiple neurotoxins, Bull. Soc. Path. Exp. 1992, 85, 481-485.
-
(1992)
Bull. Soc. Path. Exp.
, vol.85
, pp. 481-485
-
-
Catterall, W.A.1
Trainer, V.2
Baden, D.G.3
-
27
-
-
0029045608
-
Structure-activity relationship of glibenclamide analogs: A comparison of potency as levcromakalim antagonists in rat aorta vs. affinity for [3H]-glibenclamide binding to membranes from rat cerebral cortex
-
J. L. Challinor-Rogers, D. C. Kong, M. N. Iskander, G. A. McPherson, Structure-activity relationship of glibenclamide analogs: A comparison of potency as levcromakalim antagonists in rat aorta vs. affinity for [3H]-glibenclamide binding to membranes from rat cerebral cortex, J. Pharmacol. Exp. Ther. 1995, 273, 778-86.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.273
, pp. 778-786
-
-
Challinor-Rogers, J.L.1
Kong, D.C.2
Iskander, M.N.3
McPherson, G.A.4
-
28
-
-
0035955293
-
[3H]-Dofetilide binding to HERK in transfected membranes: A potential high throughput preclinical screen
-
K. Finlayson, L. Turnbull, C. T. January, J. Sharkey, J. S. Kelly, [3H]-Dofetilide binding to HERK in transfected membranes: A potential high throughput preclinical screen, Eur. J. Pharmacol. 2001, 430, 147-148.
-
(2001)
Eur. J. Pharmacol.
, vol.430
, pp. 147-148
-
-
Finlayson, K.1
Turnbull, L.2
January, C.T.3
Sharkey, J.4
Kelly, J.S.5
-
29
-
-
0027138551
-
Radioligand binding methods: practical guide and tips
-
D. B. Bylund, M. L. Toews, Radioligand binding methods: practical guide and tips, Am. J. Physiol. 1993, 265, L421-429.
-
(1993)
Am. J. Physiol.
, vol.265
-
-
Bylund, D.B.1
Toews, M.L.2
-
30
-
-
0015861774
-
Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
-
R. Cheng, G. Prusoff, Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction, Biochem. Pharmacol. 1973, 22, 3099-4006.
-
(1973)
Biochem. Pharmacol.
, vol.22
, pp. 3099-4006
-
-
Cheng, R.1
Prusoff, G.2
-
31
-
-
0000885268
-
Scintillation proximity assay: a versatile high-throughput screening technology
-
N. D. Cook, Scintillation proximity assay: a versatile high-throughput screening technology, Drug Discovery Today 1996, 1, 287-294.
-
(1996)
Drug Discovery Today
, vol.1
, pp. 287-294
-
-
Cook, N.D.1
-
32
-
-
0032943217
-
High throughput scintillation proximity assay for the identification of FKBP-12 ligands
-
F. Graziani, A. Aldegheri, G. C. Terstappen, High throughput scintillation proximity assay for the identification of FKBP-12 ligands, J. Biomol. Screen. 1999, 4, 3-7.
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 3-7
-
-
Graziani, F.1
Aldegheri, A.2
Terstappen, G.C.3
-
33
-
-
0014844688
-
Fluorescence polarization in immunochemistry
-
W. B. Dandliker,V. A. de Saussure, Fluorescence polarization in immunochemistry, Immunochemistry 1970, 7, 799-828.
-
(1970)
Immunochemistry
, vol.7
, pp. 799-828
-
-
Dandliker, W.B.1
De Saussure, V.A.2
-
34
-
-
0001301977
-
Polarisation de la lumière de fluorescence
-
P. Perrin, Polarisation De La Lumière de fluorescence, J. Phys. Radium 1926, 7, 390-401.
-
(1926)
J. Phys. Radium
, vol.7
, pp. 390-401
-
-
Perrin, P.1
-
35
-
-
0034054237
-
High throughput fluorescence polarization: a homogeneous alternative to radioligand binding for cell surface receptors
-
M. Allen, J. Reeves, G. Mellor, High throughput fluorescence polarization: a homogeneous alternative to radioligand binding for cell surface receptors, J. Biomol. Screen. 2000, 5, 63-69.
-
(2000)
J. Biomol. Screen.
, vol.5
, pp. 63-69
-
-
Allen, M.1
Reeves, J.2
Mellor, G.3
-
36
-
-
0031570739
-
A high throughput STAT binding assay using fluorescence polarization
-
P. Wu, M. Brasseur,W. Schindler, A high throughput STAT binding assay using fluorescence polarization, Anal. Biochem. 1997, 249, 29-36.
-
(1997)
Anal. Biochem.
, vol.249
, pp. 29-36
-
-
Wu, P.1
Brasseur, M.2
Schindler, W.3
-
38
-
-
0035933830
-
Cav1.3 subunits can form L-type calcium channels activating at negative voltages
-
A. Koschak, D. Reimer, I. Huber, M. Grabner, H. Glossmann, J. Engel, J. Striessnig, Cav1.3 subunits can form L-type calcium channels activating at negative voltages, J. Biol. Chem. 2001, 276, 22100-22106.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22100-22106
-
-
Koschak, A.1
Reimer, D.2
Huber, I.3
Grabner, M.4
Glossmann, H.5
Engel, J.6
Striessnig, J.7
-
39
-
-
0037432666
-
High-affinity binding of [3H]-DTZ323 to the diltiazem-binding site of L-type Ca2+ channels
-
M. Hagiwara, S. Adachi-Akahne, T. Nagao, High-affinity binding of [3H]-DTZ323 to the diltiazem-binding site of L-type Ca2+ channels, Eur. J. Pharmacol. 2003, 466, 63-71.
-
(2003)
Eur. J. Pharmacol.
, vol.466
, pp. 63-71
-
-
Hagiwara, M.1
Adachi-Akahne, S.2
Nagao, T.3
-
40
-
-
0026750523
-
Structure and functional expression of an conotoxin-sensitive human N-type calcium channel
-
M. E. Williams, et al., Structure and functional expression of an conotoxin-sensitive human N-type calcium channel, Science 1992, 257, 389-395.
-
(1992)
Science
, vol.257
, pp. 389-395
-
-
Williams, M.E.1
-
41
-
-
0035807854
-
A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity
-
P. Favreau, et al., A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity, Biochemistry 2001, 40, 14567-14575.
-
(2001)
Biochemistry
, vol.40
, pp. 14567-14575
-
-
Favreau, P.1
-
42
-
-
0034634580
-
Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes
-
R. J. Lewis, et al., Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes, J. Biol. Chem. 2000, 275, 35335-35344.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 35335-35344
-
-
Lewis, R.J.1
-
43
-
-
0026531498
-
Efficient expression of rat brain type IIA Na+ channel subunits in a somatic cell line
-
J. W. West,T. Scheuer, L. Maechler, W. A. Catterall, Efficient expression of rat brain type IIA Na+ channel subunits in a somatic cell line, Neuron 1992, 8, 59-70.
-
(1992)
Neuron
, vol.8
, pp. 59-70
-
-
West, J.W.1
Scheuer, T.2
Maechler, L.3
Catterall, W.A.4
-
44
-
-
0030037704
-
Molecular determinants of high affinity binding of ù-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel subunit
-
J. C. Rogers,Y. Qu,T. N. Tanada, T. Scheuer,W. A. Catterall, Molecular determinants of high affinity binding of ù-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the Na+ channel subunit, J. Biol. Chem. 1996, 271, 15950-15962.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15950-15962
-
-
Rogers, J.C.1
Qu, Y.2
Tanada, T.N.3
Scheuer, T.4
Catterall, W.A.5
-
45
-
-
0032191111
-
Voltage sensor-trapping: enhanced activation of sodium channels by scorpion toxin bound to the S3-S4 loop in domain II
-
S. Cestèle,Y. Qu, J. C. Rogers, H. Rochat,T. Scheuer,W. A. Catterall, Voltage sensor-trapping: enhanced activation of sodium channels by scorpion toxin bound to the S3-S4 loop in domain II, Neuron 1998, 21, 919-931.
-
(1998)
Neuron
, vol.21
, pp. 919-931
-
-
Cestèle, S.1
Qu, Y.2
Rogers, J.C.3
Rochat, H.4
Scheuer, T.5
Catterall, W.A.6
-
46
-
-
0022929642
-
Binding of [3H]-batrachotoxinin A benzoate to specific sites on rat cardiac sodium channels
-
R. S. Sheldon, N. J. Cannon, H. J. Duff, Binding of [3H]-batrachotoxinin A benzoate to specific sites on rat cardiac sodium channels, Mol. Pharmacol. 1986, 30, 617-623.
-
(1986)
Mol. Pharmacol.
, vol.30
, pp. 617-623
-
-
Sheldon, R.S.1
Cannon, N.J.2
Duff, H.J.3
-
47
-
-
0025781292
-
Cyclic AMP-dependent regulation of the number of [3H]-batrachotoxinin benzoate binding sites on rat cardiac myocytes
-
M. Taouis, R. S. Sheldon, R. J. Hill, H. J. Duff, Cyclic AMP-dependent regulation of the number of [3H]-batrachotoxinin benzoate binding sites on rat cardiac myocytes, J. Biol. Chem. 1991, 266, 10300-10304.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 10300-10304
-
-
Taouis, M.1
Sheldon, R.S.2
Hill, R.J.3
Duff, H.J.4
-
48
-
-
3342986579
-
Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays
-
A. J. Bourdelais, S. Campbell, H. Jacocks, J. Naar, J. L. Wright, J. Carsi, D. G. Baden, Brevenal is a natural inhibitor of brevetoxin action in sodium channel receptor binding assays, Cell. Mol. Neurobiol. 2004, 24, 553-63.
-
(2004)
Cell. Mol. Neurobiol.
, vol.24
, pp. 553-563
-
-
Bourdelais, A.J.1
Campbell, S.2
Jacocks, H.3
Naar, J.4
Wright, J.L.5
Carsi, J.6
Baden, D.G.7
-
49
-
-
0034614571
-
Binding properties of [3H]-PbTx-3 and [3H]-saxitoxin to brain membranes and to skeletal muscle References 185 membranes of puffer fish Fugu pardalis and the primary structure of a voltagegated Na+ channel alpha-subunit (fMNa1) from skeletal muscle of F. pardalis
-
M. Yotsu-Yamashita, K. Nishimori, Y. Nitanai, M. Isemura, A. Sugimoto, T. Yasumoto, Binding properties of [3H]-PbTx-3 and [3H]-saxitoxin to brain membranes and to skeletal muscle References 185 membranes of puffer fish Fugu pardalis and the primary structure of a voltagegated Na+ channel alpha-subunit (fMNa1) from skeletal muscle of F. pardalis, Biochem. Biophys. Res. Commun., 2000, 267, 403-412.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.267
, pp. 403-412
-
-
Yotsu-Yamashita, M.1
Nishimori, K.2
Nitanai, Y.3
Isemura, M.4
Sugimoto, A.5
Yasumoto, T.6
-
50
-
-
0033593015
-
Recreation of neuronal Kv1 channel oligomers by expression in mammalian cells using Semliki Forest virus
-
O. Shamotienko, S. Akhtar, C. Sidera, F. A. Meunier, B. Ink, M. Weir, J. O. Dolly, Recreation of neuronal Kv1 channel oligomers by expression in mammalian cells using Semliki Forest virus, Biochemistry 1999, 38, 16766-16776.
-
(1999)
Biochemistry
, vol.38
, pp. 16766-16776
-
-
Shamotienko, O.1
Akhtar, S.2
Sidera, C.3
Meunier, F.A.4
Ink, B.5
Weir, M.6
Dolly, J.O.7
-
51
-
-
0037040249
-
Characterization of a novel radiolabeled peptide selective for a subpopulation of voltagegated potassium channels in mammalian brain
-
J. Racape, A. Lecoq, R. Romi-Lebrun, J. Liu, M. Kohler, M. L. Garcia, A. Menez, S. Gasparini, Characterization of a novel radiolabeled peptide selective for a subpopulation of voltagegated potassium channels in mammalian brain, J. Biol. Chem. 2002, 277, 3886-3893.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3886-3893
-
-
Racape, J.1
Lecoq, A.2
Romi-Lebrun, R.3
Liu, J.4
Kohler, M.5
Garcia, M.L.6
Menez, A.7
Gasparini, S.8
-
52
-
-
3843149422
-
Validation of a [3H]-astemizole binding assay in HEK293 cells expressing HERG K+ channels
-
P. J. Chiu, et al.,Validation of a [3H]-astemizole binding assay in HEK293 cells expressing HERG K+ channels, J. Pharmacol. Sci. 2004, 95, 311-319.
-
(2004)
J. Pharmacol. Sci.
, vol.95
, pp. 311-319
-
-
Chiu, P.J.1
-
53
-
-
0035793207
-
[3H]-dofetilide binding in SHSY5Yand HEK293 cells expressing a HERG-like K+ channel
-
K. Finlayson, A. J. Pennington, J. S. Kelly, [3H]-dofetilide binding in SHSY5Yand HEK293 cells expressing a HERG-like K+ channel, Eur. J. Pharmacol. 2001, 412, 203-212.
-
(2001)
Eur. J. Pharmacol.
, vol.412
, pp. 203-212
-
-
Finlayson, K.1
Pennington, A.J.2
Kelly, J.S.3
-
54
-
-
0038237023
-
[125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding
-
R. Davis-Taber, et al., [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding, Mol. Pharmacol. 2003, 64, 143-153.
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 143-153
-
-
Davis-Taber, R.1
-
55
-
-
0034980730
-
Synthesis and characterization of a novel tritiated KATP channel opener with a benzopyran structure
-
P. W. Manley, C. Loffler-Walz, U. Russ, A. Hambrock,T. Moenius, U. Quast, Synthesis and characterization of a novel tritiated KATP channel opener with a benzopyran structure, Br. J. Pharmacol. 2001,133, 275-85.
-
(2001)
Br. J. Pharmacol.
, vol.133
, pp. 275-285
-
-
Manley, P.W.1
Loffler-Walz, C.2
Russ, U.3
Hambrock, A.4
Moenius, T.5
Quast, U.6
-
56
-
-
0032569024
-
The beta subunit of the high conductance calcium-activated potassium channel
-
Identification of residues involved in charybdotoxin binding
-
M. Hanner, R. Vianna-Jorge, A. Kamassah.,W. A. Schmalhofer, H. G. Knaus, G. J. Kaczorowski, M. L. Garcia, The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding, J. Biol. Chem. 1998, 273, 16289-16296.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16289-16296
-
-
Hanner, M.1
Vianna-Jorge, R.2
Kamassah, A.3
Schmalhofer, W.A.4
Knaus, H.G.5
Kaczorowski, G.J.6
Garcia, M.L.7
-
57
-
-
0030614898
-
Biochemistry
-
[125I]-Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels
-
A. Koschak, R. O. Koch, J. Liu, G. J. Kaczorowski, P. H. Reinhart, M. L. Garcia, H. G. Knaus, [125I]-Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels, Biochemistry 1997, 36, 1943-1952.
-
(1997)
, vol.36
, pp. 1943-1952
-
-
Koschak, A.1
Koch, R.O.2
Liu, J.3
Kaczorowski, G.J.4
Reinhart, P.H.5
Garcia, M.L.6
Knaus, H.G.7
-
58
-
-
0036153730
-
Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener
-
D. O. Kiesewetter, E. M. Jagoda, J. E. Starrett Jr,V. K. Gribkoff, P. Hewawasam, N. Srinivas, D. Salazar,W. C. Eckelman, Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener, Nucl. Med. Biol. 2002, 29, 55-59.
-
(2002)
Nucl. Med. Biol.
, vol.29
, pp. 55-59
-
-
Kiesewetter, D.O.1
Jagoda, E.M.2
Starrett Jr, J.E.3
Gribkoff, V.K.4
Hewawasam, P.5
Srinivas, N.6
Salazar, D.7
Eckelman, W.C.8
-
59
-
-
0020024563
-
Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes
-
M. Hugues, D. Duval, P. Kitabgi, M. Lazdunski, J. P. Vincent, Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes, J. Biol. Chem. 1982, 257, 2762-2769.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 2762-2769
-
-
Hugues, M.1
Duval, D.2
Kitabgi, P.3
Lazdunski, M.4
Vincent, J.P.5
-
60
-
-
0028281222
-
Nicotinic receptor binding of [3H]cytisine, [3H]-nicotine and [3H]-methylcarbamylcholine in rat brain
-
D. J. Anderson, S.P Arneric, Nicotinic receptor binding of [3H]cytisine, [3H]-nicotine and [3H]-methylcarbamylcholine in rat brain, Eur. J. Pharmacol. 1994, 253, 261-267.
-
(1994)
Eur. J. Pharmacol.
, vol.253
, pp. 261-267
-
-
Anderson, D.J.1
Arneric, S.P.2
-
61
-
-
0033519593
-
High affinity binding of [3H]-epibatidine to rat brain membranes
-
D. Gnadisch, E. D. London, P. Terry, G. R. Hill, A. G. Mukhin, High affinity binding of [3H]-epibatidine to rat brain membranes, Neuroreport 1999, 10, 1631-1636.
-
(1999)
Neuroreport
, vol.10
, pp. 1631-1636
-
-
Gnadisch, D.1
London, E.D.2
Terry, P.3
Hill, G.R.4
Mukhin, A.G.5
-
62
-
-
0034719376
-
Synthesis and pharmacological characterization of [125I]-iodomethyllycaconitine ([125I]-iodo-MLA)
-
A new ligand for the alpha 7 nicotinic acetylcholine receptor
-
H. A. Navarro, D. Zhong, P. Abraham, H. Xu, F. I. Carroll, Synthesis and pharmacological characterization of [125I]-iodomethyllycaconitine ([125I]-iodo-MLA). A new ligand for the alpha 7 nicotinic acetylcholine receptor, J. Med. Chem. 2000, 43, 142-145.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 142-145
-
-
Navarro, H.A.1
Zhong, D.2
Abraham, P.3
Xu, H.4
Carroll, F.I.5
-
63
-
-
0038746854
-
Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel
-
Structureactivity relationship studies using adamantane derivatives
-
H. R. Arias, J. R. Trudell, E. Z. Bayer, B. Hester, E. A. McCardy, M. P. Blanton, Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structureactivity relationship studies using adamantane derivatives, Biochemistry 2003, 42, 7358-7370.
-
(2003)
Biochemistry
, vol.42
, pp. 7358-7370
-
-
Arias, H.R.1
Trudell, J.R.2
Bayer, E.Z.3
Hester, B.4
McCardy, E.A.5
Blanton, M.P.6
-
64
-
-
0034595438
-
Modulation of [3H]-MK-801 binding to NMDA receptors in vivo and in vitro
-
F. Murray, J. Kennedy, P. H. Hutson, J. Elliot, I. Huscroft, K. Mohnen, M. G. Russell, S. Grimwood, Modulation of [3H]-MK-801 binding to NMDA receptors in vivo and in vitro, Eur. J. Pharmacol. 2000, 397, 263-270.
-
(2000)
Eur. J. Pharmacol.
, vol.397
, pp. 263-270
-
-
Murray, F.1
Kennedy, J.2
Hutson, P.H.3
Elliot, J.4
Huscroft, I.5
Mohnen, K.6
Russell, M.G.7
Grimwood, S.8
-
65
-
-
0035026740
-
Synthesis and receptor 186 7 Ion Flux and Ligand Binding Assays for Analysis of Ion Channels binding affinity of new selective GluR5 ligands
-
L. Bunch,T. H. Johansen, H. Brauner-Osborne,T. B. Stensbol,T. N. Johansen, P. Krogsgaard-Larsen, U. Madsen, Synthesis and receptor 186 7 Ion Flux and Ligand Binding Assays for Analysis of Ion Channels binding affinity of new selective GluR5 ligands, Bioorg. Med. Chem. 2001, 9, 875-879.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 875-879
-
-
Bunch, L.1
Johansen, T.H.2
Brauner-Osborne, H.3
Stensbol, T.B.4
Johansen, T.N.5
Krogsgaard-Larsen, P.6
Madsen, U.7
-
66
-
-
0034983804
-
Binding of an AMPA receptor potentiator ([3H]-LY395153) to native and recombinant AMPA receptors
-
A. M. Linden, H. Yu, H. Zarrinmayeh, W. J. Wheeler, P. Skolnick, Binding of an AMPA receptor potentiator ([3H]-LY395153) to native and recombinant AMPA receptors, Neuropharmacology 2001, 40, 1010-1018.
-
(2001)
Neuropharmacology
, vol.40
, pp. 1010-1018
-
-
Linden, A.M.1
Yu, H.2
Zarrinmayeh, H.3
Wheeler, W.J.4
Skolnick, P.5
-
67
-
-
0031813524
-
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain
-
V. Mutel, et al., Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain, J. Neurochem. 1998, 71, 418-426.
-
(1998)
J. Neurochem.
, vol.71
, pp. 418-426
-
-
Mutel, V.1
-
68
-
-
0033237379
-
High-affinity [3H] kainic acid binding to brain membranes: a reevaluation of ligand potency and selectivity
-
N. Crawford,T. K. Lang, D. S. Kerr, D. J. de Vries, High-affinity [3H] kainic acid binding to brain membranes: a reevaluation of ligand potency and selectivity, J. Pharmacol. Toxicol. Methods 1999, 42, 121-125.
-
(1999)
J. Pharmacol. Toxicol. Methods
, vol.42
, pp. 121-125
-
-
Crawford, N.1
Lang, T.K.2
Kerr, D.S.3
De Vries, D.J.4
-
69
-
-
0029828571
-
J. Neurochem.
-
Pharmacology and regional distribution of the binding of 6-[3H]-nitro-7-sulphamoylbenzo[ f ]-quinoxaline-2,3-dione to rat brain
-
K. K. Dev,V. Petersen,T. Honore, J. M. Henley, Pharmacology and regional distribution of the binding of 6-[3H]-nitro-7-sulphamoylbenzo[ f ]-quinoxaline-2,3-dione to rat brain, J. Neurochem. 1996, 67, 2609-2612.
-
(1996)
, vol.67
, pp. 2609-2612
-
-
Dev, K.K.1
Petersen, V.2
Honore, T.3
Henley, J.M.4
-
70
-
-
0034117171
-
Neurochem. Res.
-
Compounds extracted from Phyllantus and Jatropha elliptica inhibit the binding of [3H]-glutamate and [3H]-GMP-PNP in rat cerebral cortex membrane
-
L. H. Martini, C. R. Souza, P. B. Marques, J. B. Calixto, R. A. Yunes, D. O. Souza, Compounds extracted from Phyllantus and Jatropha elliptica inhibit the binding of [3H]-glutamate and [3H]-GMP-PNP in rat cerebral cortex membrane, Neurochem. Res. 2000, 25, 211-215.
-
(2000)
, vol.25
, pp. 211-215
-
-
Martini, L.H.1
Souza, C.R.2
Marques, P.B.3
Calixto, J.B.4
Yunes, R.A.5
Souza, D.O.6
-
71
-
-
0026924338
-
Eur. J. Pharmacol.
-
Modulation of [3H]3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP) binding by ligands acting at the glycine and the polyamine sites of the rat brain NMDA receptor complex
-
R. H. Porter, R. S. Briggs, P. J. Roberts, Modulation of [3H]3-((+-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid ([3H]CPP) binding by ligands acting at the glycine and the polyamine sites of the rat brain NMDA receptor complex, Eur. J. Pharmacol. 1992, 227, 83-88.
-
(1992)
, vol.227
, pp. 83-88
-
-
Porter, R.H.1
Briggs, R.S.2
Roberts, P.J.3
-
72
-
-
0030610083
-
Br. J. Pharmacol.
-
Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for GABA-gated chloride channels of insects and vertebrates
-
J. J. Rauh, et al., Effects of [3H]-BIDN, a novel bicyclic dinitrile radioligand for GABA-gated chloride channels of insects and vertebrates, Br. J. Pharmacol. 1997, 121, 1496-1505.
-
(1997)
, vol.121
, pp. 1496-1505
-
-
Rauh, J.J.1
-
73
-
-
6344265096
-
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor
-
S. K. Sullivan, R. E. Petroski, G. Verge, R. S. Gross, A. C. Foster, D. E. Grigoriadis, Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor, J. Pharmacol. Exp. Ther. 2004, 311, 537-546.
-
(2004)
, vol.311
, pp. 537-546
-
-
Sullivan, S.K.1
Petroski, R.E.2
Verge, G.3
Gross, R.S.4
Foster, A.C.5
Grigoriadis, D.E.6
-
74
-
-
0030610871
-
Neuropharmacology
-
Radioligand binding and photoaffinity labelling studies show a direct interaction of phenothiazines at 5-HT3 receptors
-
S. C. Lummis, J. Baker, Radioligand binding and photoaffinity labelling studies show a direct interaction of phenothiazines at 5-HT3 receptors, Neuropharmacology 1997, 36, 665-70.
-
(1997)
, vol.36
, pp. 665-670
-
-
Lummis, S.C.1
Baker, J.2
-
75
-
-
0026536645
-
Proc. Natl. Acad. Sci.
-
Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site, USA
-
R. J. Vandenberg, C. R. French, P. H. Barry, J. Shine, P. R. Schofield, Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site, Proc. Natl. Acad. Sci. USA. 1992, 89, 1765-1769.
-
(1992)
, vol.89
, pp. 1765-1769
-
-
Vandenberg, R.J.1
French, C.R.2
Barry, P.H.3
Shine, J.4
Schofield, P.R.5
|