The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3

Neuroscience Letters

Volumn 346, Issue 1-2, 2003, Pages 85-88

  Terstappen, Georg C ^a,b   Pellacani, Annalisa ^a   Aldegheri, Laura ^a   Graziani, Francesca ^a   Carignani, Corrado ^a   Pula, Giordano ^c   Virginio, Caterina ^a  

^a GSK   (Italy)

^b Discovery Research   (Italy)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

bis (1,3 Dibutylbarbituric acid)trimethine oxonol; Fluoxetine; HEK 293; Neuropsychiatric disorders; SK channels; Small conductance calcium activated potassium channel; TE 671; 125I Apamin binding

Indexed keywords

ALCOHOL DERIVATIVE; ANTIDEPRESSANT AGENT; APAMIN; BIS(1,3 DIBUTYLBARBITURIC ACID)TRIMETHINE OXONOL; CALCIUM ACTIVATED POTASSIUM CHANNEL; FLUOXETINE; IODINE 125; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IC 50; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL;

EID: 0037707635     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(03)00574-3     Document Type: Article

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