Noncompetitive antagonist binding sites in the Torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives

Biochemistry

Volumn 42, Issue 24, 2003, Pages 7358-7370

  Arias, Hugo R ^a   Trudell, James R ^c   Bayer, Erin Z ^b   Hester, Brent ^b   McCardy, Elizabeth A ^b   Blanton, Michael P ^b  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; HYDROPHOBICITY; THERMODYNAMICS;

ION CHANNELS;

BIOCHEMISTRY;

2 ADAMANTANAMINE; 3 (TRIFLUOROMETHYL) 3 (3 IODOPHENYL)DIAZIRINE; ADAMANTANE; ADAMANTANE DERIVATIVE; ADAMANTANEMETHYLAMINE; ADAMANTHYLETHYLAMINE; ADAMANTYLPYRIDINIUM; AMANTADINE; AMOBARBITAL; AZIDOADAMANTANE; BARBITURIC ACID; CARBON 14; ETHIDIUM; IODINE 125; ION CHANNEL; MEMANTINE; N [1 (2 THIENYL)CYCLOHEXYL] 3,4 PIPERIDINE; NICOTINIC RECEPTOR BLOCKING AGENT; PHENCYCLIDINE DERIVATIVE; TETRACAINE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; BINDING SITE; CHANNEL GATING; DRUG BINDING SITE; DRUG STRUCTURE; HYDROPHOBICITY; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERMODYNAMICS; TORPEDO;

ADAMANTANE; ALLOSTERIC SITE; ANESTHETICS, LOCAL; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; EXCITATORY AMINO ACID ANTAGONISTS; IODINE ISOTOPES; ION CHANNELS; MODELS, MOLECULAR; NICOTINIC ANTAGONISTS; PHENCYCLIDINE; PROTEIN BINDING; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TORPEDO; TRITIUM;

TORPEDO; VIOLA (ANGIOSPERM);

EID: 0038746854     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034052n     Document Type: Article

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