Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling

Cell Metabolism

Volumn 18, Issue 6, 2013, Pages 803-815

  Ozcan, Lale ^a   Cristina De Souza, Jane ^a   Harari, Alp Avi ^a   Backs, Johannes ^c,d   Olson, Eric N ^e   Tabas, Ira ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^e UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CHAPERONE; GLUCOSE; INITIATION FACTOR 2ALPHA; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATING PROTEIN KINASE 2; PALMITIC ACID; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN P58; PSEUDOKINASE TRIBBLE 3; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER CELL; MALE; MEDIATOR; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; HEPATOCYTES; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 14; OBESITY; PALMITATES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84889674935     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.10.011     Document Type: Article

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