메뉴 건너뛰기




Volumn 18, Issue 6, 2013, Pages 883-896

A systems medicine research approach for studying alcohol addiction

(23)  Spanagel, Rainer a   Durstewitz, Daniel b   Hansson, Anita a   Heinz, Andreas b   Kiefer, Falk b   Köhr, Georg a   Matthäus, Franziska b   Nöthen, Markus M c   Noori, Hamid R a   Obermayer, Klaus a   Rietschel, Marcella d   Schloss, Patrick e   Scholz, Henrike f   Schumann, Gunter g   Smolka, Michael h   Sommer, Wolfgang a   Vengeliene, Valentina a   Walter, Henrik b   Wurst, Wolfgang i   Zimmermann, Uli S h   more..


Author keywords

Alcohol addiction; brain bank; epigenetics; genome wide association study (GWAS); imaging genetics; inducible pluripotent stem cells (iPS); mathematical modeling; relapse models; transcriptomics

Indexed keywords

4 AMINOBUTYRIC ACID; ACAMPROSATE; ALCOHOL DEHYDROGENASE; ATRIAL NATRIURETIC FACTOR; CORTICOTROPIN RELEASING FACTOR; DISULFIRAM; DYNORPHIN; KAPPA OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALMEFENE; NALTREXONE; NEUROTRANSMITTER; SEROTONIN 3 RECEPTOR; TRANSFERRIN;

EID: 84889256063     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/adb.12109     Document Type: Article
Times cited : (78)

References (131)
  • 1
    • 33745588546 scopus 로고    scopus 로고
    • The limits of reductionism in medicine: Could systems biology offer an alternative?
    • Ahn AC, Tewari M, Poon CS, Phillips RS, (2006) The limits of reductionism in medicine: could systems biology offer an alternative? PLoS Med 3: e208.
    • (2006) PLoS Med , vol.3
    • Ahn, A.C.1    Tewari, M.2    Poon, C.S.3    Phillips, R.S.4
  • 2
    • 38949103745 scopus 로고    scopus 로고
    • An evaluation of γ-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: Results from the combined pharmacotherapies and behavioral interventions for alcohol dependence (COMBINE) study
    • DOI 10.1001/archpsyc.65.2.135
    • Anton RF, Oroszi G, O'Malley S, Couper D, Swift R, Pettinati H, Goldman D, (2008) An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry 65: 135-144. (Pubitemid 351222547)
    • (2008) Archives of General Psychiatry , vol.65 , Issue.2 , pp. 135-144
    • Anton, R.F.1    Oroszi, G.2    O'Malley, S.3    Couper, D.4    Swift, R.5    Pettinati, H.6    Goldman, D.7
  • 3
    • 0027374753 scopus 로고
    • Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats
    • Bals-Kubik R, Ableitner A, Herz A, Shippenberg TS, (1993) Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. J Pharmacol Exp Ther 264: 489-495. (Pubitemid 23309241)
    • (1993) Journal of Pharmacology and Experimental Therapeutics , vol.264 , Issue.1 , pp. 489-495
    • Bals-Kubik, R.1    Ableitner, A.2    Herz, A.3    Shippenberg, T.S.4
  • 4
    • 84868638394 scopus 로고    scopus 로고
    • Translational approaches to medication development
    • Bartlett S, Heilig M, (2013) Translational approaches to medication development. Curr Top Behav Neurosci 13: 543-582.
    • (2013) Curr Top Behav Neurosci , vol.13 , pp. 543-582
    • Bartlett, S.1    Heilig, M.2
  • 7
    • 38749123491 scopus 로고    scopus 로고
    • Cocaine Seeking Habits Depend upon Dopamine-Dependent Serial Connectivity Linking the Ventral with the Dorsal Striatum
    • DOI 10.1016/j.neuron.2007.12.019, PII S089662730701032X
    • Belin D, Everitt BJ, (2008) Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 57: 432-441. (Pubitemid 351179162)
    • (2008) Neuron , vol.57 , Issue.3 , pp. 432-441
    • Belin, D.1    Everitt, B.J.2
  • 8
    • 84864576315 scopus 로고    scopus 로고
    • Intrastriatal shifts mediate the transition from drug-seeking actions to habits
    • Belin-Rauscent A, Everitt BJ, Belin D, (2012) Intrastriatal shifts mediate the transition from drug-seeking actions to habits. Biol Psychiatry 72: 343-345.
    • (2012) Biol Psychiatry , vol.72 , pp. 343-345
    • Belin-Rauscent, A.1    Everitt, B.J.2    Belin, D.3
  • 9
    • 78649976095 scopus 로고    scopus 로고
    • CNR1 gene polymorphisms in addictive disorders: A systematic review and a meta-analysis
    • Benyamina A, Kebir O, Blecha L, Reynaud M, Krebs MO, (2011) CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis. Addict Biol 16: 1-6.
    • (2011) Addict Biol , vol.16 , pp. 1-6
    • Benyamina, A.1    Kebir, O.2    Blecha, L.3    Reynaud, M.4    Krebs, M.O.5
  • 11
    • 33847300120 scopus 로고    scopus 로고
    • Reduced alcohol consumption in mice lacking preprodynorphin
    • DOI 10.1016/j.alcohol.2006.12.002, PII S0741832906002643
    • Blednov YA, Walker D, Martinez M, Harris RA, (2006) Reduced alcohol consumption in mice lacking preprodynorphin. Alcohol 40: 73-86. (Pubitemid 46329324)
    • (2006) Alcohol , vol.40 , Issue.2 , pp. 73-86
    • Blednov, Y.A.1    Walker, D.2    Martinez, M.3    Harris, R.A.4
  • 13
    • 84889260238 scopus 로고    scopus 로고
    • Computational pharmacokinetics at a crossroads
    • doi: 10.1186/2193-9616-1-5.
    • Bois FY, (2013) Computational pharmacokinetics at a crossroads. In Silico Pharmacol 1: 5. doi: 10.1186/2193-9616-1-5.
    • (2013) In Silico Pharmacol , vol.1 , pp. 5
    • Bois, F.Y.1
  • 14
    • 84897055898 scopus 로고    scopus 로고
    • Global ethanol-induced enhancements of monoaminergic neurotransmission: A meta-analysis study
    • doi: 10.1111/acer.12207. [Epub ahead of print].
    • Brand I, Fliegel S, Spanagel R, Noori HR, (2013) Global ethanol-induced enhancements of monoaminergic neurotransmission: a meta-analysis study. Alcohol Clin Exp Res doi: 10.1111/acer.12207. [Epub ahead of print].
    • (2013) Alcohol Clin Exp Res
    • Brand, I.1    Fliegel, S.2    Spanagel, R.3    Noori, H.R.4
  • 16
    • 84860257642 scopus 로고    scopus 로고
    • Association of μ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: A systematic review and meta-analysis
    • Chamorro AJ, Marcos M, Mirõn-Canelo JA, Pastor I, González-Sarmiento R, Laso FJ, (2012) Association of μ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis. Addict Biol 17: 505-512.
    • (2012) Addict Biol , vol.17 , pp. 505-512
    • Chamorro, A.J.1    Marcos, M.2    Mirõn-Canelo, J.A.3    Pastor, I.4    González-Sarmiento, R.5    Laso, F.J.6
  • 20
    • 46449085813 scopus 로고    scopus 로고
    • Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    • DOI 10.1038/nature06995, PII NATURE06995
    • Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, Marinelli M, Wolf ME, (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454: 118-121. (Pubitemid 351931970)
    • (2008) Nature , vol.454 , Issue.7200 , pp. 118-121
    • Conrad, K.L.1    Tseng, K.Y.2    Uejima, J.L.3    Reimers, J.M.4    Heng, L.-J.5    Shaham, Y.6    Marinelli, M.7    Wolf, M.E.8
  • 21
    • 84876100493 scopus 로고    scopus 로고
    • Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain
    • D'Addario C, Caputi FF, Rimondini R, Gandolfi O, Del Borrello E, Candeletti S, Romualdi P, (2013) Different alcohol exposures induce selective alterations on the expression of dynorphin and nociceptin systems related genes in rat brain. Addict Biol 18: 425-433.
    • (2013) Addict Biol , vol.18 , pp. 425-433
    • D'Addario, C.1    Caputi, F.F.2    Rimondini, R.3    Gandolfi, O.4    Del Borrello, E.5    Candeletti, S.6    Romualdi, P.7
  • 23
    • 37749002295 scopus 로고    scopus 로고
    • Computational significance of transient dynamics in cortical networks
    • Durstewitz D, Deco G, (2008) Computational significance of transient dynamics in cortical networks. Eur J Neurosci 27: 217-227.
    • (2008) Eur J Neurosci , vol.27 , pp. 217-227
    • Durstewitz, D.1    Deco, G.2
  • 24
    • 34547433163 scopus 로고    scopus 로고
    • The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants
    • Edenberg HJ, (2007) The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 30: 5-13.
    • (2007) Alcohol Res Health , vol.30 , pp. 5-13
    • Edenberg, H.J.1
  • 25
    • 27644454882 scopus 로고    scopus 로고
    • Neural systems of reinforcement for drug addiction: From actions to habits to compulsion
    • DOI 10.1038/nn1579, PII N1579
    • Everitt BJ, Robbins TW, (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8: 1481-1489. (Pubitemid 41573659)
    • (2005) Nature Neuroscience , vol.8 , Issue.11 , pp. 1481-1489
    • Everitt, B.J.1    Robbins, T.W.2
  • 26
    • 84888010690 scopus 로고    scopus 로고
    • From the ventral to the dorsal striatum: Devolving views of their roles in drug addiction
    • doi: pii: S0149-7634(13)00046-8.
    • Everitt BJ, Robbins TW, (2013) From the ventral to the dorsal striatum: devolving views of their roles in drug addiction. Neurosci Biobehav Rev doi: pii: S0149-7634(13)00046-8.
    • (2013) Neurosci Biobehav Rev
    • Everitt, B.J.1    Robbins, T.W.2
  • 27
    • 84857651534 scopus 로고    scopus 로고
    • Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission
    • Femenía T, Manzanares J, (2012) Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission. Addict Biol 17: 322-337.
    • (2012) Addict Biol , vol.17 , pp. 322-337
    • Femenía, T.1    Manzanares, J.2
  • 28
    • 84872851130 scopus 로고    scopus 로고
    • Dopaminergic genes modulate response inhibition in alcohol abusing adults
    • Filbey FM, Claus ED, Morgan M, Forester GR, Hutchison K, (2012) Dopaminergic genes modulate response inhibition in alcohol abusing adults. Addict Biol 17: 1046-1056.
    • (2012) Addict Biol , vol.17 , pp. 1046-1056
    • Filbey, F.M.1    Claus, E.D.2    Morgan, M.3    Forester, G.R.4    Hutchison, K.5
  • 30
    • 84884284352 scopus 로고    scopus 로고
    • Ethanol-induced alterations of amino acids measured by in vivo microdialysis in rats: A meta-analysis
    • doi: 10.1186/2193-9616-1-7.
    • Fliegel S, Brand I, Spanagel R, Noori HR, (2013) Ethanol-induced alterations of amino acids measured by in vivo microdialysis in rats: a meta-analysis. In Silico Pharmacol 1: 7. doi: 10.1186/2193-9616-1-7.
    • (2013) In Silico Pharmacol , vol.1 , pp. 7
    • Fliegel, S.1    Brand, I.2    Spanagel, R.3    Noori, H.R.4
  • 32
    • 33750931628 scopus 로고    scopus 로고
    • Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats
    • DOI 10.1523/JNEUROSCI.3096-06.2006
    • Funk CK, O'Dell LE, Crawford EF, Koob GF, (2006) Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J Neurosci 26: 11324-11332. (Pubitemid 44772162)
    • (2006) Journal of Neuroscience , vol.26 , Issue.44 , pp. 11324-11332
    • Funk, C.K.1    O'Dell, L.E.2    Crawford, E.F.3    Koob, G.F.4
  • 33
    • 49349116344 scopus 로고    scopus 로고
    • The systems view in addiction research
    • Gebicke-Haerter PJ, Tretter F, (2008) The systems view in addiction research. Addict Biol 13: 449-454.
    • (2008) Addict Biol , vol.13 , pp. 449-454
    • Gebicke-Haerter, P.J.1    Tretter, F.2
  • 34
    • 84857657813 scopus 로고    scopus 로고
    • The effect of intravenous alcohol on the neural correlates of risky decision making in healthy social drinkers
    • Gilman JM, Smith AR, Ramchandani VA, Momenan R, Hommer DW, (2012) The effect of intravenous alcohol on the neural correlates of risky decision making in healthy social drinkers. Addict Biol 17: 465-478.
    • (2012) Addict Biol , vol.17 , pp. 465-478
    • Gilman, J.M.1    Smith, A.R.2    Ramchandani, V.A.3    Momenan, R.4    Hommer, D.W.5
  • 35
    • 21344469970 scopus 로고    scopus 로고
    • The genetics of addictions: Uncovering the genes
    • DOI 10.1038/nrg1635
    • Goldman D, Oroszi G, Ducci F, (2005) The genetics of addictions: uncovering the genes. Nat Rev Genet 6: 521-532. (Pubitemid 40910429)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.7 , pp. 521-532
    • Goldman, D.1    Oroszi, G.2    Ducci, F.3
  • 36
    • 80054801949 scopus 로고    scopus 로고
    • Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications
    • Goldstein RZ, Volkow ND, (2011) Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12: 652-669.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 652-669
    • Goldstein, R.Z.1    Volkow, N.D.2
  • 37
    • 0033842481 scopus 로고    scopus 로고
    • The tonic/phase model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving
    • Grace AA, (2000) The tonic/phase model of dopamine system regulation and its implications for understanding alcohol and psychostimulant craving. Addiction 95: 119-128.
    • (2000) Addiction , vol.95 , pp. 119-128
    • Grace, A.A.1
  • 38
    • 84886798117 scopus 로고    scopus 로고
    • A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence
    • for the ESENSE 2 Study Group.
    • Gual A, He Y, Torup L, van den Brink W, Mann K,; for the ESENSE 2 Study Group (2013) A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence. Eur Neuropsychopharmacol 23: 1432-1442.
    • (2013) Eur Neuropsychopharmacol , vol.23 , pp. 1432-1442
    • Gual, A.1    He, Y.2    Torup, L.3    Van Den Brink, W.4    Mann, K.5
  • 40
    • 76749117168 scopus 로고    scopus 로고
    • Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?
    • Heilig M, Egli M, Crabbe JC, Becker HC, (2010) Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked? Addict Biol 15: 169-184.
    • (2010) Addict Biol , vol.15 , pp. 169-184
    • Heilig, M.1    Egli, M.2    Crabbe, J.C.3    Becker, H.C.4
  • 41
    • 80054823945 scopus 로고    scopus 로고
    • Pharmacogenetic approaches to the treatment of alcohol addiction
    • Heilig M, Goldman D, Berrettini W, O'Brien CP, (2011) Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci 12: 670-684.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 670-684
    • Heilig, M.1    Goldman, D.2    Berrettini, W.3    O'Brien, C.P.4
  • 42
    • 34447644753 scopus 로고    scopus 로고
    • A key role for corticotropin-releasing factor in alcohol dependence
    • DOI 10.1016/j.tins.2007.06.006, PII S0166223607001518
    • Heilig M, Koob GF, (2007) A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30: 399-406. (Pubitemid 47090230)
    • (2007) Trends in Neurosciences , vol.30 , Issue.8 , pp. 399-406
    • Heilig, M.1    Koob, G.F.2
  • 43
    • 80052980660 scopus 로고    scopus 로고
    • Publication trends in addiction research
    • Helinski S, Spanagel R, (2011) Publication trends in addiction research. Addict Biol 16: 532-539.
    • (2011) Addict Biol , vol.16 , pp. 532-539
    • Helinski, S.1    Spanagel, R.2
  • 44
    • 84865959800 scopus 로고    scopus 로고
    • An approximation to the adaptive exponential integrate-and-fire neuron model allows fast and predictive fitting to physiological data
    • Hertäg L, Hass J, Golovko T, Durstewitz D, (2012) An approximation to the adaptive exponential integrate-and-fire neuron model allows fast and predictive fitting to physiological data. Front Comput Neurosci 6: 62.
    • (2012) Front Comput Neurosci , vol.6 , pp. 62
    • Hertäg, L.1    Hass, J.2    Golovko, T.3    Durstewitz, D.4
  • 46
    • 0043234820 scopus 로고    scopus 로고
    • Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in longterm ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure
    • Hölter SM, Danysz W, Spanagel R, (2000) Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure. J Pharmacol Exp Ther 292: 545-552. (Pubitemid 30067417)
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.292 , Issue.2 , pp. 545-552
    • Holter, S.M.1    Danysz, W.2    Spanagel, R.3
  • 48
    • 77955640603 scopus 로고    scopus 로고
    • Topiramate in the new generation of drugs: Efficacy in the treatment of alcoholic patients
    • Johnson BA, Ait-Daoud N, (2010) Topiramate in the new generation of drugs: efficacy in the treatment of alcoholic patients. Curr Pharm Des 16: 2103-2112.
    • (2010) Curr Pharm des , vol.16 , pp. 2103-2112
    • Johnson, B.A.1    Ait-Daoud, N.2
  • 50
    • 77950635127 scopus 로고    scopus 로고
    • What neurobiology cannot tell us about addiction
    • Kalant H, (2010) What neurobiology cannot tell us about addiction. Addiction 105: 780-789.
    • (2010) Addiction , vol.105 , pp. 780-789
    • Kalant, H.1
  • 51
    • 63249098863 scopus 로고    scopus 로고
    • Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry
    • Kalivas PW, (2008) Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry. Neurotox Res 14: 185-189.
    • (2008) Neurotox Res , vol.14 , pp. 185-189
    • Kalivas, P.W.1
  • 54
    • 84862661667 scopus 로고    scopus 로고
    • Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence
    • Karpyak VM, Geske JR, Colby CL, Mrazek DA, Biernacka JM, (2012) Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence. Addict Biol 17: 798-806.
    • (2012) Addict Biol , vol.17 , pp. 798-806
    • Karpyak, V.M.1    Geske, J.R.2    Colby, C.L.3    Mrazek, D.A.4    Biernacka, J.M.5
  • 57
    • 84868642952 scopus 로고    scopus 로고
    • Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder
    • Koob GF, (2013) Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci 13: 3-30.
    • (2013) Curr Top Behav Neurosci , vol.13 , pp. 3-30
    • Koob, G.F.1
  • 59
    • 84871803891 scopus 로고    scopus 로고
    • Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment
    • Kranzler HR, Armeli S, Covault J, Tennen H, (2013) Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment. Addict Biol 18: 193-201.
    • (2013) Addict Biol , vol.18 , pp. 193-201
    • Kranzler, H.R.1    Armeli, S.2    Covault, J.3    Tennen, H.4
  • 61
    • 84862667520 scopus 로고    scopus 로고
    • The genetics of the opioid system and specific drug addictions
    • Levran O, Yuferov V, Kreek MJ, (2012) The genetics of the opioid system and specific drug addictions. Hum Genet 131: 823-842.
    • (2012) Hum Genet , vol.131 , pp. 823-842
    • Levran, O.1    Yuferov, V.2    Kreek, M.J.3
  • 62
    • 84867016927 scopus 로고    scopus 로고
    • Pilot Study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro
    • Lieberman R, Levine ES, Kranzler HR, Abreu C, Covault J, (2012) Pilot Study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro. Alcohol Clin Exp Res 36: 1678-1687.
    • (2012) Alcohol Clin Exp Res , vol.36 , pp. 1678-1687
    • Lieberman, R.1    Levine, E.S.2    Kranzler, H.R.3    Abreu, C.4    Covault, J.5
  • 65
    • 78249251491 scopus 로고    scopus 로고
    • Addiction research centres and the nurturing of creativity department of addictive behaviour and addiction medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg
    • Mann K, (2010) Addiction research centres and the nurturing of creativity department of addictive behaviour and addiction medicine, Central Institute of Mental Health, Mannheim, University of Heidelberg. Addiction 105: 2057-2061.
    • (2010) Addiction , vol.105 , pp. 2057-2061
    • Mann, K.1
  • 66
    • 84875713675 scopus 로고    scopus 로고
    • Extending the treatment options in alcohol dependence: A randomized controlled study of as-needed nalmefene
    • Mann K, Bladström A, Torup L, Gual A, van den Brink W, (2013) Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene. Biol Psychiatry 73: 706-713.
    • (2013) Biol Psychiatry , vol.73 , pp. 706-713
    • Mann, K.1    Bladström, A.2    Torup, L.3    Gual, A.4    Van Den Brink, W.5
  • 70
    • 84863006865 scopus 로고    scopus 로고
    • The future of fMRI and genetics research
    • Meyer-Lindenberg A, (2012) The future of fMRI and genetics research. Neuroimage 62: 1286-1292.
    • (2012) Neuroimage , vol.62 , pp. 1286-1292
    • Meyer-Lindenberg, A.1
  • 71
    • 84857051538 scopus 로고    scopus 로고
    • Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking
    • Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R, (2012) Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology 37: 1047-1056.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1047-1056
    • Molander, A.1    Vengeliene, V.2    Heilig, M.3    Wurst, W.4    Deussing, J.M.5    Spanagel, R.6
  • 72
    • 43949084075 scopus 로고    scopus 로고
    • The endocannabinoid system: Emotion, learning and addiction
    • DOI 10.1111/j.1369-1600.2008.00104.x
    • Moreira FA, Lutz B, (2008) The endocannabinoid system: emotion, learning and addiction. Addict Biol 13: 196-212. (Pubitemid 351698889)
    • (2008) Addiction Biology , vol.13 , Issue.2 , pp. 196-212
    • Moreira, F.A.1    Lutz, B.2
  • 73
    • 0021876216 scopus 로고
    • Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
    • DOI 10.1007/BF00432213
    • Mucha RF, Herz A, (1985) Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning. Psychopharmacology (Berl) 86: 274-280. (Pubitemid 15064950)
    • (1985) Psychopharmacology , vol.86 , Issue.3 , pp. 274-280
    • Mucha, R.F.1    Herz, A.2
  • 74
    • 79957848671 scopus 로고    scopus 로고
    • κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats
    • Nealey KA, Smith AW, Davis SM, Smith DG, Walker BM, (2011) κ-opioid receptors are implicated in the increased potency of intra-accumbens nalmefene in ethanol-dependent rats. Neuropharmacology 61: 35-42.
    • (2011) Neuropharmacology , vol.61 , pp. 35-42
    • Nealey, K.A.1    Smith, A.W.2    Davis, S.M.3    Smith, D.G.4    Walker, B.M.5
  • 77
    • 84889254650 scopus 로고    scopus 로고
    • In silico pharmacology: Drug design and discovery's gate to the future
    • Noori HR, Spanagel R, (2013) In silico pharmacology: drug design and discovery's gate to the future. In Silico Pharmacol 1: 1.
    • (2013) In Silico Pharmacol , vol.1 , pp. 1
    • Noori, H.R.1    Spanagel, R.2
  • 78
    • 84866434088 scopus 로고    scopus 로고
    • Neurocircuitry for modeling drug effects
    • Noori HR, Spanagel R, Hansson AC, (2012) Neurocircuitry for modeling drug effects. Addict Biol 17: 827-864.
    • (2012) Addict Biol , vol.17 , pp. 827-864
    • Noori, H.R.1    Spanagel, R.2    Hansson, A.C.3
  • 79
    • 84875832219 scopus 로고    scopus 로고
    • Analytical strategies for large imaging genetic datasets: Experiences from the IMAGEN study
    • Nymberg C, Jia T, Ruggeri B, Schumann G, (2013) Analytical strategies for large imaging genetic datasets: experiences from the IMAGEN study. Ann N Y Acad Sci 1282: 92-106.
    • (2013) Ann N y Acad Sci , vol.1282 , pp. 92-106
    • Nymberg, C.1    Jia, T.2    Ruggeri, B.3    Schumann, G.4
  • 80
    • 0041383898 scopus 로고    scopus 로고
    • A functional polymorphism of the γ-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    • DOI 10.1038/sj.npp.1300219
    • Oslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, Volpicelli JR, O'Brien CP, (2003) A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology 28: 1546-1552. (Pubitemid 41070891)
    • (2003) Neuropsychopharmacology , vol.28 , Issue.8 , pp. 1546-1552
    • Oslin, D.W.1    Berrettini, W.2    Kranzler, H.R.3    Pettinati, H.4    Gelernter, J.5    Volpicelli, J.R.6    O'Brien, C.P.7
  • 81
    • 77953177140 scopus 로고    scopus 로고
    • Prefrontal cortex fails to learn from reward prediction errors in alcohol dependence
    • Park SQ, Kahnt T, Beck A, Cohen MX, Dolan RJ, Wrase J, Heinz A, (2010) Prefrontal cortex fails to learn from reward prediction errors in alcohol dependence. J Neurosci 30: 7749-7753.
    • (2010) J Neurosci , vol.30 , pp. 7749-7753
    • Park, S.Q.1    Kahnt, T.2    Beck, A.3    Cohen, M.X.4    Dolan, R.J.5    Wrase, J.6    Heinz, A.7
  • 83
    • 0022494591 scopus 로고
    • Psychotomimesis mediated by α opiate receptors
    • Pfeiffer A, Brantl V, Herz A, Emrich HM, (1986) Psychotomimesis mediated by kappa opiate receptors. Science 233: 774-776. (Pubitemid 16016229)
    • (1986) Science , vol.233 , Issue.4765 , pp. 774-776
    • Pfeiffer, A.1    Brantl, V.2    Herz, A.3    Emrich, H.M.4
  • 85
    • 84977897768 scopus 로고    scopus 로고
    • New measurement criteria for studying alcohol drinking and relapse in rodents
    • doi: 10.1186/2193-9616-1-13.
    • Pildaín LV, Vengeliene V, Matthäus F, (2013) New measurement criteria for studying alcohol drinking and relapse in rodents. In Silico Pharmacol doi: 10.1186/2193-9616-1-13.
    • (2013) In Silico Pharmacol
    • Pildaín, L.V.1    Vengeliene, V.2    Matthäus, F.3
  • 87
    • 84875821756 scopus 로고    scopus 로고
    • The genetics of alcohol dependence
    • Rietschel M, Treutlein J, (2012) The genetics of alcohol dependence. Ann N Y Acad Sci 1282: 39-70.
    • (2012) Ann N y Acad Sci , vol.1282 , pp. 39-70
    • Rietschel, M.1    Treutlein, J.2
  • 91
    • 33750686609 scopus 로고    scopus 로고
    • Behavioural assessment of drug reinforcement and addictive features in rodents: An overview
    • DOI 10.1111/j.1369-1600.2006.00012.x
    • Sanchis-Segura C, Spanagel R, (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 11: 2-38. (Pubitemid 46696746)
    • (2006) Addiction Biology , vol.11 , Issue.1 , pp. 2-38
    • Sanchis-Segura, C.1    Spanagel, R.2
  • 92
    • 84871796355 scopus 로고    scopus 로고
    • Functional neuroimaging studies of alcohol cue reactivity: A quantitative meta-analysis and systematic review
    • Schacht JP, Anton RF, Myrick H, (2013) Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. Addict Biol 18: 121-133.
    • (2013) Addict Biol , vol.18 , pp. 121-133
    • Schacht, J.P.1    Anton, R.F.2    Myrick, H.3
  • 94
    • 23844531242 scopus 로고    scopus 로고
    • The hangover gene defines a stress pathway required for ethanol tolerance development
    • DOI 10.1038/nature03864
    • Scholz H, Franz M, Heberlein U, (2005) The hangover gene defines a stress pathway required for ethanol tolerance. Nature 436: 845-847. (Pubitemid 41160642)
    • (2005) Nature , vol.436 , Issue.7052 , pp. 845-847
    • Scholz, H.1    Franz, M.2    Heberlein, U.3
  • 100
    • 76749131142 scopus 로고    scopus 로고
    • Consilient research approaches in studying gene x environment interactions in alcohol research
    • Sher KJ, Dick DM, Crabbe JC, Hutchison KE, O'Malley SS, Heath AC, (2010) Consilient research approaches in studying gene x environment interactions in alcohol research. Addict Biol 15: 200-216.
    • (2010) Addict Biol , vol.15 , pp. 200-216
    • Sher, K.J.1    Dick, D.M.2    Crabbe, J.C.3    Hutchison, K.E.4    O'Malley, S.S.5    Heath, A.C.6
  • 101
    • 34648832260 scopus 로고    scopus 로고
    • Dynorphin and the pathophysiology of drug addiction
    • DOI 10.1016/j.pharmthera.2007.06.011, PII S0163725807001477
    • Shippenberg TS, Zapata A, Chefer VI, (2007) Dynorphin and the pathophysiology of drug addiction. Pharmacol Ther 116: 306-321. (Pubitemid 47454747)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.2 , pp. 306-321
    • Shippenberg, T.S.1    Zapata, A.2    Chefer, V.I.3
  • 102
    • 37349041024 scopus 로고    scopus 로고
    • Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence
    • DOI 10.1016/j.biopsych.2007.01.010, PII S0006322307000704
    • Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS, Heilig MA, (2008) Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. Biol Psychiatry 63: 139-145. (Pubitemid 350299311)
    • (2008) Biological Psychiatry , vol.63 , Issue.2 , pp. 139-145
    • Sommer, W.H.1    Rimondini, R.2    Hansson, A.C.3    Hipskind, P.A.4    Gehlert, D.R.5    Barr, C.S.6    Heilig, M.A.7
  • 103
    • 67649985942 scopus 로고    scopus 로고
    • Alcoholism-a systems approach from molecular physiology to behavior
    • Spanagel R, (2009) Alcoholism-a systems approach from molecular physiology to behavior. Physiol Rev 89: 649-705.
    • (2009) Physiol Rev , vol.89 , pp. 649-705
    • Spanagel, R.1
  • 105
    • 0026559951 scopus 로고
    • Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway
    • Spanagel R, Herz A, Shippenberg TS, (1992) Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 89: 2046-2050.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2046-2050
    • Spanagel, R.1    Herz, A.2    Shippenberg, T.S.3
  • 106
    • 0342281459 scopus 로고    scopus 로고
    • Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat
    • DOI 10.1016/0014-2999(96)00174-4
    • Spanagel R, Hölter SM, Allingham K, Landgraf R, Zieglgänsberger W, (1996) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305: 39-44. (Pubitemid 26195983)
    • (1996) European Journal of Pharmacology , vol.305 , Issue.1-3 , pp. 39-44
    • Spanagel, R.1    Holter, S.M.2    Allingham, K.3    Landgraf, R.4    Zieglgansberger, W.5
  • 107
    • 84868666534 scopus 로고    scopus 로고
    • New pharmacological treatment strategies for relapse prevention
    • Spanagel R, Vengeliene V, (2013) New pharmacological treatment strategies for relapse prevention. Curr Top Behav Neurosci 13: 583-609.
    • (2013) Curr Top Behav Neurosci , vol.13 , pp. 583-609
    • Spanagel, R.1    Vengeliene, V.2
  • 113
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: Tool for the unification of biology
    • The Gene Ontology Consortium.
    • The Gene Ontology Consortium (2000) Gene ontology: tool for the unification of biology. Nat Genet 25: 25-29.
    • (2000) Nat Genet , vol.25 , pp. 25-29
  • 115
    • 16844386330 scopus 로고    scopus 로고
    • The role of the NMDA receptor in alcohol relapse: A pharmacological mapping study using the alcohol deprivation effect
    • DOI 10.1016/j.neuropharm.2005.01.002
    • Vengeliene V, Bachteler D, Danysz W, Spanagel R, (2005) The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology 48: 822-829. (Pubitemid 40489039)
    • (2005) Neuropharmacology , vol.48 , Issue.6 , pp. 822-829
    • Vengeliene, V.1    Bachteler, D.2    Danysz, W.3    Spanagel, R.4
  • 117
    • 84889248846 scopus 로고    scopus 로고
    • The alcohol deprivation effect model for studying relapse behavior: A comparison between rats and mice
    • (in press).
    • Vengeliene V, Bilbao A, Spanagel R, (2014) The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice. Alcohol (in press).
    • (2014) Alcohol
    • Vengeliene, V.1    Bilbao, A.2    Spanagel, R.3
  • 119
    • 77956158371 scopus 로고    scopus 로고
    • Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats
    • Vengeliene V, Leonardi-Essmann F, Sommer WH, Marston HM, Spanagel R, (2010) Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. Biol Psychiatry 68: 704-711.
    • (2010) Biol Psychiatry , vol.68 , pp. 704-711
    • Vengeliene, V.1    Leonardi-Essmann, F.2    Sommer, W.H.3    Marston, H.M.4    Spanagel, R.5
  • 120
    • 84872493082 scopus 로고    scopus 로고
    • The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats
    • Vengeliene V, Noori HR, Spanagel R, (2013) The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats. Alcohol Clin Exp Res 37 (Suppl 1): E322-E328.
    • (2013) Alcohol Clin Exp Res , vol.37 , Issue.SUPPL. 1
    • Vengeliene, V.1    Noori, H.R.2    Spanagel, R.3
  • 122
    • 84863435259 scopus 로고    scopus 로고
    • Validating incentive salience with functional magnetic resonance imaging: Association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients
    • Vollstädt-Klein S, Loeber S, Richter A, Kirsch M, Bach P, von der Goltz C, Hermann D, Mann K, Kiefer F, (2012) Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients. Addict Biol 17: 807-816.
    • (2012) Addict Biol , vol.17 , pp. 807-816
    • Vollstädt-Klein, S.1    Loeber, S.2    Richter, A.3    Kirsch, M.4    Bach, P.5    Von Der Goltz, C.6    Hermann, D.7    Mann, K.8    Kiefer, F.9
  • 123
    • 78649910013 scopus 로고    scopus 로고
    • Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
    • Walker BM, Zorrilla EP, Koob GF, (2011) Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addict Biol 16: 116-119.
    • (2011) Addict Biol , vol.16 , pp. 116-119
    • Walker, B.M.1    Zorrilla, E.P.2    Koob, G.F.3
  • 125
    • 77953290684 scopus 로고    scopus 로고
    • The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse
    • Wee S, Koob GF, (2010) The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology (Berl) 210: 121-135.
    • (2010) Psychopharmacology (Berl) , vol.210 , pp. 121-135
    • Wee, S.1    Koob, G.F.2
  • 127
    • 84874440008 scopus 로고    scopus 로고
    • Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use
    • Willuhn I, Burgeno LM, Everitt BJ, Phillips PE, (2012) Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use. Proc Natl Acad Sci USA 109: 20703-20708.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 20703-20708
    • Willuhn, I.1    Burgeno, L.M.2    Everitt, B.J.3    Phillips, P.E.4
  • 130


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.