Invertebrate models of alcoholism

Current Topics in Behavioral Neurosciences

Volumn 13, Issue , 2011, Pages 433-457

  Scholz, Henrike ^a   Mustard, Julie A ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Actions of ethanol; Alcohol abuse; Apis mellifera; Behaviors associated with alcoholism; Caenorhabditis elegans; Drosophila melanogaster; Ethanol metabolism; Honey bee; Intoxication; Invertebrates

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; ACETALDEHYDE; ACETYL COENZYME A; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE RECEPTOR; EPIDERMAL GROWTH FACTOR; NEUROPEPTIDE; NEUROPEPTIDE F; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR; OCTOPAMINE; RAB PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TYRAMINE; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; CENTRAL DEPRESSANT AGENT;

ALCOHOL CONSUMPTION; ALCOHOL DEHYDROGENASE GENE; ALCOHOL INTOXICATION; ALCOHOL TOLERANCE; ALCOHOL WITHDRAWAL; ALCOHOLISM; APIS MELLIFERA; ARTICLE; BEHAVIOR CHANGE; BODY EQUILIBRIUM; CAENORHABDITIS ELEGANS; DOPAMINERGIC TRANSMISSION; DROSOPHILA MELANOGASTER; DSM-IV; EGG LAYING FREQUENCY; FOOD INTAKE; GENE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HYPERACTIVITY; INVERTEBRATE MODEL; LEARNING; LIFESPAN; LOCOMOTION; MEMORY; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE BEHAVIOR; REWARD; RIGHTING REFLEX; SEDATION; SYNAPTIC TRANSMISSION; ANIMAL; DISEASE MODEL; DRUG EFFECT; GENETICS; INVERTEBRATE; METABOLISM; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ALCOHOLISM; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASE MODELS, ANIMAL; ETHANOL; HUMANS; INVERTEBRATES; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; SIGNAL TRANSDUCTION;

EID: 84857948841     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2011_128     Document Type: Article

References (120)

1. Abramson CI, Stone SM, Ortez RA, Luccardi A, Vann KL, Hanig KD, Rice J (2000) The development of an ethanol model using social insects I: behavior studies of the honey bee (Apis mellifera L.). Alcohol Clin Exp Res 24(8): 1153-1166
2. Abramson CI, Kandolf A, Sheridan A, Donohue D, Bozic J, Meyers JE, Benbassat D (2004a) Development of an ethanol model using social insects: III. Preferences for ethanol solutions. Psychol Rep 94(1): 227-239
3. Abramson CI, Place AJ, Aquino IS, Fernandez A (2004b) Development of an ethanol model using social insects: IV. Influence of ethanol on the aggression of Africanized honey bees (Apis mellifera L.). Psychol Rep 94(3 Pt 2): 1107-1115
4. Ammons AD, Hunt GJ (2008a) Identification of Quantitative Trait Loci and candidate genes influencing ethanol sensitivity in honey bees. Behav Genet 38(5): 531-553
5. Ammons AD, Hunt GJ (2008b) Characterization of honey bee sensitivity to ethanol vapor and its correlation with aggression. Alcohol 42(2): 129-136
6. Bainton RJ, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein U (2000) Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol 10(4): 187-194
7. Bell RL, Rodd ZA, Lumeng L, Murphy JM, McBride WJ (2006) The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addict Biol 11(3-4): 270-288
8. Bennett B, Downing C, Parker C, Johnson TE (2006) Mouse genetic models in alcohol research. Trends Genet 22(7): 367-374
9. Berger KH, Heberlein U, Moore MS (2004) Rapid and chronic: two distinct forms of ethanol tolerance in Drosophila. Alcohol Clin Exp Res 28(10): 1469-1480
10. Berry MD (2004) Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J Neurochem 90(2): 257-271
11. Bettinger JC, McIntire SL (2004) State-dependency in C. elegans. Genes Brain Behav 3(5): 266-272
12. Bitterman ME, Menzel R, Fietz A, Schafer S (1983) Classical conditioning of proboscis extension in honeybees (Apis mellifera). J Comp Psychol 97(2): 107-119
13. Blatt J, Roces F (2002) The control of the proventriculus in the honeybee (Apis mellifera carnica L.) II. Feedback mechanisms. J Insect Physiol 48(7): 683-691
14. Bolla RI, Weaver C, Koslowski P, Fitzsimmons K, Winter RE (1987) Characterization of a nonparasitic isolate of Bursaphelenchus xylophilus. J Nematol 19(3): 304-310
15. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu XS, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (2001) Trace amines: Identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 98(16): 8966-8971
16. Bouga M, Kilias G, Harizanis PC, Papasotiropoulos V, Alahiotis S (2005) Allozyme variability and phylogenetic relationships in honey bee (Hymenoptera: Apidae: Apis mellifera) populations from Greece and Cyprus. Biochem Genet 43(9-10): 471-483
17. Bozic J, DiCesare J, Wells H, Abramson CI (2007) Ethanol levels in honeybee hemolymph resulting from alcohol ingestion. Alcohol 41(4): 281-284
18. Brodie MS, Scholz A, Weiger TM, Dopico AM (2007) Ethanol interactions with calciumdependent potassium channels. Alcohol Clin Exp Res 31(10): 1625-1632
19. Cohan FM, Hoffmann AA (1986) Genetic divergence under uniform selection. II. Different responses to selection for knockdown resistance to ethanol among Drosophila melanogaster populations and their replicate lines. Genetics 114(1): 145-164
20. Colbert HA, Bargmann CI (1995) Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron 14(4): 803-812
21. Colombo G, Addolorato G, Agabio R, Carai MA, Pibiri F, Serra S, Vacca G, Gessa GL (2004) Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. Neurotox Res 6(5): 403-414
22. Corl AB, Rodan AR, Heberlein U (2005) Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci 8: 18-19
23. Corl AB, Berger KH, Ophir-Shohat G, Gesch J, Simms JA, Bartlett SE, Heberlein U (2009) Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell 137(5): 949-960
24. Cowmeadow RB, Krishnan HR, Atkinson NS (2005) The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila. Alcohol Clin Exp Res 29(10): 1777-1786
25. Cowmeadow RB, Krishnan HR, Ghezzi A, Al'Hasan YM, Wang YZ, Atkinson NS (2006) Ethanol tolerance caused by slowpoke induction in Drosophila. Alcohol Clin Exp Res 30(5): 745-753
26. Davenport AP, Evans PD (1984) Stress-induced changes in the octopamine levels of insect hemolymph. Insect Biochem 14(2): 135-143
27. Davies AG, McIntire SL (2004) Using C. elegans to screen for targets of ethanol and behavioraltering drugs. Biol Proced Online 6113-6119
28. Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, Bargmann CI, McIntire SL (2003) A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. Cell 115(6): 655-666
29. Davies AG, Bettinger JC, Thiele TR, Judy ME, McIntire SL (2004) Natural variation in the npr-1 gene modifies ethanol responses of wild strains of C. elegans. Neuron 42(5): 731-743
30. Davis JR, Li Y, Rankin CH (2008) Effects of developmental exposure to ethanol on Caenorhabditis elegans. Alcohol Clin Exp Res 32(5): 853-867
31. de Bono M, Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell 94(5): 679-689
32. Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behavior in the rat. Science 305: 1014-1017
33. Devineni AV, Heberlein U (2009) Preferential ethanol consumption in Drosophila models features of addiction. Curr Biol 19(24): 2126-2132
34. Dhawan R, Dusenbery DB, Williams PL (1999) Comparison of lethality, reproduction, and behavior as toxicological endpoints in the nematode Caenorhabditis elegans. J Toxicol Environ Health A 58(7): 451-462
35. Diamond I, Gordon AS (1997) Cellular and molecular neuroscience of alcoholism. Physiol Rev 77(1): 1-20
36. Dierks A, Fischer K (2008) Feeding responses and food preferences in the tropical, fruit-feeding butterfly, Bicyclus anynana. J Insect Physiol 54(9): 1363-1370
37. Dudley R (2002) Fermenting fruit and the historical ecology of ethanol ingestion: is alcoholism in modern humans an evolutionary hangover? Addiction 97(4): 381-388
38. Dzitoyeva S, Dimitrijevic N, Manev H (2003) Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci USA 100(9): 5485-5490
39. Eckenhoff RG, Yang BJ (1994) Absence of pressure antagonism of ethanol narcosis in C. elegans. Neuroreport 6(1): 77-80
40. Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI (2008) GFP reconstitution across synaptic partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron 57(3): 353-363
41. Foa L, Gasperini R (2009) Developmental roles for Homer: more than just a pretty scaffold. J Neurochem 108(1): 1-10
42. Fry JD, Saweikis M (2006) Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster. Genet Res 87(2): 87-92
43. Fukuda M (2008) Regulation of secretory vesicle traffic by Rab small GTPases. Cell Mol Life Sci 65(18): 2801-2813
44. Geer BW, Langevin ML, McKechnie SW (1985) Dietary ethanol and lipid synthesis in Drosophila melanogaster. Biochem Genet 23(7-8): 607-622
45. Geer BW, Heinstra PW, McKechnie SW (1993) The biological basis of ethanol tolerance in Drosophila. Comp Biochem Physiol B 105(2): 203-229
46. Ghezzi A, Pohl JB, Wang Y, Atkinson NS (2010) BK channels play a counter-adaptive role in drug tolerance and dependence. Proc Natl Acad Sci USA 107(37): 16360-16365
47. Gibson JB, Oakeshott JG (1981) Genetics of biochemical and behavioural aspects of alcohol metabolism. Aust N Z J Med 11(2): 128-131
48. Giles AC, Rankin CH (2009) Behavioral and genetic characterization of habituation using Caenorhabditis elegans. Neurobiol Learn Mem 92(2): 139-146
49. Gilliam M (1979) Microbiology of pollen and bee bread-the yeasts. Apidologie 10(1): 43-53
50. Glasner JD, Kocher TD, Collins JJ (1995) Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family. J Mol Evol 41(1): 46-53
51. Godenschwege TA, Reisch D, Diegelmann S, Eberle K, Funk N, Heisenberg M, Hoppe V, Hoppe J, Klagges BR, Martin JR, Nikitina EA, Putz G, Reifegerste R, Reisch N, Rister J, Schaupp M, Scholz H, Schwarzel M, Werner U, Zars TD, Buchner S, Buchner E (2004) Flies lacking all synapsins are unexpectedly healthy but are impaired in complex behaviour. Eur J Neurosci 20(3): 611-622
52. Goodrich KR, Zjhra ML, Ley CA, Raguso RA (2006) When flowers smell fermented: The chemistry and ontogeny of yeasty floral scent in pawpaw (Asimina triloba: Annonaceae). Int J Plant Sci 167(1): 33-46
53. Gordon MD, Scott K (2009) Motor control in a Drosophila taste circuit. Neuron 61(3): 373-384
54. Graham ME, Edwards MR, Holden-Dye L, Morgan A, Burgoyne RD, Barclay JW (2009) UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans. Mol Biol Cell 20(1): 43-55
55. Grell EH, Jacobson KB, Murphy JB (1968) Alterations of genetics material for analysis of alcohol dehydrogenase isozymes of Drosophila melanogaster. Ann N Y Acad Sci 151(1): 441-455
56. Heinz A (2002) Dopaminergic dysfunction in alcoholism and schizophrenia-psychopathological and behavioral correlates. Eur Psychiat 17(1): 9-16
57. Hill JK, Hamer KC, Tangah J, Dawood M (2001) Ecology of tropical butterflies in rainforest gaps. Oecologia 128(2): 294-302
58. Holmes RS (1994) Alcohol dehydrogenases: a family of isozymes with differential functions. Alcohol and alcoholism (Oxford, Oxfordshire) 2127-2130
59. Hong M, Choi MK, Lee J (2008) The anesthetic action of ethanol analyzed by genetics in Caenorhabditis elegans. Biochem Biophys Res Commun 367(1): 219-225
60. Ikemoto MJ, Inoue K, Akiduki S, Osugi T, Imamura T, Ishida N, Ohtomi M (2002) Identification of addicsin/GTRAP3-18 as a chronic morphine-augmented gene in amygdala. Neuroreport 13(16): 2079-2084
61. Ja WW, Carvalho GB, Mak EM, de la Rosa NN, Fang AY, Liong JC, Brummel T, Benzer S (2007) Prandiology of Drosophila and the CAFE assay. Proc Natl Acad Sci USA 104(20): 8253-8256
62. Jones WD (2009) The expanding reach of the GAL4/UAS system into the behavioral neurobiology of Drosophila. BMB Rep 42(11): 705-712
63. Kapfhamer D, Bettinger JC, Davies AG, Eastman CL, Smail EA, Heberlein U, McIntire SL (2008) Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Genes Brain Behav 7(6): 669-676
64. Kasanetz F, Deroche-Gamonet V, Berson N, Balado E, Lafourcade M, Manzoni O, Piazza PV (2010) Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science 328: 1709-1712
65. Kayser E-B, Morgan PG, Hoppel CL, Sedensky MM (2001) Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans. J Biol Chem 276: 205551-220558
66. Kong EC, Woo K, Li H, Lebestky T, Mayer N, Sniffen MR, Heberlein U, Bainton RJ, Hirsh J, Wolf FW (2010) A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila. PLoS One 5(4): e9954
67. Kreek MJ, Nielsen DA, LaForge KS (2004) Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromolecular Med 5(1): 85-108
68. Lai SL, Lee T (2006) Genetic mosaic with dual binary transcriptional systems in Drosophila. Nat Neurosci 9(5): 703-709
69. Laviola G, Hannan AJ, Macri S, Solinas M, Jaber M (2008) Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders. Neurobiol Dis 31(2): 159-168
70. Lee HG, Kim YC, Dunning JS, Han KA (2008) Recurring ethanol exposure induces disinhibited courtship in Drosophila. PLoS One 3(1): e1391
71. Lee J, Jee C, McIntire SL (2009) Ethanol preference in C. elegans. Genes Brain Behav 8(6): 578-585
72. Li C, Zhao X, Cao X, Chu D, Chen J, Zhou J (2008) The Drosophila homolog of jwa is required for ethanol tolerance. Alcohol Alcohol 43(5): 529-536
73. Luo L, Callaway EM, Svoboda K (2008) Genetic dissection of neural circuits. Neuron 57(5): 634-660
74. Maas JW Jr, Vogt SK, Chan GC, Pineda VV, Storm DR, Muglia LJ (2005) Calcium-stimulated adenylyl cyclases are critical modulators of neuronal ethanol sensitivity. J Neurosci 25(16): 4118-4126
75. Maleknia SD, Vail TM, Cody RB, Sparkman DO, Bell TL, Adams MA (2009) Temperaturedependent release of volatile organic compounds of eucalypts by direct analysis in real time (DART) mass spectrometry. Rapid Commun Mass Spectrom 23(15): 2241-2246
76. Martins E, Mestriner MA, Contel EP (1977) Alcohol dehydrogenase polymorphism in Apis mellifera. Biochem Genetics 15(3-4): 357-366
77. Maze IS, Wright GA, Mustard JA (2006) Acute ethanol ingestion produces dose-dependent effects on motor behavior in the honey bee (Apis mellifera). J Insect Physiol 52(11-12): 1243-1253
78. McKenzie JA, Parsons PA (1972) Alcohol Tolerance-Ecological parameter in relative success of Drosophila-melanogaster and Drosophila-simulans. Oecologia 10(4): 373-388
79. Menzel R, Giurfa M (2006) Dimensions of cognition in an insect, the honeybee. Behav Cogn Neurosci Rev 5: 24-40
80. Mitchell PH, Bull K, Glautier S, Hopper NA, Holden-Dye L, O'Connor V (2007) The concentration-dependent effects of ethanol on Caenorhabditis elegans behaviour. Pharmacogenomics J 7(6): 411-417
81. Mitchell P, Mould R, Dillon J, Glautier S, Andrianakis I, James C, Pugh A, Holden-Dye L, O'Connor V (2010) A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans. PLoS One 5: e10422
82. Moore MS, DeZazzo J, Luk AY, Tully T, Singh CM, Heberlein U (1998) Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93(6): 997-1007
83. Morgan PG, Sedensky MM (1995) Mutations affecting sensitivity to ethanol in the nematode, Caenorhabditis elegans. Alcohol Clin Exp Res 19(6): 1423-1429
84. Mustard JA, Edgar EA, Mazade RE, Wu C, Lillvis JL, Wright GA (2008) Acute ethanol ingestion impairs appetitive olfactory learning and odor discrimination in the honey bee. Neurobiol Learn Mem 90(4): 633-643
85. Nestler EJ (2002) Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem 78(3): 637-647
86. Ogueta M, Cibik O, Eltrop R, Schneider A, Scholz H (2010) The influence of ADH function on ethanol preference and tolerance in adult Drosophila melanogaster. Chem Senses 35(9): 813-822
87. Olsen SR, Wilson RI (2008) Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. Trends Neurosci 31(10): 512-520
88. Park SK, Sedore SA, Cronmiller C, Hirsh J (2000) Type II cAMP-dependent protein kinasedeficient Drosophila are viable but show developmental, circadian, and drug response phenotypes. J Biol Chem 275(27): 20588-20596
89. Parr J, Large A, Wang X, Fowler SC, Ratzlaff KL, Ruden DM (2001) The inebri-actometer: a device for measuring the locomotor activity of Drosophila exposed to ethanol vapor. J Neurosci Methods 107(1-2): 93-99
90. Petriv OI, Rachubinski RA (2004) Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans. J Biol Chem 279(19): 19996-20001
91. Premont RT, Gainetdinov RR, Caron MG (2001) Following the trace of elusive amines. Proc Natl Acad Sci USA 98(17): 9474-9475
92. Ramazani RB, Krishnan HR, Bergeson SE, Atkinson NS (2007) Computer automated movement detection for the analysis of behavior. J Neurosci Methods 162(1-2): 171-179
93. Ranger CM, Reding ME, Persad AB, Herms DA (2010) Ability of stress-related volatiles to attract and induce attacks by Xylosandrus germanus and other ambrosia beetles. Agr Forest Entomol 12(2): 177-185
94. Riley BP, Kalsi G, Kuo PH, Vladimirov V, Thiselton DL, Vittum J, Wormley B, Grotewiel MS, Patterson DG, Sullivan PF, van den Oord E, Walsh D, Kendler KS, Prescott CA (2006) Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample. Mol Psychiatry 11(11): 1025-1031
95. Rodan AR, Kiger JA Jr, Heberlein U (2002) Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J Neurosci 22(21): 9490-9501
96. Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U (2006) Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell 127(1): 199-211
97. Saeki S, Yamamoto M, Iino Y (2001) Plasticity of chemotaxis revealed by paired presentation of a chemoattractant and starvation in the nematode Caenorhabditis elegans. J Exp Biol 204(Pt 10): 1757-1764
98. Scholz H (2005) Influence of the biogenic amine tyramine on ethanol-induced behaviors in Drosophila. J Neurobiol 63(3): 199-214
99. Scholz H (2009) Intoxicated fly brains: neurons mediating ethanol-induced behaviors. J Neurogenet 23(1-2): 111-119
100. Scholz H, Ramond J, Singh CM, Heberlein U (2000) Functional ethanol tolerance in Drosophila. Neuron 28(1): 261-271
101. Scholz H, Franz M, Heberlein U (2005) The hangover gene defines a stress pathway required for ethanol tolerance development. Nature 436(7052): 845-847
102. Schuckit MA (1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151(2): 184-189
103. Singh CM, Heberlein U (2000) Genetic control of acute ethanol-induced behaviors in Drosophila. Alcohol Clin Exp Res 24(8): 1127-1136
104. Sommer W, Hyytia P, Kiianmaa K (2006) The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking. Addict Biol 11: 289-309
105. Spanagel R, Hölter SM, Allingham K, Landgraf R, Zieglgänsberger W (1996) Acomprosate and alcohol: I. Effects on alcohol intake foloowing alcohol depreivation in the rat. Eur J Pharmacol 305: 39-44
106. Strauss R (2002) The central complex and the genetic dissection of locomotor behaviour. Curr Opin Neurobiol 12(6): 633-638
107. Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56(1): 110-156
108. Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100(1): 64-119
109. Tabakoff B Ritzmann RF (1977) The effect of 6-hydroxydopamine on tolerance to and dependence of ethanol. J Pharmacol Exp Ther 203(2): 319-331
110. Thompson G, de Pomerai DI (2005) Toxicity of short-chain alcohols to the nematode Caenorhabditis elegans: a comparison of endpoints. J Biochem Mol Toxicol 19(2): 87-95
111. Thorsell A (2007) Neuropeptide Y (NPY) in alcohol intake and dependence. Peptides 28(2): 480-483
112. Treistman SN, Martin GE (2009) BK channels: Mediators and models for alcohol tolerance. Trends Neurosci 32(12): 629-637
113. Urizar NL, Yang Z, Edenberg HJ, Davis RL (2007) Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance. J Neurosci 27(17): 4541-4551
114. Wen T, Parrish CA, Xu D, Wu Q, Shen P (2005) Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity. Proc Natl Acad Sci USA 102(6): 2141-2146
115. White JG, Southgate E, Thomson JN, Brenner S (1986) The structure of the nervous system of the nematode C. elegans. Philos Trans R Soc Lond B 314: 1-340
116. Wiens F, Zitzmann A, Lachance MA, Yegles M, Pragst F, Wurst FM, von Holst D, Guan SL, Spanagel R (2008) Chronic intake of fermented floral nectar by wild treeshrews. Proc Natl Acad Sci USA 105(30): 10426-10431
117. Williamson VM, Long M, Theodoris G (1991) Isolation of Caenorhabditis elegans mutants lacking alcohol dehydrogenase activity. Biochem Genet 29(7-8): 313-323
118. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94(4): 469-492
119. Wolf FW, Rodan AR, Tsai LT, Heberlein U (2002) High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci 22(24): 11035-11044
120. Wood WB (1988) Determination of pattern and fate in early embryos of Caenorhabditis elegans. Dev Biol (N Y 1985) 557-578