Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking

Neuropsychopharmacology

Volumn 37, Issue 4, 2012, Pages 1047-1056

  Molander, Anna ^a   Vengeliene, Valentina ^a   Heilig, Markus ^b   Wurst, Wolfgang ^c,d,e,f   Deussing, Jan M ^c   Spanagel, Rainer ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

alcohol deprivation effect (ADE); alcoholism; conditional Crhr1NestinCre knockout mice; post dependent drinking; relapse; stress

Indexed keywords

ALCOHOL; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; GENE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RELAPSE; STRESS;

ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; ALCOHOLISM; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; GENE SILENCING; MALE; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRESS, PSYCHOLOGICAL;

EID: 84857051538     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.297     Document Type: Article

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