Discovery of a potent inhibitor of replication protein A protein-protein interactions using a fragment-linking approach

Journal of Medicinal Chemistry

Volumn 56, Issue 22, 2013, Pages 9242-9250

  Frank, Andreas O ^a,c   Feldkamp, Michael D ^a   Kennedy, J Phillip ^a   Waterson, Alex G ^a,b   Pelz, Nicholas F ^a   Patrone, James D ^a   Vangamudi, Bhavatarini ^a   Camper, Demarco V ^a   Rossanese, Olivia W ^a   Chazin, Walter J ^a,b   Fesik, Stephen W ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL DNA; DNA FRAGMENT; REPLICATION FACTOR A; SINGLE STRANDED DNA;

ARTICLE; BINDING SITE; CANCER CELL; CRYSTAL STRUCTURE; DNA DAMAGE; DNA REPAIR; LIGAND BINDING; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

DNA, SINGLE-STRANDED; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPLICATION PROTEIN A;

EID: 84889244724     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401333u     Document Type: Article

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