Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein a interaction motif of ATR interacting protein

Biochemistry

Volumn 52, Issue 37, 2013, Pages 6515-6524

  Feldkamp, Michael D ^a   Frank, Andreas O ^a,c   Kennedy, J Phillip ^a   Patrone, James D ^a   Vangamudi, Bhavatarini ^a   Waterson, Alex G ^b   Fesik, Stephen W ^a,b   Chazin, Walter J ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENCE ANISOTROPY; HETERONUCLEAR SINGLE-QUANTUM COHERENCES; LIGAND-BINDING SURFACES; PROTEIN-LIGAND COMPLEXES; PROTEIN-PROTEIN INTERACTIONS; SMALL MOLECULE INHIBITOR; THREE-DIMENSIONAL STRUCTURE; X RAY CRYSTAL STRUCTURES;

BINDING ENERGY; COMPLEXATION; DESIGN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULES; PATIENT TREATMENT; PEPTIDES; QUANTUM THEORY; REENGINEERING; REPAIR;

DNA;

REPLICATION FACTOR A;

AMINO TERMINAL SEQUENCE; ANISOTROPY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CANCER PATIENT; CANCER RADIOTHERAPY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA DAMAGE; GENE MUTATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; LIGAND BINDING; MOLECULAR PROBE; NUCLEAR MAGNETIC RESONANCE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA-BINDING PROTEINS; FLUORESCENCE POLARIZATION; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN INTERACTION DOMAINS AND MOTIFS; REPLICATION PROTEIN A; STATIC ELECTRICITY;

EID: 84884219122     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400542z     Document Type: Article

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