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Volumn 19, Issue 8, 2011, Pages 2589-2595

Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods

(3) Glanzer, Jason G a Liu, Shengqin a Oakley, Gregory G a,b

a UNIVERSITY OF NEBRASKA MEDICAL CENTER (United States)

b UNIVERSITY OF NEBRASKA MEDICAL CENTER (United States)

Author keywords

Docking; EMSA; High throughput screen; Inhibitors; Replication Protein A

Indexed keywords

15 CARBOXY 13 ISOPROPYLATIS 13 ENE 17,18 DIOIC ACID; DOUBLE STRANDED DNA; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; NSC 15520; PROTEIN INHIBITOR; PROTEIN P53; PROTEIN RAD9; REPLICATION FACTOR A; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING COMPETITION; COMPETITIVE INHIBITION; COMPUTER ANALYSIS; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA HELIX; DRUG SCREENING; HIGH THROUGHPUT SCREENING; IC 50; IN VITRO STUDY; INHIBITION KINETICS; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

BINDING SITES; COMPUTER SIMULATION; DNA REPAIR; DNA, SINGLE-STRANDED; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; OLIGONUCLEOTIDES; PROTEIN INTERACTION DOMAINS AND MOTIFS; REPLICATION PROTEIN A;

EUKARYOTA;

EID: 79954423814 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2011.03.012 Document Type: Article

Times cited : (37)

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