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Volumn 107, Issue , 2013, Pages 56-63

Roles of the epoxygenase CYP2J2 in the endothelium

Author keywords

Angiogenesis; Dilation; Endothelial; Epoxygenase; Inflammation; Metabolism

Indexed keywords

ALBENDAZOLE; AMIODARONE; ANGIOTENSIN II; ARACHIDONIC ACID; ASTEMIZOLE; CAREBASTINE; CYCLOSPORIN; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2J2; DANAZOL; DOCOSAHEXAENOIC ACID; EBASTINE; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; MESORIDAZINE; REACTIVE OXYGEN METABOLITE; TERFENADINE; THIORIDAZINE;

EID: 84889096477     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2013.02.003     Document Type: Review
Times cited : (53)

References (96)
  • 1
    • 0022350252 scopus 로고
    • The vascular endothelium: A survey of some newly evolving biochemical and physiological features
    • DOI 10.1007/BF01907911
    • E. Gerlach, S. Nees, and B.F. Becker The vascular endothelium: a survey of some newly evolving biochemical and physiological features Basic Res Cardiol 80 5 1985 459 474 (Pubitemid 16244319)
    • (1985) Basic Research in Cardiology , vol.80 , Issue.5 , pp. 459-474
    • Gerlach, E.1    Nees, S.2    Becker, B.F.3
  • 2
    • 0026730021 scopus 로고
    • Human cyclooxygenase-2 cDNA
    • T. Hla, and K. Neilson Human cyclooxygenase-2 cDNA Proc Natl Acad Sci USA 89 16 1992 7384 7388
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.16 , pp. 7384-7388
    • Hla, T.1    Neilson, K.2
  • 3
    • 0017094798 scopus 로고
    • An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
    • S. Moncada, R. Gryglewski, S. Bunting, and J.R. Vane An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation Nature 263 5579 1976 663 665
    • (1976) Nature , vol.263 , Issue.5579 , pp. 663-665
    • Moncada, S.1    Gryglewski, R.2    Bunting, S.3    Vane, J.R.4
  • 5
    • 0035965327 scopus 로고    scopus 로고
    • Epoxygenase pathways of arachidonic acid metabolism
    • D.C. Zeldin Epoxygenase pathways of arachidonic acid metabolism J Biol Chem 276 39 2001 36059 36062
    • (2001) J Biol Chem , vol.276 , Issue.39 , pp. 36059-36062
    • Zeldin, D.C.1
  • 6
    • 9944254760 scopus 로고    scopus 로고
    • Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids
    • DOI 10.1016/j.abb.2004.10.009, PII S0003986104005740
    • M. Spiecker, and J.K. Liao Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids Arch Biochem Biophys 433 2 2005 413 420 (Pubitemid 39592795)
    • (2005) Archives of Biochemistry and Biophysics , vol.433 , Issue.2 , pp. 413-420
    • Spiecker, M.1    Liao, J.K.2
  • 9
    • 0842312531 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
    • DOI 10.1097/00008571-200401000-00001
    • D.R. Nelson, D.C. Zeldin, S.M. Hoffman, L.J. Maltais, H.M. Wain, and D.W. Nebert Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants Pharmacogenetics 14 1 2004 1 18 (Pubitemid 38183957)
    • (2004) Pharmacogenetics , vol.14 , Issue.1 , pp. 1-18
    • Nelson, D.R.1    Zeldin, D.C.2    Hoffman, S.M.G.3    Maltais, L.J.4    Wain, H.M.5    Nebert, D.W.6
  • 10
    • 50549083650 scopus 로고    scopus 로고
    • Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide
    • K. Stark, M. Dostalek, and F.P. Guengerich Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide FEBS J 275 14 2008 3706 3717
    • (2008) FEBS J , vol.275 , Issue.14 , pp. 3706-3717
    • Stark, K.1    Dostalek, M.2    Guengerich, F.P.3
  • 11
    • 0025311273 scopus 로고
    • Cytochrome P-450 enzyme-specific control of the regio-and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase
    • J.H. Capdevila, A. Karara, D.J. Waxman, M.V. Martin, J.R. Falck, and F.P. Guenguerich Cytochrome P-450 enzyme-specific control of the regio-and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase J Biol Chem 265 19 1990 10865 10871
    • (1990) J Biol Chem , vol.265 , Issue.19 , pp. 10865-10871
    • Capdevila, J.H.1    Karara, A.2    Waxman, D.J.3    Martin, M.V.4    Falck, J.R.5    Guenguerich, F.P.6
  • 12
    • 0032502795 scopus 로고    scopus 로고
    • A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid
    • DOI 10.1074/jbc.273.15.9279
    • D.S. Keeney, C. Skinner, S. Wei, T. Friedberg, and M.R. Waterman A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity, producing a single major epoxyeicosatrienoic acid J Biol Chem 273 15 1998 9279 9284 (Pubitemid 28176221)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.15 , pp. 9279-9284
    • Keeney, D.S.1    Skinner, C.2    Wei, S.3    Friedberg, T.4    Waterman, M.R.5
  • 14
    • 0034723401 scopus 로고    scopus 로고
    • Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns
    • DOI 10.1074/jbc.275.4.2312
    • M.F. Oleksiak, S. Wu, C. Parker, S.I. Karchner, J.J. Stegeman, and D.C. Zeldin Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns J Biol Chem 275 4 2000 2312 2321 (Pubitemid 30081987)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2312-2321
    • Oleksiak, M.F.1    Wu, S.2    Parker, C.3    Karchner, S.I.4    Stegeman, J.J.5    Zeldin, D.C.6
  • 15
    • 0029039791 scopus 로고
    • Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: Regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
    • A.B. Rifkind, C. Lee, T.K. Chang, and D.J. Waxman Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes Arch Biochem Biophys 320 2 1995 380 389
    • (1995) Arch Biochem Biophys , vol.320 , Issue.2 , pp. 380-389
    • Rifkind, A.B.1    Lee, C.2    Chang, T.K.3    Waxman, D.J.4
  • 16
    • 79955947190 scopus 로고    scopus 로고
    • CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (+/-)-14,15-epoxyeicosatrienoic acid (EET)
    • R. Mitra, Z. Guo, and M. Milani CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (+/-)-14,15-epoxyeicosatrienoic acid (EET) J Biol Chem 286 20 2011 17543 17559
    • (2011) J Biol Chem , vol.286 , Issue.20 , pp. 17543-17559
    • Mitra, R.1    Guo, Z.2    Milani, M.3
  • 17
    • 0035910620 scopus 로고    scopus 로고
    • Endothelium-derived hyperpolarizing factor synthase (cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries
    • I. Fleming, U.R. Michaelis, and D. Bredenkotter Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries Circ Res 88 1 2001 44 51 (Pubitemid 32064081)
    • (2001) Circulation Research , vol.88 , Issue.1 , pp. 44-51
    • Fleming, I.1    Michaelis, U.R.2    Bredenkotter, D.3    Fisslthaler, B.4    Dehghani, F.5    Brandes, R.P.6    Busse, R.7
  • 18
    • 0030063499 scopus 로고    scopus 로고
    • Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
    • DOI 10.1074/jbc.271.7.3460
    • S. Wu, C.R. Moomaw, K.B. Tomer, J.R. Falck, and D.C. Zeldin Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart J Biol Chem 271 7 1996 3460 3468 (Pubitemid 26065653)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.7 , pp. 3460-3468
    • Wu, S.1    Moomaw, C.R.2    Tomer, K.B.3    Falck, J.R.4    Zeldin, D.C.5
  • 20
    • 0033588034 scopus 로고    scopus 로고
    • Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
    • DOI 10.1126/science.285.5431.1276
    • K. Node, Y. Huo, and X. Ruan Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids Science 285 5431 1999 1276 1279 (Pubitemid 29398616)
    • (1999) Science , vol.285 , Issue.5431 , pp. 1276-1279
    • Node, K.1    Huo, Y.2    Ruan, X.3    Yang, B.4    Spiecker, M.5    Ley, K.6    Zeldin, D.C.7    Liao, J.K.8
  • 23
    • 80054790076 scopus 로고    scopus 로고
    • Endogenous epoxygenases are modulators of monocyte/macrophage activity
    • J. Bystrom, J.A. Wray, and M.C. Sugden Endogenous epoxygenases are modulators of monocyte/macrophage activity PLoS ONE 6 10 2011 e26591
    • (2011) PLoS ONE , vol.6 , Issue.10 , pp. 26591
    • Bystrom, J.1    Wray, J.A.2    Sugden, M.C.3
  • 24
    • 33751191888 scopus 로고    scopus 로고
    • Variability of CYP2J2 expression in human fetal tissues
    • A. Gaedigk, D.W. Baker, and R.A. Totah Variability of CYP2J2 expression in human fetal tissues J Pharmacol Exp Ther 319 2 2006 523 532
    • (2006) J Pharmacol Exp Ther , vol.319 , Issue.2 , pp. 523-532
    • Gaedigk, A.1    Baker, D.W.2    Totah, R.A.3
  • 25
    • 73249132581 scopus 로고    scopus 로고
    • The cytochrome p450 homepage
    • D.R. Nelson The cytochrome p450 homepage Hum Genomics 4 1 2009 59 65
    • (2009) Hum Genomics , vol.4 , Issue.1 , pp. 59-65
    • Nelson, D.R.1
  • 26
    • 81155155630 scopus 로고    scopus 로고
    • CYP-eicosanoids-a new link between omega-3 fatty acids and cardiac disease?
    • C. Westphal, A. Konkel, and W.H. Schunck CYP-eicosanoids-a new link between omega-3 fatty acids and cardiac disease? Prostaglandins Other Lipid Mediat 96 1-4 2013 99 108
    • (2013) Prostaglandins Other Lipid Mediat , vol.96 , Issue.14 , pp. 99-108
    • Westphal, C.1    Konkel, A.2    Schunck, W.H.3
  • 27
    • 49549112885 scopus 로고    scopus 로고
    • Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes
    • K. Nakayama, T. Nitto, T. Inoue, and K. Node Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes Life Sci 83 9-10 2008 339 345
    • (2008) Life Sci , vol.83 , Issue.910 , pp. 339-345
    • Nakayama, K.1    Nitto, T.2    Inoue, T.3    Node, K.4
  • 28
    • 33644849675 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: Implications for soluble epoxide hydrolase inhibition
    • B.T. Larsen, H. Miura, and O.A. Hatoum Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition Am J Physiol Heart Circ Physiol 290 2 2006 H491 H499
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.2
    • Larsen, B.T.1    Miura, H.2    Hatoum, O.A.3
  • 29
    • 84872458939 scopus 로고    scopus 로고
    • Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo
    • S. Kundu, T. Roome, and A. Bhattacharjee Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo J Lipid Res 54 2 2013 436 447
    • (2013) J Lipid Res , vol.54 , Issue.2 , pp. 436-447
    • Kundu, S.1    Roome, T.2    Bhattacharjee, A.3
  • 30
    • 84862817897 scopus 로고    scopus 로고
    • Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo
    • D. Zhang, X. Xie, Y. Chen, B.D. Hammock, W. Kong, and Y. Zhu Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo Circ Res 110 6 2013 808 817
    • (2013) Circ Res , vol.110 , Issue.6 , pp. 808-817
    • Zhang, D.1    Xie, X.2    Chen, Y.3    Hammock, B.D.4    Kong, W.5    Zhu, Y.6
  • 31
    • 77951498924 scopus 로고    scopus 로고
    • Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice
    • M. Revermann, M. Schloss, and E. Barbosa-Sicard Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice Arterioscler Thromb Vasc Biol 30 5 2013 909 914
    • (2013) Arterioscler Thromb Vasc Biol , vol.30 , Issue.5 , pp. 909-914
    • Revermann, M.1    Schloss, M.2    Barbosa-Sicard, E.3
  • 32
    • 77957831701 scopus 로고    scopus 로고
    • Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice
    • C.R. Lee, J.D. Imig, and M.L. Edin Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice FASEB J 24 10 2013 3770 3781
    • (2013) FASEB J , vol.24 , Issue.10 , pp. 3770-3781
    • Lee, C.R.1    Imig, J.D.2    Edin, M.L.3
  • 33
    • 76149089080 scopus 로고    scopus 로고
    • Identification of novel substrates for human cytochrome P450 2J2
    • C.A. Lee, D. Neul, and A. Clouser-Roche Identification of novel substrates for human cytochrome P450 2J2 Drug Metab Dispos 38 2 2013 347 356
    • (2013) Drug Metab Dispos , vol.38 , Issue.2 , pp. 347-356
    • Lee, C.A.1    Neul, D.2    Clouser-Roche, A.3
  • 34
    • 84871539611 scopus 로고    scopus 로고
    • Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors
    • S. Ren, J. Zeng, and Y. Mei Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors Drug Metab Dispos 41 1 2013 60 71
    • (2013) Drug Metab Dispos , vol.41 , Issue.1 , pp. 60-71
    • Ren, S.1    Zeng, J.2    Mei, Y.3
  • 35
    • 33645893171 scopus 로고    scopus 로고
    • Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2
    • P. Lafite, S. Dijols, and D. Buisson Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2 Bioorg Med Chem Lett 16 10 2006 2777 2780
    • (2006) Bioorg Med Chem Lett , vol.16 , Issue.10 , pp. 2777-2780
    • Lafite, P.1    Dijols, S.2    Buisson, D.3
  • 36
    • 34547655500 scopus 로고    scopus 로고
    • Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2
    • DOI 10.1016/j.abb.2007.03.028, PII S0003986107001610
    • P. Lafite, S. Dijols, D.C. Zeldin, P.M. Dansette, and D. Mansuy Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2 Arch Biochem Biophys 464 2 2007 155 168 (Pubitemid 47210920)
    • (2007) Archives of Biochemistry and Biophysics , vol.464 , Issue.2 , pp. 155-168
    • Lafite, P.1    Dijols, S.2    Zeldin, D.C.3    Dansette, P.M.4    Mansuy, D.5
  • 37
    • 0034923447 scopus 로고    scopus 로고
    • Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells
    • B. Yang, L. Graham, and S. Dikalov Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells Mol Pharmacol 60 2 2001 310 320 (Pubitemid 32678296)
    • (2001) Molecular Pharmacology , vol.60 , Issue.2 , pp. 310-320
    • Yang, B.1    Graham, L.2    Dikalov, S.3    Mason, R.P.4    Falck, J.R.5    Liao, J.K.6    Zeldin, D.C.7
  • 39
    • 80053919098 scopus 로고    scopus 로고
    • Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart
    • M.L. Edin, Z. Wang, and J.A. Bradbury Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart FASEB J 25 10 2012 3436 3447
    • (2012) FASEB J , vol.25 , Issue.10 , pp. 3436-3447
    • Edin, M.L.1    Wang, Z.2    Bradbury, J.A.3
  • 40
    • 84869093549 scopus 로고    scopus 로고
    • Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice
    • R. Li, X. Xu, and C. Chen Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice Prostaglandins Other Lipid Mediat 99 3-4 2013 68 78
    • (2013) Prostaglandins Other Lipid Mediat , vol.99 , Issue.34 , pp. 68-78
    • Li, R.1    Xu, X.2    Chen, C.3
  • 41
    • 84864365143 scopus 로고    scopus 로고
    • Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis
    • G. Zhao, L. Tu, and X. Li Delivery of AAV2-CYP2J2 protects remnant kidney in the 5/6-nephrectomized rat via inhibition of apoptosis and fibrosis Hum Gene Ther 23 7 2012 688 699
    • (2012) Hum Gene Ther , vol.23 , Issue.7 , pp. 688-699
    • Zhao, G.1    Tu, L.2    Li, X.3
  • 42
    • 79551646708 scopus 로고    scopus 로고
    • Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice
    • Y. Deng, M.L. Edin, and K.N. Theken Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice FASEB J 25 2 2011 703 713
    • (2011) FASEB J , vol.25 , Issue.2 , pp. 703-713
    • Deng, Y.1    Edin, M.L.2    Theken, K.N.3
  • 43
    • 84889080691 scopus 로고    scopus 로고
    • Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice
    • A. Oni-Orisan, Y. Deng, and R.N. Schuck Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice Prostaglandins Other Lipid Mediat 2012
    • (2012) Prostaglandins Other Lipid Mediat
    • Oni-Orisan, A.1    Deng, Y.2    Schuck, R.N.3
  • 44
    • 0037123925 scopus 로고    scopus 로고
    • Inhibition of vascular smooth muscle cell migration by cytochrome P450 epoxygenase-derived eicosanoids
    • DOI 10.1161/01.RES.0000017727.35930.33
    • J. Sun, X. Sui, J.A. Bradbury, D.C. Zeldin, M.S. Conte, and J.K. Liao Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids Circ Res 90 9 2002 1020 1027 (Pubitemid 34633869)
    • (2002) Circulation Research , vol.90 , Issue.9 , pp. 1020-1027
    • Sun, J.1    Sui, X.2    Bradbury, J.A.3    Zeldin, D.C.4    Conte, M.S.5    Liao, J.K.6
  • 46
    • 84856747668 scopus 로고    scopus 로고
    • Epoxides and soluble epoxide hydrolase in cardiovascular physiology
    • J.D. Imig Epoxides and soluble epoxide hydrolase in cardiovascular physiology Physiol Rev 92 1 2012 101 130
    • (2012) Physiol Rev , vol.92 , Issue.1 , pp. 101-130
    • Imig, J.D.1
  • 48
    • 66349109660 scopus 로고    scopus 로고
    • Arachidonic acid cytochrome P450 epoxygenase pathway
    • A.A. Spector Arachidonic acid cytochrome P450 epoxygenase pathway J Lipid Res 50 Suppl. 2009 S52 S56
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Spector, A.A.1
  • 49
    • 83855164059 scopus 로고    scopus 로고
    • The cytochrome P450 pathway in angiogenesis and endothelial cell biology
    • I. Fleming The cytochrome P450 pathway in angiogenesis and endothelial cell biology Cancer Metastasis Rev 30 3-4 2011 541 555
    • (2011) Cancer Metastasis Rev , vol.30 , Issue.34 , pp. 541-555
    • Fleming, I.1
  • 50
    • 0041529844 scopus 로고    scopus 로고
    • Kip1
    • DOI 10.1074/jbc.M305385200
    • M. Potente, B. Fisslthaler, R. Busse, and I. Fleming 11,12- Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1 J Biol Chem 278 32 2003 29619 29625 (Pubitemid 36962345)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.32 , pp. 29619-29625
    • Potente, M.1    Fisslthaler, B.2    Busse, R.3    Fleming, I.4
  • 51
    • 0037387681 scopus 로고    scopus 로고
    • Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR)
    • U.R. Michaelis, B. Fisslthaler, M. Medhora, D. Harder, I. Fleming, and R. Busse Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR) FASEB J 17 6 2003 770 772
    • (2003) FASEB J , vol.17 , Issue.6 , pp. 770-772
    • Michaelis, U.R.1    Fisslthaler, B.2    Medhora, M.3    Harder, D.4    Fleming, I.5    Busse, R.6
  • 52
    • 33644852338 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis
    • B. Zhang, H. Cao, and G.N. Rao Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15- epoxyeicosatrienoic acid-induced angiogenesis J Biol Chem 281 2 2006 905 914
    • (2006) J Biol Chem , vol.281 , Issue.2 , pp. 905-914
    • Zhang, B.1    Cao, H.2    Rao, G.N.3
  • 53
    • 47049120789 scopus 로고    scopus 로고
    • An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis
    • S.Y. Cheranov, M. Karpurapu, D. Wang, B. Zhang, R.C. Venema, and G.N. Rao An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis Blood 111 12 2008 5581 5591
    • (2008) Blood , vol.111 , Issue.12 , pp. 5581-5591
    • Cheranov, S.Y.1    Karpurapu, M.2    Wang, D.3    Zhang, B.4    Venema, R.C.5    Rao, G.N.6
  • 54
    • 42349117330 scopus 로고    scopus 로고
    • Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids
    • DOI 10.1093/cvr/cvn006
    • G. Yan, S. Chen, B. You, and J. Sun Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids Cardiovasc Res 78 2 2008 308 314 (Pubitemid 351556100)
    • (2008) Cardiovascular Research , vol.78 , Issue.2 , pp. 308-314
    • Yan, G.1    Chen, S.2    You, B.3    Sun, J.4
  • 55
    • 22944448688 scopus 로고    scopus 로고
    • Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways
    • DOI 10.1124/jpet.105.083477
    • Y. Wang, X. Wei, and X. Xiao Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways J Pharmacol Exp Ther 314 2 2005 522 532 (Pubitemid 41043832)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.314 , Issue.2 , pp. 522-532
    • Wang, Y.1    Wei, X.2    Xiao, X.3    Hui, R.4    Card, J.W.5    Carey, M.A.6    Dao, W.W.7    Zeldin, D.C.8
  • 56
    • 84855453198 scopus 로고    scopus 로고
    • Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
    • D. Panigrahy, M.L. Edin, and C.R. Lee Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice J Clin Invest 122 1 2012 178 191
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 178-191
    • Panigrahy, D.1    Edin, M.L.2    Lee, C.R.3
  • 58
    • 84857015960 scopus 로고    scopus 로고
    • Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease
    • A.A. Elmarakby Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease Am J Physiol Regul Integr Comp Physiol 302 3 2013 R321 R330
    • (2013) Am J Physiol Regul Integr Comp Physiol , vol.302 , Issue.3
    • Elmarakby, A.A.1
  • 59
    • 0025272059 scopus 로고
    • Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats
    • DOI 10.1016/0006-291X(90)90619-X
    • W.K. Lin, J.R. Falck, and P.Y. Wong Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats Biochem Biophys Res Commun 167 3 1990 977 981 (Pubitemid 20113277)
    • (1990) Biochemical and Biophysical Research Communications , vol.167 , Issue.3 , pp. 977-981
    • Lin, W.-K.1    Falck, J.R.2    Wong, P.Y.-K.3
  • 60
    • 0034058249 scopus 로고    scopus 로고
    • Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney
    • Z. Yu, L.M. Huse, and P. Adler Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney Mol Pharmacol 57 5 2000 1011 1020 (Pubitemid 30253386)
    • (2000) Molecular Pharmacology , vol.57 , Issue.5 , pp. 1011-1020
    • Yu, Z.1    Huse, L.M.2    Adler, P.3    Graham, L.4    Ma, J.5    Zeldin, D.C.6    Kroetz, D.L.7
  • 61
    • 77954414532 scopus 로고    scopus 로고
    • Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: Role of CYP epoxygenase and soluble epoxide hydrolase
    • M.A. Nayeem, D.C. Zeldin, and M.A. Boegehold Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase Am J Physiol Regul Integr Comp Physiol 299 1 2013 R325 R333
    • (2013) Am J Physiol Regul Integr Comp Physiol , vol.299 , Issue.1
    • Nayeem, M.A.1    Zeldin, D.C.2    Boegehold, M.A.3
  • 62
    • 33845439097 scopus 로고    scopus 로고
    • Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids
    • DOI 10.1016/j.prostaglandins.2006.08.005, PII S1098882306001213, Eicosanoid-Mediated Regulation of Vascular and Renal Function
    • J.G. Jiang, R.J. Chen, and B. Xiao Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids Prostaglandins Other Lipid Mediat 82 1-4 2007 162 174 (Pubitemid 44895441)
    • (2007) Prostaglandins and Other Lipid Mediators , vol.82 , Issue.1-4 , pp. 162-174
    • Jiang, J.G.1    Chen, R.J.2    Xiao, B.3    Yang, S.4    Wang, J.N.5    Wang, Y.6    Cowart, L.A.7    Xiao, X.8    Wang, D.W.9    Xia, Y.10
  • 63
    • 77956252084 scopus 로고    scopus 로고
    • Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide
    • B. Xiao, X. Li, and J. Yan Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide J Pharmacol Exp Ther 334 3 2010 784 794
    • (2010) J Pharmacol Exp Ther , vol.334 , Issue.3 , pp. 784-794
    • Xiao, B.1    Li, X.2    Yan, J.3
  • 64
    • 84871346041 scopus 로고    scopus 로고
    • CYP2J2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia
    • F. Herse, B. Lamarca, and C.A. Hubel CYP2J2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia Circulation 126 25 2012 2990 2999
    • (2012) Circulation , vol.126 , Issue.25 , pp. 2990-2999
    • Herse, F.1    Lamarca, B.2    Hubel, C.A.3
  • 65
    • 78649446918 scopus 로고    scopus 로고
    • Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats
    • C. Zheng, L. Wang, and R. Li Gene delivery of cytochrome p450 epoxygenase ameliorates monocrotaline-induced pulmonary artery hypertension in rats Am J Respir Cell Mol Biol 43 6 2013 740 749
    • (2013) Am J Respir Cell Mol Biol , vol.43 , Issue.6 , pp. 740-749
    • Zheng, C.1    Wang, L.2    Li, R.3
  • 66
    • 57349135392 scopus 로고    scopus 로고
    • Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response
    • B. Keseru, E. Barbosa-Sicard, and R. Popp Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response FASEB J 22 12 2008 4306 4315
    • (2008) FASEB J , vol.22 , Issue.12 , pp. 4306-4315
    • Keseru, B.1    Barbosa-Sicard, E.2    Popp, R.3
  • 67
    • 72049108122 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary hypertension: Comparison of soluble epoxide hydrolase deletion vs. Inhibition
    • B. Keseru, E. Barbosa-Sicard, and R.T. Schermuly Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition Cardiovasc Res 85 1 2010 232 240
    • (2010) Cardiovasc Res , vol.85 , Issue.1 , pp. 232-240
    • Keseru, B.1    Barbosa-Sicard, E.2    Schermuly, R.T.3
  • 68
    • 79951551112 scopus 로고    scopus 로고
    • Cytochrome P450-derived epoxyeicosatrienoic acids and pulmonary hypertension: Central role of transient receptor potential C6 channels
    • A.E. Loot, and I. Fleming Cytochrome P450-derived epoxyeicosatrienoic acids and pulmonary hypertension: central role of transient receptor potential C6 channels J Cardiovasc Pharmacol 57 2 2013 140 147
    • (2013) J Cardiovasc Pharmacol , vol.57 , Issue.2 , pp. 140-147
    • Loot, A.E.1    Fleming, I.2
  • 69
    • 84866708034 scopus 로고    scopus 로고
    • 11,12-EET stimulates the association of BK channel alpha and beta(1) subunits in mitochondria to induce pulmonary vasoconstriction
    • A.E. Loot, I. Moneke, and B. Keseru 11,12-EET stimulates the association of BK channel alpha and beta(1) subunits in mitochondria to induce pulmonary vasoconstriction PLoS ONE 7 9 2013 e46065
    • (2013) PLoS ONE , vol.7 , Issue.9 , pp. 46065
    • Loot, A.E.1    Moneke, I.2    Keseru, B.3
  • 71
    • 0035844126 scopus 로고    scopus 로고
    • Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids
    • K. Node, X.L. Ruan, and J. Dai Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids J Biol Chem 276 19 2001 15983 15989
    • (2001) J Biol Chem , vol.276 , Issue.19 , pp. 15983-15989
    • Node, K.1    Ruan, X.L.2    Dai, J.3
  • 72
    • 0022982159 scopus 로고
    • Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry
    • F.A. Fitzpatrick, M.D. Ennis, M.E. Baze, M.A. Wynalda, J.E. McGee, and W.F. Liggett Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry J Biol Chem 261 32 1986 15334 15338 (Pubitemid 17218115)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.32 , pp. 15334-15338
    • Fitzpatrick, F.A.1    Ennis, M.D.2    Baze, M.E.3
  • 74
    • 38649094556 scopus 로고    scopus 로고
    • 11,12-Epoxyeicosatrienoic acid activates the L-arginine/nitric oxide pathway in human platelets
    • DOI 10.1007/s11010-007-9611-6
    • L. Zhang, Y. Cui, B. Geng, X. Zeng, and C. Tang 11,12-Epoxyeicosatrienoic acid activates the l-arginine/nitric oxide pathway in human platelets Mol Cell Biochem 308 1-2 2008 51 56 (Pubitemid 351167844)
    • (2008) Molecular and Cellular Biochemistry , vol.308 , Issue.1-2 , pp. 51-56
    • Zhang, L.1    Cui, Y.2    Geng, B.3    Zeng, X.4    Tang, C.5
  • 75
    • 84867968407 scopus 로고    scopus 로고
    • The potential use of the pregnane X receptor in cardiovascular therapy
    • K.E. Swales, and D. Bishop-Bailey The potential use of the pregnane X receptor in cardiovascular therapy Expert Rev Cardiovasc Ther 10 9 2013 1079 1082
    • (2013) Expert Rev Cardiovasc Ther , vol.10 , Issue.9 , pp. 1079-1082
    • Swales, K.E.1    Bishop-Bailey, D.2
  • 76
    • 84857943837 scopus 로고    scopus 로고
    • Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress
    • K.E. Swales, R. Moore, and N.J. Truss Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress Cardiovasc Res 93 4 2012 674 681
    • (2012) Cardiovasc Res , vol.93 , Issue.4 , pp. 674-681
    • Swales, K.E.1    Moore, R.2    Truss, N.J.3
  • 77
    • 33751112296 scopus 로고    scopus 로고
    • Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: Major roles for CYP2J2 and CYP3A
    • K.H. Liu, M.G. Kim, and D.J. Lee Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A Drug Metab Dispos 34 11 2006 1793 1797
    • (2006) Drug Metab Dispos , vol.34 , Issue.11 , pp. 1793-1797
    • Liu, K.H.1    Kim, M.G.2    Lee, D.J.3
  • 78
    • 84859903692 scopus 로고    scopus 로고
    • Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity
    • C.A. Lee, J.P. Jones 3rd, and J. Katayama Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity Drug Metab Dispos 40 5 2012 943 951
    • (2012) Drug Metab Dispos , vol.40 , Issue.5 , pp. 943-951
    • Lee, C.A.1    Jones III, J.P.2    Katayama, J.3
  • 79
    • 78650798184 scopus 로고    scopus 로고
    • Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism
    • V. Michaud, M. Frappier, M.C. Dumas, and J. Turgeon Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism PLoS ONE 5 12 2013 e15666
    • (2013) PLoS ONE , vol.5 , Issue.12 , pp. 15666
    • Michaud, V.1    Frappier, M.2    Dumas, M.C.3    Turgeon, J.4
  • 80
    • 0038650989 scopus 로고    scopus 로고
    • Verapamil: Metabolism in cultures of primary human coronary arterial endothelial cells
    • DOI 10.1124/dmd.31.7.888
    • J. Borlak, M. Walles, K. Levsen, and T. Thum Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells Drug Metab Dispos 31 7 2003 888 891 (Pubitemid 36759058)
    • (2003) Drug Metabolism and Disposition , vol.31 , Issue.7 , pp. 888-891
    • Borlak, J.1    Walles, M.2    Levsen, K.3    Thum, T.4
  • 82
    • 34047260398 scopus 로고    scopus 로고
    • Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates
    • Y. Minamiyama, S. Takemura, S. Imaoka, Y. Funae, and S. Okada Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates Drug Metab Pharmacokinet 22 1 2007 15 19
    • (2007) Drug Metab Pharmacokinet , vol.22 , Issue.1 , pp. 15-19
    • Minamiyama, Y.1    Takemura, S.2    Imaoka, S.3    Funae, Y.4    Okada, S.5
  • 84
    • 0032053799 scopus 로고    scopus 로고
    • Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4
    • DOI 10.1006/geno.1998.5235
    • J. Ma, S. Ramachandran, F.T. Fiedorek Jr., and D.C. Zeldin Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4 Genomics 49 1 1998 152 155 (Pubitemid 28194450)
    • (1998) Genomics , vol.49 , Issue.1 , pp. 152-155
    • Ma, J.1    Ramachandran, S.2    Fiedorek Jr., F.T.3    Zeldin, D.C.4
  • 87
    • 61549126887 scopus 로고    scopus 로고
    • The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile
    • J. Borgel, D. Bulut, and C. Hanefeld The CYP2J2 G-50T polymorphism and myocardial infarction in patients with cardiovascular risk profile BMC Cardiovasc Disord 8 2008 41
    • (2008) BMC Cardiovasc Disord , vol.8 , pp. 41
    • Borgel, J.1    Bulut, D.2    Hanefeld, C.3
  • 89
    • 34247182994 scopus 로고    scopus 로고
    • CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: The Atherosclerosis Risk in Communities (ARIC) study
    • DOI 10.1097/FPC.0b013e32809913ea, PII 0121301120070500000006
    • C.R. Lee, K.E. North, M.S. Bray, D.J. Couper, G. Heiss, and D.C. Zeldin CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study Pharmacogenet Genomics 17 5 2007 349 358 (Pubitemid 46608542)
    • (2007) Pharmacogenetics and Genomics , vol.17 , Issue.5 , pp. 349-358
    • Lee, C.R.1    North, K.E.2    Bray, M.S.3    Couper, D.J.4    Heiss, G.5    Zeldin, D.C.6
  • 90
    • 79960840423 scopus 로고    scopus 로고
    • Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease
    • Y. Xu, H. Ding, and J. Peng Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease Pharmacogenet Genomics 21 8 2013 489 494
    • (2013) Pharmacogenet Genomics , vol.21 , Issue.8 , pp. 489-494
    • Xu, Y.1    Ding, H.2    Peng, J.3
  • 91
    • 38349092381 scopus 로고    scopus 로고
    • A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population
    • A.V. Polonikov, V.P. Ivanov, and M.A. Solodilova A common polymorphism G-50T in cytochrome P450 2J2 gene is associated with increased risk of essential hypertension in a Russian population Dis Markers 24 2 2008 119 126
    • (2008) Dis Markers , vol.24 , Issue.2 , pp. 119-126
    • Polonikov, A.V.1    Ivanov, V.P.2    Solodilova, M.A.3
  • 93
    • 84866242598 scopus 로고    scopus 로고
    • CYP2J2-50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension
    • A. Alghasham, A. Ali, H. Ismail, M. Dowaidar, and A.A. Settin CYP2J2-50 G/T and ADRB2 G46A gene polymorphisms in Saudi subjects with hypertension Genet Test Mol Biomarkers 16 9 2013 1027 1031
    • (2013) Genet Test Mol Biomarkers , vol.16 , Issue.9 , pp. 1027-1031
    • Alghasham, A.1    Ali, A.2    Ismail, H.3    Dowaidar, M.4    Settin, A.A.5
  • 94
    • 75149160559 scopus 로고    scopus 로고
    • The common functional polymorphism-50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes
    • C. Fava, M. Montagnana, and P. Almgren The common functional polymorphism-50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes J Hypertens 28 2 2010 294 299
    • (2010) J Hypertens , vol.28 , Issue.2 , pp. 294-299
    • Fava, C.1    Montagnana, M.2    Almgren, P.3
  • 96


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