Endothelium-derived hyperpolarizing factor synthase (cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries

Circulation Research

Volumn 88, Issue 1, 2001, Pages 44-51

  Fleming, Ingrid ^a   Michaelis, U Ruth ^a   Bredenkötter, Daniel ^a   Fisslthaler, Beate ^a   Dehghani, Faramarz ^a   Brandes, Ralf P ^a   Busse, Rudi ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Coronary artery; Cytochrome P450; Endothelium derived hyperpolarizing factor; NADPH oxidase; Reactive oxygen species

Indexed keywords

CYTOCHROME P450 ISOENZYME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SYNTHETASE; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CORONARY ARTERY DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SWINE; VASCULAR ENDOTHELIUM;

EID: 0035910620     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.88.1.44     Document Type: Article

References (41)

1. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
2. Interactions of oxidants with vascular signaling systems
3. Involvement of phenyl radicals in iodonium compound inhibition of flavoprotein enzymes
4. Tetrahy-drobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase
5. Superoxide generation from endothelial nitric oxide synthase
6. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs
7. NADH oxidase activity of human xanthine oxidoreductase: Generation of superoxide anion
8. The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils: Specific labeling of a component polypeptide of the oxidase
9. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure
10. Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor
11. Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species
12. Cytochrome P450: Progress and predictions
13. Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes
14. Human umbilical vein endothelial cells express P450 2C8 mRNA: Cloning of endothelial P450 epoxygenase
15. Cytochrome P450 2C is an EDHF synthase in coronary arteries
16. Nifedipine increases cytochrome P4502C expression and EDHF-mediated responses in coronary arteries
17. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
18. Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia
19. Evaluation of five imidazopyrazinone-type chemiluminescent superoxide probes and their application to the measurement of superoxide anion generated by Listeria monocytogenes
20. Measurement of superoxide release in the phagovacuoles of immune complex-stimulated human neutrophils
21. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
22. A transferable, β-naphthoflavone-inducible, hyperpolarizing factor is synthesised by native and cultured porcine coronary endothelial cells
23. Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells
24. 2+ changes and dilation in isolated resistance arteries
25. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants
26. Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis
27. Pulsatile stretch and shear stress: Physical stimuli determining the production of endothelium-derived relaxing factors
28. Superoxide and endothelium-dependent constriction to flow in porcine small pulmonary arteries
29. Oxygen activation by cytochrome P-450
30. Constitutive and inducible expression of cytochrome P450IA1 and P450IB1 in human vascular endothelial and smooth muscle cells
31. Production of 20-HETE and its role in autoregulation of cerebral blood flow
32. Pulsatile stretch elicits the release of the endothelium-derived hyperpolarizing factor from isolated coronary arteries: A modulator of arterial compliance
33. Hypercholesterolemia increases endothelial superoxide anion production
34. Potentiation of nitric oxide-mediated vasorelaxation by xanthine oxidase inhibitors
35. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall
36. Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18
37. Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: Molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9
38. Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450
39. Oxidative stress and expression of p22phox are involved in the up-regulation of tissue factor in vascular smooth muscle cells in response to activated platelets
40. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors
41. 11,12-Epoxyeicosatrienoic acid stimulates tyrosine kinase activity in porcine aortic endothelial cells