Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo

Circulation Research

Volumn 110, Issue 6, 2012, Pages 808-817

  Zhang, Donghong ^a   Xie, Xina ^a   Chen, Yequn ^a   Hammock, Bruce D ^b   Kong, Wei ^b   Zhu, Yi ^a,c  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

activating transcription factor 6; demethylation; endothelial cells; homocysteine; soluble epoxide hydrolase

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; HOMOCYSTEINE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; SMALL INTERFERING RNA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA INTIMA; ARTICLE; BINDING SITE; CELL ACTIVATION; CHROMATIN IMMUNOPRECIPITATION; DEMETHYLATION; DNA BINDING MOTIF; DNA METHYLATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE DELETION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; UPREGULATION; VASCULAR ENDOTHELIUM;

8,11,14-EICOSATRIENOIC ACID; ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; AORTA; BASE SEQUENCE; DNA METHYLATION; ENDOTHELIAL CELLS; EPOXIDE HYDROLASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMOCYSTEINE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERHOMOCYSTEINEMIA; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PROMOTER REGIONS, GENETIC; PYRENES; RNA, SMALL INTERFERING; SOLUBILITY; UP-REGULATION;

EID: 84862817897     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.259325     Document Type: Article

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