CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)

Journal of Biological Chemistry

Volumn 286, Issue 20, 2011, Pages 17543-17559

  Mitra, Ranjana ^a,b   Guo, Zhijun ^a,b   Milani, Monica ^a,b   Mesaros, Clementina ^c   Rodriguez, Mariangellys ^a,b   Nguyen, Julia ^a,b   Luo, Xianghua ^b,d   Clarke, Duncan ^e   Lamba, Jatinder ^e   Schuetz, Erin ^f   Donner, David B ^g   Puli, Narender ^h   Falck, John R ^h   Capdevila, Jorge ⁱ   Gupta, Kalpna ^a,b   Blair, Ian A ^c   Potter, David A ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

ⁱ VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARACHIDONIC ACIDS; BREAST CANCER; BREAST CANCER CELLS; CELL CYCLE; CONCENTRATION-DEPENDENT; CYTOCHROME P450 GENES; HYDROXYLASES; MCF-7 CELLS; MITOGENESIS; NUCLEAR TRANSLOCATIONS; OVERALL SURVIVAL; POTENTIAL MECHANISM; REGIOISOMERS; RNAI SILENCING; SIGNALING PROCESS; TOTAL TURNOVER;

ANCHORAGES (FOUNDATIONS); BIOCHEMISTRY; BIOSYNTHESIS; CELL DEATH; CELL GROWTH; CLONE CELLS; CLONING; GENE EXPRESSION; GROWTH KINETICS; PHOSPHORYLATION;

DISEASES;

14,15 EPOXY 5,8,11 ICOSATRIENOIC ACID; ARACHIDONIC ACID; CYTOCHROME P450 3A4; ESTROGEN RECEPTOR; STAT3 PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE SILENCING; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MITOGENESIS; OXYGENATION; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

8,11,14-EICOSATRIENOIC ACID; ACTIVE TRANSPORT, CELL NUCLEUS; BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; CYTOCHROME P-450 CYP3A; FEMALE; G2 PHASE; GENE SILENCING; HUMANS; NEOPLASM PROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 79955947190     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.198515     Document Type: Article

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