Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart

FASEB Journal

Volumn 25, Issue 10, 2011, Pages 3436-3447

  Edin, Matthew L ^a   Wang, ZhongJing ^a   Bradbury, J Alyce ^a   Graves, Joan P ^a   Lih, Fred B ^a   DeGraff, Laura M ^a   Foley, Julie F ^a   Torphy, Robert ^a   Ronnekleiv, Oline K ^b,c   Tomer, Kenneth B ^a   Lee, Craig R ^d   Zeldin, Darryl C ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

CYP2J2; EETs; Langendorff; Leukotoxin; Reactive oxygen species

Indexed keywords

CYTOCHROME P450 2C8; EPOXYICOSATRIENOIC ACID; REACTIVE OXYGEN METABOLITE; STEARIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; CORONARY VASCULAR RESISTANCE; DISEASE PREDISPOSITION; ENDOTHELIUM; ENZYME INHIBITION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART RATE; HYDROLYSIS; ISOLATED HEART; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; REPERFUSION INJURY; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; EICOSANOIDS; ENDOTHELIUM, VASCULAR; EPOXIDE HYDROLASES; HEART; HUMANS; MICE; MICE, TRANSGENIC; OLEIC ACIDS; PROMOTER REGIONS, GENETIC; RECEPTOR PROTEIN-TYROSINE KINASES; REPERFUSION INJURY;

MUS; MUS MUSCULUS;

EID: 80053919098     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-188300     Document Type: Article

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