Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

Cardiovascular Research

Volumn 93, Issue 4, 2012, Pages 674-681

  Swales, Karen E ^a   Moore, Rick ^b   Truss, Nicola J ^c   Tucker, Arthur ^c   Warner, Timothy D ^c   Negishi, Masahiko ^b   Bishop Bailey, David ^c  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cytochrome P450; Nuclear receptors; Pregnane X receptor; Vascular endothelium; Vascular smooth muscle cells

Indexed keywords

ADENOSINE DIPHOSPHATE; CLOPIDOGREL; CYTOCHROME P450 2B; CYTOCHROME P450 2C; CYTOCHROME P450 3A; GLUTATHIONE TRANSFERASE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR; REACTIVE OXYGEN METABOLITE; XENOBIOTIC AGENT;

ANIMAL CELL; APOPTOSIS; CONTROLLED STUDY; DRUG METABOLISM; DRUG TRANSPORT; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REVIEW; SMOOTH MUSCLE FIBER; VASCULAR DISEASE; VASCULARIZATION; XENOBIOTIC METABOLISM;

ANIMALS; AORTA; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIUM, VASCULAR; GLUTATHIONE TRANSFERASE; HUMANS; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MUSCLE, SMOOTH, VASCULAR; OXIDATIVE STRESS; P-GLYCOPROTEIN; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTORS, STEROID; TICLOPIDINE; XENOBIOTICS;

EID: 84857943837     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr330     Document Type: Review

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