Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice

FASEB Journal

Volumn 24, Issue 10, 2010, Pages 3770-3781

  Lee, Craig R ^a,b   Imig, John D ^c   Edin, Matthew L ^a   Foley, Julie ^a   DeGraff, Laura M ^a   Bradbury, J Alyce ^a   Graves, Joan P ^a   Lih, Fred B ^a   Clark, James ^a   Myers, Page ^a   Perrow, A Ligon ^a   Lepp, Adrienne N ^c   Kannon, M Alison ^b   Ronnekleiv, Oline K ^d   Alkayed, Nabil J ^d,e   Falck, John R ^f   Tomer, Kenneth B ^a   Zeldin, Darryl C ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b University of North Carolina   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

CYP2C8; CYP2J2; EETs; Epoxygenase; Transgenic

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN II; CYTOCHROME P450; CYTOCHROME P450 2C8; CYTOCHROME P450 2J2; ENDOTHELIN 1; EPOXYICOSATRIENOIC ACID; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; ARACHIDONATE EPOXYGENASE; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BLOOD PRESSURE; ENDOTHELIUM; FEMALE; HYPERTENSION; KIDNEY INJURY; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; SALT INTAKE; SODIUM TRANSPORT; SYSTOLIC BLOOD PRESSURE; ANIMAL; C57BL MOUSE; CELL CULTURE; COMPLICATION; CYTOLOGY; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY DISEASES; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

MUS; MUS MUSCULUS;

ANIMALS; BASE SEQUENCE; BLOOD PRESSURE; BLOTTING, WESTERN; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ENDOTHELIUM, VASCULAR; FEMALE; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77957831701     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-160119     Document Type: Article

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