Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice

FASEB Journal

Volumn 25, Issue 2, 2011, Pages 703-713

  Deng, Yangmei ^a   Edin, Matthew L ^b   Theken, Katherine N ^a   Schuck, Robert N ^a   Flake, Gordon P ^b   Kannon, M Alison ^a   DeGraff, Laura M ^b   Lih, Fred B ^b   Foley, Julie ^b   Bradbury, J Alyce ^b   Graves, Joan P ^b   Tomer, Kenneth B ^b   Falck, John R ^c   Zeldin, Darryl C ^b   Lee, Craig R ^a  

^a University of North Carolina   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

CYP2C8; CYP2J2; EETs; Eicosanoids; EPHX2; Inflammation

Indexed keywords

ANGIOPOIETIN RECEPTOR; CYTOCHROME P450 2C8; CYTOCHROME P450 2J2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTOXIN; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; EPOXIDE HYDROLASE; EPOXYICOSATRIENOIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HYDROLYSIS; IN VIVO STUDY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG INFILTRATE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VASCULITIS; WILD TYPE;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIAL CELLS; ENDOTOXEMIA; EPOXIDE HYDROLASES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, TRANSGENIC; VASCULAR DISEASES;

MUS; MUS MUSCULUS;

EID: 79551646708     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-171488     Document Type: Article

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