The potential use of the pregnane X receptor in cardiovascular therapy

Expert Review of Cardiovascular Therapy

Volumn 10, Issue 9, 2012, Pages 1079-1082

  Swales, Karen E ^a   Bishop Bailey, David ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

atherosclerosis; cholesterol metabolism; drug metabolism; inflammation; pregnane x receptor; vascular health

Indexed keywords

ANTIINFLAMMATORY AGENT; BILE ACID; CYTOCHROME P450 2C; GLUCOSE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HORMONE RECEPTOR STIMULATING AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREGNANE X RECEPTOR; PREGNANE X RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ATHEROSCLEROSIS; BILE ACID SYNTHESIS; CARDIOVASCULAR DISEASE; CHOLESTEROL METABOLISM; COLITIS; DRUG METABOLISM; DRUG TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEART PROTECTION; HEPATITIS; HUMAN; LIPID METABOLISM; NONHUMAN; OXIDATIVE STRESS; PROTEIN TRANSPORT; REVIEW;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; HUMANS; LIGANDS; MOLECULAR TARGETED THERAPY; MUSCLE, SMOOTH, VASCULAR; RECEPTORS, STEROID;

EID: 84867968407     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.12.103     Document Type: Review

References (19)

1. Ihunnah CA, Jiang M, Xie W. Nuclear receptor PXR, transcriptional circuits and metabolic relevance. Biochim. Biophys. Acta 1812(8), 956-963 (2011)
2. Zhou C, King N, Chen KY, Breslow JL. Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice. J. Lipid Res. 50(10), 2004-2013 (2009)
3. Howe K, Sanat F, Thumser AE, Coleman T, Plant N. The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes. Xenobiotica. 41(7), 519-529 (2011)
4. Swales KE, Moore R, Truss NJ et al. Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. Cardiovasc. Res. 93(4), 674-681 (2012)
5. Hagedorn KA, Cooke CL, Falck JR, Mitchell BF, Davidge ST. Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor. Hypertension 49(2), 328-333 (2007) (Pubitemid 46143009)
6. Li T, Chen W, Chiang JY. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J. Lipid Res. 48(2), 373-384 (2007) (Pubitemid 46220604)
7. Zhou C, Verma S, Blumberg B. The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nucl. Recept. Signal. 7e001 (2009)
8. de Haan W, de Vries-van der Weij J, Mol IM et al. PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice. Biochim. Biophys. Acta 1791(3), 191-197 (2009)
9. Hoekstra M, Lammers B, Out R, Li Z, Van Eck M, Van Berkel TJ. Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice. Mol. Pharm. 6(1), 182-189 (2009)
10. Sui Y, Xu J, Rios-Pilier J, Zhou C. Deficiency of PXR decreases atherosclerosis in apoE-deficient mice. J. Lipid Res. 52(9), 1652-1659 (2011)
11. Gao J, Xie W. Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab. Dispos. 38(12), 2091-2095 (2010)
12. Hamlat N, Forcheron F, Negazzi S et al. Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance. Cardiovasc. Diabetol. 8(1), 64 (2009)
13. Glas J, Seiderer J, Fischer D et al. Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease. Inflamm. Bowel Dis. 17(9), 1917-1924 (2011)
14. Hu G, Xu C, Staudinger JL. Pregnane X receptor is SUMOylated to repress the inflammatory response. J. Pharmacol. Exp. Ther. 335(2), 342-350 (2010)
15. Wallace K, Cowie DE, Konstantinou DK et al. The PXR is a drug target for chronic inflammatory liver disease. J. Steroid Biochem. Mol. Biol. 120(2-3), 137-148 (2010)
16. Cheng J, Shah YM, Ma X et al. Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. J. Pharmacol. Exp. Ther. 335(1), 32-41 (2010)
17. Ghose R, Guo T, Vallejo JG, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab. Dispos. 39(5), 874-881 (2011)
18. Ghose R, Omoluabi O, Gandhi A et al. Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters. Life Sci. 89(1-2), 57-64 (2011)
19. Aouabdi S, Gibson G, Plant N. Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor α binding site within the proximal promoter of PXR. Drug Metab. Dispos. 34(1), 138-144 (2006) (Pubitemid 43042655)