JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide

Biochemical Pharmacology

Volumn 86, Issue 12, 2013, Pages 1747-1761

  Kim, Min Ho ^b   Son, Young Jin ^c   Lee, Sang Yeol ^d   Yang, Woo Seok ^a   Yi, Young Su ^a   Yoon, Deok Hyo ^b   Yang, Yanyan ^a   Kim, Shi Hyoung ^a   Lee, Duckhee ^e   Rhee, Man Hee ^f   Kang, Hyojeung ^f   Kim, Tae Woong ^b   Sung, Gi Ho ^g   Cho, Jae Youl ^a  

^a Sungkyunkwan University   (South Korea)

^b Kangwon National University   (South Korea)

^c Sunchon National University   (South Korea)

^d Gachon University College of Medicine   (South Korea)

^e Wonkwang University   (South Korea)

^f Kyungpook National University   (South Korea)

^g Rural Development Administration   (South Korea)

Author keywords

Amide functionality; Anti inflammatory effects; Inflammatory mediators; JAK2; Resveratrol derivatives

Indexed keywords

2,4 DIHYDROXY N (4 HYDROXYPHENYL)BENZAMIDE; ACETIC ACID; ALPHA INTERFERON; AMIDE; ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; BETA INTERFERON; COLLAGEN TYPE 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; RESVERATROL; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 2,4-DIHYDROXY-N-(4-HYDROXYPHENYL)BENZAMIDE; AUTACOID; BENZAMIDE DERIVATIVE; PRIMER DNA; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CELL DIFFERENTIATION; COLITIS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; EAR EDEMA; GASTRITIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER FUNCTION; MALE; MORNING DOSAGE; MOUSE; NONHUMAN; ORGAN WEIGHT; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; STOMACH ULCER; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL LINE; DRUG EFFECTS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BASE SEQUENCE; BENZAMIDES; CELL LINE; DNA PRIMERS; HUMANS; INFLAMMATION MEDIATORS; JANUS KINASE 2; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STILBENES; TRANSCRIPTION FACTORS;

EID: 84888878888     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.10.006     Document Type: Article

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