Lipid a receptor TLR4-mediated signaling pathways

Advances in Experimental Medicine and Biology

Volumn 667, Issue , 2009, Pages 59-68

  Akira, Shizuo ^a   Yamamoto, Masahiro ^b  

^a OSAKA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 12; LIPID A RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; RANTES; TIR DOMAIN CONTAINING ADAPTOR COMPRISE 5 FAMILY; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL PROLIFERATION; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; MICROARRAY ANALYSIS; MYRISTYLATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SPLEEN CELL; UBIQUITINATION;

HUMANS; LIPID A; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 77952525214     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-1603-7_6     Document Type: Article

References (67)

1. Freudenberg MA, Galanos C. Bacrerial lipopolysaccharides: structure, metabolism and mechanisms of action. Int Rev Immunol 1990; 6:207-21.
2. Lin WJ, Yeh WC. Implication of Toll-like receptor and tumor necrosis factor α signaling in septic shock. Shock 2005; 24:206-9.
3. Wright SD, Ramos RA, Tobias PS et al. CD 14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-3.
4. Müller JM, Ziegler-Heitbrock HW; Baeuerle P. Nuclear facror-κB, a mediator of lipopolysaccharide effects Immunobiology 1993; 187:233-56. (Pubitemid 23150770)
5. Lernaitre B. Nicolas E. Michaut L et al. The dorsoventral regulatory gene cassette sparzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86:973-83. (Pubitemid 26336801)
6. Medzhitov R. Preston-Hurlburt P. Janeway CA Jr. A human homologue of the Drosophila Toll protein signals acrivation of adaptive immunity. Nature 1997; 388:394-7. (Pubitemid 27334820)
7. Poltorak A. He X. Smirnova I et al. Defective LPS signaling in C3H/HeJ and C57BL/I0ScCr mice: mutations in Tlr4 gene. Science 1998; 282:2085-8. (Pubitemid 29001265)
8. Hoshino K. Takeuchi O. Kawai T et al. Cutting edge: Toll-like receptor 4 (TLR4)-ddicient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 1999; 162:3749-52. (Pubitemid 29314747)
9. Yamamoto M. Takeda K. Akira S. TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 2004; 40:861-8. (Pubitemid 38032809)
10. Muzio M. Ni J. Feng P et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-I signaling. Science 1997; 278:1612-5. (Pubitemid 27516277)
11. Adachi O. Kawai T. Takeda K et al. Targeted disruption of the MyD88 gene results in loss of IL-l- and IL-18-mediated function. Immunity 1998; 9:143-50. (Pubitemid 28361303)
12. Kawai T. Adachi O. Ogawa T et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11:115-22. (Pubitemid 29359962)
13. Kawai T. Takeuchi O. Fujita T et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide- inducible genes. J Immunol 2001; 167:5887-94. (Pubitemid 33062783)
14. Taniguchi T. Ogasawara K. Takaoka A et al. IRF family of transcription factors as regulators of host defense. Annu Rev Immunol. 2001; 19:623-55. (Pubitemid 32368048)
15. Sakaguchi S. Negishi H. Asagiri M et al. Essential role of IRF -3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. Biochem Biophys Res Commun 2003; 306:860-6. (Pubitemid 36776210)
16. Alexopoulou L. Holt AC. Medzhitov R et al. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 2001; 413 :732-8. (Pubitemid 33009951)
17. Yamamoto M. Sato S. Mori K et al. Cutting edge: a novel Toll/IL-l receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J Immunol 2002; 169:6668-72. (Pubitemid 36899248)
18. Oshiumi H. Matsumoto M. Funami K et al. TICAM-1. an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 2003; 4:161-7. (Pubitemid 36193018)
19. Yamamoto M. Sato S. Hemrni H et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003; 301:640-3. (Pubitemid 36927946)
20. Hoebe K. Du X. Georgel P et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 2003; 424:743-8. (Pubitemid 37021696)
21. Sato S. Sugiyama M. Yamamoto M et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associateswith TNF receptor-associated factor 6 and TANK-binding kinase 1 and activates rwo distinct transcription factors. NF-κB and IFN-regulatory factor-S, in the Toll-like receptor signaling. J Immunol2003; 171:4304-10.
22. Meylan E. Burns K. Hofmann K et al. RIPI is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nat Immunol 2004; 5:503-7. (Pubitemid 38660462)
23. Sasai M. Oshium i H. Matsumoto M et al. Cutting Edge: NF-κB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-l homology domain-containing adapter molecule-l-rnediated IFN regulatory factor 3 activation. J Immunol 2005; 174:27-30. (Pubitemid 40007387)
24. Han KJ, Su X. Xu LG et al. Mechanisms of the TRIF-induced interferon-stimulated response dement and NF-κB activation and apoptosis pathways. J Biol Chern 2004; 279:15652-61. (Pubitemid 38618967)
25. Kaiser WJ. Offermann MK. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction morif J Immunol 2005; 174:4942-52. (Pubitemid 40514460)
26. Hsu LC. Park JM. Zhang K et al. The protein kinase PKR is required for macrophage apoptosis alter activation of Toll-like receptor 4. Nature 2004; 428 :341-5. (Pubitemid 38418807)
27. Horng T. Barton GM. Medzhirov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol 2001; 2:835-41.
28. Fitzgerald KA. Palsson-McDermott EM. Bowie AG et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001; 413 :78-83. (Pubitemid 32843491)
29. Yamamoto M. Sato S. Hernrni H et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 2002; 420:324-9. (Pubitemid 35398188)
30. Horng T. Barton GM. Flavell RA et al. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 2002; 420:329-33. (Pubitemid 35398189)
31. Yamamoto M. Sato S. Hernrni H et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 2003; 4:1144-50. (Pubitemid 37428043)
32. Fitzgerald KA. Rowe DC. Barnes BJ et al. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the roll adapters TRAM and TRIF. J Exp Med 2003 ; 198:1043-55. (Pubitemid 37248620)
33. Oshiumi H, Sasai M. Shida K et al. TIR-containing adapter molecule (T IC AM)- 2, a bridging adapter recruiting to roll-like receptor 4 TICAM-I that induce s interferon-beta. J Biol Chern 2003; 278 :49751-62. (Pubitemid 37548808)
34. Akira S. Uernatsu S. Takeuchi O. Pathogen recognition and innate immun ity. Cell 2006; 124:783-801. (Pubitemid 43261452)
35. Rowe DC. McGettrick AF, Latz E et al. The myristoylation of TRIF-related adapror molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci USA 2006 ; 103:6299-304.
36. McGmrick AF, Brint EK. Palsson-McDermorr EM et al. Trif-relared adapter molecule is phosphorylated by PKC-ε during Toll-like receptor 4 signaling. Proc Natl Acad Sci USA 2006 ;103: 9196-201. (Pubitemid 43902555)
37. Kagan JC. Medzhitov R. Phosphoinositide-mediated adapror recruitment controls Toll-like recepror signaling. Cell 2006 ; 125:943-55. (Pubitemid 43795199)
38. Medvedev AE. Sabroe I. Hasday JD et al. Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J Endotoxin Res 2006 ; 12:133-50. (Pubitemid 47487520)
39. Liew FY, Xu D. Brint EK et al. Negative regulation of roll-like receptor-mediated immune responses. Nat Rev Immunol 2005 ; 5:446-58. (Pubitemid 40835033)
40. Iwami KI. Matsuguchi T. Masuda A et al. Cutting edge: naturally occurring soluble form of mouse Toll-like recepror 4 inhibits lipopol ysaccharide signaling. J Immunol 2000; 165:6682-6. (Pubitemid 32001129)
41. Chuang TH. Ulevirch RJ. Triad3A. an E3 ubiquirin-protein ligase regulating Toll-like receptors. Nat Immunol 2004 ; 5:495-502.
42. Mansell A. Smith R, Doyle SL et al. Suppressor of cyrokine signaling 1 negatively regulates Toll-like recepror signaling by mediating Mal degradation. Nat Immunol 2006; 7:148-55. (Pubitemid 43135880)
43. Nakagawa R. Naka T. Tsutsui H et al. SOCS-1 participates in negative regulation of LPS responses. Immunity 2002; 17:677-87. (Pubitemid 35351512)
44. Kinjyo I. Hanada T, Inagaki-Ohara K et al. SOCS l/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 2002 ; 17:583-91. (Pubitemid 35351504)
45. Janssens S. Burns K. Tschopp J et al. Regulation of interleukin-1- and lipopol ysaccharide-induced NF-κB activation by alternative splicing of MyD88. Cure Biol 2002 ; 12:467-71. (Pubitemid 34248892)
46. Negishi H. Ohba Y, Yanai H et al. Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Nad Acad Sci USA 2005 ; 102:15989-94. (Pubitemid 41552855)
47. Janssens S. Beyaert R. Functional diversity and regulation of different interleukin-1 recepror-associared kinase (IRAK) family members. Mol Cell 2003; 11:293-302. (Pubitemid 36293825)
48. Kobayashi K. Hernandez LD. Galan JE et al. IRAK-M is a negative regularor of Toll-like recept or signaling. Cell 2002; 110:191-202. (Pubitemid 34876547)
49. Hardy MP. O'Neill LA. The murine lRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J Biol Chern 2004 ; 279:27699-708. (Pubitemid 38812611)
50. Burns K. Clarworrhy J. Martin L et al. Tollip, a new component of the IL-IRI pathway. links IRAK to the IL-1 receptor. Nat Cell Biol 2000 ; 2:346-51.
51. Kobayashi T. Walsh MC. Choi Y. The role of TRAF6 in signal transduction and the immune response. Microbes Infect 2004; 6:1333-8. (Pubitemid 39539732)
52. Saro S. Sanjo H. Takeda K et al. Essential function for the kinase TAKI in innate and adaptive immune responses. Nat Immunol 2005; 6:1087-95. (Pubitemid 41541786)
53. Shim JH. Xiao C, Paschal AE et al. TAK1. but not TABI or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 2005 ; 19:2668-81. (Pubitemid 41627934)
54. Lee EG. Boone DL. Chai S et al. Failure to regulate TNF-induced NF-κB and cell death responses in A20 -deficient mice. Science 2000; 289:2350-4.
55. Boone DL. Turer EE. Lee EG et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol2004; 5:1052-60. (Pubitemid 41057725)
56. Sairoh T, Yamamoro M. Miyagishi M et al. A2O is a negative regularor of IFN regularory factor 3 signaling. J Immunol2005; 174:1507-12.
57. Fukao T. Tanabe M. Terauchi Yet al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 2002 ; 3:875-81.
58. Fukao T. Koyasu S. PI3K and negative regulation of TLR signaling. Trends Immunol 2003; 24:358-63. (Pubitemid 36830961)
59. Hirotani T. Yamamoro M. Kumagai Y et al. Regulation of lipopol ysaccharide-indu cible genes by MyD88 and Toll/IL-1 doma in containing adaptor inducing IFN-β. Biochem Biophys Res Commun 2005 ; 328:383-92. (Pubitemid 40208323)
60. Dana S. Novotn y M. Li X et al. Toll IL-1 receprors differ in the irability to promote the stabilization of adenosine and undine-rich elements containing mRNA. J Immunol 2004 ; 173:2755-61. (Pubitemid 39063137)
61. Yamazaki S. Mura T. Matsuo S et al. Stimulus-specific induction of a novel nuclear facror-κB regulator, IκB-ζ, via Toll/Inrerleukin-1 receptor is med iated by mRNA stabilization. J Biol Chern 2005; 280 :1678-87.
62. Yamazaki S, Muta T, Takeshige K. A novel IκB protein, IκB-ζ, induced by proinflammatory stimuli, negatively regulates nuclear factor-κB in the nuclei. J Biol Chern 2001; 276:27657-62.
63. Kitamura H, Kanehira K, Okira K et al. MAIL, a novel nuclear IκB prote in that potentiates LPS-induced IL-6 production. FEBS Lett 2000; 485 :53-6.
64. Harura H, Kato A, Todokoro K. Isolation of a novel inrerleukin-Linducible nuclear protein bearing ankyrin-repeat motifs. J Biol Chern 2001; 276:12485-8.
65. Yamamoto M. Yamazaki S. Uernatsu S et al. Regulation of Toll/Ik-1-recepror-medlated gene expression by the inducible nuclear protein IκBζ. Nature 2004; 430 :218-22. (Pubitemid 38902431)
66. Hirotani T, Lee PY, Kuwata H et al. The nuclear IκB protein IκBNS selectively inhib its lipopolysaccharide- induced IL-6 production in macrophages of the colonic lamina propria. J Immunol 2005; 174:3650-7. (Pubitemid 40354075)
67. Kuwata H, Matsumoto M. Atarashi K et al. IκBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity 2006; 24:41-51. (Pubitemid 43077199)