Impact on inflammation and recovery of skin barrier by nordihydroguaiaretic acid as a protease-activated receptor 2 antagonist

Biomolecules and Therapeutics

Volumn 20, Issue 5, 2012, Pages 463-469

  Kim, Hyo Young ^a   Goo, Jung Hyun ^a   Joo, Yeon Ah ^a   Lee, Ha Yoen ^a   Lee, Se Mi ^a   Oh, Chang Taek ^a   Ahn, Soo Mi ^a   Kim, Nam Hoon ^b   Hwang, Jae Sung ^a  

^a Kyung Hee University   (South Korea)

^b Sehwa High School   (South Korea)

Author keywords

Atopic dermatitis; Nordihydroguaiaretic acid; PAR2 antagonist; Protease activated receptor 2; Skin barrier

Indexed keywords

CALCIUM ION; DEXAMETHASONE; IMMUNOGLOBULIN E; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; INVOLUCRIN; NORDIHYDROGUAIARETIC ACID; OXAZOLONE; PROTEINASE ACTIVATED RECEPTOR 2; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATOPIC DERMATITIS; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; EPIDERMIS CELL; FEMALE; HAIRLESS MOUSE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; KERATINOCYTE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; WATER LOSS; WEIGHT REDUCTION;

EID: 84867249677     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.20.5.463     Document Type: Article

References (24)

1. Bohm, S. K., Kong, W., Bromme, D., Smeekens, S. P., Anderson, D. C., Connolly, A., Kahn, M., Nelken, N. A., Coughlin, S. R., Payan, D. G. and Bunnett, N. W. (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314, 1009-1016.
2. Buddenkotte, J., Stroh, C., Engels, I. H., Moormann, C., Shpacovitch, V. M., Seeliger, S., Vergnolle, N., Vestweber, D., Luger, T. A., Schulze-Osthoff, K. and Steinhoff, M. (2005) Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J. Invest. Dermatol. 124, 38-45.
3. Demerjian, M., Hachem, J. P., Tschachler, E., Denecker, G., Declercq, W., Vandenabeele, P., Mauro, T., Hupe, M., Crumrine, D., Roelandt, T., Houben, E., Elias, P. M. and Feingold, K. R. (2008) Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2. Am. J. Pathol. 172, 86-97.
4. Eads, D., Hansen, R., Oyegunwa, A., Cecil, C., Culver, C., Scholle, F., Petty, I. and Laster, S. (2009) Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines. J. Inflamm (Lond). 6, 2.
5. Elias, P. M. and Steinhoff, M. (2008) "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J. Invest. Dermatol. 128, 1067-1070.
6. Frateschi, S., Camerer, E., Crisante, G., Rieser, S., Membrez, M., Charles, R. P., Beermann, F., Stehle, J. C., Breiden, B., Sandhoff, K., Rotman, S., Haftek, M., Wilson, A., Ryser, S., Steinhoff, M., Coughlin, S. R. and Hummler, E. (2011) PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat. Commun. 2, 161.
7. Grant, A. D., Cottrell, G. S., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cenac, N., Zamponi, G. W., Bautista-Cruz, F., Lopez, C. B., Joseph, E. K., Levine, J. D., Liedtke, W., Vanner, S., Vergnolle, N., Geppetti, P. and Bunnett, N. W. (2007) Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J. Physiol. (Lond). 578, 715-733.
8. Hachem, J. P., Houben, E., Crumrine, D., Man, M. Q., Schurer, N., Roelandt, T., Choi, E. H., Uchida, Y., Brown, B. E., Feingold, K. R. and Elias, P. M. (2006) Serine protease signaling of epidermal permeability barrier homeostasis. J. Invest. Dermatol. 126, 2074-2086.
9. He, S., Aslam, A., Gaça, M. D., He, Y., Buckley, M. G., Hollenberg, M. D. and Walls, A. F. (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J. Pharmacol. Exp. Ther. 309, 119-126.
10. Hou, L., Kapas, S., Cruchley, A. T., Macey, M. G., Harriott, P., Chinni, C., Stone, S. R. and Howells, G. L. (1998) Immunolocalization of protease-activated receptor-2 in skin: receptor activation stimulates interleukin-8 secretion by keratinocytes in vitro. Immunology 94, 356-362.
11. Jeong, S. K., Kim, H. J., Youm, J. K., Ahn, S. K., Choi, E. H., Sohn, M. H., Kim, K. E., Hong, J. H., Shin, D. M. and Lee, S. H. (2008) Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery. J. Invest. Dermatol. 128, 1930-1939.
12. Jin, H., He, R., Oyoshi, M. and Geha, R. S. (2009) Animal models of atopic dermatitis. J. Invest. Dermatol. 129, 31-40.
13. Kang, J. S., Yoon, W. K., Han, M. H., Lee, H., Lee, C. W., Lee, K. H., Han, S. B., Lee, K., Yang, K. H., Park, S. K. and Kim, H. M. (2008) Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice. Int. Immunopharmacol. 8, 1475-1480.
14. Lee, S. E., Kim, J. M., Jeong, S. K., Jeon, J. E., Yoon, H. J., Jeong, M. K. and Lee, S. H. (2010) Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes. Arch. Dermatol. Res. 302, 745-756.
15. Mahajan, U. M., Gupta, C., Wagh, P. R., Karpe, P. A. and Tikoo, K. (2011) Alteration in inflammatory/apoptotic pathway and histone modifications by nordihydroguaiaretic acid prevents acute pancreatitis in swiss albino mice. Apoptosis 16, 1138-1149.
16. Man, M. Q., Hatano, Y., Lee, S. H., Man, M., Chang, S., Feingold, K. R., Leung, D. Y, Holleran, W., Uchida, Y. and Elias, P. M. (2008) Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J. Invest. Dermatol. 128, 79-86.
17. Nystedt, S., Ramakrishnan, V. and Sundelin, J. (1996) The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J. Biol. Chem. 271, 14910-14915.
18. Rahman, S., Ansari, R. A., Rehman, H., Parvez, S. and Raisuddin, S. (2011) Nordihydroguaiaretic acid from creosote bush (Larrea tridentata) mitigates 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory and oxidative stress responses of tumor promotion cascade in mouse skin. Evid. Based Complement Alternat. Med. 2011, 734-785.
19. Roelandt, T., Heughebaert, C., Verween, G., Giddelo, C., Verbeken, G., Pirnay, J. P., Devos, D., Crumrine, D., Roseeuw, D., Elias, P. M. and Hachem, J. P. (2011) Actin dynamics regulate immediate PAR-2-dependent responses to acute epidermal permeability barrier abrogation. J. Dermatol. Sci. 61, 101-109.
20. Steven, A. C. and Steinert, P. M. (1994) Protein composition of cor nified cell envelopes of epidermal keratinocytes. J. Cell Sci. 107, 693-700.
21. Tsujii, K., Andoh, T., Ui, H., Lee, J. B. and Kuraishi, Y. (2009) Involvement of tryptase and proteinase-activated receptor-2 in spontaneous itch-associated response in mice with atopy-like dermatitis. J. Pharmacol. Sci. 109, 388-395.
22. Vergnolle, N., Hollenberg, M. D., Sharkey, K. A. and Wallace, J. L. (1999) Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. Br. J. Pharmacol. 127, 1083-1090.
23. Vergnolle, N., Macnaughton, W. K., Al-Ani, B., Saifeddine, M., Wallace, J. L. and Hollenberg, M. D. (1998) Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc. Natl. Acad. Sci. USA 95, 7766-7771.
24. Yun, J. W., Seo, J. A., Jeong, Y. S., Bae, I. H., Jang, W. H., Lee, J., Kim, S. Y., Shin, S. S., Woo, B. Y., Lee, K. W., Lim, K. M. and Park, Y. H. (2011) TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. J. Dermatol. Sci. 62, 8-15.