SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation

Biochemical Pharmacology

Volumn 86, Issue 12, 2013, Pages 1775-1783

  Xu, Jiake ^b   Liu, Qian ^a,b   Wu, Huafei ^b   Chim, Shek Man ^b   Zhou, Lin ^b   Zhao, Jinmin ^a   Feng, Haotian ^c   Wei, Qingli ^d   Wang, Qing ^e   Zheng, Ming H ^b   Tan, Ren Xiang ^f   Gu, Qiong ^g   Xu, Jun ^g   Pavlos, Nathan ^b   Tickner, Jennifer ^b  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c NESTLÉ RESEARCH CENTER   (Switzerland)

^d QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e SOUTHERN MEDICAL UNIVERSITY   (China)

^f NANJING UNIVERSITY   (China)

^g SUN YAT SEN UNIVERSITY   (China)

Author keywords

Bone marrow cells; NF B; Osteoclastogenesis; RANKL; SC 514

Indexed keywords

CASPASE 3; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; OSTEOCLAST DIFFERENTIATION FACTOR; SC 514; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; I KAPPA B KINASE; THIOPHENE DERIVATIVE; TNFSF11 PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPORTER GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIVISION; CELL LINE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL DIVISION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; I-KAPPA B KINASE; MICE; NF-KAPPA B; OSTEOCLASTS; RANK LIGAND; SIGNAL TRANSDUCTION; THIOPHENES;

EID: 84888877952     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.09.017     Document Type: Article

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