Inhibitory effect of obovatol on nitric oxide production and activation of NF-κB/MAP kinases in lipopolysaccharide-treated RAW 264.7cells

European Journal of Pharmacology

Volumn 556, Issue 1-3, 2007, Pages 181-189

  Choi, Myoung Suk ^a   Lee, Seung Ho ^a   Cho, Ho Seong ^a   Kim, Youngsoo ^a   Yun, Yeo Pyo ^a   Jung, Hai Young ^a   Jung, Jae Kyoung ^a   Lee, Bum Chun ^b   Pyo, Hyeong Bae ^b   Hong, Jin Tae ^a  

^a Chungbuk National University   (South Korea)

^b Samsung Advanced Institute of Technology (SAIT)   (South Korea)

Author keywords

Anti inflammation; MAPK (Mitogen activated protein kinases); NF B; Nitric oxide; Obovatol

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; DNA BINDING PROTEIN; I KAPPA B; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NEOLIGNAN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OBOVATOL; PLANT EXTRACT; SC 514; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; MAGNOLIACEAE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTHRACENES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIPHENYL COMPOUNDS; BUTADIENES; CELL LINE; CYCLOOXYGENASE 2; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MAGNOLIA; MAP KINASE KINASE 4; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRILES; PHENYL ETHERS;

EID: 33846260180     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.10.054     Document Type: Article

References (38)

1. Baldwin Jr. A.S. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14 (1996) 649-683
2. Ban H.S., Suzuki K., Lim S.S., Jung S.H., Lee S.H., Ji J., Lee H.S., Lee Y.S., Shin K.H., and Ohuchi K. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-α by 2′-hydroxychalcone derivatives in RAW 264.7 cells. Biochem. Pharmacol. 67 (2004) 1549-1557
3. Cario E., Rosenberg I.M., Brandwein S.L., Beck P.L., Reinecker H.C., and Podolsky D.K. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J. Immunol. 164 (2000) 966-972
4. Chen B.C., Chen Y.H., and Lin W.W. Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced NOS 2 and COX-2 expression in J774 macrophages. Immunology 97 (1999) 124-129
5. Chen S.C., Chang Y.L., Wang D.L., and Cheng J.J. Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells. Br. J. Pharmacol. 148 (2006) 226-232
6. Chiang C.K., Sheu M.L., Hung K.Y., Wu K.D., and Liu S.H. Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. Kidney Int. 70 (2006) 682-689
7. De Leon E.J., Olmedo D.A., Solis P.N., Gupta M.P., and Terencio M.C. Diayangambin exerts immunosuppressive and anti-inflammatory effects in vitro and in vivo. Planta Med. 68 (2002) 1128-1131
8. Griscavage J.M., Wilk S., and Ignarro L.J. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-κB. Proc. Natl. Acad. Sci. 93 (1996) 3308-3312
9. Haefner B. NF-κB: arresting a major culprit in cancer. Drug Discov. Today 7 (2002) 653-663
10. Hamasaki Y., Kobayashi I., Zaitu M., Tsuji K., Kita M., Hayasaki R., Muro E., Yamamoto S., Matsuo M., Ichimaru T., and Miyazaki S. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. Planta Med. 65 (1999) 222-226
11. Hwang D., Jang B.C., Yu G., and Boudreau M. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages. Biochem. Pharmacol. 54 (1997) 87-96
12. Kim Y.H., Lee S.H., Lee J.Y., Choi S.W., Park J.W., and Kwon T.K. Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase. Eur. J. Pharmacol. 494 (2004) 1-9
13. Kim J.H., Kim D.H., Baek S.H., Lee H.J., Kim M.R., Kwon H.J., and Lee C.H. Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells. Biochem. Pharmacol. 71 (2006) 1198-1205
14. Kuprash D.V., Udalova I.A., Turetskaya R.L., Kwiatkowski D., Rice N.R., and Nedospasov S.A. Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide. J. Immunol. 162 (1999) 4045-4052
15. Kwon B.M., Kim M.K., Lee S.H., Kim J.A., Lee I.R., Kim Y.K., and Bok S.H. Acyl-CoA: cholesterol acyltransferase inhibitors from Magnolia obovata. Planta Med. 63 (1997) 550-551
16. Lee S.H., Seo G.S., and Sohn D.H. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by butein in RAW 264.7 cells. Biochem. Biophys. Res. Commun. 323 (2004) 125-132
17. Lee J.S., Jung E.S., Park J.H., Jung K.S., Lee S.Y., Hong S.T., Park E.K., Kim J.E., Park S.H., and Park D.H. Anti-inflammatory effects of Magnolol and Honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-κB activation signaling. Planta Med. 71 (2005) 338-343
18. Lee S.Y., Son D.J., Lee Y.K., Lee J.W., Lee H.J., Yun Y.W., Ha T.Y., and Hong J.T. Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-kappaB activation and target gene expression in cultured rat astrocytes. Neurosci. Res. 56 (2006) 204-212
19. Lowenstein C.J., Alley E.W., Raval R., Snowman A.M., Snyder S.H., Russel S.W., and Murphy W.J. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ lipopolysaccharide. Proc. Natl. Acad. Sci. 90 (1993) 9730-9734
20. Lyons C.R., Orloff G.J., and Cunningham J.M. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J. Biol. Chem. 267 (1992) 6370-6374
21. Marletta M.A. Nitric oxide synthase structure and mechanism. J. Biol. Chem. 268 (1993) 12231-12234
22. Matsuda H., Kageura T., Oda M., Morikawa T., Sakamoto Y., and Yoshikawa M. Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages. Chem. Pharm. Bull. (Tokyo) 49 (2001) 716-720
23. Nath J., and Powledge A. Modulation of human neutrophil inflammatory responses by nitric oxide: studies in unprimed and LPS-primed cells. J. Leukoc. Biol. 62 (1997) 805-816
24. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6 (1992) 3051-3064
25. Nunokawa Y., Ishida N., and Tanaka S. Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 191 (1993) 89-94
26. Pahl H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18 (1999) 6853-6866
27. Pergola C., Rossi A., Dugo P., Cuzzocrea S., and Sautebin L. Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide 15 (2006) 30-39
28. Rockey D.C., Chung J.J., McKee C.M., and Noble P.W. Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments. Hepatology 27 (1998) 86-92
29. Rudders S., Gaspar J., Madore R., Voland C., Grall F., Patel A., Pellacani A., Perrella M.A., Libermann T.A., and Oettgen P. ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-κB to regulate the inducible nitric-oxide synthase gene. J. Biol. Chem. 276 (2001) 3302-3309
30. Son H.J., Lee H.J., Yun-Choi H.S., and Ryu J.H. Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages. Planta Med. 66 (2000) 469-471
31. Suh S.J., Chung T.W., Son M.J., Kim S.H., Moon T.C., Son K.H., Kim H.P., Chang H.W., and Kim C.H. The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells. Arch. Biochem. Biophys. 447 (2006) 136-146
32. Thanos D., and Maniatis T. NF-κB: a lesson in family values. Cell 80 (1995) 529-532
33. Tsao L.T., Tsai P.S., Lin R.H., Huang L.J., Kuo S.C., and Wang J.P. Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by phenolic (3E)-4-(2-hydroxyphenyl)but-3-en-2-one in RAW 264.7 macrophages. Biochem. Pharmacol. 70 (2005) 618-626
34. Wang J.P., Raung S.L., Chen C.C., Kuo J.S., and Teng C.M. The inhibitory effect of magnolol on cutaneous permeability in mice is probably mediated by a nonselective vascular hyporeactivity to mediators. Naunyn-Schmiedeberg's Arch. Pharmacol. 348 (1993) 663-669
35. Xie Q.W., Kashiwabara Y., and Nathan C. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269 (1994) 4705-4708
36. Yamamoto Y., and Gaynor R.B. Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 107 (2001) 135-142
37. Zhang F.X., Kirschning C.J., Mancinelli R., Xu X.P., Jin Y., Faure E., Mantovani A., Rothe M., Muzio M., and Arditi M. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274 (1999) 7611-7614
38. Zhao Q., and Lee F.S. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β. J. Biol. Chem. 274 (1999) 8355-8358