-
1
-
-
80052320481
-
+-Cl-cotransporter via the aldosterone-SGK1-Nedd4-2 pathway
-
+-Cl-cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol 22: 1707-1719, 2011.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 1707-1719
-
-
Arroyo, J.P.1
Lagnaz, D.2
Ronzaud, C.3
Vazquez, N.4
Ko, B.S.5
Moddes, L.6
Ruffieux-Daidie, D.7
Hausel, P.8
Koesters, R.9
Yang, B.10
Stokes, J.B.11
Hoover, R.S.12
Gamba, G.13
Staub, O.14
-
2
-
-
0036203946
-
Human cortical distal nephron: Distribution of electrolyte and water transport pathways
-
Biner HL, Arpin-Bott MP, Loffing J, Wang X, Knepper M, Hebert SC, Kaissling B. Human cortical distal nephron: distribution of electrolyte and water transport pathways. J Am Soc Nephrol 13: 836-847, 2002.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 836-847
-
-
Biner, H.L.1
Arpin-Bott, M.P.2
Loffing, J.3
Wang, X.4
Knepper, M.5
Hebert, S.C.6
Kaissling, B.7
-
3
-
-
0032718691
-
+ channel lacking the pore-forming region of its alpha subunit
-
+ channel lacking the pore-forming region of its alpha subunit. J Clin Invest 104: 967-974, 1999.
-
(1999)
J Clin Invest
, vol.104
, pp. 967-974
-
-
Bonny, O.1
Chraibi, A.2
Loffing, J.3
Jaeger, N.F.4
Grunder, S.5
Horisberger, J.D.6
Rossier, B.C.7
-
4
-
-
0034106375
-
Dysfunction of epithelial sodium transport: From human to mouse
-
Bonny O, Hummler E. Dysfunction of epithelial sodium transport: from human to mouse. Kidney Int 57: 1313-1318, 2000.
-
(2000)
Kidney Int
, vol.57
, pp. 1313-1318
-
-
Bonny, O.1
Hummler, E.2
-
5
-
-
0036955984
-
A novel mutation of the epithelial Na+ channel causes type 1 pseudohypoaldosteronism
-
Bonny O, Knoers N, Monnens L, Rossier BC. A novel mutation of the epithelial Na+ channel causes type 1 pseudohypoaldosteronism. Pediatr Nephrol 17: 804-808, 2002.
-
(2002)
Pediatr Nephrol
, vol.17
, pp. 804-808
-
-
Bonny, O.1
Knoers, N.2
Monnens, L.3
Rossier, B.C.4
-
6
-
-
84856431125
-
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
-
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Valimaki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP. Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature 482: 98-102, 2012.
-
(2012)
Nature
, vol.482
, pp. 98-102
-
-
Boyden, L.M.1
Choi, M.2
Choate, K.A.3
Nelson-Williams, C.J.4
Farhi, A.5
Toka, H.R.6
Tikhonova, I.R.7
Bjornson, R.8
Mane, S.M.9
Colussi, G.10
Lebel, M.11
Gordon, R.D.12
Semmekrot, B.A.13
Poujol, A.14
Valimaki, M.J.15
De Ferrari, M.E.16
Sanjad, S.A.17
Gutkin, M.18
Karet, F.E.19
Tucci, J.R.20
Stockigt, J.R.21
Keppler-Noreuil, K.M.22
Porter, C.C.23
Anand, S.K.24
Whiteford, M.L.25
Davis, I.D.26
Dewar, S.B.27
Bettinelli, A.28
Fadrowski, J.J.29
Belsha, C.W.30
Hunley, T.E.31
Nelson, R.D.32
Trachtman, H.33
Cole, T.R.34
Pinsk, M.35
Bockenhauer, D.36
Shenoy, M.37
Vaidyanathan, P.38
Foreman, J.W.39
Rasoulpour, M.40
Thameem, F.41
Al-Shahrouri, H.Z.42
Radhakrishnan, J.43
Gharavi, A.G.44
Goilav, B.45
Lifton, R.P.46
more..
-
7
-
-
33745076253
-
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells
-
Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int 69: 2162-2170, 2006.
-
(2006)
Kidney Int
, vol.69
, pp. 2162-2170
-
-
Cai, H.1
Cebotaru, V.2
Wang, Y.H.3
Zhang, X.M.4
Cebotaru, L.5
Guggino, S.E.6
Guggino, W.B.7
-
8
-
-
84861204933
-
+:Cl-cotransporter by angiotensin II is a WNK4-dependent process
-
+:Cl-cotransporter by angiotensin II is a WNK4-dependent process. Proc Natl Acad Sci U S A 109: 7929-7934, 2012.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 7929-7934
-
-
Castaneda-Bueno, M.1
Cervantes-Perez, L.G.2
Vazquez, N.3
Uribe, N.4
Kantesaria, S.5
Morla, L.6
Bobadilla, N.A.7
Doucet, A.8
Alessi, D.R.9
Gamba, G.10
-
9
-
-
67650150964
-
Hereditary renal tubular disorders
-
Chadha V, Alon US. Hereditary renal tubular disorders. Semin Nephrol 29: 399-411, 2009.
-
(2009)
Semin Nephrol
, vol.29
, pp. 399-411
-
-
Chadha, V.1
Alon, U.S.2
-
10
-
-
79955534755
-
Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade
-
Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci 124: 1391-1395, 2011.
-
(2011)
J Cell Sci
, vol.124
, pp. 1391-1395
-
-
Chiga, M.1
Rafiqi, F.H.2
Alessi, D.R.3
Sohara, E.4
Ohta, A.5
Rai, T.6
Sasaki, S.7
Uchida, S.8
-
11
-
-
0037457954
-
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl--transporting epithelia
-
Choate KA, Kahle KT, Wilson FH, Nelson-Williams C, Lifton RP. WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl--transporting epithelia. Proc Natl Acad Sci USA 100: 663-668, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 663-668
-
-
Choate, K.A.1
Kahle, K.T.2
Wilson, F.H.3
Nelson-Williams, C.4
Lifton, R.P.5
-
12
-
-
0037020145
-
A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1
-
Darman RB, Forbush B. A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1. J Biol Chem 277: 37542-37550, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 37542-37550
-
-
Darman, R.B.1
Forbush, B.2
-
13
-
-
0344197746
-
Multiple promoters in the WNK1 gene: One controls expression of a kidney-specific kinase-defective isoform
-
Delaloy C, Lu J, Houot AM, Disse-Nicodeme S, Gasc JM, Corvol P, Jeunemaitre X. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol 23: 9208-9221, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9208-9221
-
-
Delaloy, C.1
Lu, J.2
Houot, A.M.3
Disse-Nicodeme, S.4
Gasc, J.M.5
Corvol, P.6
Jeunemaitre, X.7
-
14
-
-
0033855576
-
A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension
-
Disse-Nicodeme S, Achard JM, Desitter I, Houot AM, Fournier A, Corvol P, Jeunemaitre X. A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am J Hum Genet 67: 302-310, 2000.
-
(2000)
Am J Hum Genet
, vol.67
, pp. 302-310
-
-
Disse-Nicodeme, S.1
Achard, J.M.2
Desitter, I.3
Houot, A.M.4
Fournier, A.5
Corvol, P.6
Jeunemaitre, X.7
-
15
-
-
0035226112
-
Familial hyperkalemic hypertension (Gordon syndrome): Evidence for phenotypic variability in a study of 7 families
-
Disse-Nicodeme S, Achard JM, Potier J, Delahousse M, Fiquet-Kempf B, Stern N, Blanchard A, Guilbaud JC, Niaudet P, Chauveau D, Dussol B, Berland Y, Dequiedt P, Ader JL, Paillard M, Grunfeld JP, Fournier A, Corvol P, Jeunemaitre X. Familial hyperkalemic hypertension (Gordon syndrome): evidence for phenotypic variability in a study of 7 families. Adv Nephrol Necker Hosp 31: 55-68, 2001.
-
(2001)
Adv Nephrol Necker Hosp
, vol.31
, pp. 55-68
-
-
Disse-Nicodeme, S.1
Achard, J.M.2
Potier, J.3
Delahousse, M.4
Fiquet-Kempf, B.5
Stern, N.6
Blanchard, A.7
Guilbaud, J.C.8
Niaudet, P.9
Chauveau, D.10
Dussol, B.11
Berland, Y.12
Dequiedt, P.13
Ader, J.L.14
Paillard, M.15
Grunfeld, J.P.16
Fournier, A.17
Corvol, P.18
Jeunemaitre, X.19
-
16
-
-
0033656322
-
Molecular and pathophysiologic mechanisms of hyperkalemic metabolic acidosis
-
DuBose TD Jr. Molecular and pathophysiologic mechanisms of hyperkalemic metabolic acidosis. Trans Am Clin Climatol Assoc 111: 122-133, 2000.
-
(2000)
Trans Am Clin Climatol Assoc
, vol.111
, pp. 122-133
-
-
DuBose Jr., T.D.1
-
17
-
-
0033695807
-
Divalent cation transport by the distal nephron: Insights from Bartter's and Gitelman's syndromes
-
Ellison DH. Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes. Am J Physiol Renal Physiol 279: F616-F625, 2000.
-
(2000)
Am J Physiol Renal Physiol
, vol.279
-
-
Ellison, D.H.1
-
18
-
-
79955615992
-
MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases
-
Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR. MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. EMBO J 30: 1730-1741, 2011.
-
(2011)
EMBO J
, vol.30
, pp. 1730-1741
-
-
Filippi, B.M.1
de los Heros, P.2
Mehellou, Y.3
Navratilova, I.4
Gourlay, R.5
Deak, M.6
Plater, L.7
Toth, R.8
Zeqiraj, E.9
Alessi, D.R.10
-
20
-
-
15544384004
-
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters
-
Gamba G. Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. Physiol Rev 85: 423-493, 2005.
-
(2005)
Physiol Rev
, vol.85
, pp. 423-493
-
-
Gamba, G.1
-
21
-
-
12144272609
-
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension
-
Gamba G. Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension. Am J Physiol Renal Physiol 288: F245-F252, 2005.
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
Gamba, G.1
-
22
-
-
70349651260
-
+-Cl-cotransporter: Molecular biology, functional properties, and regulation by WNKs
-
+-Cl-cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol 297: F838-F848, 2009.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
-
-
Gamba, G.1
-
23
-
-
0028201013
-
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney
-
Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, Hebert SC. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 17713-17722
-
-
Gamba, G.1
Miyanoshita, A.2
Lombardi, M.3
Lytton, J.4
Lee, W.S.5
Hediger, M.A.6
Hebert, S.C.7
-
24
-
-
18444397746
-
Mineralocorticoid resistance
-
Geller DS. Mineralocorticoid resistance. Clin Endocrinol (Oxf) 62: 513-520, 2005.
-
(2005)
Clin Endocrinol (Oxf)
, vol.62
, pp. 513-520
-
-
Geller, D.S.1
-
25
-
-
84883269669
-
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): Cellular functions and disease implications
-
Genschik P, Sumara I, Lechner E. The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. EMBO J 32: 2307-2320, 2013.
-
(2013)
EMBO J
, vol.32
, pp. 2307-2320
-
-
Genschik, P.1
Sumara, I.2
Lechner, E.3
-
26
-
-
33845361061
-
Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: Evidence that accelerated dynamin-dependent endocytosis is not involved
-
Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'Shaughnessy KM. Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. Am J Physiol Renal Physiol 291: F1369-F1376, 2006.
-
(2006)
Am J Physiol Renal Physiol
, vol.291
-
-
Golbang, A.P.1
Cope, G.2
Hamad, A.3
Murthy, M.4
Liu, C.H.5
Cuthbert, A.W.6
O'Shaughnessy, K.M.7
-
27
-
-
23244460555
-
A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene
-
Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension 46: 295-300, 2005.
-
(2005)
Hypertension
, vol.46
, pp. 295-300
-
-
Golbang, A.P.1
Murthy, M.2
Hamad, A.3
Liu, C.H.4
Cope, G.5
Van't Hoff, W.6
Cuthbert, A.7
O'Shaughnessy, K.M.8
-
28
-
-
0023039605
-
Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate
-
Gordon RD. Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate. Hypertension 8: 93-102, 1986.
-
(1986)
Hypertension
, vol.8
, pp. 93-102
-
-
Gordon, R.D.1
-
29
-
-
0022699486
-
The syndrome of hypertension and hyperkalemia with normal glomerular filtration rate: Gordon's syndrome
-
Gordon RD. The syndrome of hypertension and hyperkalemia with normal glomerular filtration rate: Gordon's syndrome. Aust N Z J Med 16: 183-184, 1986.
-
(1986)
Aust N Z J Med
, vol.16
, pp. 183-184
-
-
Gordon, R.D.1
-
30
-
-
0037391227
-
Regulation of the epithelial sodium channel by accessory proteins
-
Gormley K, Dong Y, Sagnella GA. Regulation of the epithelial sodium channel by accessory proteins. Biochem J 371: 1-14, 2003.
-
(2003)
Biochem J
, vol.371
, pp. 1-14
-
-
Gormley, K.1
Dong, Y.2
Sagnella, G.A.3
-
31
-
-
0025817650
-
Blood pressure control-special role of the kidneys and body fluids
-
Guyton AC. Blood pressure control-special role of the kidneys and body fluids. Science 252: 1813-1816, 1991.
-
(1991)
Science
, vol.252
, pp. 1813-1816
-
-
Guyton, A.C.1
-
32
-
-
77955493607
-
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members
-
Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem 285: 25161-25167, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 25161-25167
-
-
Heise, C.J.1
Xu, B.E.2
Deaton, S.L.3
Cha, S.K.4
Cheng, C.J.5
Earnest, S.6
Sengupta, S.7
Juang, Y.C.8
Stippec, S.9
Xu, Y.10
Zhao, Y.11
Huang, C.L.12
Cobb, M.H.13
-
33
-
-
80053966270
-
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
-
Hoorn EJ, Walsh SB, McCormick JA, Furstenberg A, Yang CL, Roeschel T, Paliege A, Howie AJ, Conley J, Bachmann S, Unwin RJ, Ellison DH. The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension. Nat Med 17: 1304-1309, 2011.
-
(2011)
Nat Med
, vol.17
, pp. 1304-1309
-
-
Hoorn, E.J.1
Walsh, S.B.2
McCormick, J.A.3
Furstenberg, A.4
Yang, C.L.5
Roeschel, T.6
Paliege, A.7
Howie, A.J.8
Conley, J.9
Bachmann, S.10
Unwin, R.J.11
Ellison, D.H.12
-
34
-
-
35549003692
-
Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension
-
Huang CL, Kuo E. Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension. Nat Clin Pract Nephrol 3: 623-630, 2007.
-
(2007)
Nat Clin Pract Nephrol
, vol.3
, pp. 623-630
-
-
Huang, C.L.1
Kuo, E.2
-
35
-
-
33846884647
-
WNK4 enhances TRPV5-mediated calcium transport: Potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4
-
Jiang Y, Ferguson WB, Peng JB. WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Am J Physiol Renal Physiol 292: F545-F554, 2007.
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Jiang, Y.1
Ferguson, W.B.2
Peng, J.B.3
-
36
-
-
1242319290
-
WNK4 regulates apical and basolateral Cl-flux in extrarenal epithelia
-
Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP. WNK4 regulates apical and basolateral Cl-flux in extrarenal epithelia. Proc Natl Acad Sci USA 101: 2064-2069, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2064-2069
-
-
Kahle, K.T.1
Gimenez, I.2
Hassan, H.3
Wilson, F.H.4
Wong, R.D.5
Forbush, B.6
Aronson, P.S.7
Lifton, R.P.8
-
37
-
-
4344656182
-
WNK kinases: Molecular regulators of integrated epithelial ion transport
-
Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP. WNK kinases: molecular regulators of integrated epithelial ion transport. Curr Opin Nephrol Hypertens 13: 557-562, 2004.
-
(2004)
Curr Opin Nephrol Hypertens
, vol.13
, pp. 557-562
-
-
Kahle, K.T.1
Wilson, F.H.2
Lalioti, M.3
Toka, H.4
Qin, H.5
Lifton, R.P.6
-
38
-
-
0345659215
-
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion
-
Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP. WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet 35: 372-376, 2003.
-
(2003)
Nat Genet
, vol.35
, pp. 372-376
-
-
Kahle, K.T.1
Wilson, F.H.2
Leng, Q.3
Lalioti, M.D.4
O'Connell, A.D.5
Dong, K.6
Rapson, A.K.7
McGregor, G.G.8
Giebisch, G.9
Hebert, S.C.10
Lifton, R.P.11
-
39
-
-
0032564369
-
The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein
-
Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14552-14557
-
-
Kim, G.H.1
Masilamani, S.2
Turner, R.3
Mitchell, C.4
Wade, J.B.5
Knepper, M.A.6
-
40
-
-
0034965716
-
Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes
-
Kino T, Chrousos GP. Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes. J Endocrinol 169: 437-445, 2001.
-
(2001)
J Endocrinol
, vol.169
, pp. 437-445
-
-
Kino, T.1
Chrousos, G.P.2
-
41
-
-
33750593310
-
+-ATPase
-
+-ATPase. Kidney Int 70: 1706-1716, 2006.
-
(2006)
Kidney Int
, vol.70
, pp. 1706-1716
-
-
Kovacikova, J.1
Winter, C.2
Loffing-Cueni, D.3
Loffing, J.4
Finberg, K.E.5
Lifton, R.P.6
Hummler, E.7
Rossier, B.8
Wagner, C.A.9
-
42
-
-
33749118898
-
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
-
Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 38: 1124-1132, 2006.
-
(2006)
Nat Genet
, vol.38
, pp. 1124-1132
-
-
Lalioti, M.D.1
Zhang, J.2
Volkman, H.M.3
Kahle, K.T.4
Hoffmann, K.E.5
Toka, H.R.6
Nelson-Williams, C.7
Ellison, D.H.8
Flavell, R.9
Booth, C.J.10
Lu, Y.11
Geller, D.S.12
Lifton, R.P.13
-
43
-
-
33748496472
-
Potassium-related inherited tubulopathies
-
Landau D. Potassium-related inherited tubulopathies. Cell Mol Life Sci 63: 1962-1968, 2006.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 1962-1968
-
-
Landau, D.1
-
44
-
-
0035936780
-
Molecular mechanisms of human hypertension
-
Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 104: 545-556, 2001.
-
(2001)
Cell
, vol.104
, pp. 545-556
-
-
Lifton, R.P.1
Gharavi, A.G.2
Geller, D.S.3
-
45
-
-
0035662188
-
Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron
-
Loffing J, Loffing-Cueni D, Valderrabano V, Klausli L, Hebert SC, Rossier BC, Hoenderop JG, Bindels RJ, Kaissling B. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol 281: F1021-F1027, 2001.
-
(2001)
Am J Physiol Renal Physiol
, vol.281
-
-
Loffing, J.1
Loffing-Cueni, D.2
Valderrabano, V.3
Klausli, L.4
Hebert, S.C.5
Rossier, B.C.6
Hoenderop, J.G.7
Bindels, R.J.8
Kaissling, B.9
-
46
-
-
84859425383
-
KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron
-
Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, Delahousse M, Esnault V, Fiquet B, Houillier P, Bagnis CI, Koenig J, Konrad M, Landais P, Mourani C, Niaudet P, Probst V, Thauvin C, Unwin RJ, Soroka SD, Ehret G, Ossowski S, Caulfield M, Bruneval P, Estivill X, Froguel P, Hadchouel J, Schott JJ, Jeunemaitre X. KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat Genet 44: 456-460, S451-S453, 2012.
-
(2012)
Nat Genet
, vol.44
-
-
Louis-Dit-Picard, H.1
Barc, J.2
Trujillano, D.3
Miserey-Lenkei, S.4
Bouatia-Naji, N.5
Pylypenko, O.6
Beaurain, G.7
Bonnefond, A.8
Sand, O.9
Simian, C.10
Vidal-Petiot, E.11
Soukaseum, C.12
Mandet, C.13
Broux, F.14
Chabre, O.15
Delahousse, M.16
Esnault, V.17
Fiquet, B.18
Houillier, P.19
Bagnis, C.I.20
Koenig, J.21
Konrad, M.22
Landais, P.23
Mourani, C.24
Niaudet, P.25
Probst, V.26
Thauvin, C.27
Unwin, R.J.28
Soroka, S.D.29
Ehret, G.30
Ossowski, S.31
Caulfield, M.32
Bruneval, P.33
Estivill, X.34
Froguel, P.35
Hadchouel, J.36
Schott, J.J.37
Jeunemaitre, X.38
more..
-
47
-
-
44449116109
-
Increased urinary Na-Cl cotransporter protein in familial hyperkalaemia and hypertension
-
Mayan H, Attar-Herzberg D, Shaharabany M, Holtzman EJ, Farfel Z. Increased urinary Na-Cl cotransporter protein in familial hyperkalaemia and hypertension. Nephrol Dial Transplant 23: 492-496, 2008.
-
(2008)
Nephrol Dial Transplant
, vol.23
, pp. 492-496
-
-
Mayan, H.1
Attar-Herzberg, D.2
Shaharabany, M.3
Holtzman, E.J.4
Farfel, Z.5
-
48
-
-
4043170112
-
Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: Description of a large family with the Q565E WNK4 mutation
-
Mayan H, Munter G, Shaharabany M, Mouallem M, Pauzner R, Holtzman EJ, Farfel Z. Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. J Clin Endocrinol Metab 89: 4025-4030, 2004.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4025-4030
-
-
Mayan, H.1
Munter, G.2
Shaharabany, M.3
Mouallem, M.4
Pauzner, R.5
Holtzman, E.J.6
Farfel, Z.7
-
49
-
-
0036328423
-
Pseudohypoaldosteronism type II: Marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density
-
Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, Farfel Z. Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 87: 3248-3254, 2002.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3248-3254
-
-
Mayan, H.1
Vered, I.2
Mouallem, M.3
Tzadok-Witkon, M.4
Pauzner, R.5
Farfel, Z.6
-
50
-
-
30044442784
-
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
-
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42685-42693, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 42685-42693
-
-
Moriguchi, T.1
Urushiyama, S.2
Hisamoto, N.3
Iemura, S.4
Uchida, S.5
Natsume, T.6
Matsumoto, K.7
Shibuya, H.8
-
51
-
-
85027925594
-
Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension
-
Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T. Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med 17: 573-580, 2011.
-
(2011)
Nat Med
, vol.17
, pp. 573-580
-
-
Mu, S.1
Shimosawa, T.2
Ogura, S.3
Wang, H.4
Uetake, Y.5
Kawakami-Mori, F.6
Marumo, T.7
Yatomi, Y.8
Geller, D.S.9
Tanaka, H.10
Fujita, T.11
-
53
-
-
23744464321
-
Expression of the potassium channel ROMK in adult and fetal human kidney
-
Nusing RM, Pantalone F, Grone HJ, Seyberth HW, Wegmann M. Expression of the potassium channel ROMK in adult and fetal human kidney. Histochem Cell Biol 123: 553-559, 2005.
-
(2005)
Histochem Cell Biol
, vol.123
, pp. 553-559
-
-
Nusing, R.M.1
Pantalone, F.2
Grone, H.J.3
Seyberth, H.W.4
Wegmann, M.5
-
54
-
-
33748043980
-
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo
-
O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW. Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J Am Soc Nephrol 17: 2402-2413, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2402-2413
-
-
O'Reilly, M.1
Marshall, E.2
Macgillivray, T.3
Mittal, M.4
Xue, W.5
Kenyon, C.J.6
Brown, R.W.7
-
55
-
-
0141455346
-
WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain
-
O'Reilly M, Marshall E, Speirs HJ, Brown RW. WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol 14: 2447-2456, 2003.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 2447-2456
-
-
O'Reilly, M.1
Marshall, E.2
Speirs, H.J.3
Brown, R.W.4
-
56
-
-
0031762173
-
Linkage of Gordon's syndrome to the long arm of chromosome 17 in a region recently linked to familial essential hypertension
-
O'Shaughnessy KM, Fu B, Johnson A, Gordon RD. Linkage of Gordon's syndrome to the long arm of chromosome 17 in a region recently linked to familial essential hypertension. J Hum Hypertens 12: 675-678, 1998.
-
(1998)
J Hum Hypertens
, vol.12
, pp. 675-678
-
-
O'Shaughnessy, K.M.1
Fu, B.2
Johnson, A.3
Gordon, R.D.4
-
58
-
-
0029189663
-
Expression of the thiazide-sensitive Na-Cl cotransporter in rat and human kidney
-
Obermuller N, Bernstein P, Velazquez H, Reilly R, Moser D, Ellison DH, Bachmann S. Expression of the thiazide-sensitive Na-Cl cotransporter in rat and human kidney. Am J Physiol Renal Fluid Electrolyte Physiol 269: F900-F910, 1995.
-
(1995)
Am J Physiol Renal Fluid Electrolyte Physiol
, vol.269
-
-
Obermuller, N.1
Bernstein, P.2
Velazquez, H.3
Reilly, R.4
Moser, D.5
Ellison, D.H.6
Bachmann, S.7
-
59
-
-
84875158737
-
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: Disease-causing mutations in KLHL3 and WNK4 disrupt interaction
-
Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J 451: 111-122, 2013.
-
(2013)
Biochem J
, vol.451
, pp. 111-122
-
-
Ohta, A.1
Schumacher, F.R.2
Mehellou, Y.3
Johnson, C.4
Knebel, A.5
Macartney, T.J.6
Wood, N.T.7
Alessi, D.R.8
Kurz, T.9
-
60
-
-
33748430618
-
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells
-
Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S. Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Biochem Biophys Res Commun 349: 804-808, 2006.
-
(2006)
Biochem Biophys Res Commun
, vol.349
, pp. 804-808
-
-
Ohta, A.1
Yang, S.S.2
Rai, T.3
Chiga, M.4
Sasaki, S.5
Uchida, S.6
-
61
-
-
77954243057
-
Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule
-
Pedersen NB, Hofmeister MV, Rosenbaek LL, Nielsen J, Fenton RA. Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule. Kidney Int 78: 160-169, 2010.
-
(2010)
Kidney Int
, vol.78
, pp. 160-169
-
-
Pedersen, N.B.1
Hofmeister, M.V.2
Rosenbaek, L.L.3
Nielsen, J.4
Fenton, R.A.5
-
62
-
-
77953459148
-
Role of the WNKactivated SPAK kinase in regulating blood pressure
-
Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanovic S, Jovanovic A, O'Shaughnessy KM, Alessi DR. Role of the WNKactivated SPAK kinase in regulating blood pressure. EMBO Mol Med 2: 63-75, 2010.
-
(2010)
EMBO Mol Med
, vol.2
, pp. 63-75
-
-
Rafiqi, F.H.1
Zuber, A.M.2
Glover, M.3
Richardson, C.4
Fleming, S.5
Jovanovic, S.6
Jovanovic, A.7
O'Shaughnessy, K.M.8
Alessi, D.R.9
-
63
-
-
42149175531
-
+-Cl-cotransporter by the WNK-regulated kinases SPAK and OSR1
-
+-Cl-cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci 121: 675-684, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 675-684
-
-
Richardson, C.1
Rafiqi, F.H.2
Karlsson, H.K.3
Moleleki, N.4
Vandewalle, A.5
Campbell, D.G.6
Morrice, N.A.7
Alessi, D.R.8
-
64
-
-
67651092155
-
Clinical and molecular features of type 1 pseudohypoaldosteronism
-
Riepe FG. Clinical and molecular features of type 1 pseudohypoaldosteronism. Horm Res 72: 1-9, 2009.
-
(2009)
Horm Res
, vol.72
, pp. 1-9
-
-
Riepe, F.G.1
-
65
-
-
84873350794
-
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension
-
Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O. Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. J Clin Invest 123: 657-665, 2013.
-
(2013)
J Clin Invest
, vol.123
, pp. 657-665
-
-
Ronzaud, C.1
Loffing-Cueni, D.2
Hausel, P.3
Debonneville, A.4
Malsure, S.R.5
Fowler-Jaeger, N.6
Boase, N.A.7
Perrier, R.8
Maillard, M.9
Yang, B.10
Stokes, J.B.11
Koesters, R.12
Kumar, S.13
Hummler, E.14
Loffing, J.15
Staub, O.16
-
66
-
-
51149104842
-
WNK kinases, renal ion transport and hypertension
-
San-Cristobal P, de los Heros P, Ponce-Coria J, Moreno E, Gamba G. WNK kinases, renal ion transport and hypertension. Am J Nephrol 28: 860-870, 2008.
-
(2008)
Am J Nephrol
, vol.28
, pp. 860-870
-
-
San-Cristobal, P.1
de los Heros, P.2
Ponce-Coria, J.3
Moreno, E.4
Gamba, G.5
-
67
-
-
63149133727
-
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway
-
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci U S A 106: 4384-4389, 2009.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4384-4389
-
-
San-Cristobal, P.1
Pacheco-Alvarez, D.2
Richardson, C.3
Ring, A.M.4
Vazquez, N.5
Rafiqi, F.H.6
Chari, D.7
Kahle, K.T.8
Leng, Q.9
Bobadilla, N.A.10
Hebert, S.C.11
Alessi, D.R.12
Lifton, R.P.13
Gamba, G.14
-
68
-
-
2342488106
-
Inactivating mutations of the mineralocorticoid receptor in Type I pseudohypoaldosteronism
-
Sartorato P, Khaldi Y, Lapeyraque AL, Armanini D, Kuhnle U, Salomon R, Caprio M, Viengchareun S, Lombes M, Zennaro MC. Inactivating mutations of the mineralocorticoid receptor in Type I pseudohypoaldosteronism. Mol Cell Endocrinol 217: 119-125, 2004.
-
(2004)
Mol Cell Endocrinol
, vol.217
, pp. 119-125
-
-
Sartorato, P.1
Khaldi, Y.2
Lapeyraque, A.L.3
Armanini, D.4
Kuhnle, U.5
Salomon, R.6
Caprio, M.7
Viengchareun, S.8
Lombes, M.9
Zennaro, M.C.10
-
69
-
-
0037968583
-
Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism
-
Sartorato P, Lapeyraque AL, Armanini D, Kuhnle U, Khaldi Y, Salomon R, Abadie V, Di Battista E, Naselli A, Racine A, Bosio M, Caprio M, Poulet-Young V, Chabrolle JP, Niaudet P, De Gennes C, Lecornec MH, Poisson E, Fusco AM, Loli P, Lombes M, Zennaro MC. Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism. J Clin Endocrinol Metab 88: 2508-2517, 2003.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2508-2517
-
-
Sartorato, P.1
Lapeyraque, A.L.2
Armanini, D.3
Kuhnle, U.4
Khaldi, Y.5
Salomon, R.6
Abadie, V.7
Di Battista, E.8
Naselli, A.9
Racine, A.10
Bosio, M.11
Caprio, M.12
Poulet-Young, V.13
Chabrolle, J.P.14
Niaudet, P.15
De Gennes, C.16
Lecornec, M.H.17
Poisson, E.18
Fusco, A.M.19
Loli, P.20
Lombes, M.21
Zennaro, M.C.22
more..
-
70
-
-
84877340391
-
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4
-
Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP. Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci USA 110: 7838-7843, 2013.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 7838-7843
-
-
Shibata, S.1
Zhang, J.2
Puthumana, J.3
Stone, K.L.4
Lifton, R.P.5
-
71
-
-
0032816182
-
Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain
-
Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S. Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell 10: 2361-2375, 1999.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 2361-2375
-
-
Soltysik-Espanola, M.1
Rogers, R.A.2
Jiang, S.3
Kim, T.A.4
Gaedigk, R.5
White, R.A.6
Avraham, H.7
Avraham, S.8
-
73
-
-
84880944866
-
KLHL2 interacts with and ubiquitinates WNK kinases
-
Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S. KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun 437: 457-462, 2013.
-
(2013)
Biochem Biophys Res Commun
, vol.437
, pp. 457-462
-
-
Takahashi, D.1
Mori, T.2
Wakabayashi, M.3
Mori, Y.4
Susa, K.5
Zeniya, M.6
Sohara, E.7
Rai, T.8
Sasaki, S.9
Uchida, S.10
-
74
-
-
77957850277
-
Pathophysiological roles of WNK kinases in the kidney
-
Uchida S. Pathophysiological roles of WNK kinases in the kidney. Pflügers Arch 460: 695-702, 2010.
-
(2010)
Pflügers Arch
, vol.460
, pp. 695-702
-
-
Uchida, S.1
-
75
-
-
33846071005
-
Flexible and floating choroid plexus cyst of the third ventricle: An ultrasonographic video documentation
-
van Baalen A, Stephani U. Flexible and floating choroid plexus cyst of the third ventricle: an ultrasonographic video documentation. Childs Nerv Syst 23: 259-261, 2007.
-
(2007)
Childs Nerv Syst
, vol.23
, pp. 259-261
-
-
van Baalen, A.1
Stephani, U.2
-
76
-
-
84883403721
-
WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron
-
Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J. WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron. Proc Natl Acad Sci USA 110: 14366-14371, 2013.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 14366-14371
-
-
Vidal-Petiot, E.1
Elvira-Matelot, E.2
Mutig, K.3
Soukaseum, C.4
Baudrie, V.5
Wu, S.6
Cheval, L.7
Huc, E.8
Cambillau, M.9
Bachmann, S.10
Doucet, A.11
Jeunemaitre, X.12
Hadchouel, J.13
-
77
-
-
26844532768
-
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases
-
Vitari AC, Deak M, Morrice NA, Alessi DR. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391: 17-24, 2005.
-
(2005)
Biochem J
, vol.391
, pp. 17-24
-
-
Vitari, A.C.1
Deak, M.2
Morrice, N.A.3
Alessi, D.R.4
-
78
-
-
33745530924
-
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1
-
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J 397: 223-231, 2006.
-
(2006)
Biochem J
, vol.397
, pp. 223-231
-
-
Vitari, A.C.1
Thastrup, J.2
Rafiqi, F.H.3
Deak, M.4
Morrice, N.A.5
Karlsson, H.K.6
Alessi, D.R.7
-
79
-
-
33744811449
-
WNK1 kinase isoform switch regulates renal potassium excretion
-
Wade JB, Fang L, Liu J, Li D, Yang CL, Subramanya AR, Maouyo D, Mason A, Ellison DH, Welling PA. WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci USA 103: 8558-8563, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 8558-8563
-
-
Wade, J.B.1
Fang, L.2
Liu, J.3
Li, D.4
Yang, C.L.5
Subramanya, A.R.6
Maouyo, D.7
Mason, A.8
Ellison, D.H.9
Welling, P.A.10
-
80
-
-
84875813488
-
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
-
Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S. Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep 3: 858-868, 2013.
-
(2013)
Cell Rep
, vol.3
, pp. 858-868
-
-
Wakabayashi, M.1
Mori, T.2
Isobe, K.3
Sohara, E.4
Susa, K.5
Araki, Y.6
Chiga, M.7
Kikuchi, E.8
Nomura, N.9
Mori, Y.10
Matsuo, H.11
Murata, T.12
Nomura, S.13
Asano, T.14
Kawaguchi, H.15
Nonoyama, S.16
Rai, T.17
Sasaki, S.18
Uchida, S.19
-
81
-
-
17944373014
-
Human hypertension caused by mutations in WNK kinases
-
Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
-
(2001)
Science
, vol.293
, pp. 1107-1112
-
-
Wilson, F.H.1
Disse-Nicodeme, S.2
Choate, K.A.3
Ishikawa, K.4
Nelson-Williams, C.5
Desitter, I.6
Gunel, M.7
Milford, D.V.8
Lipkin, G.W.9
Achard, J.M.10
Feely, M.P.11
Dussol, B.12
Berland, Y.13
Unwin, R.J.14
Mayan, H.15
Simon, D.B.16
Farfel, Z.17
Jeunemaitre, X.18
Lifton, R.P.19
-
82
-
-
85023194402
-
Pseudohypoaldosteronism type II
-
In:, edited by Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, and Stephens K. Seattle, WA: University of Washington
-
Wilson FH, Kahle KT. Pseudohypoaldosteronism type II. In: Gene-Reviews, edited by Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, and Stephens K. Seattle, WA: University of Washington, 1993.
-
(1993)
Gene-Reviews
-
-
Wilson, F.H.1
Kahle, K.T.2
-
83
-
-
0037457965
-
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
-
Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 100: 680-684, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 680-684
-
-
Wilson, F.H.1
Kahle, K.T.2
Sabath, E.3
Lalioti, M.D.4
Rapson, A.K.5
Hoover, R.S.6
Hebert, S.C.7
Gamba, G.8
Lifton, R.P.9
-
84
-
-
33746977635
-
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome
-
Xie J, Craig L, Cobb MH, Huang CL. Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol 21: 1231-1236, 2006.
-
(2006)
Pediatr Nephrol
, vol.21
, pp. 1231-1236
-
-
Xie, J.1
Craig, L.2
Cobb, M.H.3
Huang, C.L.4
-
85
-
-
0034595634
-
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
-
Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 275: 16795-16801, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 16795-16801
-
-
Xu, B.1
English, J.M.2
Wilsbacher, J.L.3
Stippec, S.4
Goldsmith, E.J.5
Cobb, M.H.6
-
86
-
-
36048938340
-
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex
-
Yang CL, Zhu X, Ellison DH. The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest 117: 3403-3411, 2007.
-
(2007)
J Clin Invest
, vol.117
, pp. 3403-3411
-
-
Yang, C.L.1
Zhu, X.2
Ellison, D.H.3
-
87
-
-
78149310726
-
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction
-
Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH. SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol 21: 1868-1877, 2010.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 1868-1877
-
-
Yang, S.S.1
Lo, Y.F.2
Wu, C.C.3
Lin, S.W.4
Yeh, C.J.5
Chu, P.6
Sytwu, H.K.7
Uchida, S.8
Sasaki, S.9
Lin, S.H.10
-
88
-
-
34247617951
-
Molecular pathogenesis of pseudohypoaldosteronism type II: Generation and analysis of a Wnk4(D561A/+) knockin mouse model
-
Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab 5: 331-344, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 331-344
-
-
Yang, S.S.1
Morimoto, T.2
Rai, T.3
Chiga, M.4
Sohara, E.5
Ohno, M.6
Uchida, K.7
Lin, S.H.8
Moriguchi, T.9
Shibuya, H.10
Kondo, Y.11
Sasaki, S.12
Uchida, S.13
-
89
-
-
10744226663
-
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention
-
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 100: 14109-14114, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 14109-14114
-
-
Zambrowicz, B.P.1
Abuin, A.2
Ramirez-Solis, R.3
Richter, L.J.4
Piggott, J.5
BeltrandelRio, H.6
Buxton, E.C.7
Edwards, J.8
Finch, R.A.9
Friddle, C.J.10
Gupta, A.11
Hansen, G.12
Hu, Y.13
Huang, W.14
Jaing, C.15
Key Jr., B.W.16
Kipp, P.17
Kohlhauff, B.18
Ma, Z.Q.19
Markesich, D.20
Payne, R.21
Potter, D.G.22
Qian, N.23
Shaw, J.24
Schrick, J.25
Shi, Z.Z.26
Sparks, M.J.27
Van Sligtenhorst, I.28
Vogel, P.29
Walke, W.30
Xu, N.31
Zhu, Q.32
Person, C.33
Sands, A.T.34
more..
-
90
-
-
84856347768
-
Aldosterone resistance: Structural and functional considerations and new perspectives
-
Zennaro MC, Hubert EL, Fernandes-Rosa FL. Aldosterone resistance: structural and functional considerations and new perspectives. Mol Cell Endocrinol 350: 206-215, 2012.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 206-215
-
-
Zennaro, M.C.1
Hubert, E.L.2
Fernandes-Rosa, F.L.3
-
91
-
-
84863253986
-
WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway
-
Zhou B, Wang D, Feng X, Zhang Y, Wang Y, Zhuang J, Zhang X, Chen G, Delpire E, Gu D, Cai H. WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway. Am J Physiol Renal Physiol 302: F533-F539, 2012.
-
(2012)
Am J Physiol Renal Physiol
, vol.302
-
-
Zhou, B.1
Wang, D.2
Feng, X.3
Zhang, Y.4
Wang, Y.5
Zhuang, J.6
Zhang, X.7
Chen, G.8
Delpire, E.9
Gu, D.10
Cai, H.11
-
92
-
-
75149175239
-
WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway
-
Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, Cai H. WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway. J Am Soc Nephrol 21: 82-92, 2010.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 82-92
-
-
Zhou, B.1
Zhuang, J.2
Gu, D.3
Wang, H.4
Cebotaru, L.5
Guggino, W.B.6
Cai, H.7
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