Divalent cation transport by the distal nephron: Insights from Bartter's and Gitelman's syndromes

American Journal of Physiology - Renal Physiology

Volumn 279, Issue 4 48-4, 2000, Pages

  Ellison, David H ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Mail Code PP262   (United States)

Author keywords

Aldosterone; Bumetanide sensitive sodium potassium 2 chloride cotransporter; Calcium; Chloride; Distal; Diuretics; Heart failure; Kidney tubules; Loop of Henle; Magnesium; Sodium; Thiazide; Thiazide sensitive sodium chloride cotransporter; Voltage

Indexed keywords

CALCIUM; MAGNESIUM; THIAZIDE DIURETIC AGENT;

BARTTER SYNDROME; CATION TRANSPORT; GITELMAN SYNDROME; HUMAN; KIDNEY DISTAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0033695807     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.279.4.f616     Document Type: Review

References (112)

1. Expression of the thiazide-sensitive Na-Cl cotransporter by rabbit distal convoluted tubule cells
2. Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease
3. Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndromes
4. Genetic heterogeneity in tubular hypomagnesemia-hypokalemia with hypocalcuria (Gitelman's syndrome)
5. Genotype-phenotype correlations in normotensive patients with primary renal tubular hypokalemic metabolic alkalosis
6. 11β-hydroxysteroid dehydrogenase, mineralocorticoid receptor and thiazide-sensitive Na-Cl cotransporter expression by distal tubules
7. Macula densa control of renin secretion and glomerular vascular tone: Evidence for common cellular mechanisms
8. Micropuncture study of magnesium transport along the nephron in the young rat
9. Micropuncture study of renal magnesium transport in magnesium-loaded rats
10. Tubular chloride transport and the mode of action of some diuretics
11. Furosemide effect on isolated perfused tubules
12. + exchanger isoform NHE2 in rat kidney
13. Adrenocortical steroids increase renal thiazide diuretic receptor density and response
14. +-conducting ion channels in the kidney
15. Correction of hypokalemia with antialdosterone therapy in Gitelman's syndrome
16. Comparison of calcium and sodium transport in early and late rat distal tubules: Effect of amiloride
17. Localization of diuretic action in microperfused rat distal tubules: Ca and Na transport
18. On the hypocalciuric action of chlorothiazide
19. Relationship between clearances of Ca and Na: Effect of distal diuretics and PTH
20. Calcium and sodium transport by the distal convoluted tubule of the rat
21. 2+ uptake in mouse distal convoluted tubule cells
22. 2+ uptake in immortalized mouse distal convoluted tubule cells
23. Aldosterone potentiates hormone-stimulated Mg2+ uptake in distal convoluted tubule cells
24. Ultrastructure of three-dimensionally localized distal nephron segments in superficial cortex of the rat kidney
25. Effects of chlorothiazide and amipramizide (MK 870) on the renal excretion of calcium, phosphate and magnesium
26. Effects of ethacrynic acid and furosemide on urinary calcium, phosphate and magnesium
27. Cell-specific expression of epithelial sodium channel α, β, and γ subunits in aldosterone-responsive epithelia from the rat: Localization by in situ hybridization and immunocytochemistry
28. Intracellular magnesium loss after diuretic administration
29. Effect of diuretics on urinary excretion of phosphate, calcium, and magnesium in thyroparathyroidectomized dogs
30. Molecular localization of Na and Ca transport pathways along the renal distal tubule
31. Thiazide-sensitive sodium chloride cotransport in the early distal tubule
32. Adaptation of the distal convoluted tubule of the rat: Structural and functional effects of dietary salt intake and chronic diuretic infusion
33. Codependence of renal calcium and sodium transport
34. Cellular calcium transport in renal epithelia: Measurement, mechanisms, and regulation
35. Mechanism of calcium transport stimulated by chlorothiazide in mouse distal convoluted tubule cells
36. Bartter's syndrome: A disorder characterized by high urinary prostaglandins and a dependence of hyperreninemia on prostaglandin synthesis
37. +, a prerequisite for active NaCl transport in the cortical thick ascending limb of Henle's loop of rabbit kidney
38. Cellular mechanism of action of loop diuretics on the thick ascending limb of Henle's loop
39. Bartter's syndrome: Unraveling the pathophysiologic enigma
40. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule
41. 3-responsive epithelia
42. The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium
43. Thiazide treatment of systemic hypertension: Effects on serum magnesium and ventricular ectopy
44. Effect of aldosterone on the metabolism of magnesium
45. Tubular action of diuretics: Distal effects on electrolyte transport and acidification
46. 2+
47. Studies on the pathogenesis of hypokalemia in Gitelman's syndrome: Role of bicarbonaturia and hypomagnesemia
48. Apical localization of the Na-K-Cl cotransporter, rBSCl, on rat thick ascending limbs
49. Effects of graded solute diuresis on renal tubular sodium transport in the rat
50. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein
51. Structural organization of the mammalian kidney
52. Relationship of diuretic therapy and serum magnesium levels among participants in the multiple risk factor intervention trial
53. Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's Syndrome
54. Effects of parathyroidectomy and cyclic AMP on renal transport of phosphate, calcium, and magnesium
55. Molecular pathogenesis of Bartter's and Gitelman's syndromes
56. Simultaneous Mg, Ca, P,K,Na and Cl analysis in rat tubular fluid. II. During acute Mg plasma loading
57. Linkage of Gitelman syndrome to the thiazide-sensitive cotransporter gene with identification of mutations in three Dutch families
58. Linkage of Gitelman syndrome to the thiazide-sensitive sodium-chloride cotransporter gene with identification of mutations in Dutch families
59. Thiazide treatment of rats provokes apoptosis in distal tubule cells
60. Localization of epithelial sodium channel and aquaporin-2 in rabbit kidney cortex
61. Segmentation of the mouse distal nephron: Morphology and distribution of transport proteins
62. The acute effect of adrenal steroids on the interrelationships between the renal excretion of sodium, calcium, and magnesium
63. The effect of long-term desoxycorticosterone acetate administration on the renal excretion of calcium and magnesium
64. Gitelman syndrome is caused by mutations in the human Na-Cl cotransporter gene: Molecular analysis in Italian families
65. 2+ channels sensitive to dihydropyridines and activated by hyperpolarizing voltages
66. Changes of fractional renal clearance of magnesium after spironolactone administration in normal subjects
67. Expression of the thiazide-sensitive Na-Cl cotransporter in rat and human kidhey
68. Expression of the Na-K- 2Cl cotransporter by macula densa and thick ascending limb cells of rat and rabbit nephron
69. Luminal calcium regulates potassium transport by the renal distal tubule
70. Pathophysiologic effects and strategies for longterm diuretic treatment of hypertension
71. A rat kidney-specific calcium transporter in the distal nephron
72. The effect of spironolactone on morbidity and mortality in patients with severe heart failure
73. Immunomagnetic separation, primary culture, and characterization of cortical thick ascending limb plus distal convoluted tubule cells from mouse kidney
74. Localization of the thiazide sensitive Na-Cl cotransporter, rTSC1, in the rat kidhey
75. Gitelman's syndrome (Bartter's variant) maps to the thiazide-sensitive cotransporter gene locus on chromosome 16q13 in a large kindred
76. Familial hypomagnesemia with hypercalciuria and nephrocalcinosis
77. Variant of Bartter's syndrome with a distal tubular rather than loop of Henle defect
78. Effect of calcitonin on calcium and magnesium transport in rat nephron
79. Renal magnesium handling: New insights in understanding old problems
80. Intraluminal and contraluminal magnesium on magnesium and calcium transfer in the rat nephron
81. Magnesium transport in the nephron
82. Mammalian distal tubule: Physiology, pathophysiology, and molecular anatomy
83. 2+ exchanger in rabbit kidney
84. Mechanisms of disease: Genetic disorders of renal electrolyte transport
85. Developmental expression of sodium entry pathways in rat distal nephron
86. - cotransporter of the distal convoluted tubule
87. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type. III
88. Genotypephenotype correlation of NCCT mutations and Gitelman's syndrome
89. Bartter's syndrome: Hypokalaemic alkalosis with hypercalciuria is caused by mutations in the Na-K-2Cl cotransproter NKCC2
90. + channel, ROMK
91. The molecular basis of inherited hypokalemic alkalosis: Bartter's and Gitelman's syndromes
92. Mutations in renal ion transporters cause Gitelman's and Bartter's syndromes of inherited hypokalemic alkalosis
93. Ion transporter mutations in Gitelman's and Bartter's syndromes
94. Ion transporter mutations in Gitelman's and Bartter's syndromes
95. Mutations in Na(K)Cl transporters in Gitelman's and Bartter's syndromes
96. 2+ resorption
97. Gitelman's variant of Bartter's syndrome, inherited hypokalemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
98. Direct demonstration of macula densa-mediated renin secretion
99. + transport
100. Attenuation by spironolactone of the magnesiuric effect of acute frusemide administration in patients with liver cirrhosis and ascites
101. Bartter's syndrome: Evidence suggesting a distal tubular defect in a hypocalciuric variant of the syndrome
102. Association of a mutation in thiazide-sensitive Na-Cl cotransporter with familial Gitelman's syndrome
103. Novel molecular variants of the Na-K- 2Cl cotransporter gene are responsible for antenatal Bartter syndrome
104. Adrenal steroids stimulate thiazide-sensitive NaCl transport by the rat renal distal tubule
105. NaCl cotransporter and 11-β-hydroxysteroid dehydrogenase are coexpressed in rabbit distal convoluted tubule
106. The rabbit DCT does not express ENaC (amiloride-sensitive) activity
107. Effects of diuretic drugs on Na, Cl, and K transport by rat renal distal tubule
108. Flow dependent transport processes: Filtration, absorption, secretion
109. Localization of the ROMK protein on the apical membranes of rat kidney nephron segments
110. Localization of bumetanide- and thiazide-sensitive Na-K-Cl cotransporters along the rat nephron
111. Electrophysiological characterization of rabbit distal convoluted tubule cell