The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

Nature Medicine

Volumn 17, Issue 10, 2011, Pages 1304-1309

  Hoorn, Ewout J ^a   Walsh, Stephen B ^b   McCormick, James A ^a   Fürstenberg, Antje ^b   Yang, Chao Ling ^a   Roeschel, Tom ^c   Paliege, Alexander ^c   Howie, Alexander J ^b   Conley, James ^a   Bachmann, Sebastian ^c   Unwin, Robert J ^b   Ellison, David H ^a,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; BENDROFLUMETHIAZIDE; CALCINEURIN INHIBITOR; HYDROCHLOROTHIAZIDE; SODIUM CHLORIDE COTRANSPORTER; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME PHOSPHORYLATION; HYPERTENSION; KIDNEY TRANSPLANTATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALT INTAKE; TREATMENT OUTCOME; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; BENDROFLUMETHIAZIDE; CALCINEURIN; CALCIUM; CELL LINE; CHLORIDES; CREATININE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYDROCHLOROTHIAZIDE; HYPERTENSION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KIDNEY; MICE; MICE, KNOCKOUT; SODIUM CHLORIDE SYMPORTERS; TACROLIMUS;

MUS;

EID: 80053966270     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2497     Document Type: Article

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