Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: Evidence that accelerated dynamin-dependent endocytosis is not involved

American Journal of Physiology - Renal Physiology

Volumn 291, Issue 6, 2006, Pages

  Golbang, Amir P ^a   Cope, Georgina ^a   Hamad, Abbas ^a   Murthy, Meena ^a   Liu, Che Hsiung ^a   Cuthbert, Alan W ^a   O'Shaughnessy, Kevin M ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Kidney transporters; Regulation of membrane expression; WNK kinases

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; DYNAMIN; PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; PROTEIN SERINE THREONINE KINASE; SODIUM CHLORIDE COTRANSPOTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOTINYLATION; CELL MEMBRANE; ENDOCYTOSIS; GORDON SYNDROME; IMMUNOBLOTTING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 33845361061     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00468.2005     Document Type: Article

References (25)

1. Cope G, Golbang A, Murthy M, Hamad A, Liu CH, Hoff WV, Cuthbert A, and O'Shaughnessy KM. The origin of hyperkalaemia in Gordon's syndrome: WNK1 interacts directly with the potassium channel ROMK to reduce its surface expression in Xenopus oocytes. J Hum Hypertens 19: 832, 2005.
2. Cope G, Golbang A, and O'Shaughnessy KM. WNK kinases and the control of blood pressure. Pharmacol Ther 106: 221-231, 2005.
3. Cruz DN, Simon DB, Nelson-Williams C, Farhi A, Finberg K, Burleson L, Gill JR, and Lifton RP. Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension 37: 1458-1464, 2001.
4. Delaloy C, Lu J, Houot AM, Disse-Nicodeme S, Gasc JM, Corvol P, and Jeunemaitre X. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol 23: 9208-9221, 2003.
5. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, and Hebert SC. Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994.
6. Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, and O'Shaughnessy KM. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension 46: 295-300, 2005.
7. Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, and Lifton RP. WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet 35: 372-376, 2003.
8. Kahle KT, Wilson FH, and Lifton RP. Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch. Trends Endocrinol Metab 16: 98-103, 2005.
9. Lifton RP, Gharavi AG, and Geller DS. Molecular mechanisms of human hypertension. Cell 104: 545-556, 2001.
10. Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, and Farfel Z. Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 87: 3248-3254, 2002.
11. Morsing P, Velazquez H, Wright FS, and Ellison DH. Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion. Am J Physiol Renal Fluid Electrolyte Physiol 261: F137-F143, 1991.
12. Shimkets RA, Lifton RP, and Canessa CM. The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. J Biol Chem 272: 25537-25541, 1997.
13. Subramanya AR, Yang CL, Zhu X, and Ellison DH. Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Am J Physiol Renal Physiol In press.
14. Syme CA, Friedman PA, and Bisello A. Parathyroid hormone receptor trafficking contributes to the activation of extracellular signal-regulated kinases but is not required for regulation of cAMP signaling. J Biol Chem 280: 11281-11288, 2005.
15. Tavernier G, Barbe P, Galitzky J, Berlan M, Caput D, Lafontan M, and Langin D. Expression of beta3-adrenoceptors with low lipolytic action in human subcutaneous white adipocytes. J Lipid Res 37: 87-97, 1996.
16. Van der Bliek AM, Redelmeier TE, Damke H, Tisdale EJ, Meyerowitz EM, and Schmid SL. Mutations in human dynamin block an intermediate stage in coated vesicle formation. J Cell Biol 122: 553-563, 1993.
17. Velazquez H, Bartiss A, Bernstein P, and Ellison DH. Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. Am J Physiol Renal Fluid Electrolyte Physiol 270: F211-F219, 1996.
18. +- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C. J Membr Biol 196: 71-81, 2003.
19. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, and Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
20. Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, and Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 100: 680-684, 2003.
21. Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, and Cobb MH. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 275: 16795-16801, 2000.
22. Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, and Cobb MH. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Cell Res 15: 6-10, 2005.
23. Yang CL, Angell J, Mitchell R, and Ellison DH. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111: 1039-1045, 2003.
24. Yang CL, Zhu X, Wang Z, Subramanya AR, and Ellison DH. Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest 115: 1379-1387, 2005.
25. Zeng WZ, Babich V, Ortega B, Quigley R, White SJ, Welling PA, and Huang CL. Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am J Physiol Renal Physiol 283: F630-F639, 2002.