Increased urinary Na-Cl cotransporter protein in familial hyperkalaemia and hypertension

Nephrology Dialysis Transplantation

Volumn 23, Issue 2, 2008, Pages 492-496

  Mayan, Haim ^a   Attar Herzberg, Dana ^a   Shaharabany, Miriam ^a   Holtzman, Eliezer J ^a   Farfel, Zvi ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

Familial hyperkalaemia and hypertension; Na Cl cotransporter; Pseudohypoaldosteronism type II; Urine proteomics; WNK4 kinase

Indexed keywords

PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; SODIUM CHLORIDE COTRANSPORTER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERKALEMIA; HYPERTENSION; KIDNEY DISTAL TUBULE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEOMICS; URINALYSIS; WESTERN BLOTTING;

ADULT; FEMALE; HUMANS; HYPERKALEMIA; HYPERTENSION; MALE; MIDDLE AGED; MUTATION; PROTEIN-SERINE-THREONINE KINASES; PSEUDOHYPOALDOSTERONISM; SODIUM CHLORIDE SYMPORTERS;

EID: 44449116109     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm641     Document Type: Article

References (28)

1. Lifton RP, Ghaharavi DS, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104: 545-556
2. Paver WKA, Pauline GJ. Hypertension and hyperpotassemia without renal disease in a young male. Med J Aust 1964; 2: 305-306
3. Farfel Z, Rosenthal T, Shibolet S et al. Familial hyperkalaemia and hypertension. Harefuah 1976; 90: 468-470
4. Gordon RD, Klemm SA, Tunny TJ et al. Gordon's Syndrome: a sodium-volume dependent form of hypertension with a genetic basis. In: Laragh JH, Brenner BM (eds). Hypertension: pathophysiology, diagnosis, and management . New York: Raven Press, 1995; 2111-2123
5. Farfel Z, Iaina A, Rosenthal T et al. Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels: possible cell membrane defect. Arch Intern Med 1978; 138: 1828-1832
6. Wilson F, Disse-Nicodeme S, Choate K et al. Human hypertension caused by mutations in WNK kinases. Science 2001; 293: 1107-1112
7. Wilson FH, Kahle KT, Sabath E et al. Molecular pathogenesis of inherited hypertension with hyperkalaemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 2003; 100: 680-684
8. Yang CL, Angell J, Mitchell R et al. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 2003; 111: 1039-1045
9. Cai H, Cebotaru V, Wang YH et al. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int 2006; 69: 2162-2170
10. + secretion. Nature Genet 2003; 35: 372-376
11. Cl-permeability and phosphorylates claudins. Proc Natl Acad Sci USA 2004; 101: 4690-4694
12. - permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci USA 2004; 101: 14877-14882
13. Lalioti MD, Zhang J, Volkman HM et al. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 2006; 38: 1124-1132
14. D561A/+ knockin mouse model. Cell Metabolism 2007; 5: 331-344
15. Mayan H, Vered I, Mouallem M et al. Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 2002; 87: 3248-3254
16. Mayan H, Munter G, Shaharabany M et al. Hypercalciuria in familial hyperkalaemia and hypertension accompanies hyperkalaemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. J Clin Endocrinol Metab 2004; 89: 4025-30
17. Hoorn EJ, Pisitkun T, Zieste R et al. Prospects for urinary proteomics: exosomes as a source of urinary biomarkers. Nephrology 2005; 10: 283-290
18. Wen H, Frokiaer J, Kwon TH et al. Urinary excretion of Aquaporin-2 in rat is mediated by a vasopressin-dependent apical pathway. J Am Soc Nephrol 1999; 10: 1416-1429
19. Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA 2004; 101: 13368-13373
20. Kanno K, Sasaki S, Hirata Y et al. Urinary excretion of Aquaporine-2 in patients with diabetes insipidus. N Engl J Med 1995; 332: 1540-1545
21. + transporter proteins in urine. J Am Soc Nephrol 2000; 11: 2128-2132
22. Vitari AC, Deak M, Morrice NA et al. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 2005; 391: 17-24
23. Moriguchi T, Urushiyama S, Hisamoto N et al. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE-related kinases, SPAK and OSR1. J Biol Chem 2005; 280: 42685-42693
24. Gagnon KBE, England R, Delpire E. Volume sensitivity of cation-Cl-cotransporters is modulated by the interaction of two kinases: Ste-20-related proline-alanine-rich kinase and WNK4. Am J Physiol Cell Physiol 2006; 290: C134-142
25. Schambelan M, Sebastian A, Rector FC. Mineralocorticoid-resistant renal hyperkalaemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption. Kidney Int 1981; 19: 716-727
26. Lee JW, Joo KW, Chang HR et al. Urine immunoblotting of sodium chloride cotransporter in patients with Gitelman's syndrome: its implications in differential diagnosis. [Abstract]. J Am Soc Nephrol 2004; 15: 312A
27. Hadchouel J, Delaloy C, Faure S et al. Familial Hyperkalemic Hypertension. J Am Soc Nephrol 2006; 17: 208-217
28. Achard JM, Warnock DG, Disse-Nicodeme S et al. Familial hyperkalemic hypertension: phenotypic analysis in a large family with the WNK1 deletion mutation. Am J Med 2003; 114: 495-498