메뉴 건너뛰기




Volumn 13, Issue 5, 2004, Pages 557-562

WNK kinases: Molecular regulators of integrated epithelial ion transport

Author keywords

Epithelia; Hypertension; Kinases; Na Cl cotransporter (NCCT); Paracellular; Renal outer medullary potassium channel (ROMK)

Indexed keywords

COTRANSPORTER; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KINASE; PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; PROTEIN SERINE THREONINE KINASE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

EID: 4344656182     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200409000-00012     Document Type: Review
Times cited : (63)

References (27)
  • 1
    • 75949143620 scopus 로고
    • Hypertension and hyperpotassaemia without renal disease in a young male
    • Paver WK, Pauline GJ. Hypertension and hyperpotassaemia without renal disease in a young male. Med J Aust 1964; 35:305-306.
    • (1964) Med J Aust , vol.35 , pp. 305-306
    • Paver, W.K.1    Pauline, G.J.2
  • 3
    • 0019480065 scopus 로고
    • Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption
    • Schambelan M, Sebastian A, Rector FC Jr. Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption. Kidney Int 1981; 19:716-727.
    • (1981) Kidney Int , vol.19 , pp. 716-727
    • Schambelan, M.1    Sebastian, A.2    Rector Jr., F.C.3
  • 4
    • 0026023350 scopus 로고
    • Increased chloride reabsorption as an inherited renal tubular defect in familial type II pseudohypoaldosteronism
    • Take C, Ikeda K, Kurasawa T, Kurokawa K. Increased chloride reabsorption as an inherited renal tubular defect in familial type II pseudohypoaldosteronism. N Engl J Med 1991; 324:472-476.
    • (1991) N Engl J Med , vol.324 , pp. 472-476
    • Take, C.1    Ikeda, K.2    Kurasawa, T.3    Kurokawa, K.4
  • 5
    • 19244386918 scopus 로고    scopus 로고
    • Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21
    • Mansfield TA, Simon DB, Farfel Z, et al. Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet 1997; 16:202-205.
    • (1997) Nat Genet , vol.16 , pp. 202-205
    • Mansfield, T.A.1    Simon, D.B.2    Farfel, Z.3
  • 6
    • 0033855576 scopus 로고    scopus 로고
    • A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension
    • Disse-Nicodeme S, Achard JM, Desitter I, et al. A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension. Am J Hum Genet 2000; 67:302-310.
    • (2000) Am J Hum Genet , vol.67 , pp. 302-310
    • Disse-Nicodeme, S.1    Achard, J.M.2    Desitter, I.3
  • 7
    • 17944373014 scopus 로고    scopus 로고
    • Human hypertension caused by mutations in WNK kinases
    • Wilson FH, Disse-Nicodeme S, Choate KA, et al. Human hypertension caused by mutations in WNK kinases. Science 2001; 5532:1107-1112.
    • (2001) Science , vol.5532 , pp. 1107-1112
    • Wilson, F.H.1    Disse-Nicodeme, S.2    Choate, K.A.3
  • 8
    • 11144355904 scopus 로고    scopus 로고
    • Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: Implication of clinical phenotypes
    • Kamide K, Takiuchi S, Tanaka C, et al. Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes. Am J Hypertens 2004; 17:446-449.
    • (2004) Am J Hypertens , vol.17 , pp. 446-449
    • Kamide, K.1    Takiuchi, S.2    Tanaka, C.3
  • 9
    • 0034595634 scopus 로고    scopus 로고
    • WNK1, a novel mammalian serine/ threonine protein kinase lacking the catalytic lysine in subdomain II
    • Xu B, English JM, Wilsbacher JL, et al. WNK1, a novel mammalian serine/ threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 2000; 275:16795-16801.
    • (2000) J Biol Chem , vol.275 , pp. 16795-16801
    • Xu, B.1    English, J.M.2    Wilsbacher, J.L.3
  • 10
    • 2242435334 scopus 로고    scopus 로고
    • Regulation of WNK1 by an autoinhibitory domain and autophosphorylation
    • Xu BE, Min X, Stippec S, et al. Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem 2002; 277:48456-48462.
    • (2002) J Biol Chem , vol.277 , pp. 48456-48462
    • Xu, B.E.1    Min, X.2    Stippec, S.3
  • 11
    • 0036328423 scopus 로고    scopus 로고
    • Pseudohypoaldosteronism type II: Marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density
    • Mayan H, Vered I, Mouallem M, et al. Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 2002; 87:3248-3254.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3248-3254
    • Mayan, H.1    Vered, I.2    Mouallem, M.3
  • 12
    • 9044235777 scopus 로고    scopus 로고
    • Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
    • Simon DB, Nelson-Williams C, Bia MJ, et al. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 1996; 12:24-30.
    • (1996) Nat Genet , vol.12 , pp. 24-30
    • Simon, D.B.1    Nelson-Williams, C.2    Bia, M.J.3
  • 13
    • 0037457965 scopus 로고    scopus 로고
    • Molecular pathogenesis of inherited hypertension with hyperkalemia; the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
    • Wilson FH, Kahle KT, Sabath E, et al. Molecular pathogenesis of inherited hypertension with hyperkalemia; the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A 2003; 100:680-684. This study demonstrates the inhibition of NCCT by WNK4 and that inhibition is kinase-dependent and results from the loss of NCCT from the cell surface. Both PHAII mutations tested lose inhibitory activity.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 680-684
    • Wilson, F.H.1    Kahle, K.T.2    Sabath, E.3
  • 14
    • 0037382807 scopus 로고    scopus 로고
    • WNK kinases regulate thiazide-sensitive Na-Cl cotransport
    • Yang CL, Angell J, Mitchell R, et al. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 2003; 111:1039-1045. This study demonstrates the inhibition of NCCT by WNK4, and suggests that WNK1 inhibits WNK4.
    • (2003) J Clin Invest , vol.111 , pp. 1039-1045
    • Yang, C.L.1    Angell, J.2    Mitchell, R.3
  • 15
    • 0035936780 scopus 로고    scopus 로고
    • Molecular mechanisms of human hypertension
    • Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104:545-556.
    • (2001) Cell , vol.104 , pp. 545-556
    • Lifton, R.P.1    Gharavi, A.G.2    Geller, D.S.3
  • 16
    • 0345659215 scopus 로고    scopus 로고
    • + secretion
    • + secretion. Nat Genet 2003; 35:372-376. This study established that WNK4 inhibits ROMK activity and that PHAII mutations show increased inhibition. It established that WNK4 can independently regulate NCCT and ROMK, explaining the PHAII phenotype and establishing WNK4 as a molecular switch.
    • (2003) Nat Genet , vol.35 , pp. 372-376
    • Kahle, K.T.1    Wilson, F.H.2    Leng, Q.3
  • 17
    • 11144354175 scopus 로고    scopus 로고
    • Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins
    • Yamauchi K, Rai T, Kobayashi K, et al. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A 2004; 101:4690-4694. This study provides evidence for the role of WNK4 in the regulation of paracellular chloride ion flux.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4690-4694
    • Yamauchi, K.1    Rai, T.2    Kobayashi, K.3
  • 19
    • 0037457954 scopus 로고    scopus 로고
    • WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse CI-transporting epithelia
    • Choate KA, Kahle KT, Wilson FH, et al. WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse CI-transporting epithelia. Proc Natl Acad Sci U S A 2003; 100:663-668.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 663-668
    • Choate, K.A.1    Kahle, K.T.2    Wilson, F.H.3
  • 20
    • 1242319290 scopus 로고    scopus 로고
    • - flux in extrarenal epithelia
    • - flux in extrarenal epithelia. Proc Natl Acad Sci U S A 2004; 101:2064-2069. This study demonstrates the presence of WNK4 in polarized epithelia in diverse tissues involved in chloride ion flux.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2064-2069
    • Kahle, K.T.1    Gimenez, I.2    Hassan, H.3
  • 21
    • 1842689693 scopus 로고    scopus 로고
    • Comparison of WNK4 and WNK1 kinase and inhibiting activities
    • Wang Z, Yang CL, Ellison DH. Comparison of WNK4 and WNK1 kinase and inhibiting activities. Biochem Biophys Res Commun 2004; 317:939-944.
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 939-944
    • Wang, Z.1    Yang, C.L.2    Ellison, D.H.3
  • 22
    • 0141455346 scopus 로고    scopus 로고
    • WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain
    • O'Reilly M, Marshall E, Speirs HJ, et al. WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol 2003; 14:2447-2456. The demonstration of a kidney-specific WNK1 isoform without a kinase domain, and its expression in the DCT of the nephron.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2447-2456
    • O'Reilly, M.1    Marshall, E.2    Speirs, H.J.3
  • 23
    • 0344197746 scopus 로고    scopus 로고
    • Multiple promoters in the WNK1 gene: One controls expression of a kidney-specific kinase-defective isoform
    • Delaloy C, Lu J, Houot AM, et al. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol 2003; 23:9208-9221. The demonstration of multiple transcription start sites and WNK1 isoforms in the kidney, as well as a conserved enhancer element conserved among genes expressed in DCT.
    • (2003) Mol Cell Biol , vol.23 , pp. 9208-9221
    • Delaloy, C.1    Lu, J.2    Houot, A.M.3
  • 24
    • 10744226663 scopus 로고    scopus 로고
    • WNK1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention
    • Zambrowicz BP, Abuin A, Ramirez-Solis R, et al. WNK1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A 2003; 100:14109-14114. The targeted disruption of WNK1 is homozygous lethal; however, the heterozygous knockout mouse shows reduced blood pressure.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14109-14114
    • Zambrowicz, B.P.1    Abuin, A.2    Ramirez-Solis, R.3
  • 25
    • 1542314814 scopus 로고    scopus 로고
    • WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate
    • Vitari AC, Deak M, Collins BJ, et al. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J 2004; 378:257-268. This interesting finding raises the possibility that insulin signaling may regulate WNK activity.
    • (2004) Biochem J , vol.378 , pp. 257-268
    • Vitari, A.C.1    Deak, M.2    Collins, B.J.3
  • 26
    • 1542319971 scopus 로고    scopus 로고
    • WNK1 activates ERK5 by a MEKK2/3-dependent mechanism
    • Xu BE, Stippec S, Lenertz L, et al. WNK1 activates ERK5 by a MEKK2/3-dependent mechanism. J Biol Chem 2004; 279:7826-7831. This study puts WNK1 upstream of ERK5 signaling.
    • (2004) J Biol Chem , vol.279 , pp. 7826-7831
    • Xu, B.E.1    Stippec, S.2    Lenertz, L.3
  • 27
    • 0030956083 scopus 로고    scopus 로고
    • Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials
    • Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997; 277:1624-1632.
    • (1997) JAMA , vol.277 , pp. 1624-1632
    • Whelton, P.K.1    He, J.2    Cutler, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.