Long-term Phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing Aβ

Frontiers in Bioscience - Elite

Volumn 3 E, Issue 4, 2011, Pages 1375-1384

  Ricobaraza, Ana ^a   Cuadrado Tejedor, Mar ^a   Garcia Osta, Ana ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Alzheimer; Inflammation; Phenylbutyrate; Synaptic plasticity; amyloid

Indexed keywords

4 PHENYLBUTYRIC ACID; AMYLOID BETA PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; TAU PROTEIN; ARYLBUTYRIC ACID DERIVATIVE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE ASSOCIATION; INFLAMMATION; LONG TERM CARE; MEMORY DISORDER; MOUSE; NEUROPATHOLOGY; NEUROPHARMACOLOGY; NEUROPROTECTION; NONHUMAN; TG2576 MOUSE; ANIMAL; DRUG ANTAGONISM; IMMUNOHISTOCHEMISTRY; MAZE TEST; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALIA; MUS;

AMYLOID BETA-PEPTIDES; ANIMALS; BLOTTING, WESTERN; IMMUNOHISTOCHEMISTRY; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; PHENYLBUTYRATES;

EID: 80053586271     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. K. Blennow, M. J. De Leon and H. Zetterberg: Alzheimer's disease. Lancet, 368, 387-403 (2006) (Pubitemid 44108123)
2. S. C. Domingues, A. G. Henriques, W. Wu, E. F. Da Cruz E Silva and O. A. Da Cruz E Silva: Altered subcellular distribution of the Alzheimer's amyloid precursor protein under stress conditions. Ann N Y Acad Sci, 1096, 184-195 (2007) (Pubitemid 47092512)
3. A. Weidemann, G. Konig, D. Bunke, P. Fischer, J. M. Salbaum, C. L. Masters and K. Beyreuther: Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell, 57, 115-126 (1989) (Pubitemid 19098873)
4. M. Schroder: Endoplasmic reticulum stress responses. Cell Mol Life Sci, 65, 862-894 (2008)
5. J. Hardy and D. J. Selkoe: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science, 297, 353-356 (2002) (Pubitemid 34790756)
6. J. J. Hoozemans, E. S. Van Haastert, D. A. Nijholt, A. J. Rozemuller, P. Eikelenboom and W. Scheper: The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus. Am J Pathol, 174, 1241-1251 (2009)
7. F. M. La Ferla, K. N. Green and S. Oddo: Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci, 8, 499-509 (2007)
8. U. Unterberger, R. Hoftberger, E. Gelpi, H. Flicker, H. Budka and T. Voigtlander: Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. J Neuropathol Exp Neurol, 65, 348-357 (2006) (Pubitemid 44264832)
9. A. Salminen, A. Kauppinen, T. Suuronen, K. Kaarniranta and J. Ojala: ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation, 6, 41 (2009)
10. P. Cras, M. Kawai, S. Siedlak, P. Mulvihill, P. Gambetti, D. Lowery, P. Gonzalez-De Whitt, B. Greenberg and G. Perry: Neuronal and microglial involvement in betaamyloid protein deposition in Alzheimer's disease. Am J Pathol, 137, 241-246 (1990) (Pubitemid 20232984)
11. S. Haga, K. Akai and T. Ishii: Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol, 77, 569-575 (1989) (Pubitemid 19125369)
12. C. Pereira, E. Ferreiro, S. M. Cardoso and C. R. De Oliveira: Cell degeneration induced by amyloid-beta peptides: implications for Alzheimer's disease. J Mol Neurosci, 23, 97-104 (2004) (Pubitemid 41359192)
13. A. Ricobaraza, M. Cuadrado-Tejedor, A. Perez-Mediavilla, D. Frechilla, J. Del Rio and A. Garcia-Osta: Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology, 34, 1721-1732 (2009)
14. X. Qi, T. Hosoi, Y. Okuma, M. Kaneko and Y. Nomura: Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol Pharmacol, 66, 899-908 (2004) (Pubitemid 39319462)
15. W. Qi, J. Mu, Z. F. Luo, W. Zeng, Y. H. Guo, Q. Pang, Z. L. Ye, L. Liu, F. H. Yuan and B. Feng: Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. Metabolism (2010)
16. A. Ricobaraza, M. Cuadrado-Tejedor, S. Marco, I. Perez-Otano and A. Garcia-Osta: Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease. Hippocampus (2010)
17. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang and G. Cole: Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science, 274, 99-102 (1996) (Pubitemid 26332733)
18. S. A. Frautschy, F. Yang, M. Irrizarry, B. Hyman, T. C. Saido, K. Hsiao and G. M. Cole: Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol, 152, 307-17 (1998) (Pubitemid 28028071)
19. K. Terai, A. Iwai, S. Kawabata, Y. Tasaki, T. Watanabe, K. Miyata and T. Yamaguchi: beta-amyloid deposits in transgenic mice expressing human beta-amyloid precursor protein have the same characteristics as those in Alzheimer's disease. Neuroscience, 104, 299-310 (2001) (Pubitemid 32493724)
20. T. Kawarabayashi, L. H. Younkin, T. C. Saido, M. Shoji, K. H. Ashe and S. G. Younkin: Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci, 21, 372-381 (2001) (Pubitemid 32107428)
21. R. C. Rubenstein and P. L. Zeitlin: Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Am J Physiol Cell Physiol, 278, 259-267 (2000)
22. S. M. Rahman, I. Qadri, R. C. Janssen and J. E. Friedman: Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis. J Lipid Res, 50, 2193-202 (2009)
23. M. N. Reed, P. Liu, L. A. Kotilinek and K. H. Ashe: Effect size of reference memory deficits in the Morris water maze in Tg2576 mice. Behav Brain Res, 212, 115-120 (2010)
24. C. V. Vorhees and M. T. Williams: Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc, 1, 848-858 (2006)
25. M. A. Westerman, D. Cooper-Blacketer, A. Mariash, L. Kotilinek, T. Kawarabayashi, L. H. Younkin, G. A. Carlson, S. G. Younkin and K. H. Ashe: The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci, 22, 1858-1867 (2002) (Pubitemid 35386304)
26. P. N. Pompl, M. J. Mullan, K. Bjugstad and G. W. Arendash: Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APP (SW) transgenic mouse model for Alzheimer's disease. J Neurosci Methods, 87, 87-95 (1999) (Pubitemid 29087089)
27. T. A. Comery, R. L. Martone, S. Aschmies, K. P. Atchison, G. Diamantidis, X. Gong, H. Zhou, A. F. Kreft, M. N. Pangalos, J. Sonnenberg-Reines, J. S. Jacobsen and K. L. Marquis: Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. J Neurosci, 25, 8898-8902 (2005) (Pubitemid 41384457)
28. J. C. Dodart, K. R. Bales, K. S. Gannon, S. J. Greene, R. B. De Mattos, C. Mathis, C. A. De Long, S. Wu, X. Wu, D. M. Holtzman and S. M. Paul: Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci, 5, 452-457 (2002) (Pubitemid 34454251)
29. W. C. Benzing, J. R. Wujek, E. K. Ward, D. Shaffer, K. H. Ashe, S. G. Younkin and K. R. Brunden: Evidence for glial-mediated inflammation in aged APP (SW) transgenic mice. Neurobiol Aging, 20, 581-589 (1999) (Pubitemid 30064403)
30. G. P. Lim, T. Chu, F. Yang, W. Beech, S. A. Frautschy and G. M. Cole: The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci, 21, 8370-8377 (2001) (Pubitemid 33051435)
31. W. F. Yu, Z. Z. Guan, N. Bogdanovic and A. Nordberg: High selective expression of alpha7 nicotinic receptors on astrocytes in the brains of patients with sporadic Alzheimer's disease and patients carrying Swedish APP 670/671 mutation: a possible association with neuritic plaques. Exp Neurol, 192, 215-225 (2005) (Pubitemid 40208555)
32. L. Song, P. De Sarno and R. S. Jope: Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation. J Biol Chem, 277, 44701-44708 (2002) (Pubitemid 36159060)