-
1
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
Jaenisch R. and Bird A. (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33: 245-254
-
(2003)
Nat. Genet.
, vol.33
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
2
-
-
0042528729
-
Heterochromatin and epigenetic control of gene expression
-
Grewal S. I. and Moazed D. (2003) Heterochromatin and epigenetic control of gene expression. Science 301: 798-802
-
(2003)
Science
, vol.301
, pp. 798-802
-
-
Grewal, S.I.1
Moazed, D.2
-
3
-
-
0032960181
-
Cancer epigenetics comes of age
-
Jones P. A. and Laird P. W. (1999) Cancer epigenetics comes of age. Nat. Genet. 21: 163-167
-
(1999)
Nat. Genet.
, vol.21
, pp. 163-167
-
-
Jones, P.A.1
Laird, P.W.2
-
4
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones P. A. and Baylin S. B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3: 415-428
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
5
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman J. G. and Baylin S. B. (2003) Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349: 2042-2054
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
6
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
Knudson A. G. Jr (1971) Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68: 820-823
-
(1971)
Proc. Natl. Acad. Sci. USA
, vol.68
, pp. 820-823
-
-
Knudson Jr., A.G.1
-
7
-
-
0030739106
-
Molecular basis of HNPCC: Mutations of MMR genes
-
Papadopoulos N. and Lindblom A. (1997) Molecular basis of HNPCC: mutations of MMR genes. Human Mut. 10: 89-99
-
(1997)
Human Mut.
, vol.10
, pp. 89-99
-
-
Papadopoulos, N.1
Lindblom, A.2
-
8
-
-
13144266670
-
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
-
Herman J. G., Umar A., Polyak K., Graff J. R., Ahuja N., Issa J. P. et al. (1998) Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95: 6870-6875
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6870-6875
-
-
Herman, J.G.1
Umar, A.2
Polyak, K.3
Graff, J.R.4
Ahuja, N.5
Issa, J.P.6
-
11
-
-
0035874892
-
6- methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis
-
6-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res. 61: 4689-4692
-
(2001)
Cancer Res.
, vol.61
, pp. 4689-4692
-
-
Esteller, M.1
Risques, R.A.2
Toyota, M.3
Capella, G.4
Moreno, V.5
Peinado, M.A.6
-
12
-
-
0032706744
-
hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis
-
Esteller M., Catasus L., Matias-Guiu X., Mutter G. L., Prat J., Baylin S. B. et al. (1999) hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis. Am. J. Pathol. 155: 1767-1772
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1767-1772
-
-
Esteller, M.1
Catasus, L.2
Matias-Guiu, X.3
Mutter, G.L.4
Prat, J.5
Baylin, S.B.6
-
13
-
-
0034662626
-
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer
-
Esteller M., Sparks A., Toyota M., Sanchez-Cespedes M., Capella G., Peinado M. A. et al. (2000) Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res. 60: 4366-4371
-
(2000)
Cancer Res.
, vol.60
, pp. 4366-4371
-
-
Esteller, M.1
Sparks, A.2
Toyota, M.3
Sanchez-Cespedes, M.4
Capella, G.5
Peinado, M.A.6
-
14
-
-
0034282793
-
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1
-
Fleisher A. S., Esteller M., Harpaz N., Leytin A., Rashid A., Xu Y. et al. (2000) Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res. 60: 4864-4868
-
(2000)
Cancer Res.
, vol.60
, pp. 4864-4868
-
-
Fleisher, A.S.1
Esteller, M.2
Harpaz, N.3
Leytin, A.4
Rashid, A.5
Xu, Y.6
-
15
-
-
0037115964
-
Gene silencing in phenomena related to DNA repair
-
Mukai T. and Sekiguchi M. (2002) Gene silencing in phenomena related to DNA repair. Oncogene 21: 9033-9042
-
(2002)
Oncogene
, vol.21
, pp. 9033-9042
-
-
Mukai, T.1
Sekiguchi, M.2
-
16
-
-
0032574814
-
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
-
Kawate H., Sakumi K., Tsuzuki T., Nakatsuru Y., Ishikawa T., Takahashi S. et al. (1998) Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. Proc. Natl. Acad. Sci. USA 95: 5116-5120
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 5116-5120
-
-
Kawate, H.1
Sakumi, K.2
Tsuzuki, T.3
Nakatsuru, Y.4
Ishikawa, T.5
Takahashi, S.6
-
17
-
-
0037463277
-
CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection
-
Matsukura S., Soejima H., Nakagawachi T., Yakushiji H., Ogawa A., Fukuhara M. et al. (2003) CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection. Br. J. Cancer 88: 521-529
-
(2003)
Br. J. Cancer
, vol.88
, pp. 521-529
-
-
Matsukura, S.1
Soejima, H.2
Nakagawachi, T.3
Yakushiji, H.4
Ogawa, A.5
Fukuhara, M.6
-
19
-
-
0037005988
-
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
-
Esteller M., Gaidano G., Goodman S. N., Zagonel V., Capello D., Botto B. et al. (2002) Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. J. Natl. Cancer Inst. 94: 26-32
-
(2002)
J. Natl. Cancer Inst.
, vol.94
, pp. 26-32
-
-
Esteller, M.1
Gaidano, G.2
Goodman, S.N.3
Zagonel, V.4
Capello, D.5
Botto, B.6
-
20
-
-
0035665415
-
6-methylguanine-DNA methyltransferase in hepatocellular, gastric and breast cancers
-
6-methylguanine-DNA methyltransferase in hepatocellular, gastric and breast cancers. Ann. Surg. Oncol. 8: 807-816
-
(2001)
Ann. Surg. Oncol.
, vol.8
, pp. 807-816
-
-
Matsukura, S.1
Miyazaki, K.2
Yakushiji, H.3
Ogawa, A.4
Harimaya, K.5
Nakabeppu, Y.6
-
21
-
-
0036256948
-
Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma
-
Kohya N., Miyazaki K., Matsukura S., Yakushiji H., Kitajima Y., Kitahara K. et al. (2002) Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Ann. Surg. Oncol. 9: 371-379
-
(2002)
Ann. Surg. Oncol.
, vol.9
, pp. 371-379
-
-
Kohya, N.1
Miyazaki, K.2
Matsukura, S.3
Yakushiji, H.4
Kitajima, Y.5
Kitahara, K.6
-
22
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller M., Garcia-Foncillas J., Andion E., Goodman S. N., Hidalgo O. F., Vanaclocha V. et al. (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343: 1350-1354
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
Garcia-Foncillas, J.2
Andion, E.3
Goodman, S.N.4
Hidalgo, O.F.5
Vanaclocha, V.6
-
23
-
-
0036494563
-
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice
-
Eads C. A., Nickel A. E. and Laird P. W. (2002) Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res. 62: 1296-1299
-
(2002)
Cancer Res.
, vol.62
, pp. 1296-1299
-
-
Eads, C.A.1
Nickel, A.E.2
Laird, P.W.3
-
24
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee I., Bachman K. E., Park B. H., Jair K. W., Yen R. W., Schuebel K. E. et al. (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416: 552-556
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
Jair, K.W.4
Yen, R.W.5
Schuebel, K.E.6
-
25
-
-
0034720284
-
CpG methylation is maintained in human cancer cells lacking DNMT1
-
Rhee I., Jair K. W., Yen R. W., Lengauer C., Herman J. G., Kinzler K. W. et al. (2000) CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404: 1003-1007
-
(2000)
Nature
, vol.404
, pp. 1003-1007
-
-
Rhee, I.1
Jair, K.W.2
Yen, R.W.3
Lengauer, C.4
Herman, J.G.5
Kinzler, K.W.6
-
26
-
-
0035839136
-
Translating the histone code
-
Jenuwein T. and Allis C. D. (2001) Translating the histone code. Science 293: 1074-1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
27
-
-
0036591878
-
The many faces of histone lysine methylation
-
Lachner M. and Jenuwein T. (2002) The many faces of histone lysine methylation. Curr. Opin. Cell Biol. 14: 286-298
-
(2002)
Curr. Opin. Cell Biol.
, vol.14
, pp. 286-298
-
-
Lachner, M.1
Jenuwein, T.2
-
28
-
-
0027535235
-
Effects of DNA methylation on DNA-binding proteins and gene expression
-
Tate P. H. and Bird A. P. (1993) Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev. 3: 226-231
-
(1993)
Curr. Opin. Genet. Dev.
, vol.3
, pp. 226-231
-
-
Tate, P.H.1
Bird, A.P.2
-
29
-
-
0037591867
-
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression
-
Fujita N., Watanabe S., Ichimura T., Tsuruzoe S., Shinkai Y., Tachibana M. et al. (2003) Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. J. Biol. Chem. 278: 24132-24138
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24132-24138
-
-
Fujita, N.1
Watanabe, S.2
Ichimura, T.3
Tsuruzoe, S.4
Shinkai, Y.5
Tachibana, M.6
-
30
-
-
0037423186
-
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
-
Fuks F., Hurd P. J., Wolf D., Nan X., Bird A. P. and Kouzarides T. (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem. 278: 4035-4040
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4035-4040
-
-
Fuks, F.1
Hurd, P.J.2
Wolf, D.3
Nan, X.4
Bird, A.P.5
Kouzarides, T.6
-
32
-
-
0037115392
-
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
-
Fahrner J. A., Eguchi S., Herman J. G. and Baylin S. B. (2002) Dependence of histone modifications and gene expression on DNA hypermethylation in cancer. Cancer Res. 62: 7213-7218
-
(2002)
Cancer Res.
, vol.62
, pp. 7213-7218
-
-
Fahrner, J.A.1
Eguchi, S.2
Herman, J.G.3
Baylin, S.B.4
-
33
-
-
0037215568
-
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer
-
Kondo Y., Shen L. and Issa J. P. (2003) Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol. Cell. Biol. 23: 206-215
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 206-215
-
-
Kondo, Y.1
Shen, L.2
Issa, J.P.3
-
34
-
-
0035891265
-
A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
-
Tamaru H. and Selker E. U. (2001) A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414: 277-283
-
(2001)
Nature
, vol.414
, pp. 277-283
-
-
Tamaru, H.1
Selker, E.U.2
-
35
-
-
0037041422
-
Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase
-
Jackson J. P., Lindroth A. M., Cao X. and Jacobsen S. E. (2002) Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416: 556-560
-
(2002)
Nature
, vol.416
, pp. 556-560
-
-
Jackson, J.P.1
Lindroth, A.M.2
Cao, X.3
Jacobsen, S.E.4
|