-
1
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature 2001; 411:366-374.
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
2
-
-
0035093737
-
DNA double-strand breaks: Signaling, repair and the cancer connection
-
Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001;27:247-254.
-
(2001)
Nat Genet
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
3
-
-
0033590179
-
DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
-
Dasika GK, Lin SC, Zhao S, Sung P, Tomkinson A, Lee EY. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 1999;18:7883-7899.
-
(1999)
Oncogene
, vol.18
, pp. 7883-7899
-
-
Dasika, G.K.1
Lin, S.C.2
Zhao, S.3
Sung, P.4
Tomkinson, A.5
Lee, E.Y.6
-
4
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000;408:433-439.
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
-
5
-
-
0033399453
-
Anticancer drug targets: Cell cycle and checkpoint control
-
Shapiro GI, Harper JW. Anticancer drug targets: cell cycle and checkpoint control. J Clin Invest 1999;104:1645-1653.
-
(1999)
J Clin Invest
, vol.104
, pp. 1645-1653
-
-
Shapiro, G.I.1
Harper, J.W.2
-
6
-
-
0030802463
-
Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function
-
Bracey TS, Williams AC, Paraskeva C. Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function. Clin Cancer Res 1997;3:1371-1381.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1371-1381
-
-
Bracey, T.S.1
Williams, A.C.2
Paraskeva, C.3
-
7
-
-
0033533612
-
14-3-3 Sigma is required to prevent mitotic catastrophe after DNA damage
-
Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14-3-3 Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 1999;401:616-620.
-
(1999)
Nature
, vol.401
, pp. 616-620
-
-
Chan, T.A.1
Hermeking, H.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
-
8
-
-
0029808466
-
Cell cycle checkpoints: Preventing an identity crisis
-
Elledge SJ. Cell cycle checkpoints: preventing an identity crisis. Science 1996; 274:1664-1672.
-
(1996)
Science
, vol.274
, pp. 1664-1672
-
-
Elledge, S.J.1
-
9
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003;3:155-168.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
10
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham RT Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001;15:2177-2196.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
11
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 2003;13:49-58.
-
(2003)
Semin Cancer Biol
, vol.13
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
12
-
-
0037099586
-
Tyrosine phosphorylation of Mdm2 by c-Abl: Implications for p53 regulation
-
Goldberg Z, Vogt Sionov R, Berger M, et al. Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. Embo J 2002;21:3715-3727.
-
(2002)
Embo J
, vol.21
, pp. 3715-3727
-
-
Goldberg, Z.1
Vogt Sionov, R.2
Berger, M.3
-
13
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
14
-
-
13944257800
-
Transcription, apoptosis and p53: Catch-22
-
Schuler M, Green DR. Transcription, apoptosis and p53: catch-22. Trends Genet 2005; 21:182-187.
-
(2005)
Trends Genet
, vol.21
, pp. 182-187
-
-
Schuler, M.1
Green, D.R.2
-
15
-
-
0033985661
-
Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization
-
Nie Y, Li HH, Bula CM, Liu X. Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization. Mol Cell Biol 2000;20:741-748.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 741-748
-
-
Nie, Y.1
Li, H.H.2
Bula, C.M.3
Liu, X.4
-
16
-
-
0029122607
-
P53 dependent growth suppression by the c-Abl nuclear tyrosine kinase
-
Goga A, Liu X, Hambuch TM, et al. p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase. Oncogene 1995;11:791-799.
-
(1995)
Oncogene
, vol.11
, pp. 791-799
-
-
Goga, A.1
Liu, X.2
Hambuch, T.M.3
-
17
-
-
2342459790
-
DNA damage-induced apoptosis
-
Norbury CJ, Zhivotovsky B. DNA damage-induced apoptosis. Oncogene 2004;23: 2797-2808.
-
(2004)
Oncogene
, vol.23
, pp. 2797-2808
-
-
Norbury, C.J.1
Zhivotovsky, B.2
-
18
-
-
0028292480
-
Identification of a p53-dependent negative response element in the bcl-2 gene
-
Miyashita T, Harigai M, Hanada M, Reed JC. Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 1994;54:3131-3135.
-
(1994)
Cancer Res
, vol.54
, pp. 3131-3135
-
-
Miyashita, T.1
Harigai, M.2
Hanada, M.3
Reed, J.C.4
-
19
-
-
2342461756
-
To die or not to die: How does p53 decide?
-
Slee EA, O'Connor DJ, Lu X. To die or not to die: how does p53 decide? Oncogene 2004; 23:2809-2818.
-
(2004)
Oncogene
, vol.23
, pp. 2809-2818
-
-
Slee, E.A.1
O'Connor, D.J.2
Lu, X.3
-
20
-
-
0037349289
-
P53 has a direct apoptogenic role at the mitochondria
-
Mihara M, Erster S, Zaika A, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003;11:577-590.
-
(2003)
Mol Cell
, vol.11
, pp. 577-590
-
-
Mihara, M.1
Erster, S.2
Zaika, A.3
-
21
-
-
3242690522
-
In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
-
Erster S, Mihara M, Kim RH, Petrenko O, Moll UM. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol 2004;24:6728-6741.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6728-6741
-
-
Erster, S.1
Mihara, M.2
Kim, R.H.3
Petrenko, O.4
Moll, U.M.5
-
22
-
-
18644376568
-
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage
-
Deverman BE, Cook BL, Manson SR, et al. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 2002;111:51-62.
-
(2002)
Cell
, vol.111
, pp. 51-62
-
-
Deverman, B.E.1
Cook, B.L.2
Manson, S.R.3
-
23
-
-
0028070989
-
P53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
-
Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994;370:220-223.
-
(1994)
Nature
, vol.370
, pp. 220-223
-
-
Caelles, C.1
Helmberg, A.2
Karin, M.3
-
24
-
-
0030812331
-
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
-
Kaghad M, Bonnet H, Yang A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997;90:809-819.
-
(1997)
Cell
, vol.90
, pp. 809-819
-
-
Kaghad, M.1
Bonnet, H.2
Yang, A.3
-
25
-
-
0032161624
-
P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
-
Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998; 2:305-316.
-
(1998)
Mol Cell
, vol.2
, pp. 305-316
-
-
Yang, A.1
Kaghad, M.2
Wang, Y.3
-
26
-
-
0036468523
-
On the shoulders of giants: P63, p73 and the rise of p53
-
Yang A, Kaghad M, Caput D, McKeon F. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet 2002;18:90-95.
-
(2002)
Trends Genet
, vol.18
, pp. 90-95
-
-
Yang, A.1
Kaghad, M.2
Caput, D.3
McKeon, F.4
-
27
-
-
0033600234
-
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
-
Gong JG, Costanzo A, Yang HQ, et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature 1999;399:806-809.
-
(1999)
Nature
, vol.399
, pp. 806-809
-
-
Gong, J.G.1
Costanzo, A.2
Yang, H.Q.3
-
28
-
-
0033600240
-
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis
-
Agami R, Blandino G, Oren M, Shaul Y Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 1999;399:809-813.
-
(1999)
Nature
, vol.399
, pp. 809-813
-
-
Agami, R.1
Blandino, G.2
Oren, M.3
Shaul, Y.4
-
29
-
-
0033600235
-
P73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
-
Yuan ZM, Shioya H, Ishiko T, et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 1999;399:814-817.
-
(1999)
Nature
, vol.399
, pp. 814-817
-
-
Yuan, Z.M.1
Shioya, H.2
Ishiko, T.3
-
30
-
-
0037041392
-
P63 and p73 are required for p53-dependent apoptosis in response to DNA damage
-
Flores ER, Tsai KY, Crowley D, et al. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 2002;416:560-564.
-
(2002)
Nature
, vol.416
, pp. 560-564
-
-
Flores, E.R.1
Tsai, K.Y.2
Crowley, D.3
-
31
-
-
7444221823
-
Role of DNA mismatch repair in apoptotic responses to therapeutic agents
-
Meyers M, Hwang A, Wagner MW, Boothman DA. Role of DNA mismatch repair in apoptotic responses to therapeutic agents. Environ Mol Mutagen 2004;44:249-264.
-
(2004)
Environ Mol Mutagen
, vol.44
, pp. 249-264
-
-
Meyers, M.1
Hwang, A.2
Wagner, M.W.3
Boothman, D.A.4
-
33
-
-
1842841660
-
Mutations in DNA mismatch repair genes: Implications for DNA damage signaling and drug sensitivity (review)
-
Fedier A, Fink D. Mutations in DNA mismatch repair genes: implications for DNA damage signaling and drug sensitivity (review). Int J Oncol 2004;24:1039-1047.
-
(2004)
Int J Oncol
, vol.24
, pp. 1039-1047
-
-
Fedier, A.1
Fink, D.2
-
34
-
-
0033168064
-
Apoptosis induced by overexpression of hMSH2 or hMLH1
-
Zhang H, Richards B, Wilson T, et al. Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res 1999;59:3021-3027.
-
(1999)
Cancer Res
, vol.59
, pp. 3021-3027
-
-
Zhang, H.1
Richards, B.2
Wilson, T.3
-
35
-
-
0033616583
-
MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1
-
Bellacosa A, Cicchillitti L, Schepis F, et al. MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci USA 1999;96:3969-3974.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3969-3974
-
-
Bellacosa, A.1
Cicchillitti, L.2
Schepis, F.3
-
36
-
-
0033607055
-
HMutSalpha-and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage
-
Duckett DR, Bronstein SM, Taya Y, Modrich P. hMutSalpha-and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage. Proc Natl Acad Sci USA 1999;96:12, 384-12, 388.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 12384-12388
-
-
Duckett, D.R.1
Bronstein, S.M.2
Taya, Y.3
Modrich, P.4
-
37
-
-
3042791562
-
ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage
-
Luo Y, Lin FT, Lin WC. ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol Cell Biol 2004;24:6430-6444.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6430-6444
-
-
Luo, Y.1
Lin, F.T.2
Lin, W.C.3
-
38
-
-
0344284564
-
Wang JY Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
-
Epub 2003 Feb 24
-
Shimodaira H, Yoshioka-Yamashita A, Kolodner RD, Wang JY Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci USA 2003;100:2420-2425. Epub 2003 Feb 24.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2420-2425
-
-
Shimodaira, H.1
Yoshioka-Yamashita, A.2
Kolodner, R.D.3
-
39
-
-
0742324404
-
Life and death decisions by E2F-1
-
Bell LA, Ryan KM. Life and death decisions by E2F-1. Cell Death Differ 2004;11:137-142.
-
(2004)
Cell Death Differ
, vol.11
, pp. 137-142
-
-
Bell, L.A.1
Ryan, K.M.2
-
40
-
-
0034028030
-
Repair of O(6)-alkylguanine by alkyltransferases
-
Pegg AE. Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res 2000;462:83-100.
-
(2000)
Mutat Res
, vol.462
, pp. 83-100
-
-
Pegg, A.E.1
-
41
-
-
0032723363
-
Signaling mismatch repair in cancer
-
Fishel R. Signaling mismatch repair in cancer. Nat Med 1999;5:1239-1241.
-
(1999)
Nat Med
, vol.5
, pp. 1239-1241
-
-
Fishel, R.1
-
42
-
-
0033039014
-
Marsischky GT Eukaryotic DNA mismatch repair
-
Kolodner RD, Marsischky GT Eukaryotic DNA mismatch repair. Curr Opin Genet Dev 1999;9:89-96.
-
(1999)
Curr Opin Genet Dev
, vol.9
, pp. 89-96
-
-
Kolodner, R.D.1
-
44
-
-
0034717309
-
Rapid destruction of human Cdc25A in response to DNA damage
-
Mailand N, Falck J, Lukas C, et al. Rapid destruction of human Cdc25A in response to DNA damage. Science 2000;288:1425-1429.
-
(2000)
Science
, vol.288
, pp. 1425-1429
-
-
Mailand, N.1
Falck, J.2
Lukas, C.3
-
45
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001;410:842-847.
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
46
-
-
0034234211
-
Cooperative effects of genes controlling the G(2)/M checkpoint
-
Chan TA, Hwang PM, Hermeking H, Kinzler KW, Vogelstein B. Cooperative effects of genes controlling the G(2)/M checkpoint. Genes Dev 2000;14:1584-1588.
-
(2000)
Genes Dev
, vol.14
, pp. 1584-1588
-
-
Chan, T.A.1
Hwang, P.M.2
Hermeking, H.3
Kinzler, K.W.4
Vogelstein, B.5
-
47
-
-
0035810054
-
Regulation of the G2/M transition by p53
-
Taylor WR, Stark GR. Regulation of the G2/M transition by p53. Oncogene 2001;20: 1803-1815.
-
(2001)
Oncogene
, vol.20
, pp. 1803-1815
-
-
Taylor, W.R.1
Stark, G.R.2
-
48
-
-
0034704182
-
Waiting for anaphase: Mad2 and the spindle assembly checkpoint
-
Shah JV, Cleveland DW. Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell 2000;103:997-1000.
-
(2000)
Cell
, vol.103
, pp. 997-1000
-
-
Shah, J.V.1
Cleveland, D.W.2
-
50
-
-
0033179760
-
BCL-2 family members and the mitochondria in apoptosis
-
Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999;13:1899-1911.
-
(1999)
Genes Dev
, vol.13
, pp. 1899-1911
-
-
Gross, A.1
McDonnell, J.M.2
Korsmeyer, S.J.3
|