Subretinal transfection of chitosan-loaded TLR3-siRNA for the treatment of experimental autoimmune uveitis

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART A, 2013, Pages 726-735

  Chen, Song ^a   Yan, Hua ^a   Sun, Bei ^a   Zuo, Aijun ^b   Liang, Dongchun ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Chitosan; Experimental autoimmune uveitis; Retinal pigment epithelium; siRNA; Toll like receptor 3

Indexed keywords

CHITOSAN; FIREFLY LUCIFERASE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 17RA; INTERLEUKIN 6; INTERLEUKIN 8; LIGAND; PATTERN RECOGNITION RECEPTOR; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE UVEITIS; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL VIABILITY; COMPARATIVE STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE SILENCING; IN VITRO GENE TRANSFER; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RNA EXTRACTION; TH17 CELL; TRANSGENIC MOUSE;

CHITOSAN; EXPERIMENTAL AUTOIMMUNE UVEITIS; RETINAL PIGMENT EPITHELIUM; SIRNA; TOLL LIKE RECEPTOR-3;

ANIMALS; ANTIGENS, CD4; AUTOIMMUNE DISEASES; CHITOSAN; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE KNOCKDOWN TECHNIQUES; INTERFERON-GAMMA; INTERLEUKIN-6; LUCIFERASES, FIREFLY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RETINAL PIGMENT EPITHELIUM; RNA, SMALL INTERFERING; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TRANSFECTION; UVEITIS;

EID: 84888365116     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.09.005     Document Type: Article

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