Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 23, 2011, Pages 9554-9559

  Bhattacharyya, Sandip ^a   Zhao, Yuxing ^b   Kay, Thomas W H ^b   Muglia, Louis J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

JAK; Knockout mice

Indexed keywords

ALPHA INTERFERON RECEPTOR; BETA INTERFERON RECEPTOR; DEXAMETHASONE; INTERFERON; JANUS KINASE 2; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DEXAMETHASONE; GLUCOCORTICOIDS; INTERFERON REGULATORY FACTOR-3; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-6; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; POLY I-C; RECEPTORS, INTERFERON; STAT1 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TOLL-LIKE RECEPTORS;

MUS;

EID: 79959355521     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017296108     Document Type: Article

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