메뉴 건너뛰기




Volumn 55, Issue 5, 2011, Pages 565-575

Suppression of interleukin-17-producing T-helper 17 cells by retinal pigment epithelial cells

Author keywords

Cytokine; Immune regulation; RPE cells; T cells; Th17 cells

Indexed keywords

INTERLEUKIN 17; RECOMBINANT INTERLEUKIN 6; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA2; SMALL INTERFERING RNA;

EID: 80054767681     PISSN: 00215155     EISSN: 16132246     Source Type: Journal    
DOI: 10.1007/s10384-011-0064-9     Document Type: Article
Times cited : (12)

References (40)
  • 1
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • 16648838 10.1038/nature04753 1:CAS:528:DC%2BD28XksVGns7g%3D
    • E Bettelli Y Carrier W Gao T Korn TB Strom M Oukka, et al. 2006 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 235 238 16648838 10.1038/nature04753 1:CAS:528:DC%2BD28XksVGns7g%3D
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 2
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • DOI 10.1016/j.immuni.2006.01.001, PII S1074761306000045
    • M Veldhoen RJ Hocking CJ Atkins RM Locksley B Stockinger 2006 TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Immunity 24 179 189 16473830 10.1016/j.immuni.2006. 01.001 1:CAS:528:DC%2BD28XitVOks7s%3D (Pubitemid 43214587)
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 3
    • 27544490377 scopus 로고    scopus 로고
    • + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • DOI 10.1038/ni1254, PII N1254
    • LE Harrington RD Hatton PR Mangan H Turner TL Murphy KM Murphy, et al. 2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat Immunol 6 1123 1132 16200070 10.1038/ni1254 1:CAS:528:DC%2BD2MXhtFamsb7J (Pubitemid 41541790)
    • (2005) Nature Immunology , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 4
    • 70349408821 scopus 로고    scopus 로고
    • Systemic nonarticular manifestations of rheumatoid arthritis: Focus on inflammatory mechanisms
    • 19022481 10.1016/j.semarthrit.2008.08.003 1:CAS:528:DC%2BD1MXht1WkurjO
    • LW Moreland JR Curtis 2009 Systemic nonarticular manifestations of rheumatoid arthritis: focus on inflammatory mechanisms Semin Arthritis Rheum 39 132 143 19022481 10.1016/j.semarthrit.2008.08.003 1:CAS:528:DC%2BD1MXht1WkurjO
    • (2009) Semin Arthritis Rheum , vol.39 , pp. 132-143
    • Moreland, L.W.1    Curtis, J.R.2
  • 5
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • DOI 10.1136/gut.52.1.65
    • S Fujino A Andoh S Bamba A Ogawa K Hata Y Araki, et al. 2003 Increased expression of interleukin 17 in inflammatory bowel disease Gut 52 65 70 12477762 10.1136/gut.52.1.65 1:CAS:528:DC%2BD3sXmtVyqsw%3D%3D (Pubitemid 36020767)
    • (2003) Gut , vol.52 , Issue.1 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3    Ogawa, A.4    Hata, K.5    Araki, Y.6    Bamba, T.7    Fujiyama, Y.8
  • 6
    • 0036351437 scopus 로고    scopus 로고
    • Cytokine profile in Behçet's disease patients: Relationship with disease activity
    • DOI 10.1080/030097402320318387
    • K Hamzaoui A Hamzaoui F Guemira M Bessioud M Hamza K Ayed 2002 Cytokine profile in Behcets disease patients. Relationship with disease activity Scand J Rheumatol 31 205 210 12369651 10.1080/030097402320318387 (Pubitemid 34971876)
    • (2002) Scandinavian Journal of Rheumatology , vol.31 , Issue.4 , pp. 205-210
    • Hamzaoui, K.1    Hamzaoui, A.2    Guemira, F.3    Bessioud, M.4    Hamza, M.5    Ayed, K.6
  • 8
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • DOI 10.1074/jbc.M207577200
    • S Aggarwal N Ghilardi MH Xie FJ de Sauvage AL Gurney 2003 Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J Biol Chem 278 1910 1914 12417590 10.1074/jbc.M207577200 1:CAS:528:DC%2BD3sXisFyksA%3D%3D (Pubitemid 36801431)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.3 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.-H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 9
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • DOI 10.1016/j.immuni.2004.08.018, PII S1074761304002717
    • JK Kolls A Linden 2004 Interleukin-17 family members and inflammation Immunity 21 467 476 15485625 10.1016/j.immuni.2004.08.018 1:CAS:528: DC%2BD2cXpvVygt7k%3D (Pubitemid 39370503)
    • (2004) Immunity , vol.21 , Issue.4 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 10
    • 65649103330 scopus 로고    scopus 로고
    • Cytokine profiles in toxoplasmic and viral uveitis
    • 19302012 10.1086/597478 1:CAS:528:DC%2BD1MXltVOmsbo%3D
    • I Lahmar A Abou-Bacar T Abdelrahman M Guinard H Babba S Ben Yahia, et al. 2009 Cytokine profiles in toxoplasmic and viral uveitis J Infect Dis 199 1239 1249 19302012 10.1086/597478 1:CAS:528:DC%2BD1MXltVOmsbo%3D
    • (2009) J Infect Dis , vol.199 , pp. 1239-1249
    • Lahmar, I.1    Abou-Bacar, A.2    Abdelrahman, T.3    Guinard, M.4    Babba, H.5    Ben Yahia, S.6
  • 11
    • 0026780741 scopus 로고
    • Cytokines and uveitis, a review
    • 1505201 10.3109/02713689209001814
    • AF De Vos R Hoekzema A Kijlstra 1992 Cytokines and uveitis, a review Curr Eye Res 11 581 597 1505201 10.3109/02713689209001814
    • (1992) Curr Eye Res , vol.11 , pp. 581-597
    • De Vos, A.F.1    Hoekzema, R.2    Kijlstra, A.3
  • 12
    • 34250005444 scopus 로고    scopus 로고
    • H17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
    • DOI 10.1038/nm1585, PII NM1585
    • A Amadi-Obi CR Yu X Liu RM Mahdi GL Clarke RB Nussenblatt, et al. 2007 TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 Nat Med 13 711 718 17496900 10.1038/nm1585 1:CAS:528:DC%2BD2sXmtFeks7c%3D (Pubitemid 46889754)
    • (2007) Nature Medicine , vol.13 , Issue.6 , pp. 711-718
    • Amadi-Obi, A.1    Yu, C.-R.2    Liu, X.3    Mahdi, R.M.4    Clarke, G.L.5    Nussenblatt, R.B.6    Gery, I.7    Lee, Y.S.8    Egwuagu, C.E.9
  • 13
  • 14
    • 63249084553 scopus 로고    scopus 로고
    • Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis
    • 10.1093/rheumatology/ken489 1:CAS:528:DC%2BD1MXjsFeku7Y%3D
    • T Yoshimura KH Sonoda N Ohguro Y Ohsugi T Ishibashi DJ Cua, et al. 2009 Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis Rheumatology (Oxford) 48 347 354 10.1093/rheumatology/ken489 1:CAS:528:DC%2BD1MXjsFeku7Y%3D
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 347-354
    • Yoshimura, T.1    Sonoda, K.H.2    Ohguro, N.3    Ohsugi, Y.4    Ishibashi, T.5    Cua, D.J.6
  • 15
    • 68949086496 scopus 로고    scopus 로고
    • Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells
    • 19542467 10.4049/jimmunol.0900241 1:CAS:528:DC%2BD1MXnsVOqsLo%3D
    • Y Cui H Shao C Lan H Nian RL OBrien WK Born, et al. 2009 Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells J Immunol 183 560 567 19542467 10.4049/jimmunol.0900241 1:CAS:528:DC%2BD1MXnsVOqsLo%3D
    • (2009) J Immunol , vol.183 , pp. 560-567
    • Cui, Y.1    Shao, H.2    Lan, C.3    Nian, H.4    Obrien, R.L.5    Born, W.K.6
  • 16
    • 34247586615 scopus 로고    scopus 로고
    • Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: Initial encounter with autoantigen defines disease phenotype
    • J Tang W Zhu PB Silver SB Su CC Chan RR Caspi 2007 Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype J Immunol 178 5578 5587 17442940 1:CAS:528: DC%2BD2sXktlWiurY%3D (Pubitemid 46674353)
    • (2007) Journal of Immunology , vol.178 , Issue.9 , pp. 5578-5587
    • Tang, J.1    Zhu, W.2    Silver, P.B.3    Su, S.-B.4    Chan, C.-C.5    Caspi, R.R.6
  • 17
    • 0037815115 scopus 로고    scopus 로고
    • Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4
    • DOI 10.1084/jem.20030097
    • S Sugita JW Streilein 2003 Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4 J Exp Med 198 161 171 12835481 10.1084/jem.20030097 1:CAS:528:DC%2BD3sXlsVersrs%3D (Pubitemid 36870196)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.1 , pp. 161-171
    • Sugita, S.1    Streilein, J.W.2
  • 18
    • 1642310491 scopus 로고    scopus 로고
    • + Iris Pigment Epithelial Cells Express Their Own B7-2 to Achieve Global Suppression of T Cell Activation
    • S Sugita TF Ng J Schwartzkopff JW Streilein 2004 CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation J Immunol 172 4184 4194 15034031 1:CAS:528:DC%2BD2cXitlOqsb4%3D (Pubitemid 38375231)
    • (2004) Journal of Immunology , vol.172 , Issue.7 , pp. 4184-4194
    • Sugita, S.1    Ng, T.F.2    Schwartzkopff, J.3    Streilein, J.W.4
  • 19
    • 33750482270 scopus 로고    scopus 로고
    • Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta
    • DOI 10.1016/j.exer.2006.08.005, PII S0014483506003423
    • S Sugita Y Futagami SB Smith H Naggar M Mochizuki 2006 Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta Exp Eye Res 83 1459 1471 16996057 10.1016/j.exer.2006.08.005 1:CAS:528:DC%2BD28XhtFKmu7rF (Pubitemid 44648106)
    • (2006) Experimental Eye Research , vol.83 , Issue.6 , pp. 1459-1471
    • Sugita, S.1    Futagami, Y.2    Smith, S.B.3    Naggar, H.4    Mochizuki, M.5
  • 20
    • 66849099171 scopus 로고    scopus 로고
    • T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions
    • 19182257 10.1167/iovs.08-2846
    • S Sugita Y Usui S Horie Y Futagami H Aburatani, et al. 2009 T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions Invest Ophthalmol Vis Sci 50 2862 2870 19182257 10.1167/iovs.08-2846
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 2862-2870
    • Sugita, S.1    Usui, Y.2    Horie, S.3    Futagami, Y.4    Aburatani, H.5
  • 23
    • 71849111126 scopus 로고    scopus 로고
    • Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells
    • 19017942 1:CAS:528:DC%2BD1cXhtl2gs7nF
    • S Sugita S Horie O Nakamura Y Futagami H Takase H Keino, et al. 2008 Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells J Immunol 181 7525 7536 19017942 1:CAS:528:DC%2BD1cXhtl2gs7nF
    • (2008) J Immunol , vol.181 , pp. 7525-7536
    • Sugita, S.1    Horie, S.2    Nakamura, O.3    Futagami, Y.4    Takase, H.5    Keino, H.6
  • 24
    • 77954136126 scopus 로고    scopus 로고
    • Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions
    • 19801522 10.4049/jimmunol.0901623 1:CAS:528:DC%2BD1MXht1Whsb7I
    • S Sugita S Horie O Nakamura K Maruyama H Takase Y Usui, et al. 2009 Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions J Immunol 183 5013 5022 19801522 10.4049/jimmunol.0901623 1:CAS:528:DC%2BD1MXht1Whsb7I
    • (2009) J Immunol , vol.183 , pp. 5013-5022
    • Sugita, S.1    Horie, S.2    Nakamura, O.3    Maruyama, K.4    Takase, H.5    Usui, Y.6
  • 26
    • 70349258447 scopus 로고    scopus 로고
    • Role of ocular pigment epithelial cells in immune privilege
    • 10.1007/s00005-009-0030-0
    • S Sugita 2009 Role of ocular pigment epithelial cells in immune privilege Arch Immunol Ther Exp (Warsz) 57 263 268 10.1007/s00005-009-0030-0
    • (2009) Arch Immunol Ther Exp (Warsz) , vol.57 , pp. 263-268
    • Sugita, S.1
  • 27
    • 0023213620 scopus 로고
    • Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes
    • RR Caspi FG Roberge RB Nussenblatt 1987 Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes Science 237 1029 1032 2956685 10.1126/science.2956685 1:STN:280:DyaL2s3pt1Wgsg%3D%3D (Pubitemid 17131200)
    • (1987) Science , vol.237 , Issue.4818 , pp. 1029-1032
    • Caspi, R.R.1    Roberge, F.G.2    Nussenblatt, R.B.3
  • 28
    • 0030757911 scopus 로고    scopus 로고
    • Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): Induction of protective tolerance in primed animals
    • SR Thurau CC Chan RB Nussenblatt RR Caspi 1997 Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals Clin Exp Immunol 109 370 376 9276535 10.1046/j.1365-2249.1997.4571356.x 1:STN:280:DyaK2svitVGmsg%3D%3D (Pubitemid 27308427)
    • (1997) Clinical and Experimental Immunology , vol.109 , Issue.2 , pp. 370-376
    • Thurau, S.R.1    Chan, C.-C.2    Nussenblatt, R.B.3    Caspi, R.R.4
  • 30
    • 0038125664 scopus 로고    scopus 로고
    • Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms
    • DOI 10.1076/ocii.11.2.91.15914
    • K Ishida N Panjwani Z Cao JW Streilein 2003 Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms Ocul Immunol Inflamm 11 91 105 14533028 10.1076/ocii.11.2.91.15914 1:CAS:528:DC%2BD3sXotVektLc%3D (Pubitemid 37088581)
    • (2003) Ocular Immunology and Inflammation , vol.11 , Issue.2 , pp. 91-105
    • Ishida, K.1    Panjwani, N.2    Cao, Z.3    Streilein, J.W.4
  • 32
    • 0033775229 scopus 로고    scopus 로고
    • Evidence that retinal pigment epithelium functions as an immune-privileged tissue
    • 11006240 1:STN:280:DC%2BD3cvot1ygtA%3D%3D
    • H Wenkel JW Streilein 2000 Evidence that retinal pigment epithelium functions as an immune-privileged tissue Invest Ophthalmol Vis Sci 41 3467 3473 11006240 1:STN:280:DC%2BD3cvot1ygtA%3D%3D
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3467-3473
    • Wenkel, H.1    Streilein, J.W.2
  • 34
    • 0033862741 scopus 로고    scopus 로고
    • IL-6 antagonizes TGF-β and abolishes immune privilege in eyes with endotoxin-induced uveitis
    • K Ohta S Yamagami AW Taylor JW Streilein 2000 IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxin-induced uveitis Invest Ophthalmol Vis Sci 41 2591 2599 10937571 1:STN:280:DC%2BD3czps1ajtA%3D%3D (Pubitemid 30624387)
    • (2000) Investigative Ophthalmology and Visual Science , vol.41 , Issue.9 , pp. 2591-2599
    • Ohta, K.1    Yamagami, S.2    Taylor, A.W.3    Streilein, J.W.4
  • 35
    • 0348223787 scopus 로고    scopus 로고
    • + Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
    • DOI 10.1084/jem.20030152
    • W Chen W Jin N Hardegen KJ Lei L Li N Marinos, et al. 2003 Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3 J Exp Med 198 1875 1886 14676299 10.1084/jem.20030152 1:CAS:528:DC%2BD3sXpvFaktLg%3D (Pubitemid 38032120)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.12 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.-J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 36
    • 0025707731 scopus 로고
    • Aqueous human contains transforming growth factor-β and a small (< 3500 daltons) inhibitor of thymocyte proliferation
    • RD Granstein R Staszewski TL Knisely E Zeira R Nazareno M Latina DM Albert 1990 Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation J Immunol 144 3021 3027 2324494 1:CAS:528:DyaK3cXitlekur8%3D (Pubitemid 20149474)
    • (1990) Journal of Immunology , vol.144 , Issue.8 , pp. 3021-3027
    • Granstein, R.D.1    Staszewski, R.2    Knisely, T.L.3    Zeira, E.4    Nazareno, R.5    Latina, M.6    Albert, D.M.7
  • 37
    • 9144225574 scopus 로고    scopus 로고
    • + T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody
    • DOI 10.1128/CDLI.11.6.1075-1084.2004
    • DT Nardelli MA Burchill DM England J Torrealba SM Callister RF Schell 2004 Association of CD4+CD25+ T cells with prevention of severe destructive arthritis in Borrelia burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody Clin Diagn Lab Immunol 11 1075 1084 15539509 1:CAS:528:DC%2BD2cXhtFShsrrO (Pubitemid 39540847)
    • (2004) Clinical and Diagnostic Laboratory Immunology , vol.11 , Issue.6 , pp. 1075-1084
    • Nardelli, D.T.1    Burchill, M.A.2    England, D.M.3    Torrealba, J.4    Callister, S.M.5    Schell, R.F.6
  • 38
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
    • EB Samoilova JL Horton B Hilliard TS Liu Y Chen 1998 IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells J Immunol 161 6480 6486 9862671 1:CAS:528:DyaK1cXotFWqs7c%3D (Pubitemid 28562184)
    • (1998) Journal of Immunology , vol.161 , Issue.12 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Liu, T.-S.T.4    Chen, Y.5
  • 39
    • 34250157039 scopus 로고    scopus 로고
    • Minimally activated CD8 autoreactive T cells specific for IRBP express a high level of Foxp3 and are functionally suppressive
    • DOI 10.1167/iovs.06-1189
    • Y Peng G Han H Shao Y Wang HJ Kaplan D Sun 2007 Characterization of IL-17+ interphotoreceptor retinoid-binding protein-specific T cells in experimental autoimmune uveitis Invest Ophthalmol Vis Sci 48 4153 4161 17724201 10.1167/iovs.06-1189 (Pubitemid 351261292)
    • (2007) Investigative Ophthalmology and Visual Science , vol.48 , Issue.5 , pp. 2178-2184
    • Peng, Y.1    Shao, H.2    Ke, Y.3    Zhang, P.4    Han, G.5    Kaplan, H.J.6    Sun, D.7
  • 40
    • 67649662167 scopus 로고    scopus 로고
    • Suppression of experimental autoimmune uveoretinitis by Anti-IL-17 antibody
    • 19373578 10.1080/02713680902741696
    • R Zhang J Qian J Guo YF Yuan K Xue 2009 Suppression of experimental autoimmune uveoretinitis by Anti-IL-17 antibody Curr Eye Res 34 297 303 19373578 10.1080/02713680902741696
    • (2009) Curr Eye Res , vol.34 , pp. 297-303
    • Zhang, R.1    Qian, J.2    Guo, J.3    Yuan, Y.F.4    Xue, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.