Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3

Molecular Therapy

Volumn 20, Issue 1, 2012, Pages 101-108

  Kleinman, Mark E ^a   Kaneko, Hiroki ^a   Cho, Won Gil ^a,b   Dridi, Sami ^a   Fowler, Benjamin J ^a   Blandford, Alexander D ^a   Albuquerque, Romulo J C ^a   Hirano, Yoshio ^a   Terasaki, Hiroko ^c   Kondo, Mineo ^d   Fujita, Takashi ^e   Ambati, Balamurali K ^f,g   Tarallo, Valeria ^a   Gelfand, Bradley D ^a   Bogdanovich, Sasha ^a   Baffi, Judit Z ^a   Ambati, Jayakrishna ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Yonsei University Wonju College of Medicine   (South Korea)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DOUBLE STRANDED RNA; INTERFERON REGULATORY FACTOR 3; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOSENSOR; CELL ACTIVATION; CELL DISRUPTION; CELL PERMEABILIZATION; CONTROLLED STUDY; EYE TOXICITY; GEOGRAPHIC ATROPHY; HUMAN; HUMAN CELL; INTERNALIZATION; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RETINA PIGMENT DEGENERATION; RNA INTERFERENCE;

MUS;

EID: 84856958561     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.212     Document Type: Article

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