Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists

Journal of Lipid Research

Volumn 53, Issue 10, 2012, Pages 2126-2132

  Curtiss, Linda K ^a   Black, Audrey S ^a   Bonnet, David J ^a   Tobias, Peter S ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Agonists; Inflammation; Lipids; Macrophages; Receptors

Indexed keywords

LIPOPEPTIDE; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 6;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; BINDING AFFINITY; CONTROLLED STUDY; DISEASE MARKER; ENZYME DEFICIENCY; GENOTYPE; LIPID DIET; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; STEREOLOGY;

ANIMALS; ATHEROSCLEROSIS; DIET, HIGH-FAT; LIGANDS; LIPOPEPTIDES; MALE; MICE; MICE, TRANSGENIC; RECEPTORS, LDL; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 6;

EID: 84866148207     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M028431     Document Type: Article

References (18)

1. Libby, P., Y. Okamoto, V. Z. Rocha, and E. Folco. 2010. Inflammation in atherosclerosis: transition from theory to practice. Circ. J. 74: 213-220.
2. Curtiss, L. K., and P. S. Tobias. 2007. The toll of toll-like receptors, especially toll-like receptor 2, on murine atherosclerosis. Curr. Drug Targets. 8: 1230-1238.
3. Hayashi, C., A. G. Madrigal, X. Liu, T. Ukai, S. Goswami, C. V. Gudino, F. C. Gibson III, and C. A. Genco. 2010. Pathogen-mediated inflammatory atherosclerosis is mediated in part via toll-like receptor 2-induced inflammatory responses. J. Innate Immun. 2: 334-343.
4. Sorokin, L. 2010. The impact of the extracellular matrix on inflammation . Nat. Rev. Immunol. 10: 712-723.
5. Dunzendorfer, S., H. K. Lee, and P. S. Tobias. 2004. Flow-dependent regulation of endothelial toll-like receptor 2 expression through inhibition of sp1 activity. Circ. Res. 95: 684-691.
6. Mullick, A. E., P. S. Tobias, and L. K. Curtiss. 2005. Modulation of atherosclerosis in mice by toll-like receptor 2. J. Clin. Invest. 115: 3149-3156.
7. Mullick, A. E., K. Soldau, W. B. Kiosses, T. A. Bell III, P. S. Tobias, and L. K. Curtiss. 2008. Increased endothelial expression of toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events. J. Exp. Med. 205: 373-383.
8. Omueti, K. O., J. M. Beyer, C. M. Johnson, E. A. Lyle, and R. I. Tapping. 2005. Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J. Biol. Chem. 280: 36616-36625.
9. Buwitt-Beckmann, U., H. Heine, K. H. Wiesmuller, G. Jung, R. Brock, and A. J. Ulmer. 2005. Lipopeptide structure determines TLR2 dependent cell activation level. FEBS J. 272: 6354-6364.
10. Hoebe, K., P. Georgel, S. Rutschmann, X. Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung, U. Zahringer, et al. 2005. Cd36 is a sensor of diacylglycerides. Nature. 433: 523-527.
11. Schiller, N. K., A. S. Black, G. P. Bradshaw, D. J. Bonnet, and L. K. Curtiss. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J. Lipid Res. 45: 1398-1409.
12. Takeuchi, O., S. Sato, T. Horiuchi, K. Hoshino, K. Takeda, Z. Dong, R. L. Modlin, and S. Akira. 2002. Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169: 10-14.
13. Stewart, C. R., L. M. Stuart, K. Wilkinson, J. M. van Gils, J. Deng, A. Halle, K. J. Rayner, L. Boyer, R. Zhong, W. A. Frazier, et al. 2010. Cd36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11: 155-161.
14. Zhao, Z., M. C. de Beer, L. Cai, R. Asmis, F. C. de Beer, W. J. de Villiers, and D. R. van der Westhuyzen. 2005. Low-density lipoprotein from apolipoprotein E-deficient mice induces macrophage lipid accumulation in a CD36 and scavenger receptor class A-dependent manner. Arterioscler. Thromb. Vasc. Biol. 25: 168-173.
15. He, Z. Q., Y. Zhen, C. Liang, H. Wang, and Z. G. Wu. 2008. Vicious cycle composed of gut flora and visceral fat. Med. Hypotheses. 70: 808-811.
16. Ott, S. J., N. E. El Mokhtari, M. Musfeldt, S. Hellmig, S. Freitag, A. Rehman, T. Kuhbacher, S. Nikolaus, P. Namsolleck, M. Blaut, et al. 2006. Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease. Circulation, 113: 929-937.
17. Henrichot, E., C. E. Juge-Aubry, A. Pernin, J. C. Pache, V. Velebit, J. M. Dayer, P. Meda, C. Chizzolini, and C. A. Meier. 2005. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Arterioscler. Throm. Vasc. Biol. 25: 2594-2599.
18. Mathieu, P., I. Lemieux, and J. P. Després. 2010. Obesity, inflammation, and cardiovascular risk. Clin. Pharmacol. Ther. 87: 407-416.