Inhibition of TLR3-mediated proinflammatory effects by alkylphosphocholines in human retinal pigment epithelial cells

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 9, 2011, Pages 6536-6544

  Wörnle, Markus ^a   Merkle, Monika ^b   Wolf, Armin ^a   Ribeiro, Andrea ^a   Himmelein, Susanne ^a   Kernt, Marcus ^a   Kampik, Anselm ^a   Eibl Lindner, Kirsten H ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Klinikum Traunstein   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLPHOSPHORYLCHOLINE; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; CYTOKINE; GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHOLIPID DERIVATIVE; RETINOIC ACID INDUCIBLE PROTEIN I; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; EYE PROTEIN; FIBROBLAST GROWTH FACTOR 2; NERVE GROWTH FACTOR; PHOSPHORYLCHOLINE; PIGMENT EPITHELIUM DERIVED FACTOR; PIGMENT EPITHELIUM-DERIVED FACTOR; POLYINOSINIC POLYCYTIDYLIC ACID; SERINE PROTEINASE INHIBITOR; TLR3 PROTEIN, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA MACULA AGE RELATED DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; TIME;

APOPTOSIS; CELLS, CULTURED; CYTOKINES; DEAD-BOX RNA HELICASES; DOSE-RESPONSE RELATIONSHIP, DRUG; EYE PROTEINS; FIBROBLAST GROWTH FACTOR 2; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; NERVE GROWTH FACTORS; PHOSPHORYLCHOLINE; POLY I-C; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SERPINS; TIME FACTORS; TOLL-LIKE RECEPTOR 3; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80054691614     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6993     Document Type: Article

References (26)

1. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-κB by toll-like receptor 3. Nature. 2001;413:732-738.
2. Kumar MV, Nagineni CN, Chin MS, Hooks JJ, Detrick B. Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells. J Neuroimmunol. 2004;153:7-15.
3. Zhang X, Kimura Y, Fang C, et al. Regulation of Toll-like receptormediated inflammatory response by complement in vivo. Blood. 2007;110:228-236 (erratum: Blood. 2007;110:3841).
4. Holz F, Wolfensberger T, Piguet B, et al. Bilateral macular drusen in age-related macular degeneration: prognosis and risk factors. Ophthalmology. 1994;101:1522-1528.
5. Bird A, Bressler N, Bressler S, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration: the International ARM Epidemiology Study Group. Surv Ophthalmol. 1995;39:367-374.
6. Funk M, Karl D, Georgopoulos M, et al. Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab. Ophthalmology. 2009;116:2393-2399.
7. Clark SJ, Bishop PN, Day AJ. Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology. Biochem Soc Trans. 2010;38:1342-1348.
8. Yang Z, Stratton C, Francis PJ, et al. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008;259:1456-1463.
9. Fritsche LG, Lauer N, Hartmann A, et al. An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Hum Mol Genet. 2010;19:4694-4704.
10. Vitour D, Meurs EF. Regulation of interferon production by RIG-I and LGP2: a lesson in self-control. Sci STKE. 2007;384:20.
11. Chen M, Forrester JV, Xu H. Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. Exp Eye Res. 2007;84:635-645.
12. Seddon JM, George S, Rosner B, Rifai N. Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin-6 and other cardiovascular biomarkers. Arch Ophthalmol. 2005;123:774-782.
13. Austin BA, Liu B, Li Z, Nussenblatt RB. Biologically active fibronectin fragments stimulate release of MCP-1 and catabolic cytokines from murine retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2009;50:2896-2902.
14. Jonas JB, Tao Y, Neumaier M, Findeisen P. Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration. Arch Ophthalmol. 2010;128:1281-1286.
15. Goverdhan SV, Ennis S, Hannan SR, et al. Interleukin-8 promoter polymorphism-251A/T is a risk factor for age-related macular degeneration. Br J Ophthalmol. 2008;92:537-540.
16. Kurji KH, Ciu JZ, Lin T, et al. Microarray analysis identifies changes in inflammatory gene expression in response to amyloid-beta stimulation of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010;51:1151-1163.
17. Eibl KH, Banas B, Schoenfeld CL, et al. Alkylphosphocholines inhibit proliferation of human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2003;44:3556-3561.
18. Eibl KH, Banas B, Kook D, et al. Alkylphosphocholines: a new therapeutic option in glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 2004;45:2619-2624.
19. Eibl KH, Kook D, Priglinger S, et al. Inhibition of human retinal pigment epithelial cell attachment, spreading, and migration by alkylphosphocholines. Invest Ophthalmol Vis Sci. 2006;47:364-370.
20. Eibl KH, Lewis GP, Betts K, et al. The effect of alkylphosphocholines in intraretinal proliferation initiated by experimental retinal detachment. Invest Ophthalmol Vis Sci. 2007;48:1305-1311.
21. Leonard R, Hardy J, van Tienhoven G, et al. Randomized, doubleblind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. J Clin Oncol. 2001;21:4150-4159.
22. Sundar S, Jha TK, Thakur CP, et al. Oral miltefoesine for Indian visceral leishmaniasis. N Engl J Med. 2002;347:1739-1746.
23. Wörnle M, Schmid H, Banas B, et al. Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis. Am J Pathol. 2006; 168:370-385.
24. Matsukura S, Kokubu F, Kurikawa M, et al. Role of RIG-I, MDA-5, and PKR on the expression of inflammatory chemokines induced by synthetic dsRNA in airway epithelial cells. Int Arch Allergy Immunol 2007;143(suppl 1):80-83.
25. Marshall-Clarke S, Downes JE, Haga IR, et al. Polyinosinic acid is a ligand for Toll-like receptor 3. J Biol Chem. 2007;282:24759-24766.
26. Botos I, Liu L, Wang Y, Segal DM, Davies DR. The toll-like receptor 3:dsRNA signaling complex. Biochim Biophys Acta. 2009;1789: 667-674.