Elevated homocysteine level in siblings of patients with schizophrenia

Psychiatry Research

Volumn 210, Issue 3, 2013, Pages 769-772

  Geller, Vadim ^a   Friger, Michael ^a   Sela, Ben Ami ^b   Levine, Joseph ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

Homocysteine; Schizophrenia; Siblings

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE DURATION; ETHNICITY; FEMALE; GENDER BIAS; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; PARANOID SCHIZOPHRENIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RISK ASSESSMENT; RISK FACTOR; SCHIZOPHRENIA; SIBLING; BLOOD; CASE CONTROL STUDY; MIDDLE AGED; SEX DIFFERENCE; YOUNG ADULT;

ADULT; CASE-CONTROL STUDIES; FEMALE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; RISK FACTORS; SCHIZOPHRENIA; SEX FACTORS; SIBLINGS; YOUNG ADULT;

EID: 84888295810     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2013.08.016     Document Type: Article

References (36)

1. Adler Nevo G., Meged S., Sela B.A., Hanoch-Levi A., Hershko R., Weizman A. Homocysteine levels in adolescent schizophrenia patients. European Neuropsychopharmacology 2006, 16:588-591.
2. Allen N.C., Bagade S., McQueen M.B., Ioannidis J.P., Kavvoura F.K., Khoury M.J., Tanzi R.E., Bertram L. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature Genetics 2008, 40:827-834.
3. Applebaum J., Shimon H., Sela B.A., Belmaker R.H., Levine J. Homocysteine levels in newly admitted schizophrenic patients. Journal of Psychiatric Research 2004, 38:413-416.
4. Araki A., Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. Journal of Chromatography 1987, 422:43-52.
5. Bathum L., Petersen I., Christiansen L., Konieczna A., Sorensen T.I., Kyvik K.O. Genetic and environmental influences on plasma homocysteine: results from a Danish twin study. Clinical Chemistry 2007, 53:971-979.
6. Berg K., Malinow M.R., Kierulf P., Upson B. Population variation and genetics of plasma homocyst(e)ine level. Clinical Genetics 1992, 41:315-321.
7. Bleich S., Frieling H., Hillemacher T. Elevated prenatal homocysteine levels and the risk of schizophrenia. Archives of General Psychiatry 2007, 64:980-981.
8. Brown A.S., Susser E.S. Homocysteine and schizophrenia: from prenatal to adult life. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2005, 29:1175-1180.
9. Cesari M., Burlina A.B., Narkiewicz K., Sartori M.T., Sacchetto A., Rossi G.P. Are fasting plasma homocysteine levels heritable? A study of normotensive twins. Journal of Investigative Medicine 2000, 48:351-358.
10. Cohen S.M., Nichols A., Wyatt R., Pollin W. The administration of methionine to chronic schizophrenic patients: a review of ten studies. Biological Psychiatry 1974, 8:209-225.
11. Feng L.G., Song Z.W., Xin F., Hu J. Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: a Chinese Han population-based case-control study. Psychiatry Research 2009, 168:205-208.
12. Greenwood T.A., Braff D.L., Light G.A., Cadenhead K.S., Calkins M.E., Dobie D.J., Freedman R., Green M.F., Gur R.E., Gur R.C., Mintz J., Nuechterlein K.H., Olincy A., Radant A.D., Seidman L.J., Siever L.J., Silverman J.M., Stone W.S., Swerdlow N.R., Tsuang D.W., Tsuang M.T., Turetsky B.I., Schork N.J. Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Archives of General Psychiatry 2007, 64:1242-1250.
13. Jonsson E.G., Larsson K., Vares M., Hansen T., Wang A.G., Djurovic S., Ronningen K.S., Andreassen O.A., Agartz I., Werge T., Terenius L., Hall H. Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2008, 147 B:976-982.
14. Kale A., Naphade N., Sapkale S., Kamaraju M., Pillai A., Joshi S., Mahadik S. Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. Psychiatry Research 2010, 175:47-53.
15. Kevere L., Purvina S., Bauze D., Zeibarts M., Andrezina R., Piekuse L., Brekis E., Purvins I. Homocysteine and MTHFR C677T polymorphism in children and adolescents with psychotic and mood disorders. Nordic Journal of Psychiatry 2013, (2013 Apr 16. [Epub ahead of print]).
16. Kruman I.I., Culmsee C., Chan S.L., Kruman Y., Guo Z., Penix L., Mattson M.P. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. Journal of Neuroscience 2000, 20:6920-6926.
17. Levine J., Stahl Z., Sela B.A., Gavendo S., Ruderman V., Belmaker R.H. Elevated homocysteine levels in young male patients with schizophrenia. American Journal of Psychiatry 2002, 159:1790-1792.
18. Lewerin C., Matousek M., Steen G., Johansson B., Steen B., Nilsson-Ehle H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. American Journal of Clinical Nutrition 2005, 81:1155-1162.
19. Lipton S.A., Kim W.K., Choi Y.B., Kumar S., D'Emilia D.M., Rayudu P.V., Arnelle D.R., Stamler J.S. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:5923-5928.
20. Muntjewerff J.W., Gellekink H., den Heijer M., Hoogendoorn M.L., Kahn R.S., Sinke R.J., Blom H.J. Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia. European Neuropsychopharmacology 2008, 18:99-106.
21. Muntjewerff J.W., Kahn R.S., Blom H.J., den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Molecular Psychiatry 2006, 11:143-149.
22. Peerbooms O., Rutten B.P., Decoster J., van Os J., Kenis G., De Hert M., van Winkel R. No association between MTHFR C677T or A1298C and age at onset of schizophrenia. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2010, 153 B:1362-1363. (author reply 1361).
23. Reed T., Malinow M.R., Christian J.C., Upson B. Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins. Clinical Genetics 1991, 39:425-428.
24. Roffman J.L., Gollub R.L., Calhoun V.D., Wassink T.H., Weiss A.P., Ho B.C., White T., Clark V.P., Fries J., Andreasen N.C., Goff D.C., Manoach D.S. MTHFR 677C->T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val->Met. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:17573-17578.
25. Roffman J.L., Weiss A.P., Deckersbach T., Freudenreich O., Henderson D.C., Purcell S., Wong D.H., Halsted C.H., Goff D.C. Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia. Schizophrenia Research 2007, 92:181-188.
26. Roffman J.L., Weiss A.P., Deckersbach T., Freudenreich O., Henderson D.C., Wong D.H., Halsted C.H., Goff D.C. Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2008, 147 B:990-995.
27. Roffman J.L., Weiss A.P., Purcell S., Caffalette C.A., Freudenreich O., Henderson D.C., Bottiglieri T., Wong D.H., Halsted C.H., Goff D.C. Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia. Biological Psychiatry 2008, 63:42-48.
28. Sachdev P., Parslow R., Salonikas C., Lux O., Wen W., Kumar R., Naidoo D., Christensen H., Jorm A. Homocysteine and the brain in midadult life: evidence for an increased risk of leukoaraiosis in men. Archives of Neurology 2004, 61:1369-1376.
29. Sachdev P.S. Homocysteine and brain atrophy. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2005, 29:1152-1161.
30. Saetre P., Vares M., Werge T., Andreassen O.A., Arinami T., Ishiguro H., Nanko S., Tan E.C., Han D.H., Roffman J.L., Muntjewerff J.W., Jagodzinski P.P., Kempisty B., Hauser J., Vilella E., Betcheva E., Nakamura Y., Regland B., Agartz I., Hall H., Terenius L., Jonsson E.G. Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2011, 156:215-224.
31. Selhub J. Homocysteine metabolism. Annual Review of Nutrition 1999, 19:217-246.
32. Seshadri S., Beiser A., Selhub J., Jacques P.F., Rosenberg I.H., D'Agostino R.B., Wilson P.W., Wolf P.A. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. New England Journal of Medicine 2002, 346:476-483.
33. Shlafman N., Shaldubin S., Applebaum J., Belmaker R.H., Levine J. No gross abnormality of plasma homocysteine after acute methionine loading in clinically stabilized patients with schizophrenia. Asian Journal of Psychiatry 2010, 3:64-66.
34. Siva A., De Lange M., Clayton D., Monteith S., Spector T., Brown M.J. The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. Quarterly Journal of Medicine 2007, 100:495-499.
35. Stahl Z., Belmaker R.H., Friger M., Levine J. Nutritional and life style determinants of plasma homocysteine in schizophrenia patients. European Neuropsychopharmacology 2005, 15:291-295.
36. Vares M., Saetre P., Deng H., Cai G., Liu X., Hansen T., Rasmussen H.B., Werge T., Melle I., Djurovic S., Andreassen O.A., Agartz I., Hall H., Terenius L., Jonsson E.G. Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2010, 153B:610-618.