Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study

Psychiatry Research

Volumn 168, Issue 3, 2009, Pages 205-208

  Feng, Lei guang ^a   Song, Zhi wei ^a   Xin, Feng ^a   Hu, Jian ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

5,10 Methylenetetrahydrofolate reductase (MTHFR); Homocysteine; Polymerase chain reaction restriction fragment length polymorphism (PCR RFLP); Schizophrenia; Variation

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CHINA; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PATHOGENESIS; POLYMERASE CHAIN REACTION; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SCHIZOPHRENIA; SEX DIFFERENCE;

ADULT; CASE-CONTROL STUDIES; CHINA; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RISK FACTORS; SCHIZOPHRENIA;

EID: 67650479568     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2008.05.009     Document Type: Article

References (35)

1. Applebaum J., Shimon H., Sela B.A., Belmaker R.H., and Levine J. Homocysteine levels in newly admitted schizophrenic patients. Journal of Psychiatric Research 38 (2004) 413-416
2. Arinami T., Yamada N., Yamakawa-Kobayashi K., Hamaguchi H., and Toru M. Methylenetetrahydrofolate reductase variant and schizophrenia/depression. American Journal of Medical Genetics 74 (1997) 526-528
3. Badner J.A., and Gershon E.S. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Molecular Psychiatry 7 (2002) 405-411
4. Bjelland I., Tell G.S., Vollset S.M., Refsum H., and Ueland P.M. Folate, vitamin B12, Homocysteine and the MTHFR 677C-T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. American Journal of Medical Genetics 60 (2003) 618-626
5. Blom H.J., Shaw G.M., den Heijer M., and Finnell R.H. Neural tube defects and folate: case far from closed. Nature Reviews. Neuroscience 7 (2006) 724-731
6. Bottiglieri T., Parnetti L., Arning E., Ortiz T., Amici S., Lanari A., and Gallai V. Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia. Mechanism of Ageing and Development 122 (2001) 2013-2023
7. Brody L.C., Conley M., Cox C., Kirke P.N., McKeever M.P., and Mills J.I. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. American Journal of Human Genetics 71 (2002) 1207-1215
8. Carlsson A., and Linquist M. Effect of chlorpromazine and haloperidol on formation of 3-methoxytyramine and norepinephrine in mouse brain. Acta Pharmacologica Et Toxicologica (Copenhagen) 20 (1963) 140-144
9. Crow T.J. Positive and negative schizophrenic symptoms and the role of dopamine. The British Journal of Psychiatry: The Journal of Mental Science 137 (1980) 383-386
10. Dedoussis G.V., Panagiotakos D.B., and Pitsavos C. An association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and inflammation markers related to cardiovascular disease. International Journal of Cardiology 100 (2005) 409-414
11. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., and Matthews R.G. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase [letter]. Nature Genetics 10 (1995) 111-113
12. Girelli D., Friso S., Trabetti E., Olivieri O., Russo C., and Pessotto R. Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction. Blood 91 (1998) 4158-4163
13. Goyette P., Pai A., and Milos R. Gene structure of human and mouse methylenetetrahydrofolate reductase. Mammalian Genome 9 (1998) 652
14. Goyette P., Sumner J.S., Milos R., Duncan A.M., Rosenblatt D.S., and Matthews R.G. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nature Genetics 7 (1994) 195-200
15. Horvath A., Morava E., Toth G., Czako M., Melegh B., and Kosztolanyi G. Vascular diseases, spina bifida and schizophrenia in a single family associated with the heterozygote mutation of the heat-sensitive variant of methylenetetrahydrofolate reductase. Orvosi Hetilap 142 27 (2001) 1445-1448
16. Kruman I.I., and Culmsee C. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. The Journal of Neuroscience 20 (2000) 6920-6926
17. Joober R., Benkelfat C., Lal S., Bloom D., Labelle A., Lalonde P., Turecki G., Rozen R., and Rouleau G.A. Association between the methylenetetrahydrofolate reductase 677C->T missense mutation and schizophrenia. Molecular Psychiatry 5 (2000) 323-326
18. Kunugi H., Fukuda R., and Hattori M. C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses. Molecuar Psychiatry 3 (1998) 435-437
19. Lee Y.S., Han D.H., Jeon C.M., Lyoo I.K., Na C., and Chae S.L. Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients. Neuroreport 17 (2006) 743-746
20. Lee Y.S., Han D.H., Jeon C.M., Lyoo I.K., Na C., Seiya M., Anthony S., and LaMantia. Recent advances in the neurobiology of schizophrenia. Molecular Interventions 3 (2003) 27-39
21. Levine J., Stahl Z., Sela B.A., Gavendo S., Ruderman V., and Belmaker R.H. Elevated homocysteine levels in young male patients with schizophrenia. The American Journal of Psychiatry 159 (2002) 1790-1792
22. Mamdani F., Jaitovich Groisman I., and Alda M. Long-term responsiveness to lithium as a pharmacogenetic outcome variable: treatment and etiologic implications. Current Psychiatry Reports 5 (2003) 484-492
23. Michelon L., and Vallada H. Genetics of bipolar disorder. Revista Brasileira De Psiquiatria Suppl 3 (2004) 12-16
24. Miriuka S.G., Langman L.J., and Evrovski J. Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients. Transplant International 18 (2005) 29-35
25. Muntjewerff J.W., Hoogendoorn M.L., Aukes J.M., Kahn R.S., Sinke R.J., Blom H.J., and den Heijer M. No evidence for a preferential transmission of the MTHFR 677T allele in families with schizophrenia offspring. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144B (2007) 891-894
26. Muntjewerff J.W., Hoogendoorn M.L., Kahn R.S., Sinke R.J., Den Heijer M., and Kluijtmans L.A. Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 135 (2005) 69-72
27. Muntjewerff J.W., Kahn R.S., Blom H.J., and den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Molecular Psychiatry 11 (2006) 143-149
28. Muntjewerff J.W., van der Put N., Eskes T., Ellenbroek B., Steegers E., Blom H., and Zitman F. Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia. Psychiatry Research 121 (2003) 1-9
29. Pasquier F., Lebert F., and Petit H. Methylenetetrahydrofolate reductase deficiency revealed by a neuropathy in a psychotic adult. Journal of Neurology, Neurosurgery, and Psychiatry 57 (1994) 765-766
30. Rozen R. Genetic predisposition to hyperhomocysteinemia:deficiency of methylenetetrahydrofolate reductase. Thrombosis and Haemostasis 78 (1997) 523-526
31. Sazci A., Ergül E., Güzelhan Y., Kaya G., and Kara I. Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Brain Research. Molecular Brain Research 117 (2003) 104-107
32. Thaker G.K., and Carpenter Jr. W.T. Advances in schizophrenia. Nature Medicine 7 (2001) 667-671
33. Van der Put N.M., Steegers-Theunissen R.P., Frosst P., Trijbels F.J., Eskes T.K., and van den Heuvel L.P. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346 (1995) 1070-1071
34. Virgos C., Martorell L., Simo J.M., Valero J., Figuera L., and Joven J. Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia. Neuroreport 10 (1999) 2035-2038
35. Wald D.S., Law M., and Morris J.K. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ (Clinical research ed.) 325 (2002) 1202-1208