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Volumn 156, Issue 2, 2011, Pages 215-224

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: A combined analysis of independent samples

(22)  Saetre, Peter a   Vares, Maria a   Werge, Thomas b   Andreassen, Ole A c,d   Arinami, Tadao e   Ishiguro, Hiroki e   Nanko, Shinichiro f   Tan, Ene Choo g,h   Han, Doug Hyun i   Roffman, Joshua L j   Muntjewerff, Jan Willem k   Jagodzinski, Pawel P l   Kempisty, Bartosz l   Hauser, Joanna l   Vilella, Elisabet m   Betcheva, Elitza n   Nakamura, Yusuke o   Regland, Björn p   Agartz, Ingrid a,c,q   Hall, Håkan a,r   more..


Author keywords

Age of onset; Methylenetetrahydrofolate reductase gene (MTHFR); Schizophrenia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 79551714936     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31160     Document Type: Article
Times cited : (23)

References (71)
  • 3
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 6
    • 33645739107 scopus 로고    scopus 로고
    • Kaplan & Sadock's Comprehensive Textbook of Psychiatry
    • In: Sadock BJ, Sadock VA, editors. Philadephia, Pa, USA; London, UK: Lippincott Williams & Wilkins. .
    • Buchanan RW, Carpenter WT. 2005. Concept of schizophrenia. In: Sadock BJ, Sadock VA, editors. Kaplan & Sadock's Comprehensive Textbook of Psychiatry. Philadephia, Pa, USA; London, UK: Lippincott Williams & Wilkins. 1329.
    • (2005) Concept of schizophrenia. , pp. 1329
    • Buchanan, R.W.1    Carpenter, W.T.2
  • 8
    • 0026753733 scopus 로고
    • The significance of age of onset for schizophrenia
    • DeLisi LE. 1992. The significance of age of onset for schizophrenia. Schizophr Bull 18:209-215.
    • (1992) Schizophr Bull , vol.18 , pp. 209-215
    • DeLisi, L.E.1
  • 9
    • 0036630169 scopus 로고    scopus 로고
    • Mutations C677T and A1298C of the 5,10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease
    • Domagala TB, Adamek L, Nizankowska E, Sanak M, Szczeklik A. 2002. Mutations C677T and A1298C of the 5, 10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease. Blood Coagul Fibrinolysis 13:423-431.
    • (2002) Blood Coagul Fibrinolysis , vol.13 , pp. 423-431
    • Domagala, T.B.1    Adamek, L.2    Nizankowska, E.3    Sanak, M.4    Szczeklik, A.5
  • 10
    • 0031030695 scopus 로고    scopus 로고
    • The long-term course of childhood-onset schizophrenia: A 42-year followup
    • Eggers C, Bunk D. 1997. The long-term course of childhood-onset schizophrenia: A 42-year followup. Schizophr Bull 23:105-117.
    • (1997) Schizophr Bull , vol.23 , pp. 105-117
    • Eggers, C.1    Bunk, D.2
  • 11
    • 36849066949 scopus 로고    scopus 로고
    • Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants
    • Ellingrod VL, Miller del D, Taylor SF, Moline J, Holman T, Kerr J. 2008. Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants. Schizophr Res 98:47-54.
    • (2008) Schizophr Res , vol.98 , pp. 47-54
    • Ellingrod, V.L.1    Miller del, D.2    Taylor, S.F.3    Moline, J.4    Holman, T.5    Kerr, J.6
  • 13
    • 67650479568 scopus 로고    scopus 로고
    • Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study
    • Feng LG, Song ZW, Xin F, Hu J. 2009. Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study. Psychiatry Res 168:205-208.
    • (2009) Psychiatry Res , vol.168 , pp. 205-208
    • Feng, L.G.1    Song, Z.W.2    Xin, F.3    Hu, J.4
  • 14
    • 0345059817 scopus 로고    scopus 로고
    • Can meta-analysis be trusted?
    • Field AP. 2001. Can meta-analysis be trusted? Psychologist 16:642-645.
    • (2001) Psychologist , vol.16 , pp. 642-645
    • Field, A.P.1
  • 16
    • 33845887461 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: A HuGE review
    • Gilbody S, Lewis S, Lightfoot T. 2007. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: A HuGE review. Am J Epidemiol 165:1-13.
    • (2007) Am J Epidemiol , vol.165 , pp. 1-13
    • Gilbody, S.1    Lewis, S.2    Lightfoot, T.3
  • 18
    • 0035057410 scopus 로고    scopus 로고
    • C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: Incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease
    • Hanson NQ, Aras O, Yang F, Tsai MY. 2001. C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: Incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease. Clin Chem 47:661-666.
    • (2001) Clin Chem , vol.47 , pp. 661-666
    • Hanson, N.Q.1    Aras, O.2    Yang, F.3    Tsai, M.Y.4
  • 22
    • 0034061368 scopus 로고    scopus 로고
    • Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis
    • Isotalo PA, Donnelly JG. 2000. Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis. Mol Diagn 5:59-66.
    • (2000) Mol Diagn , vol.5 , pp. 59-66
    • Isotalo, P.A.1    Donnelly, J.G.2
  • 23
    • 0033794925 scopus 로고    scopus 로고
    • Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: An examination of C677T and A1298C mutations
    • Isotalo PA, Wells GA, Donnelly JG. 2000. Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: An examination of C677T and A1298C mutations. Am J Hum Genet 67:986-990.
    • (2000) Am J Hum Genet , vol.67 , pp. 986-990
    • Isotalo, P.A.1    Wells, G.A.2    Donnelly, J.G.3
  • 24
    • 0024506702 scopus 로고
    • The spectrum of structural brain changes in schizophrenia: Age of onset as a predictor of cognitive and clinical impairments and their cerebral correlates
    • Johnstone EC, Owens DG, Bydder GM, Colter N, Crow TJ, Frith CD. 1989. The spectrum of structural brain changes in schizophrenia: Age of onset as a predictor of cognitive and clinical impairments and their cerebral correlates. Psychol Med 19:91-103.
    • (1989) Psychol Med , vol.19 , pp. 91-103
    • Johnstone, E.C.1    Owens, D.G.2    Bydder, G.M.3    Colter, N.4    Crow, T.J.5    Frith, C.D.6
  • 28
    • 33846551159 scopus 로고    scopus 로고
    • Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia
    • Kempisty B, Bober A, Luczak M, Czerski P, Szczepankiewicz A, Hauser J, Jagodzinski PP. 2007. Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia. Eur Psychiatry 22:39-43.
    • (2007) Eur Psychiatry , vol.22 , pp. 39-43
    • Kempisty, B.1    Bober, A.2    Luczak, M.3    Czerski, P.4    Szczepankiewicz, A.5    Hauser, J.6    Jagodzinski, P.P.7
  • 32
    • 33745476473 scopus 로고    scopus 로고
    • Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients
    • Lee YS, Han DH, Jeon CM, Lyoo IK, Na C, Chae SL, Cho SC. 2006. Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients. Neuroreport 17:743-746.
    • (2006) Neuroreport , vol.17 , pp. 743-746
    • Lee, Y.S.1    Han, D.H.2    Jeon, C.M.3    Lyoo, I.K.4    Na, C.5    Chae, S.L.6    Cho, S.C.7
  • 34
    • 17744388125 scopus 로고    scopus 로고
    • A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk
    • Lewis SJ, Zammit S, Gunnell D, Smith GD. 2005. A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk. Am J Med Genet Part B 135B:2-4.
    • (2005) Am J Med Genet Part B , vol.135 B , pp. 2-4
    • Lewis, S.J.1    Zammit, S.2    Gunnell, D.3    Smith, G.D.4
  • 35
    • 0034808335 scopus 로고    scopus 로고
    • A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk
    • Lievers KJ, Boers GH, Verhoef P, den Heijer M, Kluijtmans LA, van der Put NM, Trijbels FJ, Blom HJ. 2001. A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk. J Mol Med 79:522-528.
    • (2001) J Mol Med , vol.79 , pp. 522-528
    • Lievers, K.J.1    Boers, G.H.2    Verhoef, P.3    den Heijer, M.4    Kluijtmans, L.A.5    van der Put, N.M.6    Trijbels, F.J.7    Blom, H.J.8
  • 37
    • 0142188577 scopus 로고    scopus 로고
    • Homocysteine metabolism and B-vitamins in schizophrenic patients: Low plasma folate as a possible independent risk factor for schizophrenia
    • Muntjewerff JW, van der Put N, Eskes T, Ellenbroek B, Steegers E, Blom H, Zitman F. 2003. Homocysteine metabolism and B-vitamins in schizophrenic patients: Low plasma folate as a possible independent risk factor for schizophrenia. Psychiatry Res 121:1-9.
    • (2003) Psychiatry Res , vol.121 , pp. 1-9
    • Muntjewerff, J.W.1    van der Put, N.2    Eskes, T.3    Ellenbroek, B.4    Steegers, E.5    Blom, H.6    Zitman, F.7
  • 38
    • 17744400085 scopus 로고    scopus 로고
    • Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: A Dutch population based case-control study
    • Muntjewerff JW, Hoogendoorn ML, Kahn RS, Sinke RJ, Den Heijer M, Kluijtmans LA, Blom HJ. 2005. Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: A Dutch population based case-control study. Am J Med Genet Part B 135B:69-72.
    • (2005) Am J Med Genet Part B , vol.135 B , pp. 69-72
    • Muntjewerff, J.W.1    Hoogendoorn, M.L.2    Kahn, R.S.3    Sinke, R.J.4    Den Heijer, M.5    Kluijtmans, L.A.6    Blom, H.J.7
  • 39
    • 31544442693 scopus 로고    scopus 로고
    • Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: A meta-analysis
    • Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M. 2006. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: A meta-analysis. Mol Psychiatry 11:143-149.
    • (2006) Mol Psychiatry , vol.11 , pp. 143-149
    • Muntjewerff, J.W.1    Kahn, R.S.2    Blom, H.J.3    den Heijer, M.4
  • 44
    • 70349895262 scopus 로고    scopus 로고
    • Age at onset and cognition in schizophrenia: Meta-analysis
    • Rajji TK, Ismail Z, Mulsant BH. 2009. Age at onset and cognition in schizophrenia: Meta-analysis. Br J Psychiatry 195:286-293.
    • (2009) Br J Psychiatry , vol.195 , pp. 286-293
    • Rajji, T.K.1    Ismail, Z.2    Mulsant, B.H.3
  • 45
    • 0025456715 scopus 로고
    • Structural brain abnormalities in the major psychoses: A quantitative review of the evidence from computerized imaging
    • Raz S, Raz N. 1990. Structural brain abnormalities in the major psychoses: A quantitative review of the evidence from computerized imaging. Psychol Bull 108:93-108.
    • (1990) Psychol Bull , vol.108 , pp. 93-108
    • Raz, S.1    Raz, N.2
  • 51
    • 0003759539 scopus 로고
    • Meta-analytic procedures for social research
    • Newbury Park, CA: Sage.
    • Rosenthal R. 1991. Meta-analytic procedures for social research. Newbury Park, CA: Sage.
    • (1991)
    • Rosenthal, R.1
  • 52
    • 0036223658 scopus 로고    scopus 로고
    • Homocysteine and methylenetetrahydrofolate reductase genotype: Association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters
    • Rothenbacher D, Fischer HG, Hoffmeister A, Hoffmann MM, Marz W, Bode G, Rosenthal J, Koenig W, Brenner H. 2002. Homocysteine and methylenetetrahydrofolate reductase genotype: Association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters. Atherosclerosis 162:193-200.
    • (2002) Atherosclerosis , vol.162 , pp. 193-200
    • Rothenbacher, D.1    Fischer, H.G.2    Hoffmeister, A.3    Hoffmann, M.M.4    Marz, W.5    Bode, G.6    Rosenthal, J.7    Koenig, W.8    Brenner, H.9
  • 53
    • 0141448781 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia
    • Sazci A, Ergul E, Guzelhan Y, Kaya G, Kara I. 2003. Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia. Brain Res Mol Brain Res 117:104-107.
    • (2003) Brain Res Mol Brain Res , vol.117 , pp. 104-107
    • Sazci, A.1    Ergul, E.2    Guzelhan, Y.3    Kaya, G.4    Kara, I.5
  • 54
    • 25644431912 scopus 로고    scopus 로고
    • Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: Association is significant in men but not in women
    • Sazci A, Ergul E, Kucukali I, Kara I, Kaya G. 2005. Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene with schizophrenia: Association is significant in men but not in women. Prog Neuropsychopharmacol Biol Psychiatry 29:1113-1123.
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , pp. 1113-1123
    • Sazci, A.1    Ergul, E.2    Kucukali, I.3    Kara, I.4    Kaya, G.5
  • 55
    • 0034894325 scopus 로고    scopus 로고
    • Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: A case-control study
    • Shen H, Spitz MR, Wang LE, Hong WK, Wei Q. 2001. Polymorphisms of methylene-tetrahydrofolate reductase and risk of lung cancer: A case-control study. Cancer Epidemiol Biomarkers Prev 10:397-401.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 397-401
    • Shen, H.1    Spitz, M.R.2    Wang, L.E.3    Hong, W.K.4    Wei, Q.5
  • 56
    • 50249135384 scopus 로고    scopus 로고
    • Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes
    • Shi J, Gershon ES, Liu C. 2008. Genetic associations with schizophrenia: Meta-analyses of 12 candidate genes. Schizophr Res 104:96-107.
    • (2008) Schizophr Res , vol.104 , pp. 96-107
    • Shi, J.1    Gershon, E.S.2    Liu, C.3
  • 58
    • 0033607241 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults
    • Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G. 1999. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 96:12810-12815.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12810-12815
    • Skibola, C.F.1    Smith, M.T.2    Kane, E.3    Roman, E.4    Rollinson, S.5    Cartwright, R.A.6    Morgan, G.7
  • 59
    • 0035870245 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population
    • Song C, Xing D, Tan W, Wei Q, Lin D. 2001. Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a Chinese population. Cancer Res 61:3272-3275.
    • (2001) Cancer Res , vol.61 , pp. 3272-3275
    • Song, C.1    Xing, D.2    Tan, W.3    Wei, Q.4    Lin, D.5
  • 62
    • 11144222668 scopus 로고    scopus 로고
    • Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders
    • Tan EC, Chong SA, Lim LC, Chan AO, Teo YY, Tan CH, Mahendran R. 2004. Genetic analysis of the thermolabile methylenetetrahydrofolate reductase variant in schizophrenia and mood disorders. Psychiatr Genet 14:227-231.
    • (2004) Psychiatr Genet , vol.14 , pp. 227-231
    • Tan, E.C.1    Chong, S.A.2    Lim, L.C.3    Chan, A.O.4    Teo, Y.Y.5    Tan, C.H.6    Mahendran, R.7
  • 66
    • 0033551550 scopus 로고    scopus 로고
    • Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: Lack of association with schizophrenia
    • Virgos C, Martorell L, Simo JM, Valero J, Figuera L, Joven J, Labad A, Vilella E. 1999. Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: Lack of association with schizophrenia. Neuroreport 10:2035-2038.
    • (1999) Neuroreport , vol.10 , pp. 2035-2038
    • Virgos, C.1    Martorell, L.2    Simo, J.M.3    Valero, J.4    Figuera, L.5    Joven, J.6    Labad, A.7    Vilella, E.8
  • 67
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. 1998. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169-172.
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 71
    • 33746792898 scopus 로고    scopus 로고
    • C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: A meta-analysis of genetic association studies
    • Zintzaras E. 2006. C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: A meta-analysis of genetic association studies. Psychiatr Genet 16:105-115.
    • (2006) Psychiatr Genet , vol.16 , pp. 105-115
    • Zintzaras, E.1


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