Genetic and environmental influences on plasma homocysteine: Results from a Danish twin study

Clinical Chemistry

Volumn 53, Issue 5, 2007, Pages 971-979

  Bathum, Lise ^a,b   Petersen, Inge ^b   Christiansen, Lene ^a,b   Konieczna, Agnieszka ^a   Sørensen, Thorkild I A ^c   Kyvik, Kirsten O ^b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c The Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE; METHIONINE SYNTHASE;

ADULT; AGED; ARTICLE; BIOMETRY; BLOOD LEVEL; COHORT ANALYSIS; CONFIDENCE INTERVAL; DATA ANALYSIS; ENVIRONMENTAL FACTOR; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; GENOTYPE; HERITABILITY; HUMAN; MALE; NUCLEOTIDE SEQUENCE; QUANTITATIVE GENETICS; REGISTER; SINGLE NUCLEOTIDE POLYMORPHISM; TWIN PREGNANCY;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADOLESCENT; ADULT; AGE FACTORS; ENVIRONMENT; FEMALE; GENETIC MARKERS; GENOTYPE; HOMOCYSTEINE; HUMANS; LINKAGE (GENETICS); MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; NICOTINAMIDE N-METHYLTRANSFERASE; POLYMORPHISM, GENETIC; SEX FACTORS; TWINS;

EID: 34248340354     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2006.082149     Document Type: Article

References (31)

1. Gueant-Rodriguez RM, Juilliere Y, Candito M, Adjalla CE, Gibelin P, Herbeth B, et al. Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thromb Haemost 2005;94:510-5.
2. Cronin S, Furie KL, Kelly PJ. Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Stroke 2005;36:1581-7.
3. Morris MS, Jacques PF, Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone 2005;37:234-42.
4. Troen A, Rosenberg I. Homocysteine and cognitive function. Semin Vasc Med 2005;5:209-14.
5. Nurk E, Refsum H, Tell GS, Engedal K, Vollset SE, Ueland PM, et al. Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol 2005;58:847-57.
6. Bostom AG, Silbershatz H, Rosenberg IH, Selhub J, D'Agostino RB, Wolf PA, et al. Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women. Arch Intern Med 1999;159:1077-80.
7. Vollset S, Refsum H, Tverdal A, Nygård O, Nordrehaug J, Tell GS, et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study. Am J Clin Nutr 2001;74:130-6.
8. Kluijtmans LA, Young I, Boreham C, Murray L, McMaster D, McNulty H, et al. Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003;101:2483-8.
9. Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, et al. The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr 2006;136:1731S-40S.
10. Gellekink H, den Heijer M, Heil SG, Blom HJ. Genetic determinants of plasma total homocysteine. Semin Vasc Med 2005;5:98-109.
11. Reed T, Malinow M, Chistian J, Upson B. Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins. Clin Genet 1991;39:425-8.
12. Cesari M, Burlina AB, Narkiewicz K, Sartori MT, Sacchetto A, Rossi GP. Are fasting plasma homocyst(e)ine levels heritable? A study of normotensive twins. J Investig Med 2000;48:351-8.
13. Vermeulen SH, van der Vleuten GM, de Graff J, Hermus AR, Blom HJ, Stalenhoef AF, et al. A genome-wide linkage scan for homocysteine levels suggests three regions of interest. J Thromb Haemost 2006;4:1303-7.
14. de Bree A, Verschuren WM, Bjorke-Monsen AL, van der Put NM, Heil SG, Trijbels FJ, et al. Effect of the methylenetetrahydrofolate reductase 677C->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr 2003;77:687-93.
15. Beyer K, Lao JI, Latorre P, Riutort N, Matute B, Fernandez-Figueras MT, et al. Methionine synthase polymorphism is a risk factor for Alzheimer disease. Neuroreport 2003;14:1391-4.
16. Souto JC, Blanco-Vaca F, Soria JM, Buil A, Almasy L, Ordonez-Llanos J, et al. A genomewide exploration suggests a new candidate gene at chromosome 11q23 as the major determinant of plasma homocysteine levels: results from the GAIT project. Am J Hum Genet 2005;76:925-33.
17. Skytthe A, Kyvik KO, Holm N, Vaupel JW, Christensen K. The Danish twin registry: 127 cohorts of twins. Twin Research 2002;5:352-7.
18. Schousboe K, Visscher PM, Henriksen JE, Hopper JL, Sorensen TI, Kyvik KO. Twin study of genetic and environmental influences on glucose tolerance and indices of insulin sensitivity and secretion. Diabetologia 2003;46:1276-83.
19. Bathum L, Hjelmborg JvB, Christiansen L, McGue M, Jeune B, Christensen K. Methylenetetrahydrofolate reductase 677C>T and methionine syntase 2756A>G mutations: no impact on survival, cognitive functioning or cognitive decline in nonagenarians. J Gerontol A Biol Sci Med Sci 2007;62:196-201.
20. Neale MC. Mx:Statistical Modeling, 3rd ed. Box 980126 MCV, Richmond VA 23298 1998.
21. Akaike H. Factor analysis and AIC. Psychometrika 1987;52:317-32.
22. Beekman M, Posthuma D, Heijmans BT, Lakenberg N, Suchiman HE, Snieder H, et al. Combined association and linkage analysis applied to the APOE locus. Genet Epidemiol 2004;26:328-37.
23. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002;30:97-101.
24. Fulker DW, Cherny SS, Sham PC, Hewitt JK. Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 1999;64:259-67.
25. Posthuma D, de Geus EJ, Boomsma DI, Neale MC. Combined linkage and association tests in mx. Behav Genet 2004;34:179-96.
26. Nygard O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998;67:263-70.
27. Sassi S, Cosmi B, Palareti G, Legnani C, Grossi G, Musolesi S, et al. Influence of age, sex and vitamin status on fasting and post-methionine load plasma homocysteine levels. Haematologica 2002;87:957-64.
28. Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004;291:565-75.
29. den Heijer M, Willems HP, Blom HJ, Gerrits WB, Cattaneo M, Eichinger S, et al. Homocysteine lowering by B vitamins and the secondary prevention of deep-vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial. Blood 2007;109:139-44.
30. Spence JD, Bang H, Chambless LE, Stampfer MJ. Vitamin Intervention for Stroke Prevention Trial. An efficacy analysis. Stroke 2005;36:2404-9.
31. Lewis SJ, Ebrahim S, Davey SG. Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ 2005;331:1053.