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Volumn 175, Issue 1-2, 2010, Pages 47-53

Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: Implications for altered one-carbon metabolism

Author keywords

Cortisol; Docosahexaenoic acid; Folic acid; Homocysteine; Schizophrenia; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; DOCOSAHEXAENOIC ACID; FOLIC ACID; HOMOCYSTEINE; HYDROCORTISONE;

EID: 72049102379     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2009.01.013     Document Type: Article
Times cited : (164)

References (75)
  • 5
    • 0037783989 scopus 로고    scopus 로고
    • Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia
    • Arvindakshan M., Ghate M., Ranjekar P.K., Evans D.R., and Mahadik S.P. Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophrenia Research 62 (2003) 195-204
    • (2003) Schizophrenia Research , vol.62 , pp. 195-204
    • Arvindakshan, M.1    Ghate, M.2    Ranjekar, P.K.3    Evans, D.R.4    Mahadik, S.P.5
  • 6
    • 0035869237 scopus 로고    scopus 로고
    • Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group
    • Assies J., Lieverse R., Vreken P., Wanders R.J., Dingemans P.M., and Linszen D.H. Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group. Biological Psychiatry 49 (2001) 510-522
    • (2001) Biological Psychiatry , vol.49 , pp. 510-522
    • Assies, J.1    Lieverse, R.2    Vreken, P.3    Wanders, R.J.4    Dingemans, P.M.5    Linszen, D.H.6
  • 7
    • 34347335713 scopus 로고    scopus 로고
    • Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease
    • Boldyrev A.A., and Johnson P. Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease. Journal of Alzheimer's Disease 11 (2007) 219-228
    • (2007) Journal of Alzheimer's Disease , vol.11 , pp. 219-228
    • Boldyrev, A.A.1    Johnson, P.2
  • 8
    • 43049104493 scopus 로고    scopus 로고
    • No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients
    • Bromberg A., Levine J., Nemetz B., Belmaker R.H., and Agam G. No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients. Schizophrenia Research 101 1-3 (2008) 50-57
    • (2008) Schizophrenia Research , vol.101 , Issue.1-3 , pp. 50-57
    • Bromberg, A.1    Levine, J.2    Nemetz, B.3    Belmaker, R.H.4    Agam, G.5
  • 13
    • 0034703861 scopus 로고    scopus 로고
    • Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia
    • Devlin A.M., Ling E.H., Peerson J.M., Clarke R., Smith A.D., and Halsted C.H. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Human Molecular Genetics 9 (2000) 2837-2844
    • (2000) Human Molecular Genetics , vol.9 , pp. 2837-2844
    • Devlin, A.M.1    Ling, E.H.2    Peerson, J.M.3    Clarke, R.4    Smith, A.D.5    Halsted, C.H.6
  • 15
    • 34547768323 scopus 로고    scopus 로고
    • The role of one-carbon metabolism in schizophrenia and depression
    • Frankenburg F.R. The role of one-carbon metabolism in schizophrenia and depression. Harvard Revews in Psychiatry 15 (2007) 146-160
    • (2007) Harvard Revews in Psychiatry , vol.15 , pp. 146-160
    • Frankenburg, F.R.1
  • 22
    • 37049002256 scopus 로고    scopus 로고
    • Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients
    • Kale A., Joshi S., Naphade N., Sapkale S., Raju M.S.V.K., Pillai A., Nasrallah H., and Mahadik S. Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. Schizophrenia Research 98 (2008) 295-301
    • (2008) Schizophrenia Research , vol.98 , pp. 295-301
    • Kale, A.1    Joshi, S.2    Naphade, N.3    Sapkale, S.4    Raju, M.S.V.K.5    Pillai, A.6    Nasrallah, H.7    Mahadik, S.8
  • 23
    • 0023606101 scopus 로고
    • The Positive and Negative Syndrome Scale (PANSS) for schizophrenia
    • Kay S., Fiszbein A., and Opler L.A. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13 (1987) 261-275
    • (1987) Schizophrenia Bulletin , vol.13 , pp. 261-275
    • Kay, S.1    Fiszbein, A.2    Opler, L.A.3
  • 25
    • 0036842383 scopus 로고    scopus 로고
    • Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics
    • Khan M.M., Evans D.R., Gunna V., Scheffer R.E., Parikh V.V., and Mahadik S.P. Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics. Schizophrenia Research 58 (2002) 1-10
    • (2002) Schizophrenia Research , vol.58 , pp. 1-10
    • Khan, M.M.1    Evans, D.R.2    Gunna, V.3    Scheffer, R.E.4    Parikh, V.V.5    Mahadik, S.P.6
  • 26
    • 0019119493 scopus 로고
    • An immunoassay for plasma cortisol based on chemiluminescence
    • Kohen F., Pazzagli M., Kim J.B., and Lindner H.R. An immunoassay for plasma cortisol based on chemiluminescence. Steroids 36 (1980) 421-437
    • (1980) Steroids , vol.36 , pp. 421-437
    • Kohen, F.1    Pazzagli, M.2    Kim, J.B.3    Lindner, H.R.4
  • 27
    • 0034980155 scopus 로고    scopus 로고
    • Schizophrenia and liver dysfunction
    • Krøll J. Schizophrenia and liver dysfunction. Medical Hypotheses 56 (2001) 634-636
    • (2001) Medical Hypotheses , vol.56 , pp. 634-636
    • Krøll, J.1
  • 28
    • 34548299108 scopus 로고    scopus 로고
    • Schizophrenia and Liver Dysfunction Caused by Portacaval Shunting
    • Krøll J. Schizophrenia and Liver Dysfunction Caused by Portacaval Shunting. Current Psychiatry Reviews 8 (2007) 205-212
    • (2007) Current Psychiatry Reviews , vol.8 , pp. 205-212
    • Krøll, J.1
  • 33
    • 34748873413 scopus 로고    scopus 로고
    • Phospholipids in schizophrenia
    • Lieberman J.A., Stroup T.S., and Perkins D.O. (Eds), American Psychiatric Publishing, Washington, DC
    • Mahadik S.P., and Yao J.K. Phospholipids in schizophrenia. In: Lieberman J.A., Stroup T.S., and Perkins D.O. (Eds). Textbook of Schizophrenia (2006), American Psychiatric Publishing, Washington, DC 117-135
    • (2006) Textbook of Schizophrenia , pp. 117-135
    • Mahadik, S.P.1    Yao, J.K.2
  • 34
    • 0000925013 scopus 로고    scopus 로고
    • Membrane peroxidation and the neuropathology of schizophrenia
    • Peet M., Glen I., and Horrobin D. (Eds), Marius Press, Lancashire, UK
    • Mahadik S.P., Sitasawad V., and Mulchandani M. Membrane peroxidation and the neuropathology of schizophrenia. In: Peet M., Glen I., and Horrobin D. (Eds). Phospholipid Spectrum Disorders in Psychiatry (1999), Marius Press, Lancashire, UK 99-111
    • (1999) Phospholipid Spectrum Disorders in Psychiatry , pp. 99-111
    • Mahadik, S.P.1    Sitasawad, V.2    Mulchandani, M.3
  • 35
    • 0001850776 scopus 로고    scopus 로고
    • Cultural and socioeconomic differences in dietary intake of essential fatty acids and antioxidants: effects on the outcome
    • Horrobin D., Glen A.L., and Peet M. (Eds), Marius Press, Carnforth, UK
    • Mahadik S.P., Mulchandani M., Hegde M.V., and Ranjekar P.K. Cultural and socioeconomic differences in dietary intake of essential fatty acids and antioxidants: effects on the outcome. In: Horrobin D., Glen A.L., and Peet M. (Eds). Phospholipid Spectrum Psychiatric Disorders (1999), Marius Press, Carnforth, UK 167-179
    • (1999) Phospholipid Spectrum Psychiatric Disorders , pp. 167-179
    • Mahadik, S.P.1    Mulchandani, M.2    Hegde, M.V.3    Ranjekar, P.K.4
  • 36
    • 0035033906 scopus 로고    scopus 로고
    • Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia
    • Mahadik S.P., Evans D., and Lal H. Oxidative stress and role of antioxidant and omega-3 essential fatty acid supplementation in schizophrenia. Progress in Neuro-psychopharmacology and Biological Psychiatry 25 (2001) 463-493
    • (2001) Progress in Neuro-psychopharmacology and Biological Psychiatry , vol.25 , pp. 463-493
    • Mahadik, S.P.1    Evans, D.2    Lal, H.3
  • 37
    • 0021043946 scopus 로고
    • Fatty acids in plasma and red cell membranes
    • Manku M.S., Horrobin D.F., Huang S., and Morse N. Fatty acids in plasma and red cell membranes. Lipids 18 (1983) 906-908
    • (1983) Lipids , vol.18 , pp. 906-908
    • Manku, M.S.1    Horrobin, D.F.2    Huang, S.3    Morse, N.4
  • 38
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • Mattson M.P., and Shea T.B. Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends in Neuroscience 26 (2003) 137-146
    • (2003) Trends in Neuroscience , vol.26 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 39
    • 33847314119 scopus 로고    scopus 로고
    • Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications
    • McNamara R.K., Jandacek R., Rider T., Tso P., Hahn C.G., Richtand N.M., and Stanford K.E. Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. Schizophrenia Research 91 (2007) 37-50
    • (2007) Schizophrenia Research , vol.91 , pp. 37-50
    • McNamara, R.K.1    Jandacek, R.2    Rider, T.3    Tso, P.4    Hahn, C.G.5    Richtand, N.M.6    Stanford, K.E.7
  • 40
    • 12344284589 scopus 로고    scopus 로고
    • Plasma folate and homocysteine levels may be related to interictal "schizophrenia-like" psychosis in patients with epilepsy
    • Monji A., Yanagimoto K., Maekawa T., Sumida Y., Yamazaki K., and Kojima K. Plasma folate and homocysteine levels may be related to interictal "schizophrenia-like" psychosis in patients with epilepsy. Journal of Clinical Psychopharmacology 25 (2005) 3-5
    • (2005) Journal of Clinical Psychopharmacology , vol.25 , pp. 3-5
    • Monji, A.1    Yanagimoto, K.2    Maekawa, T.3    Sumida, Y.4    Yamazaki, K.5    Kojima, K.6
  • 42
    • 0142188577 scopus 로고    scopus 로고
    • Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia
    • Muntjewerff J.W., van der Put N., Eskes T., Ellenbroek B., Steegers E., Blom H., and Zitman F. Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia. Psychiatry Research 121 (2003) 1-9
    • (2003) Psychiatry Research , vol.121 , pp. 1-9
    • Muntjewerff, J.W.1    van der Put, N.2    Eskes, T.3    Ellenbroek, B.4    Steegers, E.5    Blom, H.6    Zitman, F.7
  • 45
    • 26444447578 scopus 로고    scopus 로고
    • Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia?
    • Picker J.D., and Coyle J.T. Do maternal folate and homocysteine levels play a role in neurodevelopmental processes that increase risk for schizophrenia?. Harvard Reviews in Psychiatry 13 (2005) 197-205
    • (2005) Harvard Reviews in Psychiatry , vol.13 , pp. 197-205
    • Picker, J.D.1    Coyle, J.T.2
  • 46
    • 0033831799 scopus 로고    scopus 로고
    • Folate administration increases n-3 polyunsaturated fatty acids in rat plasma and tissue lipids
    • Pita M.L., and Delgado M.J. Folate administration increases n-3 polyunsaturated fatty acids in rat plasma and tissue lipids. Thrombosis and Haemostasis 84 (2000) 420-423
    • (2000) Thrombosis and Haemostasis , vol.84 , pp. 420-423
    • Pita, M.L.1    Delgado, M.J.2
  • 49
    • 33646470470 scopus 로고    scopus 로고
    • Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring
    • Rao S., Joshi S., Kale A., Hegde M., and Mahadik S. Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring. Metabolism: Clinical and Experimental 55 (2006) 628-634
    • (2006) Metabolism: Clinical and Experimental , vol.55 , pp. 628-634
    • Rao, S.1    Joshi, S.2    Kale, A.3    Hegde, M.4    Mahadik, S.5
  • 51
    • 25644439046 scopus 로고    scopus 로고
    • Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses
    • Reif A., Pfuhlmann B., and Lesch K.P. Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses. Progress in Neuro-psychopharmacol Biological Psychiatry 29 (2005) 1162-1168
    • (2005) Progress in Neuro-psychopharmacol Biological Psychiatry , vol.29 , pp. 1162-1168
    • Reif, A.1    Pfuhlmann, B.2    Lesch, K.P.3
  • 53
    • 21244462690 scopus 로고    scopus 로고
    • Transcranial magnetic stimulation for the deficit syndrome of schizophrenia: a pilot investigation
    • Sachdev P., Loo C., Mitchell P., and Malhi G. Transcranial magnetic stimulation for the deficit syndrome of schizophrenia: a pilot investigation. Psychiatry and Clinical Neuroscience 59 (2005) 354-357
    • (2005) Psychiatry and Clinical Neuroscience , vol.59 , pp. 354-357
    • Sachdev, P.1    Loo, C.2    Mitchell, P.3    Malhi, G.4
  • 54
    • 9244234323 scopus 로고    scopus 로고
    • Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics
    • Sharma R.P. Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics. Schizophrenia Research 72 (2005) 79-90
    • (2005) Schizophrenia Research , vol.72 , pp. 79-90
    • Sharma, R.P.1
  • 55
    • 16844374541 scopus 로고    scopus 로고
    • The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia
    • Shoval G., and Weizman A. The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. European Neuropsychopharmacology 15 (2005) 319-329
    • (2005) European Neuropsychopharmacology , vol.15 , pp. 319-329
    • Shoval, G.1    Weizman, A.2
  • 57
    • 0019581668 scopus 로고
    • Highlights of the National Institutes of Health Program in Biomedical and Behavioral Nutrition and Research Training-with the emphasis on total parenteral and enteral nutrition
    • Simopoulos A.P. Highlights of the National Institutes of Health Program in Biomedical and Behavioral Nutrition and Research Training-with the emphasis on total parenteral and enteral nutrition. American Journal of Clinical Nutrition 34 (1981) 1187-1190
    • (1981) American Journal of Clinical Nutrition , vol.34 , pp. 1187-1190
    • Simopoulos, A.P.1
  • 58
    • 0031917081 scopus 로고    scopus 로고
    • A prevalence study of folate deficiency in a psychiatric in-patient population
    • Skerritt U.M. A prevalence study of folate deficiency in a psychiatric in-patient population. Acta Psychiatrica Scandinavica 97 (1998) 228-232
    • (1998) Acta Psychiatrica Scandinavica , vol.97 , pp. 228-232
    • Skerritt, U.M.1
  • 59
    • 0342635164 scopus 로고
    • Recent advances in the biochemistry of schizophrenia
    • Smythies J.R. Recent advances in the biochemistry of schizophrenia. Guy's Gazette 14 (1966) 2-7
    • (1966) Guy's Gazette , vol.14 , pp. 2-7
    • Smythies, J.R.1
  • 60
    • 0021036077 scopus 로고
    • The transmethylation and one-carbon cycle hypotheses of schizophrenia
    • Smythies J.R. The transmethylation and one-carbon cycle hypotheses of schizophrenia. Psychological Medicine 13 (1983) 711-714
    • (1983) Psychological Medicine , vol.13 , pp. 711-714
    • Smythies, J.R.1
  • 61
    • 0031057859 scopus 로고    scopus 로고
    • Disturbances of one-carbon metabolism in neuropsychiatric disorders: a review
    • Smythies J.R., Gottfries C.G., and Regland B. Disturbances of one-carbon metabolism in neuropsychiatric disorders: a review. Biological Psychiatry 41 (1997) 230-233
    • (1997) Biological Psychiatry , vol.41 , pp. 230-233
    • Smythies, J.R.1    Gottfries, C.G.2    Regland, B.3
  • 62
    • 27644477064 scopus 로고    scopus 로고
    • Relationship between cognition and work functioning among patients with schizophrenia in an urban area of India
    • Srinivasan L., and Tirupati S. Relationship between cognition and work functioning among patients with schizophrenia in an urban area of India. Psychiatric Services 56 (2005) 1423-1428
    • (2005) Psychiatric Services , vol.56 , pp. 1423-1428
    • Srinivasan, L.1    Tirupati, S.2
  • 63
    • 16844374176 scopus 로고    scopus 로고
    • Nutritional and life style determinants of plasma homocysteine in schizophrenia patients
    • Stahl Z., Belmaker R.H., Friger M., and Levine J. Nutritional and life style determinants of plasma homocysteine in schizophrenia patients. European Neuropsychopharmacology 15 (2005) 291-295
    • (2005) European Neuropsychopharmacology , vol.15 , pp. 291-295
    • Stahl, Z.1    Belmaker, R.H.2    Friger, M.3    Levine, J.4
  • 65
    • 4544227485 scopus 로고    scopus 로고
    • Twenty-year course of schizophrenia: the Madras Longitudinal Study
    • Thara R. Twenty-year course of schizophrenia: the Madras Longitudinal Study. Canadian Journal of Psychiatry 49 (2004) 564-569
    • (2004) Canadian Journal of Psychiatry , vol.49 , pp. 564-569
    • Thara, R.1
  • 69
    • 0026762553 scopus 로고
    • Do essential fatty acids play a role in brain and behavioral development?
    • Wainwright P.E. Do essential fatty acids play a role in brain and behavioral development?. Neuroscience and Biobehavoral Reviews 16 (1992) 193-205
    • (1992) Neuroscience and Biobehavoral Reviews , vol.16 , pp. 193-205
    • Wainwright, P.E.1
  • 70
    • 0034672197 scopus 로고    scopus 로고
    • Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia
    • Walder D.J., Walker E.F., and Levine R.J. Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia. Biological Psychiatry 48 (2000) 1221-1231
    • (2000) Biological Psychiatry , vol.48 , pp. 1221-1231
    • Walder, D.J.1    Walker, E.F.2    Levine, R.J.3
  • 72
    • 0035054355 scopus 로고    scopus 로고
    • Oxidative damage and schizophrenia: an overview of the evidence and its therapeutic implications
    • Yao J.K., Reddy R.D., and van Kammen D.P. Oxidative damage and schizophrenia: an overview of the evidence and its therapeutic implications. CNS Drugs 15 (2001) 287-310
    • (2001) CNS Drugs , vol.15 , pp. 287-310
    • Yao, J.K.1    Reddy, R.D.2    van Kammen, D.P.3
  • 73
    • 0037108020 scopus 로고    scopus 로고
    • Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipids metabolites
    • Yao J.K., Stanley J.A., Reddy R.D., Keshavan M.S., and Pettegrew J.W. Correlations between peripheral polyunsaturated fatty acid content and in vivo membrane phospholipids metabolites. Biological Psychiatry 52 (2002) 823-830
    • (2002) Biological Psychiatry , vol.52 , pp. 823-830
    • Yao, J.K.1    Stanley, J.A.2    Reddy, R.D.3    Keshavan, M.S.4    Pettegrew, J.W.5
  • 74
  • 75
    • 0036157214 scopus 로고    scopus 로고
    • Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography
    • Zighetti M.L., Chantarangkul V., Tripodi A., Mannucci P.M., and Cattaneo M. Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography. Haematologica 87 (2002) 89-94
    • (2002) Haematologica , vol.87 , pp. 89-94
    • Zighetti, M.L.1    Chantarangkul, V.2    Tripodi, A.3    Mannucci, P.M.4    Cattaneo, M.5


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