MTHFR 677C → T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val → Met

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 45, 2008, Pages 17573-17578

  Roffman, Joshua L ^a   Gollu, Randy L ^a   Calhoun, Vince D ^b,c   Wassink, Thomas H ^d   Weiss, Anthony P ^a   Ho, Beng C ^d   White, Tonya ^e   Clark, Vincent P ^c,f   Fries, Jill ^c   Andreasen, Nancy C ^d   Goff, Donald C ^a   Manoach, Dara S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b University of New Mexico   (United States)

^c MIND RESEARCH NETWORK   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

^f UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Dopamine; Folate; Functional MRI; Genetics; Methylation

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CATECHOL METHYLTRANSFERASE; DOPAMINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ADULT; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULA; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; WORKING MEMORY; COMPARATIVE STUDY; GENETIC POLYMORPHISM; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; UNITED STATES;

CATECHOL O-METHYLTRANSFERASE; DOPAMINE; GENOTYPE; HUMANS; MAGNETIC RESONANCE IMAGING; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; PREFRONTAL CORTEX; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; UNITED STATES;

EID: 56249097252     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803727105     Document Type: Article

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