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Volumn 19, Issue 11, 2013, Pages 2282-2294

Therapeutic evaluation of ex vivo-generated versus natural regulatory t-cells in a mouse model of chronic gut inflammation

Author keywords

Crohn's disease; Cytokines; Foxp3; IL 17; IL 6; ITregs; T cells

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 35; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3;

EID: 84888246103     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e31829c32dd     Document Type: Article
Times cited : (19)

References (77)
  • 1
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474:307-317.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 2
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007;117:514-521.
    • (2007) J Clin Invest , vol.117 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 3
    • 70049098536 scopus 로고    scopus 로고
    • Regulatory T cells reinforce intestinal homeostasis
    • Barnes MJ, Powrie F. Regulatory T cells reinforce intestinal homeostasis. Immunity. 2009;31:401-411.
    • (2009) Immunity , vol.31 , pp. 401-411
    • Barnes, M.J.1    Powrie, F.2
  • 4
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140:1756-1767.
    • (2011) Gastroenterology , vol.140 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 5
    • 33746377279 scopus 로고    scopus 로고
    • Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
    • Izcue A, Coombes JL, Powrie F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev. 2006;212:256-271.
    • (2006) Immunol Rev , vol.212 , pp. 256-271
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 6
    • 33645075732 scopus 로고    scopus 로고
    • In vivo sites and cellular mechanisms of T reg cell-mediated suppression
    • Rudensky AY, Campbell DJ. In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med. 2006;203:489-492.
    • (2006) J Exp Med , vol.203 , pp. 489-492
    • Rudensky, A.Y.1    Campbell, D.J.2
  • 7
    • 33746342994 scopus 로고    scopus 로고
    • Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease
    • Sakaguchi S, Ono M, Setoguchi R, et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev. 2006;212:8-27.
    • (2006) Immunol Rev , vol.212 , pp. 8-27
    • Sakaguchi, S.1    Ono, M.2    Setoguchi, R.3
  • 8
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol. 2007;8:457-462.
    • (2007) Nat Immunol , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 9
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005; 22:329-341.
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3
  • 11
    • 36249022697 scopus 로고    scopus 로고
    • Competition for cytokines: T(reg) cells take all
    • Scheffold A, Murphy KM, Hofer T. Competition for cytokines: T(reg) cells take all. Nat Immunol. 2007;8:1285-1287.
    • (2007) Nat Immunol , vol.8 , pp. 1285-1287
    • Scheffold, A.1    Murphy, K.M.2    Hofer, T.3
  • 12
    • 33750375612 scopus 로고    scopus 로고
    • Characterization of Foxp3+CD4 +CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis
    • Uhlig HH, Coombes J, Mottet C, et al. Characterization of Foxp3+CD4 +CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol. 2006;177:5852-5860.
    • (2006) J Immunol , vol.177 , pp. 5852-5860
    • Uhlig, H.H.1    Coombes, J.2    Mottet, C.3
  • 14
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • Benson MJ, Pino-Lagos K, Rosemblatt M, et al. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med. 2007;204:1765-1774.
    • (2007) J Exp Med , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3
  • 15
    • 84876176361 scopus 로고    scopus 로고
    • Induced CD4(+)Foxp3(+) regulatory T cells in immune tolerance
    • Bilate AM, Lafaille JJ. Induced CD4(+)Foxp3(+) regulatory T cells in immune tolerance. Annu Rev Immunol. 2011.
    • (2011) Annu Rev Immunol
    • Bilate, A.M.1    Lafaille, J.J.2
  • 16
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+
    • Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+. J Exp Med. 2003;198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 17
    • 34548564632 scopus 로고    scopus 로고
    • In vitro generation of CD4+ CD25+ regulatory cells from murine naive T cells
    • Fantini MC, Dominitzki S, Rizzo A, et al. In vitro generation of CD4+ CD25+ regulatory cells from murine naive T cells. Nat Protoc. 2007;2: 1789-1794.
    • (2007) Nat Protoc , vol.2 , pp. 1789-1794
    • Fantini, M.C.1    Dominitzki, S.2    Rizzo, A.3
  • 18
    • 55549084247 scopus 로고    scopus 로고
    • Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    • Hill JA, Hall JA, Sun CM, et al. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity. 2008;29:758-770.
    • (2008) Immunity , vol.29 , pp. 758-770
    • Hill, J.A.1    Hall, J.A.2    Sun, C.M.3
  • 19
    • 35748934494 scopus 로고    scopus 로고
    • Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells
    • Kang SG, Lim HW, Andrisani OM, et al. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-3733.
    • (2007) J Immunol , vol.179 , pp. 3724-3733
    • Kang, S.G.1    Lim, H.W.2    Andrisani, O.M.3
  • 20
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007;204:1757-1764.
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3
  • 21
    • 51049092467 scopus 로고    scopus 로고
    • Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    • Jaensson E, Uronen-Hansson H, Pabst O, et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med. 2008;205:2139-2149.
    • (2008) J Exp Med , vol.205 , pp. 2139-2149
    • Jaensson, E.1    Uronen-Hansson, H.2    Pabst, O.3
  • 22
    • 84862777225 scopus 로고    scopus 로고
    • Extrathymically generated regulatory T cells control mucosal TH2 inflammation
    • Josefowicz SZ, Niec RE, Kim HY, et al. Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature. 2012;482: 395-399.
    • (2012) Nature , vol.482 , pp. 395-399
    • Josefowicz, S.Z.1    Niec, R.E.2    Kim, H.Y.3
  • 23
    • 0035284804 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10
    • Annacker O, Pimenta-Araujo R, Burlen-Defranoux O, et al. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol. 2001;166:3008-3018.
    • (2001) J Immunol , vol.166 , pp. 3008-3018
    • Annacker, O.1    Pimenta-Araujo, R.2    Burlen-Defranoux, O.3
  • 24
    • 20444414184 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis
    • Denning TL, Kim G, Kronenberg M. Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis. J Immunol. 2005;174:7487-7491.
    • (2005) J Immunol , vol.174 , pp. 7487-7491
    • Denning, T.L.1    Kim, G.2    Kronenberg, M.3
  • 25
    • 79251534981 scopus 로고    scopus 로고
    • CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cellinduced colitis
    • Endharti AT, Okuno Y, Shi Z, et al. CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cellinduced colitis. J Immunol. 2011;186:41-52.
    • (2011) J Immunol , vol.186 , pp. 41-52
    • Endharti, A.T.1    Okuno, Y.2    Shi, Z.3
  • 26
    • 33646251141 scopus 로고    scopus 로고
    • Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
    • Fantini MC, Becker C, Tubbe I, et al. Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut. 2006;55:671-680.
    • (2006) Gut , vol.55 , pp. 671-680
    • Fantini, M.C.1    Becker, C.2    Tubbe, I.3
  • 27
    • 0242412365 scopus 로고    scopus 로고
    • A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation
    • Foussat A, Cottrez F, Brun V, et al. A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation. J Immunol. 2003;171:5018-5026.
    • (2003) J Immunol , vol.171 , pp. 5018-5026
    • Foussat, A.1    Cottrez, F.2    Brun, V.3
  • 28
    • 79251543298 scopus 로고    scopus 로고
    • The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells
    • Fujimoto M, Nakano M, Terabe F, et al. The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells. J Immunol. 2011;186:32-40.
    • (2011) J Immunol , vol.186 , pp. 32-40
    • Fujimoto, M.1    Nakano, M.2    Terabe, F.3
  • 29
    • 79959554060 scopus 로고    scopus 로고
    • Natural but not inducible regulatory T cells require TNF-{alpha} signaling for in vivo function
    • Housley WJ, Adams CO, Nichols FC, et al. Natural but not inducible regulatory T cells require TNF-{alpha} signaling for in vivo function. J Immunol. 2011.
    • (2011) J Immunol
    • Housley, W.J.1    Adams, C.O.2    Nichols, F.C.3
  • 30
    • 79952201845 scopus 로고    scopus 로고
    • Ex vivo generation of regulatory T cells: Characterization and therapeutic evaluation in a model of chronic colitis
    • Karlsson F, Robinson-Jackson SA, Gray L, et al. Ex vivo generation of regulatory T cells: characterization and therapeutic evaluation in a model of chronic colitis. Methods Mol Biol. 2011;677:47-61.
    • (2011) Methods Mol Biol , vol.677 , pp. 47-61
    • Karlsson, F.1    Robinson-Jackson, S.A.2    Gray, L.3
  • 31
    • 70249138405 scopus 로고    scopus 로고
    • SHIP regulates the reciprocal development of T regulatory and Th17 cells
    • Locke NR, Patterson SJ, Hamilton MJ, et al. SHIP regulates the reciprocal development of T regulatory and Th17 cells. J Immunol. 2009;183:975-983.
    • (2009) J Immunol , vol.183 , pp. 975-983
    • Locke, N.R.1    Patterson, S.J.2    Hamilton, M.J.3
  • 32
    • 67349179096 scopus 로고    scopus 로고
    • LFA-1 is critical for regulatory T cell homeostasis and function
    • Wohler J, Bullard D, Schoeb T, et al. LFA-1 is critical for regulatory T cell homeostasis and function. Mol Immunol. 2009;46:2424-2428.
    • (2009) Mol Immunol , vol.46 , pp. 2424-2428
    • Wohler, J.1    Bullard, D.2    Schoeb, T.3
  • 33
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007;450:566-569.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 34
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4 +CD25+ regulatory T cells
    • Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4 +CD25+ regulatory T cells. J Immunol. 2003;170:3939-3943.
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 35
    • 77957161848 scopus 로고    scopus 로고
    • A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2
    • Piconese S, Pittoni P, Burocchi A, et al. A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2. Eur J Immunol. 2010; 40:2902-2913.
    • (2010) Eur J Immunol , vol.40 , pp. 2902-2913
    • Piconese, S.1    Pittoni, P.2    Burocchi, A.3
  • 36
    • 59749087126 scopus 로고    scopus 로고
    • DC activated via dectin-1 convert Treg into IL-17 producers
    • Osorio F, LeibundGut-Landmann S, Lochner M, et al. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol. 2008;38: 3274-3281.
    • (2008) Eur J Immunol , vol.38 , pp. 3274-3281
    • Osorio, F.1    Leibundgut-Landmann, S.2    Lochner, M.3
  • 37
    • 34948883517 scopus 로고    scopus 로고
    • OX40 costimulation turns off Foxp3+ Tregs
    • Vu MD, Xiao X, Gao W, et al. OX40 costimulation turns off Foxp3+ Tregs. Blood. 2007;110:2501-2510.
    • (2007) Blood , vol.110 , pp. 2501-2510
    • Vu, M.D.1    Xiao, X.2    Gao, W.3
  • 38
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells induce CD4 +CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
    • Xu L, Kitani A, Fuss I, et al. Cutting edge: regulatory T cells induce CD4 +CD25-Foxp3-T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol. 2007;178:6725-6729.
    • (2007) J Immunol , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3
  • 39
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang XO, Nurieva R, Martinez GJ, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008;29:44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3
  • 40
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, Bailey-Bucktrout SL, Jeker LT, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009;10:1000-1007.
    • (2009) Nat Immunol , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 41
    • 77957371028 scopus 로고    scopus 로고
    • Stability of the regulatory T cell lineage in vivo
    • Rubtsov YP, Niec RE, Josefowicz S, et al. Stability of the regulatory T cell lineage in vivo. Science. 2010;329:1667-1671.
    • (2010) Science , vol.329 , pp. 1667-1671
    • Rubtsov, Y.P.1    Niec, R.E.2    Josefowicz, S.3
  • 42
    • 47249124078 scopus 로고    scopus 로고
    • Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities
    • Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev. 2008; 223:371-390.
    • (2008) Immunol Rev , vol.223 , pp. 371-390
    • Brusko, T.M.1    Putnam, A.L.2    Bluestone, J.A.3
  • 43
    • 79958814636 scopus 로고    scopus 로고
    • Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    • Hippen KL, Merkel SC, Schirm DK, et al. Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant. 2011;11:1148-1157.
    • (2011) Am J Transplant , vol.11 , pp. 1148-1157
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 44
    • 79956258982 scopus 로고    scopus 로고
    • Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    • Hippen KL, Merkel SC, Schirm DK, et al. Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity. Sci Transl Med. 2011;3:83ra41.
    • (2011) Sci Transl Med , vol.3
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 45
    • 33746369415 scopus 로고    scopus 로고
    • Regulatory T-cell physiology and application to treat autoimmunity
    • Tang Q, Bluestone JA. Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev. 2006;212:217-237.
    • (2006) Immunol Rev , vol.212 , pp. 217-237
    • Tang, Q.1    Bluestone, J.A.2
  • 46
    • 65449136307 scopus 로고    scopus 로고
    • A central role for induced regulatory T cells in tolerance induction in experimental colitis
    • Haribhai D, Lin W, Edwards B, et al. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol. 2009; 182:3461-3468.
    • (2009) J Immunol , vol.182 , pp. 3461-3468
    • Haribhai, D.1    Lin, W.2    Edwards, B.3
  • 47
    • 33644844649 scopus 로고    scopus 로고
    • Statistical analysis of real-time PCR data
    • Yuan JS, Reed A, Chen F, et al. Statistical analysis of real-time PCR data. BMC Bioinformatics. 2006;7:85.
    • (2006) BMC Bioinformatics , vol.7 , pp. 85
    • Yuan, J.S.1    Reed, A.2    Chen, F.3
  • 48
    • 59449094473 scopus 로고    scopus 로고
    • T cell transfer model of chronic colitis: Concepts, considerations, and tricks of the trade
    • Ostanin DV, Bao J, Koboziev I, et al. T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am J Physiol Gastrointest Liver Physiol. 2009;296:G135-G146.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Ostanin, D.V.1    Bao, J.2    Koboziev, I.3
  • 49
    • 34447544599 scopus 로고    scopus 로고
    • T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis
    • Ostanin DV, Furr KL, Pavlick KP, et al. T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1706-G1714.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Ostanin, D.V.1    Furr, K.L.2    Pavlick, K.P.3
  • 51
    • 79953873761 scopus 로고    scopus 로고
    • Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: Translating preclinical data into new drug therapies
    • Koboziev I, Karlsson F, Zhang S, et al. Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies. Inflamm Bowel Dis. 2011;17:1229-1245.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1229-1245
    • Koboziev, I.1    Karlsson, F.2    Zhang, S.3
  • 52
    • 84863011078 scopus 로고    scopus 로고
    • Induced Foxp3(+) regulatory T cells a potential new weapon to treat autoimmune and inflammatory diseases
    • Lan Q, Fan H, Quesniaux V, et al. Induced Foxp3(+) regulatory T cells: A potential new weapon to treat autoimmune and inflammatory diseases J Mol Cell Biol. 2012;4:22-28.
    • (2012) J Mol Cell Biol , vol.4 , pp. 22-28
    • Lan, Q.1    Fan, H.2    Quesniaux, V.3
  • 53
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton AM, Korty PE, Tran DQ, et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol. 2010;184: 3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3
  • 54
    • 84859123340 scopus 로고    scopus 로고
    • Phenotypic and functional properties of Helios+ regulatory T cells
    • Zabransky DJ, Nirschl CJ, Durham NM, et al. Phenotypic and functional properties of Helios+ regulatory T cells. PLoS One. 2012;7:e34547.
    • (2012) PLoS One , vol.7
    • Zabransky, D.J.1    Nirschl, C.J.2    Durham, N.M.3
  • 55
    • 33847376532 scopus 로고    scopus 로고
    • Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells
    • Garin MI, Chu CC, Golshayan D, et al. Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells. Blood. 2007;109:2058-2065.
    • (2007) Blood , vol.109 , pp. 2058-2065
    • Garin, M.I.1    Chu, C.C.2    Golshayan, D.3
  • 56
    • 73349115263 scopus 로고    scopus 로고
    • Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
    • Klunker S, Chong MM, Mantel PY, et al. Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. J Exp Med. 2009;206:2701-2715.
    • (2009) J Exp Med , vol.206 , pp. 2701-2715
    • Klunker, S.1    Chong, M.M.2    Mantel, P.Y.3
  • 57
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I, Lopes-Carvalho T, Ostler D, et al. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med. 2003;197:403-411.
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3
  • 58
    • 33750816452 scopus 로고    scopus 로고
    • CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes
    • Soler D, Chapman TR, Poisson LR, et al. CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol. 2006;177:6940-6951.
    • (2006) J Immunol , vol.177 , pp. 6940-6951
    • Soler, D.1    Chapman, T.R.2    Poisson, L.R.3
  • 59
    • 77951888705 scopus 로고    scopus 로고
    • Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit
    • DeNucci CC, Pagan AJ, Mitchell JS, et al. Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit. J Immunol. 2010;184:2458-2467.
    • (2010) J Immunol , vol.184 , pp. 2458-2467
    • Denucci, C.C.1    Pagan, A.J.2    Mitchell, J.S.3
  • 60
    • 33845917707 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover
    • Venturi GM, Conway RM, Steeber DA, et al. CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. J Immunol. 2007;178:291-300.
    • (2007) J Immunol , vol.178 , pp. 291-300
    • Venturi, G.M.1    Conway, R.M.2    Steeber, D.A.3
  • 61
    • 23244463009 scopus 로고    scopus 로고
    • Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis
    • Bagavant H, Tung KS. Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis. J Immunol. 2005; 175:944-950.
    • (2005) J Immunol , vol.175 , pp. 944-950
    • Bagavant, H.1    Tung, K.S.2
  • 62
    • 58849112222 scopus 로고    scopus 로고
    • Cutting edge: Antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease
    • Huter EN, Stummvoll GH, DiPaolo RJ, et al. Cutting edge: Antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease. J Immunol. 2008;181:8209-8213.
    • (2008) J Immunol , vol.181 , pp. 8209-8213
    • Huter, E.N.1    Stummvoll, G.H.2    Dipaolo, R.J.3
  • 63
    • 78049373227 scopus 로고    scopus 로고
    • Cutting edge: All-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu
    • Zhou X, Kong N, Wang J, et al. Cutting edge: All-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J Immunol. 2010;185:2675-2679.
    • (2010) J Immunol , vol.185 , pp. 2675-2679
    • Zhou, X.1    Kong, N.2    Wang, J.3
  • 64
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q, Henriksen KJ, Bi M, et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med. 2004;199: 1455-1465.
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3
  • 65
    • 84864424816 scopus 로고    scopus 로고
    • Antigen-specific transforming growth factor beta-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance
    • Kong N, Lan Q, Chen M, et al. Antigen-specific transforming growth factor beta-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum. 2012;64: 2548-2558.
    • (2012) Arthritis Rheum , vol.64 , pp. 2548-2558
    • Kong, N.1    Lan, Q.2    Chen, M.3
  • 66
    • 68949217711 scopus 로고    scopus 로고
    • Transforming growth factor-beta and all-trans retinoic acid generate ex vivo transgenic regulatory T cells with intestinal homing receptors
    • Moore C, Sauma D, Morales J, et al. Transforming growth factor-beta and all-trans retinoic acid generate ex vivo transgenic regulatory T cells with intestinal homing receptors. Transplant Proc. 2009;41:2670-2672.
    • (2009) Transplant Proc , vol.41 , pp. 2670-2672
    • Moore, C.1    Sauma, D.2    Morales, J.3
  • 67
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D, Park Y, Kim G, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science. 2007;317:256-260.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3
  • 68
    • 77954730539 scopus 로고    scopus 로고
    • Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine
    • Wang C, Kang SG, HogenEsch H, et al. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol. 2010;184:5519-5526.
    • (2010) J Immunol , vol.184 , pp. 5519-5526
    • Wang, C.1    Kang, S.G.2    Hogenesch, H.3
  • 69
    • 39649112192 scopus 로고    scopus 로고
    • Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids
    • Mora JR. Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids. Inflamm Bowel Dis. 2008;14:275-289.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 275-289
    • Mora, J.R.1
  • 70
    • 78649826858 scopus 로고    scopus 로고
    • CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype
    • Kitamura K, Farber JM, Kelsall BL. CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype. J Immunol. 2010;185:3295-3304.
    • (2010) J Immunol , vol.185 , pp. 3295-3304
    • Kitamura, K.1    Farber, J.M.2    Kelsall, B.L.3
  • 71
    • 79955931063 scopus 로고    scopus 로고
    • Role of the endothelium in inflammatory bowel diseases
    • Cromer WE, Mathis JM, Granger DN, et al. Role of the endothelium in inflammatory bowel diseases. World J Gastroenterol. 2011;17:578-593.
    • (2011) World J Gastroenterol , vol.17 , pp. 578-593
    • Cromer, W.E.1    Mathis, J.M.2    Granger, D.N.3
  • 73
    • 79954486763 scopus 로고    scopus 로고
    • Regulatory T cells and Foxp3
    • Rudensky AY. Regulatory T cells and Foxp3. Immunol Rev. 2011;241: 260-268.
    • (2011) Immunol Rev , vol.241 , pp. 260-268
    • Rudensky, A.Y.1
  • 74
    • 47249166438 scopus 로고    scopus 로고
    • Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
    • Zheng SG, Wang J, Horwitz DA. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J Immunol. 2008;180:7112-7116.
    • (2008) J Immunol , vol.180 , pp. 7112-7116
    • Zheng, S.G.1    Wang, J.2    Horwitz, D.A.3
  • 75
    • 79958021546 scopus 로고    scopus 로고
    • IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo
    • Chen Q, Kim YC, Laurence A, et al. IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol. 2011; 186:6329-6337.
    • (2011) J Immunol , vol.186 , pp. 6329-6337
    • Chen, Q.1    Kim, Y.C.2    Laurence, A.3
  • 76
    • 0029589620 scopus 로고
    • Apoptosis of T cells mediated by galectin-1
    • Perillo NL, Pace KE, Seilhamer JJ, et al. Apoptosis of T cells mediated by galectin-1. Nature. 1995;378:736-739.
    • (1995) Nature , vol.378 , pp. 736-739
    • Perillo, N.L.1    Pace, K.E.2    Seilhamer, J.J.3
  • 77
    • 67649794885 scopus 로고    scopus 로고
    • Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments
    • Rabinovich GA, Ilarregui JM. Conveying glycan information into T-cell homeostatic programs: A challenging role for galectin-1 in inflammatory and tumor microenvironments. Immunol Rev. 2009;230:144-159.
    • (2009) Immunol Rev , vol.230 , pp. 144-159
    • Rabinovich, G.A.1    Ilarregui, J.M.2


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